Suppression of Aldosterone Synthesis and Secretion by Channel Antagonists by Keiichi Ikeda, Tsuyoshi Isaka, Kouki Fujioka, Yoshinobu Manome, Katsuyoshi Tojo

“…Therefore, the use of such dihydropyridine CCBs to treat aldosterone-related hypertension may prove beneficial to circumvent such therapeutic problems. In this paper, we discuss the mechanism of action of CCBs on aldosterone production and clinical perspectives for CCB use to inhibit MR activity in hypertensive patients.…”
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Prescribers’ approval rate of pharmacist-initiated interventions to optimise patients’ clinical status of hypertension in the ambulatory care setting by Brajković Andrea, Bićanić Lucija Ana, Orehovački Helena, Prkačin Ingrid, Oliveira Djenane Ramalho De, Mucalo Iva

“…The average number of drug therapy problems (DTPs) per patient totaled 3.53 ± 1.80, where 98 % of patients had one or more DTPs, 48 % had 4 or more DTPs, whereas 26 % had 5 or more DTPs. Sub-therapeutic dosage (32.6 %) and the need for additional drug therapy (30.9 %) were the two most commonly identified DTPs. …”
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Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization by Xianghui Huang, Jia Xu, Ye Xu, Bingxin Huangfu, Feng Zhang, Yanzhou Hu, Ruxin Gao, Xinxin Ren, Boyang Zhang, Kunlun Huang, Xiaoyun He

“…However, to date, no approved therapeutic drugs have been developed. Dietary interventions with natural products have shown promise in preventing and treating NAFLD. …”
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Application of psychobiotics in clinical treatment of mental disorders: Neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety by Jingwei Cui, Wenxin Wang, Yue Tang, Siyuan Feng, Hong Liu, Zikai Hao

“…It is proposed that the novel therapeutic approach of using Bacillus licheniformis as an adjuvant treatment for patients with depression shows a certain degree of feasibility. …”
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Acute management of massive pulmonary embolism in pregnancy by Shahin Qadri, Shahin Qadri, Ashwini Bilagi, Ashwini Bilagi, Abha Sinha, Derek Connolly, Derek Connolly, Derek Connolly, Richard Murrin, Shagaf Bakour, Shagaf Bakour, Shagaf Bakour

“…Thrombolysis for massive PE during pregnancy and the postpartum period has shown to be associated with high maternal and fetal survival (94% and 88%). But other therapeutic options such as (catheter [or surgical] thrombectomy, ECMO) should be considered in the postpartum period, given the high risk of major bleeding with thrombolysis.…”
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The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy by Natalia Simionescu, Radu Zonda, Anca Roxana Petrovici, Adriana Georgescu

“…However, EVs carrying specific miRNAs or miRNA inhibitors have great potential as therapeutic nanotools in GB, and several studies have investigated this possibility on in vitro and in vivo models. …”
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PLK3 weakens antioxidant defense and inhibits proliferation of porcine Leydig cells under oxidative stress by Chujie Chen, Jinyan He, Weixian Huang, Dong Xu, Zhaohui Li, Anqi Yang

“…This study deepens our understanding of how LCs respond to OS and provides new therapeutic targets for enhancing cellular resistance to oxidative damage and promoting tissue health.…”
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Design and evaluation of screening and self-care (mobile) application for oral and dental problems and emergencies by Sedighe Sadat Hashemikamangar, Aidin Sooratgar, Mina Khayamzadeh, Shayan Momeni, Ali Asghar Safaei, Behnaz Behniafar

“…Materials and method: A system made up of web and mobile apps is proposed and evaluated for screening and self-care of oral and dental problems and for providing advice on dental emergencies and therapeutic measures. This system was developed and made available to users under the name of 'Dandanyar'. …”
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Onychomycosis Caused by Fusarium spp. in Dakar, Senegal: Epidemiological, Clinical, and Mycological Study by Khadim Diongue, Mouhamadou Ndiaye, Mame Cheikh Seck, Mamadou Alpha Diallo, Aïda Sadikh Badiane, Daouda Ndiaye

“…Because of the risk of disseminated infection in immunocompromised patients, realization of susceptibility tests is necessary to ensure better therapeutic management.…”
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Hydrogen Sulfide Inhibits High Glucose-Induced sFlt-1 Production via Decreasing ADAM17 Expression in 3T3-L1 Adipocytes by Tian-xiao Hu, Gang Wang, Wei Wu, Lu Gao, Qing-ying Tan, Jing Wang

“…Exogenous H2S donor NaHS has a potential therapeutic value for diabetic vascular complications.…”
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Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs by Jiajie Jia, Jiajie Jia, Lu Wang, Lu Wang, Yue Zhou, Peng Zhang, Xiaoping Chen

“…As emerging evidence suggests that SKM-EVs are involved in the development and regulation of type 2 diabetes (T2D), systemic inflammation, and other chronic diseases, we also highlight the potential of SKM-EVs as therapeutic targets and diagnostic biomarkers, emphasizing the need for further research to elucidate the complex mechanisms underlying intercellular communication in physiological and pathological contexts.…”
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Photo-curing hyaluronic acid-Janus antibacterial packs as O2 generator precisely modulate the infectious microenvironment for antibiotic-free periodontal therapy by Runxiu Wei, Gaojie Li, Yuying Huang, Linjing Mi, Jiamin Wu, Huan Huang, Na Yin, Yuling Chen, Qiang Yang, Wenjun Zhang, Bingzhi Sun, Ran Sun, Ling Guo, Min Feng

“…In light of their precise elimination of bacterial colonization and modulation of the infectious microenvironment, the H-Janus antibacterial packs show promising therapeutic potential for preventing the recurrence of periodontal pathogens following scaling and root planning.…”
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Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced Osteoporosis by Oršolić Nada, Jeleč Željko, Nemrava Johann, Balta Vedran, Gregorović Gordana, Jeleč Dražen

“…According to the results, quercetin could be an effective substitution for alendronate in 13cRA-induced osteoporosis. Good therapeutic potential of quercetin on rat skeletal system is based partly on its antioxidant capacity and estrogenic activity.…”
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Construction and Evaluation of a Subcutaneous Splenic Injection Port for Serial Intraportal Vein Cell Delivery in Murine Disease Models by Toshio Miki, Chika Takano, Irving M. Garcia, Brendan H. Grubbs

“…Liver-directed cell transplantation is, therefore, an attractive therapeutic option to treat various metabolic disorders as well as liver diseases. …”
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Optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity: A mixture design approach by Faiza Imtiaz, Dildar Ahmed, Osama A. Mohammed, Umer Younas, Munawar Iqbal

“…This study highlights the development of optimized plant extract mixtures as a natural therapeutic strategy specifically designed to combat oxidative stress-related diseases, offering a potential alternative to conventional treatments.…”
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Biofilm Formation and Detection of Fluoroquinolone- and Carbapenem-Resistant Genes in Multidrug-Resistant Acinetobacter baumannii by María-Guadalupe Avila-Novoa, Oscar-Alberto Solís-Velázquez, Daniel-Eduardo Rangel-López, Jean-Pierre González-Gómez, Pedro-Javier Guerrero-Medina, Melesio Gutiérrez-Lomelí

“…These properties, combined with the role of A. baumannii as a nosocomial pathogen, increase the probability of A. baumannii causing nosocomial infections and outbreaks as a complication during therapeutic treatments and emphasize the need to control A. baumannii biofilms in hospital environments.…”
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Disease-Specific Autoantibodies Induce Trained Immunity in RA Synovial Tissues and Its Gene Signature Correlates with the Response to Clinical Therapy by Xiaoli Dai, Xiaoqiu Dai, Zheng Gong, Chen Yang, Keqin Zeng, Fang-Yuan Gong, Qiao Zhong, Xiao-Ming Gao

“…We conclude that RA-specific autoantibodies can train monocytes in the inflamed lesion as early as the asymptomatic stage, which may not merely improve understanding of disease progression but may also suggest therapeutic and/or preventive strategies for autoimmune diseases.…”
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Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma by Nan Yang, Yunchuan Yang, Wanqi Zhang, Xinying Li, Hao Jiang, Huiling Kou, Junbo Zhang, Yuanyuan Wang, Liuchang Tan, Yuangang Lu

“…The integration of PDD-guided resection with PDT offers a highly safe and effective therapeutic strategy for cSCC.…”
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Progress in the role of nanoparticles in the diagnosis and treatment of bone and joint tuberculosis by Yitong Ding, Baiyun Li, Yangfei Yi, Can Liu, Jie Wen, Jie Wen, Xiaohong Jian, Yufei Li

“…These technologies are adaptable to resource-limited settings, enabling earlier patient intervention and mitigating disease progression risk. In therapeutic applications, nanomaterials prolong drug retention in bone tissue through targeted delivery, thereby decreasing medication frequency and minimizing toxic side effects, which significantly improves treatment efficacy. …”
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Optimizing children's hand orthosis design: A study on contact pressure distribution using FSR sensors by Dhaval Patel, Ivaylo Mitev, Thomas Rockenbauer, Thomas Antretter, Sandra Schloegl, Margit Lang

“…The design and comfort of hand orthoses for children are crucial for effective therapeutic outcomes. This research primarily aims to measure the contact force between the hand and orthoses in children under 10 years old and use this data as a loading condition for topology optimization to reduce high-pressure areas, thereby enhancing wear comfort. …”
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