Posttraumatic Bacillus cereus Endophthalmitis: Clinical Characteristics and Antibiotic Susceptibilities by Feng Mei, Jiaqi Lin, Manli Liu, Yao Yang, Xiaofeng Lin, Fang Duan

“…The visual outcomes of posttraumatic Bacillus cereus endophthalmitis were generally poor regardless of the prophylactic and therapeutic measures administered. Vitrectomy combined with silicone oil tamponade could help to save the eyeball. …”
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Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy by Veronica Tisato, Paolo Perri, Erika Rimondi, Elisabetta Melloni, Giuseppe Lamberti, Daniela Milani, Paola Secchiero, Giorgio Zauli

“…Photorefractive keratectomy (PRK) represents a therapeutic option to remodel corneal stroma and to compensate refractive errors, which involves inflammatory and/or regenerative processes. …”
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Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial‐mesenchymal transition and modulating SIRT1/β‐catenin signaling pathway in breast cancer by Xiaoxia Jin, Yingze Wei, Yushan Liu, Xiaoyun Lu, Fei Ding, Jiatai Wang, Shuyun Yang

“…RES reversed EMT properties of MCF7/ADR cells by modulating the connection between SIRT1 and β‐catenin, which provides a hopeful therapeutic avenue to conquer DOX‐resistance and thereby prolong survival rates in breast cancer patients.…”
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ASB1 engages with ELOB to facilitate SQOR ubiquitination and H2S homeostasis during spermiogenesis by Jinxing Lv, Tiantian Wu, Jiajia Xue, Cong Shen, Wenxin Gao, Xia Chen, Yueshuai Guo, Mingxi Liu, Jun Yu, Xiaoyan Huang, Bo Zheng

“…Overall, our findings offer valuable insights into the role of ASB1 during spermiogenesis and propose H2S supplementation as a promising therapeutic approach for oxidative stress-related male infertility.…”
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Dynamic Support Culture of Murine Skeletal Muscle-Derived Stem Cells Improves Their Cardiogenic Potential In Vitro by Klaus Neef, Philipp Treskes, Guoxing Xu, Florian Drey, Sureshkumar Perumal Srinivasan, Tomo Saric, Erastus Nembo, Judith Semmler, Filomain Nguemo, Christof Stamm, Douglas B. Cowan, Antje-Christin Deppe, Maximilian Scherner, Thorsten Wittwer, Jürgen Hescheler, Thorsten Wahlers, Yeong-Hoon Choi

“…Autologous cells with the potential to regenerate damaged heart tissue would be an ideal source for cell therapeutic approaches. Here, we compared different methods of conditional culture for increasing the yield and cardiogenic potential of murine skeletal muscle-derived stem cells. …”
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Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism by Felix Pfister, Lucas R. Carnell, Lisa Löffler, Philipp Boosz, Niels Schaft, Jan Dörrie, René Stein, Malte Lenz, Erdmann Spiecker, Christian M. Huber, Sami Haddadin, Carola Berking, Christoph Alexiou, Christina Janko

“…Abstract Therapies against hematological malignancies using chimeric antigen receptors (CAR)‐T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to limited tumor trafficking and infiltration, as well as the scarcity of cancer‐specific solid tumor antigens. …”
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NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression by Shuangyan Li, Lishan Yan, Chaoying Li, Lijuan Lou, Fengjiao Cui, Xiao Yang, Fuchu He, Ying Jiang

“…These findings highlight a cholesterol transport-independent mechanism by which NPC1 contributes to the stability of TGFBR1 in HCC and suggest potential therapeutic strategies targeting NPC1 for HCC treatment.…”
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Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer Patients by Paolo Vescovi, Elisabetta Merigo, Marco Meleti, Maddalena Manfredi, Carlo Fornaini, Samir Nammour

“…One hundred ninety patients affected by BRONJ were observed between January 2004 and November 2011 and 166 treated sites were subdivided in five groups on the basis of the therapeutical approach (medical or surgical, traditional or laser-assisted approach, with or without Low Level Laser Therapy (LLLT)). …”
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In silico data mining of large-scale databases for the virtual screening of human interleukin-2 inhibitors by Halim Sobia Ahsan, Zaheer-Ul-Haq, Khan Ajmal, Al-Rawahi Ahmed, Al-Harrasi Ahmed

“…Hence, IL-2 is now emerging as a target for novel therapeutic approaches in several autoimmune disorders. …”
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Unveiling the molecular and cellular links between obstructive sleep apnea-hypopnea syndrome and vascular aging by Wei Liu, Le Zhang, Wenhui Liao, Huiguo Liu, Wukaiyang Liang, Jinhua Yan, Yi Huang, Tao Jiang, Qian Wang, Cuntai Zhang, Peifang Wei

“…Taken together, these findings suggest that OSAHS may serve as a novel risk factor for VA and related vascular disorders, and that targeting these features may offer therapeutic potential to mitigate the vascular risks associated with OSAHS.…”
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Natrium Alginate and Graphene Nanoplatelets-Based Efficient Material for Resveratrol Delivery by Cristina Mormile, Ocsana Opriș, Stefano Bellucci, Ildiko Lung, Irina Kacso, Alexandru Turza, Adina Stegarescu, Septimiu Tripon, Maria-Loredana Soran, Ioana Bâldea

“…In this study, alginate-based composite beads were developed for the delivery of resveratrol, a compound with therapeutic potential. Two formulations were prepared: one with sodium alginate and resveratrol (AR) and another incorporating graphene nanoplatelets (AGR) to improve drug release control. …”
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Optimized production and antiviral activity evaluation of recombinant chicken interferon-alpha using an improved Baculovirus expression system by Yuxia Zhang, Wenwen Dong, Feng Li, Kai Meng, Guiming Li, Xiaoyuan Yuan

“…These findings present an alternative approach for the efficient production of chIFN-α for therapeutic applications.…”
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Loss of correlated proteasomal subunit expression selectively promotes the 20SHigh state which underlies luminal breast tumorigenicity by Rangapriya Sundararajan, Shubhada R. Hegde, Ashish Kumar Panda, Joel Christie, Nikhil Gadewal, Prasanna Venkatraman

“…Disrupting this connectivity by depleting PSMD9 in MCF7 cells introduces structural anomalies in the proteasome, and shifts dependence from 20SHigh to a deregulated 26SHigh state invoking anti-tumor responses which opens up clinically-relevant therapeutic possibilities.…”
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Thermal ablation for the treatment of malignant thyroid nodules: present and future by Yan Hu, Wei Zhou, Shangyan Xu, Wanru Jia, Guiping Zhang, Yuan Cao, Qianru Zhang, Lu Zhang, Weiwei Zhan

“…However, the advent and evolution of thermal ablation (TA) techniques, encompassing radiofrequency ablation, laser ablation, and microwave ablation, have emerged as a novel therapeutic avenue for patients with MTC, particularly for those deemed unsuitable for surgery due to high risks or for those who refuse surgery. …”
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Acne Vulgaris Management: A Review of First-Line and Advanced Pharmacological Treatments by Krzysztof Dobrzeniecki, Anna Zygmunt, Karolina Karoń, Łukasz Karoń, Patrycja Karnas-Bogacka

“…Summary: Early intervention is crucial to mitigate the risk of scarring and psychosocial consequences. Emerging therapeutic strategies have the potential to enhance treatment outcomes. …”
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The Response Regulator OmpR Negatively Controls the Expression of Genes Implicated in Tilimycin and Tilivalline Cytotoxin Production in <i>Klebsiella oxytoca</i> by Ramón G. Varela-Nájera, Miguel A. De la Cruz, Jorge Soria-Bustos, Carmen González-Horta, Ma Carmen E. Delgado-Gardea, Jorge A. Yáñez-Santos, María L. Cedillo, Hidetada Hirakawa, James G. Fox, Blanca Sánchez-Ramírez, Miguel A. Ares

“…This research deepens our understanding of the mechanisms of toxigenic <i>K. oxytoca</i> and opens promising avenues for targeting OmpR for new therapeutic interventions. By focusing on this innovative approach, we can develop more effective solutions to combat this pressing health challenge, ultimately improving patient outcomes against this pathogen.…”
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Interleukin-1β Enhances Umbilical Cord Mesenchymal Stem Cell Adhesion Ability on Human Umbilical Vein Endothelial Cells via LFA-1/ICAM-1 Interaction by Tsai-Yi Wu, Ya-Han Liang, Jiahn-Chun Wu, Hwai-Shi Wang

“…The implications of these findings could enhance the therapeutic potential of MSCs.…”
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Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2 by Qi Dong, Haoyuan Fu, Wenxiao Li, Xinyu Ji, Yingchao Yin, Yiran Zhang, Yanbo Zhu, Guoqiang Li, Huiyang Jia, Heng Zhang, Haofei Wang, Jinglue Hu, Ganggang Wang, Zhihao Wu, Yingze Zhang, Sujuan Xu, Zhiyong Hou

“…Taken together, our findings suggest that FXR plays pivotal roles in osteoblast differentiation by regulating RUNX2 stability and that targeting FXR may be a promising therapeutic approach for osteoporosis.…”
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Bian-stone ironing and rubbing therapy combined with Traditional Chinese Medicine penetration therapy for postoperative constipation in a lung cancer patient undergoing chemotherap... by GAO Yaqian (高雅倩), GUO Huanli (郭换利), HUANG Yanping (黄砚萍), FENG Wenying (冯文英), ZHANG Guohong (张国红), ZHANG Xuelian (张雪莲)

“…At the same time, nursing interventions such as defecation guidance, dietary regulation, exercise, and medication guidance were adopted to further improve clinical symptoms and achieve significant therapeutic effects on constipation. (本文总结1例砭石熨摩中药透入治疗肺癌患者化疗后便秘的护理经验。…”
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Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells by Jie-Jen Lee, Yi-Chiung Hsu, Ying-Syuan Li, Shih-Ping Cheng

“…In the present study, we aimed to investigate the therapeutic potential of novel galectin-3 inhibitors by treating thyroid cancer cells with different concentrations of GB1107 or TD139. …”
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