Human epididymis protein 4-annexin II binding promotes aberrant epithelial-fibroblast crosstalk in pulmonary fibrosis by Weishuai Zheng, Menglin Zou, Xingxing Hu, Han Gao, Weiwei Song, Qinhui Hou, Yuan Liu, Zhenshun Cheng

“…These data suggest that HE4 can serve as a potential therapeutic target in the treatment of IPF.…”
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Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms by Cesar Augusto Roque‐Borda, Laura Maria Duran Gleriani Primo, Kaila Petronila Medina‐Alarcón, Isabella C. Campos, Camila de Fátima Nascimento, Mauro M. S. Saraiva, Angelo Berchieri Junior, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini, João Perdigão, Fernando Rogério Pavan, Fernando Albericio

“…AMPs, which can be produced as part of the innate immune response or synthesized therapeutically, have broad‐spectrum antimicrobial activity, often disrupting microbial cell membranes and causing cell death. …”
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Alternative treatment methods for bovine mastitis: prospects and limitations (review) by V. D. Zubareva, O. V. Sokolova, M. V. Bytov, A. S. Krivonogova, S. V. Volskaya

“…Taking into account the risks associated with antibiotic therapy, such as decreased drug effectiveness due to occurrence of bacterial resistant strains, food safety issues, environmental impact and restrictions on the use of antibacterial drugs in veterinary medicine, an increasing number of scientific studies are addressing new therapeutic agents that can serve as an alternative to conventional therapy. …”
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Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants by Yanru Long, Houhui Shi, Jiatian Ye, Xiaorong Qi

“…In this review, we will discuss the complex relationship between oxidative stress and ovarian cancer, as well as the role and therapeutic potential of antioxidants in ovarian cancer, thus guiding future research and clinical interventions.…”
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<i>Mycobacterium abscessus—</i>An Emerging True Pathogen: A Case Report by Shruti Appaswamy, Bhavesh D Rathod

“…It is one of the commonly identified NTM species responsible for severe respiratory, skin, and mucosal infections in humans and is often regarded one of the most antibiotic-resistant mycobacteria, leaving us with few therapeutic options. Although historically known to cause infections in immunocompromised individuals, the incidence of infections in immunocompetent humans is on the rise, giving it the status of a true pathogen. …”
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Impact of Temozolomide on Immune Response during Malignant Glioma Chemotherapy by Sadhak Sengupta, Jaclyn Marrinan, Caroline Frishman, Prakash Sampath

“…Malignant glioma, or glioblastoma, is the most common and lethal form of brain tumor with a median survival time of 15 months. The established therapeutic regimen includes a tripartite therapy of surgical resection followed by radiation and temozolomide (TMZ) chemotherapy, concurrently with radiation and then as an adjuvant. …”
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Marked Rebound of Platelet Count in the Early Postpartum Period in a Patient with Essential Thrombocythemia by Yoshinori Hashimoto, Rina Hosoda, Hiromi Omura, Takayuki Tanaka

“…However, there is insufficient information on when therapeutic interventions are necessary and how they should be performed. …”
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Uncovering the significance of CBX3 as an up-and-coming biomarker in cardio-vascular health by Muhammad Aamir Wahab, Nunzio Del Gaudio, Biagio Gargiulo, Vincenzo Quagliariello, Nicola Maurea, Michele Grieco, Rosaria Benedetti, Angela Nebbioso, Lucia Altucci, Mariarosaria Conte

“…This review outlines the role of CBX3 in mechanisms associated with CVD and feasibility for optimizing pre-existing therapy and developing new therapeutic strategies based on personalized medicine.…”
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Concordance between the Different Cardiovascular Risk Scores in People with Rheumatoid Arthritis and Psoriasis Arthritis by Cristina Gonzalez-Martin, Silvia Grande Morais, Sonia Pertega-Diaz, Teresa Seoane-Pillado, Vanesa Balboa-Barreiro, Raquel Veiga-Seijo

“…Measurements: sociodemographic, anthropometric variables of the disease, comorbidity, cardiovascular risk, and therapeutic management. Results. 151 subjects (75 RA and 76 PsA) were studied. …”
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Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon by Kishor Butte, Munira Momin, Hemant Deshmukh

“…The higher incidences of side effects of existing drugs have shifted researchers and clinicians to explore the dietary phytoconstituents for its therapeutic potentials. The present study is based on compression coated curcumin tablet for the colon. …”
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Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway by Chun Yang, Shengnan Sun, Qi Zhang, Jia Guo, Tengfei Wu, Ying Liu, Min Yang, Yan Zhang, Yinghua Peng

“…Mesenchymal stem cells (MSCs) are multipotent cells that have therapeutic potentials mainly through paracrine action via secreting growth factors and cytokines. …”
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A New Hope in Immunotherapy for Malignant Gliomas: Adoptive T Cell Transfer Therapy by Dong-Sup Chung, Hye-Jin Shin, Yong-Kil Hong

“…Immunotherapy emerged as a promising therapeutic approach to highly incurable malignant gliomas due to tumor-specific cytotoxicity, minimal side effect, and a durable antitumor effect by memory T cells. …”
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The Tao of Hematopoietic Stem Cells: Toward a Unified Theory of Tissue Regeneration by Kevin D. Bunting, Robert G. Hawley

“…Preclinical amelioration of liver disease and myocardial infarcts by HSC-enriched bone marrow cell populations raises the possibility that HSC transplants have the potential to provide therapeutic benefit for a wide variety of diseases. …”
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Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations... by Anthony Altieri, Grace V. Visser, Matthew B. Buechler

“…Finally, we will outline how novel research identifying key regulators of ECM deposition is critical for therapeutic development for fibrotic diseases and cancer.…”
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Injectable double network hydrogel with adjustable stiffness for modulation of macrophage polarization by Jinxin Wu, Bing Han, Shili Ai, Aijing Wang, Yilin Song, Moran Jin, Xiaozhong Qu, Xiaoyan Wang

“…Additionally, the critical role of integrins in mediating mechanical transduction may provide new therapeutic targets for treating certain stiffness-related inflammatory diseases.…”
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Hemodynamic disturbance and mTORC1 activation: Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome by Ming-Yuan Liu, Meili Wang, Junjun Liu, An-Qiang Sun, Chang-Shun He, Xin Cong, Wei Kong, Wei Li

“…Crucially, our research demonstrates a direct linkage between the activation of the mTORC1 pathway and the intensity in OSS. Therapeutic administration of rapamycin suppresses mTORC1 activity, leading to the attenuation of aberrant SMC behavior, reduced inflammatory infiltration, and restoration of extracellular matrix integrity—collectively decelerating TAA advancement in our mouse model. …”
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Icaritin alleviates motor impairment and osteoporosis in Parkinson’s disease mice via the ER-PI3K/Akt pathway by Xianmei Lin, Xinyu Zhou, Xingman Liu, Lingqiong Xia, Jing Cai, Nanqu Huang, Yong Luo, Weidong Wu

“…These findings suggest ICT may offer therapeutic potential in managing OVX-induced motor dysfunction and PD.…”
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Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, Morocco by Abdelmounaim Laabar, Imad Kabach, Sara El Asri, Amr Kchikich, Soufiane Drioua, Ayoub El Hamri, Moulay El Abbes Faouzi

“…Moreover, their antiglycation effects, marked by the prevention of advanced glycation end products and protein damage, highlight their potential in maintaining cellular integrity.These findings suggest that Sonchus oleraceus and Lobularia maritima extracts possess promising antioxidant, antidiabetic, and anti-inflammatory properties, paving the way for their therapeutic application in managing diabetes, oxidative stress, and related conditions.…”
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Human head and neck cancer cell lines response to cold atmospheric plasma activated media is affected by the chemistry of culture media by Viviana di Giacomo, Marwa Balaha, Asia Pece, Ilaria Cela, Gianluca Fulgenzi, Giovanna Orsini, Tatiana Spadoni, Tirtha Raj Acharya, Nagendra Kumar Kaushik, Eun Ha Choi, Monica Rapino, Mariangela Mazzone, Gabriella Mincione, Gianluca Sala, Eloisa Sardella, Vittoria Perrotti

“…In our work, we assessed the potential application of indirect CAP, by using plasma activated media (PAM) and plasma-treated liquids (PTL), as therapeutic strategies for HNSCC treatment. The impact of PAM obtained from exposure to CAP for different times was evaluated in three head and neck cancer (HNC) cell lines (HSC3, FaDu, CAL-27). …”
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Analysis of toxicity and mechanisms of busulfan in non-obstructive azoospermia: A genomic and toxicological approach integrating molecular docking, single-cell sequencing, and expe... by Yanggang Hong, Qichao Yuan, Yi Wang, Deqi Wang, Xiaoju Guan, Congde Chen

“…These findings offer new insights into the mechanisms of busulfan-induced NOA and suggest potential therapeutic targets for preserving male fertility in chemotherapy patients. …”
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