3D Segmentation and Visualization of Skin Vasculature Using Line-Field Confocal Optical Coherence Tomography by Oliver Mayer, Hanna Wirsching, Sophia Schlingmann, Julia Welzel, Sandra Schuh

“…These visualizations provide insights into vessel morphology, spatial arrangements, and blood flow patterns, which are crucial for assessing tumor growth and potential therapeutic responses. The findings indicate that 3D reconstructions from LC-OCT can uncover vascular details previously undetectable by two-dimensional imaging techniques, making it a valuable tool in dermatology for both clinical diagnostics and research. …”
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Protein Glycation in Diabetes as Determined by Mass Spectrometry by Annunziata Lapolla, Laura Molin, Pietro Traldi

“…The development of mass spectrometric techniques able to give highly specific and reliable results in proteome field is of wide interest for physicians, giving them new tools to monitor the disease progression and the possible complications related to diabetes, as well as the effectiveness of therapeutic treatments. This paper reports and discusses some of the data pertaining protein glycation in diabetic subjects obtained by matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS). …”
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Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review by Jiangyu Wu, Weizhe Huang, Ziying He

“…RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small interfering RNAs (siRNA) are used to specifically downregulate the expression of the targeted gene, known as the term “gene silencing.” …”
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VMAT2-Deficient Mice Display Nigral and Extranigral Pathology and Motor and Nonmotor Symptoms of Parkinson's Disease by Tonya N. Taylor, W. Michael Caudle, Gary W. Miller

“…The multisystem nature of the VMAT2-deficient mice may be useful in developing therapeutic strategies that go beyond the dopamine system.…”
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Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology by Robin Christ, Devon Siemes, Shuo Zhao, Lars Widera, Philippa Spangenberg, Julia Lill, Stephanie Thiebes, Jenny Bottek, Lars Borgards, Andreia G. Pinho, Nuno A. Silva, Susana Monteiro, Selina K. Jorch, Matthias Gunzer, Bente Siebels, Hannah Voss, Hartmut Schlüter, Olga Shevchuk, Jianxu Chen, Daniel R. Engel

“…Overall, our findings elucidate the critical role of TNF-α in EHEC-induced brain pathology and highlight a potential therapeutic target for mitigating neuroinflammation, microglial activation and injury associated with EHEC infection. …”
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Genes related to neural tube defects and glioblastoma by Rui Cao, Yurong Liu, Kaixin Wei, Ning Jin, Yuxiang Liang, Ruifang Ao, Weiwei Pan, Xiang Wang, Xiuwei Wang, Li Zhang, Jun Xie

“…Overall, our results demonstrated that Fgf1 abnormally expressed at different developmental stages, it may be a potentially prenatal biomarker for NTDs and potential therapeutic target for GBM. Pazopanib may be a new drug for the treatment of GBM tumors.…”
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Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease by Caterina Oriana Aragona, Egidio Imbalzano, Federica Mamone, Valentina Cairo, Alberto Lo Gullo, Angela D’Ascola, Maria Adriana Sardo, Michele Scuruchi, Giorgio Basile, Antonino Saitta, Giuseppe Mandraffino

“…Due to their capability of proliferation, circulation, and the development of functional progeny, great interest has been directed to therapeutic use of progenitor cells in atherosclerotic diseases. …”
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Interference of a phytoconstituent from Nymphaea lotus-derived ligand N-acetyl glucosamine with signaling receptors in diabetes mellitus development: A targeted computational analy... by Sunday Amos Onikanni, Tran Nhat-Phong Dao, Adewale Oluwaseun Fadaka, Halliru Zailani, Oluwafemi Shittu Bakare, Omolola Esther Amos, Ashwil Klein, Valens Munyembaraga, Morenike Grace Ajayi, Adebola Iyabode Akinjokun, Babatunji Emmanuel Oyinloye, Leandro Miranda-Alves

“…This suggests that Nymphaea lotus and its bioactive compounds have promising medicinal value for managing type 2 diabetes, warranting further research into their therapeutic potential.…”
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Population Based Trends in the Incidence of Hospital Admission for the Diagnosis of Hepatorenal Syndrome: 1998–2011 by Manish Suneja, Fan Tang, Joseph E. Cavanaugh, Linnea A. Polgreen, Philip M. Polgreen

“…Understanding the incidence and mortality trends in hepatorenal syndrome will help inform future studies regarding the safety and efficacy of potential therapeutic interventions. Design and Methods. We conducted a retrospective cohort study using the Nationwide Inpatient Sample. …”
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CITMIC: Comprehensive Estimation of Cell Infiltration in Tumor Microenvironment based on Individualized Intercellular Crosstalk by Xilong Zhao, Jiashuo Wu, Jiyin Lai, Bingyue Pan, Miao Ji, Xiangmei Li, Yalan He, Junwei Han

“…In conclusion, CITMIC offers a more comprehensive description of TME cell composition by considering cell‐cell crosstalk, providing an important reference for the discovery of predictive biomarkers and the development of new therapeutic strategies.…”
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Severity of Oral Mucositis in Children following Chemotherapy and Radiotherapy and Its Implications at a Single Oncology Centre in Durango State, Mexico by Ramón G. Carreón-Burciaga, Enrique Castañeda-Castaneira, Rogelio González-González, Nelly Molina-Frechero, Enrique Gaona, Ronell Bologna-Molina

“…It is important to implement therapeutic protocols that help maintain excellent oral health and reduce the risk of oral mucositis. …”
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From pain to meningitis: bacteria hijack nociceptors to promote meningitis by Huazhen Liu, Xingxing Kong, Yuqin Zeng, Jinyun Chen, Zhanpeng Chen, Lanlan Liu, Quan Ma, Xuhui Liu, Xuhui Liu, Shuihua Lu

“…Understanding this neuroimmune axis may open potential therapeutic targets for treating bacterial meningitis by enhancing host defenses and mitigating pain. …”
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Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy by Zhian Chen, Yutong Wang, Zhenhao Li, Meijuan Chen, Yingshi Li, Chuyue Lu, Zhenyu Lin, Hua Zheng, Lujia Chen, Qianbing Zhang

“…Lysosomes is emerging as a promising therapeutic target for improving immunotherapy, which dysfunction would trigger lysosomal membrane permeabilization increase and subsequent leakage of reduced iron, which contributed to ferroptosis through cell-intrinsic Fenton chemistry. …”
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Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis by Liliana R. Balahura, Aida Selaru, Sorina Dinescu, Marieta Costache

“…So far, many efforts have been made in order to extend the knowledge of inflammasome implications and how its components could be targeted as therapeutic agents. Additionally, microRNAs (miRNAs), evolutionary conserved noncoding molecules, have emerged as pivotal players during numerous biological events by regulating gene and protein expression. …”
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Nanostructural and nanomechanical alterations of photosensitized lipid membranes due to light induced formation of reactive oxygen species by Ádám Zolcsák, Bálint Kiss, Tamás Bozó, Judit Somkuti, István Vona, Miklós Kellermayer, Levente Herenyi

“…Since PSs are accumulated preferably in lipid membranes, the study of photoinduced damage to membrane lipids can greatly increase our understanding of the effect of ROS on membranes in pathological as well as therapeutic conditions. We aimed to characterize the topographical and nanomechanical changes in supported lipid bilayers (SLBs) evoked by light-induced ROS formation. …”
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A comprehensive review on multifunctional bioactive properties of elm oyster mushroom Hypsizygus ulmarius (Bull.) Redhead (Agaricomycetes): Current research, challenges and future... by Aditya, Neeraj, J.N. Bhatia, Ajar Nath Yadav

“…Hypsizygus ulmarius shows great potential as a valuable source of several nutrients and bioactive chemicals that may have therapeutic qualities. The immunomodulatory, anti-oxidant, anti-inflammatory and potential anti-cancer properties of this mushroom provide opportunities for further future research in the creation of beneficial functional foods, dietary supplements and pharmaceutical interventions to enhance human health.…”
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Mutations in human prion-like domains: pathogenic but not always amyloidogenic by Andrea Bartolomé-Nafría, Javier García-Pardo, Salvador Ventura

“…Understanding the molecular basis of this discrepancy might provide insights for developing targeted therapeutic strategies to combat hnRNP-associated diseases.…”
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Magnetic beads as intravesical foreign bodies in children: our clinical experience by Yefeng Zeng, Shaogang Huang, Zhilin Yang, Xianbin Gu, Xuerui Sun, Pengyu Chen, Shoulin Li

“…PurposeTo analyze the clinical data of five patients involving intravesical magnetic beads, summarizing diagnostic and therapeutic experiences.MethodsFrom January 2018 to November 2023, five pediatric patients were treated for intravesical magnetic beads at Shenzhen Children's Hospital. …”
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Prevention of LPS-Induced Acute Lung Injury in Mice by Progranulin by Zhongliang Guo, Qinchuan Li, Yang Han, Yongjie Liang, Zengguang Xu, Tao Ren

“…Despite decades of research, few therapeutic strategies for clinical ARDS have emerged. …”
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Modulation of behavior before COVID-19, in contact patients treated at the Villa Azucarera isolation center by Isela Casas Olazabal, Enia Lorenzo Pérez, Maria Cristina Pérez Guerrero, Jaqueline García Rodríguez, Ricardo Vázquez Casas

“…<br /><strong>Conclusions:</strong> The attitude of the patient during the surveillance in the institution changes from an explicit rejection at the beginning, to an acceptance at the time of discharge, and an increase in the perception of the risk of becoming ill due to the increase in the level of information and of the therapeutic relationship established with health personnel.…”
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