Trazodone Addition to Paroxetine and Mirtazapine in a Patient with Treatment-Resistant Depression: The Pros and Cons of Combining Three Antidepressants by Rui Lopes, José Carlos Alves, Raquel Garcia Rego

“…This may be related to the possibility of higher side-effect burden and to doubts about its pharmacological effectiveness and therapeutic advantage compared to other standard treatment options. …”
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Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine by Jingkai Zhang, Chang Liu, Jun Li, Tao Yu, Jing Ruan, Fan Yang

“…Abstract Harnessing the robust electromechanical couplings, piezoelectric materials not only enable efficient bio‐energy harvesting, physiological sensing and actuating but also open enormous opportunities for therapeutic treatments through surface polarization directly interacting with electroactive cells, tissues, and organs. …”
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Biophysical Insights into Cancer Transformation and Treatment by Jiří Pokorný, Alberto Foletti, Jitka Kobilková, Anna Jandová, Jan Vrba, Jan Vrba, Martina Nedbalová, Aleš Čoček, Andrea Danani, Jack A. Tuszyński

“…Disturbed electrodynamic interaction forces between cancer and healthy cells may favor local invasion and metastasis. A therapeutic strategy of targeting dysfunctional mitochondria for restoration of their physiological functions makes it possible to switch on the natural apoptotic pathway blocked in cancer transformed cells. …”
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Proteomic Analysis of Exudates from Chronic Ulcer of Diabetic Foot Treated with Scorpion Antimicrobial Peptide by Zhixiang Tan, Zhiguo Yu, Xiaobo Xu, Lanxia Meng, Mosheng Yu, Rui Tao, Yingliang Wu, Zhanyong Zhu

“…Scorpion peptides have good therapeutic effect on chronic ulcer of diabetic foot, but the related pharmacological mechanism has remained unclear. …”
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Clinician’s Attitudes to the Introduction of Routine Weighing in Pregnancy by Tim Hasted, Helen Stapleton, Michael M. Beckmann, Shelley A. Wilkinson

“…Issues included access to resources and staff; the ability to provide appropriate counselling and evidence-based interventions; and the impact of weighing on patients and the therapeutic relationship. Conclusion. Many clinicians supported the practice of routine weighing in pregnancy, but barriers were also identified. …”
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Risk Factors and Medico-Economic Effect of Pancreatic Fistula after Pancreaticoduodenectomy by Renping Huang, Bing Liu, Hua Chen, Xuewei Bai, Rui Kong, Gang Wang, Yongwei Wang, Bei Sun, Yinghui Guan

“…It is critical that surgeons know the risk factors related to PF and CR-PF so as to take corresponding therapeutic regimens for each patient.…”
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Preparation of Ethosome Gel with Total Flavonoids from <i>Vernonia anthelmintica</i> (L.) Willd. for the Treatment of Vitiligo by Dongmei Qin, Yongjie Cui, Mengyue Zheng, Zhiguo Yang, Xinbing Wang

“…In vitro analyses demonstrated sustained release characteristics of the gel and considerable therapeutic effectiveness against vitiligo resulting from hydroquinone exposure. …”
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Primary Neuroendocrine Tumor of the Parotid Gland: A Case Report and a Comprehensive Review of a Rare Entity by Olga Martínez-Sáez, Javier Molina-Cerrillo, Carmen Moreno García del Real, Rafael Barberá Durban, Juan J. Díez, Teresa Alonso-Gordoa, Enrique Grande Pulido

“…Regardless of their low frequency, it is imperative to accurately differentiate these tumors from the much more common squamous cell carcinomas and from metastasis from another primary tumor due to the completely different therapeutic approaches and prognosis. The diagnosis is based on the recognition of the typical neuroendocrine architecture and immunohistochemical staining and on an exhaustive work-up. …”
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Can a Positive Allosteric Modulation of GABAergic Receptors Improve Motor Symptoms in Patients with Parkinson’s Disease? The Potential Role of Zolpidem in the Treatment of Parkinso... by Antonio Daniele, Francesco Panza, Antonio Greco, Giancarlo Logroscino, Davide Seripa

“…Various studies suggest that therapeutic strategies based on nondopaminergic drugs might be helpful in PD. …”
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Development and pan-cancer validation of an epigenetics-based random survival forest model for prognosis prediction and drug response in OS by Chaoyi Yin, Kede Chi, Zhiqing Chen, Shabin Zhuang, Yongsheng Ye, Binshan Zhang, Cailiang Cai

“…Risk stratification analysis revealed distinct therapeutic response patterns, with low-risk groups showing enhanced sensitivity to traditional chemotherapy drugs while high-risk groups responded better to targeted therapies.ConclusionOur epigenetics-based model demonstrates excellent prognostic accuracy (AUC&gt;0.997 in internal validation, 0.832–0.929 in external cohorts) and provides a practical tool for treatment stratification. …”
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Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice by Talero Elena, Di Paola Rosanna, Mazzon Emanuela, Emanuela Esposito, Motilva Virginia, Cuzzocrea Salvatore

“…In the present study, we evaluated the possible therapeutic effect of this peptide in an experimental model of acute inflammation, the carrageenan- (CAR-) induced pleurisy. …”
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Hyperbaric Oxygen Therapy in Retinal Arterial Occlusion: Epidemiology, Clinical Approach, and Visual Outcomes by Ana Sofia Lopes, Rita Basto, Susana Henriques, Luísa Colaço, Filomena Costa e Silva, Isabel Prieto, Francisco Guerreiro

“…It seems to be an effective and safe therapeutic option for a pathology that still remains without approved treatment.…”
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Skeletal interoception and prospective application in biomaterials for bone regeneration by Long Bai, Jilong Li, Guangfeng Li, Dongyang Zhou, Jiacan Su, Changsheng Liu

“…It emphasizes the need for further research to fully understand the mechanisms of skeletal interoception and to harness its therapeutic potential fully.…”
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Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy by Rui-Qi Wang, Zhi-Min Deng, Gan-Tao Chen, Fang-Fang Dai, Liang-Bin Xia

“…Through this review, we suggest potential clinical management strategies and research avenues aimed at offering enhancements and therapeutic insights for miscarriages linked to obesity and its associated risk factors.…”
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Extended UVB Exposures Alter Tumorigenesis and Treatment Efficacy in a Murine Model of Cutaneous Squamous Cell Carcinoma by Erin M. Burns, Kathleen L. Tober, Judith A. Riggenbach, Donna F. Kusewitt, Gregory S. Young, Tatiana M. Oberyszyn

“…These data support the commonly assumed but not previously demonstrated fact that increased cumulative UVB exposure increases the risk of UVB-induced SCC development and can also affect therapeutic efficacies. Our study suggests that cessation of UVB exposure by at-risk patients may decrease tumor development and that topical NSAIDs such as diclofenac may be chemopreventive.…”
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Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023) by Hesham R. El-Seedi, Mohamed S. Refaey, Nizar Elias, Mohamed F. El-Mallah, Faisal M. K. Albaqami, Ismail Dergaa, Ming Du, Mohamed F. Salem, Haroon Elrasheid Tahir, Maria Dagliaa, Nermeen Yosri, Hongcheng Zhang, Awg H. El-Seedi, Zhiming Guo, Shaden A. M. Khalifa

“…Abstract Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential therapeutic applications, particularly in oncology. …”
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Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis by Sunish Mohanan, Brian D. Cherrington, Sachi Horibata, John L. McElwee, Paul R. Thompson, Scott A. Coonrod

“…Next generation isozyme-specific PAD inhibitors may have therapeutic potential to regulate both the inflammatory tumor microenvironment and tumor cell growth.…”
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cGAS-STING targeting offers therapy choice in lung diseases by Yu Wang, Xuan Zhang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang

“…Then, we focus on summarizing a list of bioactive small-molecule compounds which inhibit the cGAS-STING pathway, reviewing their potential mechanisms.These review highlights a novel groundbreaking therapeutic possibilities through targeting cGAS-STING in lung diseases.…”
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Very Late Onset Obsessive-Compulsive Disorder followed by Parkinson Disease: A Case Report by Boaventura Rodrigo Constantino Rodrigues de Ornelas Afonso, Paulo Alexandre Sousa Martins

“…By unraveling the underlying pathomechanisms and shared pathways, invaluable insights into the etiology and progression of these disorders could be offered, potentially paving the way for more effective diagnostic and therapeutic strategies.…”
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Monitoring and management of adverse effects associated with trastuzumab deruxtecan: a UAE-specific consensus by Emad Dawoud, Fathi Azribi, Aref Chehal, Shaheenah Dawood, Syed Hammad Tirmazy, Dina Hamza, Hassan Jaafar, Hussam Marashi

“…Although early diagnosis contributes to favorable prognoses, novel treatment modalities like antibody-drug conjugates (ADCs) have significantly broadened the therapeutic landscape for patients in metastatic settings. …”
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