Repetitive Noninvasive Monitoring of HSV1-tk-Expressing T Cells Intravenously Infused into Nonhuman Primates Using Positron Emission Tomography and Computed Tomography with F-FEAU by Gianpietro Dotti, Mei Tian, Barbara Savoldo, Amer Najjar, Laurence J.N. Cooper, James Jackson, Amanda Smith, Osama Mawlawi, Rajesh Uthamanthil, Agatha Borne, David Brammer, Vincenzo Paolillo, Mian Alauddin, Carlos Gonzalez, David Steiner, William K. Decker, Frank Marini, Steven Kornblau, Catherine M. Bollard, Elizabeth J. Shpall, Juri G. Gelovani

“…Noninvasive imaging of adoptively transferred CTLs using molecular-genetic reporter imaging with positron emission tomography and computed tomography (PET-CT) represents an innovative approach to understanding the long-term migratory patterns and therapeutic potential of adoptively transferred T cells. …”
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Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide by Maria Voukali, Irene Kastrinelli, Sapfo Stragalinou, Dimitra Tasiopoulou, Pinelopi Paraskevopoulou, Nicholas Katsilambros, Alexandros Kokkinos, Nicholas Tentolouris, Ioannis Ioannidis

“…Therapeutic approaches based on the actions of the incretin hormone GLP-1 have been widely established in the management of T2DM. …”
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Percutaneous thoracostomy with thoracic lavage for traumatic hemothorax: a performance improvement initiative by Michael A Vella, Ryan Peter Dumas, Jeremy W Cannon, Ali Ali, Jay Yelon, Carl A Beyer, Martha M Brinson, Nathaniel McLauchlan, Sarah M Joergensen

“…Seven patients were discharged home in stable condition, one was discharged to an acute rehabilitation facility, and one was discharged to a skilled nursing facility.Conclusions Percutaneous thoracostomy with pleural lavage is clinically feasible and effective and warrants further evaluation with a multicenter clinical trial.Level of evidence Therapeutic/care management, level V.…”
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Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures by Melissa Lo Monaco, Greet Merckx, Jessica Ratajczak, Pascal Gervois, Petra Hilkens, Peter Clegg, Annelies Bronckaers, Jean-Michel Vandeweerd, Ivo Lambrichts

“…Due to the restricted intrinsic capacity of resident chondrocytes to regenerate the lost cartilage postinjury, stem cell-based therapies have been proposed as a novel therapeutic approach for cartilage repair. Moreover, stem cell-based therapies using mesenchymal stem cells (MSCs) or induced pluripotent stem cells (iPSCs) have been used successfully in preclinical and clinical settings. …”
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Prevalence of anhedonia in women with deep endometriosis by Aida Mallorquí, Alessandra Fortuna, Emma Segura, Gemma Cardona, Marta Espinosa, Lara Quintas-Marquès, Meritxell Gracia, Elena Angulo-Antúnez, Francisco Carmona, María-Angeles Martínez-Zamora

“…Overall, our study highlights the impact of chronic pain on hedonic functioning in DE. Therapeutic approaches targeting hedonic capacity in DE patients are crucial for restoring health and well-being.…”
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Clinicopathological, Histopathological, and Immunohistochemical Analysis of Mandibular Fibrosarcoma in a DSH Cat: A Case Report by Mahmood Ahmadi‐hamedani, Hamid Reza Moslemi, Sahar Ghaffari Khaligh, Mehdi Sedghi, Kimia Sattari

“…During the inspection of the oral cavity, unilateral swelling was observed on the ventral side of the jaw. Before any therapeutic intervention, a cell blood count (CBC) test and FNA cytology were conducted. …”
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Subarachnoid hemorrhage triggered by spinal cord vascular malformation in a pediatric patient: case report and review of literature by Ye Zhang, Liaoyuan Zheng, Yongwei Huang, Zongping Li, Jing Feng

“…Early and accurate diagnosis, followed by appropriate treatment through microsurgical resection or endovascular embolization, can significantly improve therapeutic outcomes in children with SCVMs.…”
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Establishment and Characterization of a Human Small Cell Osteosarcoma Cancer Stem Cell Line: A New Possible In Vitro Model for Discovering Small Cell Osteosarcoma Biology by Gaia Palmini, Roberto Zonefrati, Cecilia Romagnoli, Alessandra Aldinucci, Carmelo Mavilia, Gigliola Leoncini, Alessandro Franchi, Rodolfo Capanna, Maria Luisa Brandi

“…This will represent a first step into the study of the biology of these cells to discover new molecular targets molecules for new incisive therapeutic strategies against this highly aggressive OSA.…”
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Development of Solid Nanosystem for Delivery of Chlorhexidine with Increased Antimicrobial Activity and Decreased Cytotoxicity: Characterization and In Vitro and In Ovo Toxicologic... by Alexandra-Ioana Dănilă, Mihai Romînu, Krisztina Munteanu, Elena-Alina Moacă, Andreea Geamantan-Sîrbu, Iustin Olariu, Diana Marian, Teodora Olariu, Ioana-Cristina Talpoş-Niculescu, Raluca Mioara Cosoroabă, Ramona Popovici, Ştefania Dinu

“…Despite this, future research should focus on optimizing this type of nanosystem and conducting comprehensive in vivo studies to validate its therapeutic efficacy and safety in clinical settings.…”
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The role of natural products targeting macrophage polarization in sepsis-induced lung injury by Yake Li, Sinan Ai, Yuan Li, Wangyu Ye, Rui Li, Xiaolong Xu, Qingquan Liu

“…This work provides valuable insights into the therapeutic potential of NPs in targeting macrophage polarization to treat SALI. …”
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Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior by M. Leo, M. Schulte, L.-I. Schmitt, M. Schäfers, C. Kleinschnitz, T. Hagenacker

“…These results suggest that the involvement of TRPV1 in TNF-induced pain offers new TRPV1-based experimental therapeutic approaches and demonstrates the analgesic potential of RTX in inflammatory pain diseases.…”
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Brain Oxygenation During Exercise in Different Types of Chronic Lung Disease: A Narrative Review by Stella Kritikou, Andreas Zafeiridis, Georgia Pitsiou, Ioannis Gkalgkouranas, Leonidas Kastritseas, Afroditi Boutou, Konstantina Dipla

“…Understanding the effects of chronic lung disease on cerebral oxygenation during exercise may improve our understanding of exercise intolerance mechanisms and help identify therapeutic strategies to enhance brain health and exercise capacity in these patients.…”
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Dextran-Polyacrylamide as Matrices for Creation of Anticancer Nanocomposite by G. Telegeev, N. Kutsevol, V. Chumachenko, A. Naumenko, P. Telegeeva, S. Filipchenko, Yu. Harahuts

“…Taking into account the fact that our nanoparticles will act mainly on malignant phagocytic cells and do not affect healthy cells, they can thus potentially be used for the therapeutic treatment of tumor cells having phagocytic activity. …”
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Evolution of Cerebral Atrophy in a Patient with Super Refractory Status Epilepticus Treated with Barbiturate Coma by Christopher R. Newey, Pravin George, Premkumar Nattanmai, Christine Ahrens, Stephen Hantus, Aarti Sarwal

“…Further research into direct effects of therapeutic coma is warranted.…”
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Evaluation of the relationships between psychiatric comorbidity and seizure semiology in psychogenic non-epileptic seizure patients by Gülce Coşku Yılmaz, Hatice Sabiha Türe, Esin Evren Kılıçaslan, Galip Akhan

“…This phenomenon renders PNES a shared affliction within the domains of neurology and psychiatry, thereby mandating the implementation of diverse therapeutic approaches in the management of the condition. …”
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Establishment and characterization of a sigmoid colon cancer organoid with spinal metastasis by Jingyao Chen, Jingyao Chen, Shumin Cheng, Liang Gu, Liang Gu, Zhangsen Huang, Zhangsen Huang, Changhua Zhang, Changhua Zhang, Chunhui Sun, Chunhui Sun, Chunhui Sun, Songyao Chen, Songyao Chen

“…In order to find effective therapeutic agents, we need to know the biological characteristics of such patients from related models.MethodsWe collected sigmoid colon cancer tissue from a young female subject who was diagnosed with sigmoid colon cancer with multiple spinal metastases. …”
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Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits by Shoucui Gao, Xiaojing Wang, Daxing Cheng, Jiayan Li, Lu Li, Linwu Ran, Sihai Zhao, Jianglin Fan, Enqi Liu

“…High levels of plasma high-density lipoprotein-cholesterol (HDL-C) are inversely associated with the risk of atherosclerosis and other cardiovascular diseases; thus, pharmacological inhibition of cholesteryl ester transfer protein (CETP) is considered to be a therapeutic method of raising HDL-C levels. However, many CETP inhibitors have failed to achieve a clinical benefit despite raising HDL-C. …”
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Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC by Kai-Xia Zhou, Shan Huang, Li-Peng Hu, Xue-Li Zhang, Wei-Ting Qin, Yan-Li Zhang, Lin-Li Yao, Yanqiu Yu, Yao-Qi Zhou, Lei Zhu, Jianguang Ji, Zhi-Gang Zhang

“…Tumor immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Karyopherin alpha 2 (KPNA2), a member of the nuclear transporter family, is elevated in multiple human cancers and accelerates carcinogenesis. …”
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Knowledge and Attitude of Pharmacy Students Regarding Timing of Prescribed Medicines Administration: Chronotherapy by Humayun Mirza, Ayesha Mansoor, Farheen Ahmad, Warda Idrees, Talmeez Zeb, Amir Naveed

“…The introduction highlights the significance of considering the optimal time for drug administration in patient care, emphasizing the impact of biological rhythms on therapeutic outcomes. Study type, settings & duration: This cross-sectional study was conducted at Lahore Medical & Dental College, Lahore, Pakistan from May to August 2021.   …”
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Comparing the Effectiveness of Dialectical Behavior Therapy and Acceptance and Commitment Therapy on Psychological Flexibility in Mothers of Children with Learning Disabilities by Zahra Shafeie, Mohammad Ghamari, Aboutaleb Saadati Shamir

“…Conclusions: In light of these results, professionals in the fields of psychology and counseling are advised to consider implementing these educational and therapeutic approaches to enhance the psychological flexibility of mothers raising children with specific learning disabilities.…”
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