PD-L1 Blockade Attenuated Sepsis-Induced Liver Injury in a Mouse Cecal Ligation and Puncture Model by Weimin Zhu, Rui Bao, Xiaohua Fan, Tianzhu Tao, Jiali Zhu, Jiafeng Wang, Jinbao Li, Lulong Bo, Xiaoming Deng

“…Thus, anti-PD-L1 antibody might have a therapeutic potential in attenuating liver injury in sepsis.…”
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Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives by Nikolaos Nektarios Karamanolis, Dimitris Kounatidis, Natalia G. Vallianou, Krystalia Dimitriou, Eleni Tsaroucha, Georgios Tsioulos, Ioanna A. Anastasiou, Evangelos Mavrothalassitis, Irene Karampela, Maria Dalamaga

“…Cancer persists as a significant global health challenge, claiming millions of lives annually despite remarkable strides in therapeutic innovation. Challenges such as drug resistance, toxicity, and suboptimal efficacy underscore the need for novel treatment paradigms. …”
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Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis by Yuchao Chen, Huazhen Liu, Yuming He, Bin Yang, Weihui Lu, Zhenhua Dai

“…In particular, this review highlights the immunoregulatory function of exosomes derived from immune or non-immune cells and exosome-based therapeutic applications in psoriasis, including their drug delivery systems. …”
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Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations by Mikołaj Kamiński, Karolina Skonieczna-Żydecka, Igor Łoniewski, Anastasios Koulaouzidis, Wojciech Marlicz

“…Additionally, meta-analyses often indicate a group of probiotics rather than individual strains, and they create difficulty for physicians in making therapeutic choices. More CIC patient randomised clinical studies utilising well-defined strains, or combinations, are necessary.…”
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Trichosanthes dioica Roxb.: A vegetable with diverse pharmacological properties by Mahia Khandaker, Saleha Akter, Mohammad Zafar Imam

“…This review will expand our understanding of the therapeutic potential of T. dioica and their phytochemical basis which may help in further research on this species. …”
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Meta-narrative review: the impact of music therapy on sleep and future research directions by Qiaoqiao Gou, Meihui Li, Xiaoyu Wang, Xinran Yuan, Mingyi Yang, Junrui Li, Bo Wang, Dan Yang, Xiubo Ren, Miaomiao Yang, Siqi Liu, Ningning Liu, Jiaqi Han, Qiujian Xu

“…Key recommendations include personalized music selection, development of age-appropriate interventions, and minimization of external interferences to maximize therapeutic outcomes. Additionally, incorporating variables like psychological status, lifestyle, and environmental factors may offer a more comprehensive understanding of music therapy’s long-term adaptability and effectiveness for diverse populations. …”
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FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy by Na Zhang, Yang Meng, Song Mao, Huiling Ni, Canhua Huang, Licong Shen, Kun Fu, Lu Lv, Chunhong Yu, Piyanat Meekrathok, Chunmei Kuang, Fang Chen, Yu Zhang, Kai Yuan

“…Collectively, our study highlights O-GlcNAcylation as a useful stratification marker and a therapeutic vulnerability for the advanced, poorly differentiated EC cases.…”
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tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination by Chao Wang, Bing Yu, Han Zhou, Huanting Li, Shifang Li, Xiaolu Li, Wentao Wang, Yugong Feng, Tao Yu

“…These findings highlight the potential of tRF-AspGTC as a promising diagnostic biomarker and therapeutic target for IAs.…”
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3D Bioprinting Strategies for Melatonin‐Loaded Polymers in Bone Tissue Engineering by Damla Aykora, Ayhan Oral, Cemre Aydeğer, Metehan Uzun

“…Polymer‐based biomaterials are mostly used for the controlled release of various drugs, therapeutic agents, mesenchymal stem cells, ions, and growth factors. …”
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In Vivo Hypoglycaemic Effect and Inhibitory Mechanism of the Branch Bark Extract of the Mulberry on STZ-Induced Diabetic Mice by Hua-Yu Liu, Meng Fang, Yu-Qing Zhang

“…To understand this therapeutic effect and the regulatory mechanisms of BBE in diabetic mice, a qRT-PCR experiment was performed, indicating that the mulberry BBE can regulate the mRNA expression of glycometabolism genes in diabetic mice, including glucose-6-phosphatase (G6Pase), glucokinase (GCK), and phosphoenolpyruvate carboxykinase (PEPCK), thereby regulating sugar metabolism and reducing the blood glucose level in diabetic mice. …”
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Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment by Christian Klein, Maria Amann, Jacob Gadwa, Laurel B Darragh, Miles Piper, Diemmy Nguyen, Sana D Karam, Michael W Knitz, Justin Yu, Nicholas Olimpo, Sophia Corbo, Jessica I Beynor, Brooke Neupert, Alexander T Nguyen, Chloe Hodgson, Khalid NM Abdelazeem, Anthony Saviola, Laurene Pousse, Ali Bransi, Mudita Pincha

“…Consequently, the depletion of Tregs restores the therapeutic efficacy of our treatment and abrogates the disparity between models. …”
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Protective Effect of Adipose-Derived Mesenchymal Stem Cell Secretome against Hepatocyte Apoptosis Induced by Liver Ischemia-Reperfusion with Partial Hepatectomy Injury by Zhihui Jiao, Yajun Ma, Yue Wang, Tao Liu, Qianzhen Zhang, Xiaoning Liu, Chenxi Piao, Boyang Liu, Hongbin Wang

“…Our findings indicate that ADSCs exert therapeutic effects in a paracrine manner through their secretome, which can be a viable alternative to cell-based regenerative therapies.…”
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Synthesis of Surfactants Derived from 2-Mercaptobenzimidazole and Study of Their Acute Toxicity and Analgesic and Psychotropic Activities by Terence Nguema Ongone, Latyfa El Ouasif, Mostafa El Ghoul, Redouane Achour, Hind Chakchak, Meryem El Jemli, Yahia Cherrah, Katim Alaoui, Amina Zellou

“…The acute toxicity of these salts is evaluated according to OECD 423 Guidelines at the doses of 300 and 2000 mg/kg; their peripheral analgesic effect is studied using the Koster test at the therapeutic dose of 200 mg/kg and their sedative action is evaluated using Traction, Chimney, Hole-board, and Rotarod tests at the doses of 200 and 400 mg/kg. …”
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Synthesis, biological evaluations, and in silico assessments of phenylamino quinazolinones as tyrosinase inhibitors by Sara Moghadam Farid, Shahram Moradi Dehaghi, Aida Iraji, Mohammad Mahdavi, Mina Saeedi

“…Overall, these findings contribute to a deeper understanding of the potential therapeutic value of these derivatives as tyrosinase inhibitors.…”
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Diagnostics and treatment of biliary dyskinesia: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, Yu. O. Shulpekova, Ye. K. Baranskaya, A. V. Okhlobystin, A. S. Trukhmanov, T. L. Lapina, A. A. Sheptulin

“…To exclude organic biliary diseases with confidence, informative modern diagnostic tests of biliary tract visualization should be applied. Therapeutic approach should include correction of diet and lifestyle modification, administration of antispasmodic medications and agents modulating the state of nervous system, in selected cases the option of papillosphincterotomy should be considered.…”
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T Regulatory and T Helper 17 Cells in Primary Sjögren’s Syndrome: Facts and Perspectives by Alessia Alunno, Francesco Carubbi, Onelia Bistoni, Sara Caterbi, Elena Bartoloni, Giulia Mirabelli, Francesca Cannarile, Paola Cipriani, Roberto Giacomelli, Roberto Gerli

“…We believe that these insights into pSS pathogenesis may provide the basis for successful therapeutic intervention in this disease.…”
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The Role of Inflammatory Cytokines and lncRNAs in the Pathogenesis of Atherosclerosis and Other Inflammatory Diseases: Focus on Sarcoidosis and Alzheimer’s Disease by Aldona Sokołowska, Julia Buszek, Piotr Czerniak, Adrianna Antoszewska, Weronika Bargiel, Dominika Bąk, Halszka Wajdowicz, Mateusz Warzocha

“…Aim of the Study This study synthesizes current knowledge on the interplay between cytokines and lncRNAs across these conditions, emphasizing their potential as biomarkers and therapeutic targets. Materials and Methods Through a systematic review of recent studies, we identify key pathways and discuss translational implications for novel interventions. …”
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Effects of Intravenous Administration of Human Umbilical Cord Blood Stem Cells in 3-Acetylpyridine-Lesioned Rats by Lucía Calatrava-Ferreras, Rafael Gonzalo-Gobernado, Antonio S. Herranz, Diana Reimers, Teresa Montero Vega, Adriano Jiménez-Escrig, Luis Alberto Richart López, Eulalia Bazán

“…The aim of this work was to investigate the potential therapeutic activity of HuUCBMCs in the 3-acetylpyridine (3-AP) rat model of cerebellar ataxia. …”
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Targeting uric acid: a promising intervention against oxidative stress and neuroinflammation in neurodegenerative diseases by Lin Xu, Chengwei Li, Tiantian Wan, Xinyi Sun, Xiaojie Lin, Dong Yan, Jianjun Li, Penghui Wei

“…Based on this, the review underscores the significance of UA as a potential biomarker and aims to provide a comprehensive understanding of its potential as a therapeutic target, while also addressing possible challenges to clinical implementation.…”
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Lipopolysaccharide affects metabolic processes and energy homeostasis in the corpus luteum by Karol Mierzejewski, Robert Stryiński, Iwona Bogacka, Monika Golubska, Mónica Carrera, Aleksandra Kurzynska

“…Understanding the intricate interplay between inflammatory processes and reproductive organ’s function is crucial for the development of effective therapeutic strategies to alleviate reproductive disorders and improve fertility.MethodsThe aim of this study was to determine the in vitro effects of lipopolysaccharide (LPS) on the proteomic profile of the porcine CL in the mid-luteal phase of the estrous cycle using LC-MS/MS analysis. …”
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