pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity by Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Thais Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Bianca Balbino, Camila Marques, Maura Rosane Valerio Ikoma, Ana Paula Masson, Célio Lopes Silva, Alexandrina Sartori

“…EAE has also been extensively employed to evaluate potentially therapeutic schemes. Considering the presence of an immune response directed to heat shock proteins (hsps) in autoimmune diseases and the immunoregulatory potential of these molecules, we evaluated the effect of a previous immunization with a genetic vaccine containing the mycobacterial hsp65 gene on EAE development. …”
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Undifferentiated Adipose Tissue Stem Cell Transplantation Promotes Hepatic Regeneration, Ameliorates Histopathologic Damage of the Liver, and Upregulates the Expression of Liver Re... by Konstantinos G. Apostolou, Ioannis G. Papanikolaou, Charalampos Katselis, Themistoklis Feretis, Dimitrios Kletsas, Manousos M. Konstadoulakis, Maria Lymperi, Angelica A. Saetta, Spiros Tsikalakis, George Agrogiannis, Efstratios Patsouris, George C. Zografos, Apostolos E. Papalois

“…Adipose tissue stem cells (ADSCs) present a promising therapeutic method to alleviate liver failure (LF). …”
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Diagnosis and Treatment of Postoperative Myocardial Infarction: A Retrospective Cohort Study on 600 Cardiac Surgery Patients by Saimir Kuci, Marsela Goga, Alfred Ibrahimi, Ervin Bejko, Stavri Llazo, Jonela Burimi, Esmerilda Bulku, Andi Kacani, Ermal Likaj, Ali Refatllari, Selman Dumani, Klodian Krakulli, Arber Aliu, Fjorba Mana, Devis Pellumbi, Aferdita Veseli, Edlira Rruci, Laureta Dibra, Arben Baboci, Edvin Prifti, Altin Veshti

“…The incidence, diagnosis, and management of PMI were evaluated, focusing on diagnostic methods, therapeutic interventions, and the role of intra-aortic balloon pumps (IABPs). …”
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Impaired insight in schizophrenia is associated with higher frontoparietal cerebral blood flow: an arterial spin labeling study by Jianmeng Song, Edgardo Carmona-Torres, Yasaman Kambari, Sofia Chavez, Fumihiko Ueno, Teruki Koizum, Aron Amaev, Ali Abdolizadeh, Vincenzo De Luca, Daniel M. Blumberger, Gary Remington, Bruce Pollock, Ariel Graff-Guerrero, Philip Gerretsen

“…These neuroimaging findings can serve as therapeutic targets for intervention, such as with non-invasive brain stimulation.…”
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Unravelling the Enigma of Highly Superior Autobiographical Memory: Signs, Symptoms and Treatment Perspectives: A Narrative Review by Rohit Wani, Bhagyesh Sapkale, Supriya Meshram, Sachin R Gedam

“…This review calls for more research, hoping to stimulate interest in therapeutic interventions designed for patients with HSAM, ultimately leading to a greater understanding of this intriguing cognitive phenomenon.…”
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The Impact of Endometriosis on Mental Health - A Literature Review of Depression and Anxiety Symptoms by Julia Woźniak, Sabina Kadłubek, Magdalena Mąka, Natalia Kapturska, Szymon Kalinowski, Kinga Cymerys, Piotr Kardaszewski, Jakub Kamiński, Dominik Sikora, Ewa Góralczyk

“…Conclusions:  Multidisciplinary team is essential in order to provide intervention strategies leading to greater therapeutic outcomes in endometriosis treatment. Endometriosis and mental disorders are inextricably connected. …”
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Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients by Ovidiu Balacescu, Loredana Balacescu, Oana Virtic, Simona Visan, Claudia Gherman, Flaviu Drigla, Laura Pop, Gabriela Bolba-Morar, Carmen Lisencu, Bogdan Fetica, Oana Tudoran, Ioana Berindan-Neagoe

“…In this study, we explored blood transcriptional patterns of patients with two subtypes of HER2 negative breast cancers, with different prognosis and therapeutic outcome. Peripheral blood samples from seven healthy female donors and 29 women with breast cancer including 14 triple-negative breast cancers and 15 hormone-dependent breast cancers were evaluated by microarray. …”
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Changes in Angiotensin Receptor Distribution and in Aortic Morphology Are Associated with Blood Pressure Control in Aged Metabolic Syndrome Rats by Verónica Guarner-Lans, Elizabeth Soria-Castro, Rocío Torrico-Lavayen, Araceli Patrón-Soberano, Karla G. Carvajal-Aguilera, Vicente Castrejón-Tellez, María Esther Rubio-Ruiz

“…RAS might participate in a compensatory mechanism decreasing blood pressure and allowing MS rats to reach 18 months of age and it might form part of therapeutical procedures to ameliorate MS. We studied histological changes and distribution of RAS receptors in aortas of MS aged rats. …”
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Availability of Antimalarial Drugs and Evaluation of the Attitude and Practices for the Treatment of Uncomplicated Malaria in Bangui, Central African Republic by Alexandre Manirakiza, Siméon Pierre Njuimo, Alain Le Faou, Denis Malvy, Pascal Millet

“…This study was undertaken to evaluate the quality of the treatment of uncomplicated malaria cases in Bangui, an area with multidrug-resistant parasites, at a time preceding implementation of a new therapeutic policy relying on the artemisinin derivative combined treatment artemether-lumefantrine. …”
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Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

“…G protein-coupled receptors (GPCRs) represent the largest family of membrane receptors and are highly effective targets for therapeutic drugs. GPCRs couple different downstream effectors, including G proteins (such as Gi/o, Gs, G12, and Gq) and β-arrestins (such as β-arrestin 1 and β-arrestin 2) to mediate diverse cellular and physiological responses. …”
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Kinetics and Kinematics of Shape Tracing in Children with Probable Developmental Coordination Disorder (pDCD) by Michal Hochhauser, Yfat Ben Refael, Esther Adi-Japha, Rachel Bartov

“…Insights into early shape-tracing processes beyond product outcomes are essential for therapeutic and educational interventions, with digitized tablets offering a novel tool for assessing graphomotor skills in children with DCD.…”
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A systematic screening assay identifies efficient small guide RNAs for CRISPR activation by Elin Arvidsson, Diana Duarte Lobo, Diana Duarte Lobo, Ermelinda Sabarese, Fabio Duarte, Rui Jorge Nobre, Rui Jorge Nobre, Rui Jorge Nobre, Luis Quintino, Cecilia Lundberg

“…The overall workflow was validated using therapeutically relevant genes for neurodegenerative diseases, including Tfeb, Adam17, and Sirt1. …”
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Acute toxicity test of Rhizophora apiculata bark extract on rat liver and kidney histology using fixed dose method by Syazili Mustofa, Ilma Puteri Hutami, Dwi Sarwindah

“… Background: The therapeutic properties of the ethanol extract derived from the stem bark of Rhizophora apiculata have been investigated. …”
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Indolent B-Cell Lymphomas Associated with HCV Infection: Clinical and Virological Features and Role of Antiviral Therapy by Luca Arcaini, Michele Merli, Stefano Volpetti, Sara Rattotti, Manuel Gotti, Francesco Zaja

“…The aim of this paper is to illustrate the relationship between HCV infection and different subtypes of indolent B-cell lymphomas and to systematically summarize the data from the therapeutic studies that reported the use of antiviral treatment as hematological therapy in patients with HCV-associated indolent lymphomas.…”
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F4/80+ Host Macrophages Are a Barrier to Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Engraftment In Vivo by Heather L. Thompson, Nico van Rooijen, Bryce T. McLelland, Jennifer O. Manilay

“…Understanding how embryonic stem cells and their derivatives interact with the adult host immune system is critical to developing their therapeutic potential. Murine embryonic stem cell-derived hematopoietic progenitors (ESHPs) were generated via coculture with the bone marrow stromal cell line, OP9, and then transplanted into NOD.SCID.Common Gamma Chain (NSG) knockout mice, which lack B, T, and natural killer cells. …”
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Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease: A Comparative Study Involving Different Biological Agents by Ryuji Ohashi, Ryuji Fukazawa, Makoto Watanabe, Hanako Tajima, Noriko Nagi-Miura, Naohito Ohno, Shinichi Tsuchiya, Yuh Fukuda, Shunichi Ogawa, Yasuhiko Itoh

“…In conclusion, etanercept was most effective in suppressing CAWS-induced vasculitis and can be a new therapeutic intervention for KD.…”
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ANGPTL4 induces Kupffer cell M2 polarization to mitigate acute rejection in liver transplantation by Weifeng Huang, Liqing Jiang, Yingsong Jiang, Shanshan Li, Wanqi Liu, Kezhen Zong, Dadi Peng, Zhongjun Wu, Zuotian Huang

“…The results emphasize the promise of ANGPTL4 as a therapeutic target to reduce AR and improve liver transplant outcomes by influencing hepatocyte-KC interactions.…”
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Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice by Peter C. Cook, Sheila L. Brown, Emma L. Houlder, Julio Furlong-Silva, Daniel P. Conn, Stefano A. P. Colombo, Syed Baker, Freya R. Svedberg, Gareth Howell, Margherita Bertuzzi, Louis Boon, Joanne E. Konkel, Christopher R. Thornton, Judith E. Allen, Andrew S. MacDonald

“…These data highlight distinct DC subsets as potential therapeutic targets for the treatment of pulmonary fungal disease.…”
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Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review by Ubaid Ansari, Jimmy Wen, Burhaan Syed, Dawnica Nadora, Romteen Sedighi, Denise Nadora, Vincent Chen, Forshing Lui

“…Understanding NP2's multifaceted roles may reveal novel therapeutic targets and improve the clinical outcomes for these neurological disorders. …”
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Hydroxyapatite Chitosan Gradient Pore Scaffold Activates Oxidative Phosphorylation Pathway to Induce Bone Formation by Zeliang Zhang, Wei Shang, Lisong Lin

“…These results highlight the potential therapeutic application of HAMT-CHS scaffolds.…”
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