The emerging roles of aberrant alternative splicing in glioma by Reda Ben Mrid, Sara El Guendouzi, Marco Mineo, Rachid El Fatimy

“…In this review, we explore how AS events, spliceosome components, and their regulatory mechanisms play a critical role in glioma development, highlighting their potential as targets for innovative therapeutic strategies against this challenging cancer.…”
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Two Small Peptides from <i>Buthus martensii</i> Hydrolysates Exhibit Antitumor Activity Through Inhibition of TNF-α-Mediated Signal Transduction Pathways by Mengshuang Zhu, Shanshan Zhang, Jiyang Tang, Hairong Hou, Lizhen Wang, Houwen Lin, Xuanming Zhang, Meng Jin

“…In silico prediction of therapeutic targets, MGC-803 cells and transgenic zebrafish models, and immunoblotting experiments were used to reveal the molecular mechanism of action of the peptides. …”
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Matrix Metalloproteinases: Inflammatory Regulators of Cell Behaviors in Vascular Formation and Remodeling by Qishan Chen, Min Jin, Feng Yang, Jianhua Zhu, Qingzhong Xiao, Li Zhang

“…Regarding the importance of vascular cells in abnormal angiogenesis and vascular remodeling, regulation of vascular cell behaviors through modulating expression and activation of MMPs shows therapeutic potential.…”
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Endoscopic Mucosal Resection Performed Underwater for Nonampullary Duodenal Epithelial Tumor: Evaluation of Feasibility and Safety by Goro Shibukawa, Atsushi Irisawa, Ai Sato, Yoko Abe, Akane Yamabe, Noriyuki Arakawa, Yusuke Takasaki, Takumi Maki, Yoshitsugu Yoshida, Ryo Igarashi, Shogo Yamamoto, Tsunehiko Ikeda, Hiroshi Hojo

“…UW-EMR may be a safe and effective treatment method for SNADET, if its therapeutic indication is adequately considered.…”
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Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation by Yong Yi, Guoqiang Wang, Wenhua Zhang, Shuhan Yu, Junjie Fei, Tingting An, Jianqiao Yi, Fengtian Li, Ting Huang, Jian Yang, Mengmeng Niu, Yang Wang, Chuan Xu, Zhi-Xiong Jim Xiao

“…Together, these findings reveal a role for MT-CO2 in adapting to metabolic stress and highlight MT-CO2 as a putative therapeutic target for Ras-driven cancers.…”
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Inhibitory Effect of Matrine on Blood-Brain Barrier Disruption for the Treatment of Experimental Autoimmune Encephalomyelitis by Su Zhang, Quan-Cheng Kan, Yuming Xu, Guang-Xian Zhang, Lin Zhu

“…In the present study, we show that MAT treatment had a therapeutic effect comparable to dexamethasone (DEX) in EAE rats, with reduced Evans Blue extravasation, increased expression of collagen IV, the major component of the basement membrane, and the structure of tight junction (TJ) adaptor protein Zonula occludens-1 (ZO-1). …”
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Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis by Xiaohan Liu, Yang Zhang, Youzhao Wang, Yujie Yang, Zhe Qiao, Ping Zhan, Huiying Jin, Qianqian Xu, Wei Tang, Yu Sun, Yan Zhang, Fan Yi, Min Liu

“…Thus, this study indicates that MYDGF derived from tubules may be an effective therapeutic strategy for patients with CKD.…”
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A Case of Variceal Bleeding with Cricopharyngeal Web: A Challenge to Variceal Band Ligation by Dandi Kranthi, Debabrata Banerjee, Amol S Dahale, Abhijeet Karad, Yogesh Bade

“…The present report contributes to the literature by documenting an unusual clinical scenario that required modification of the standard therapeutic approach to achieve haemostasis in a life-threatening situation.…”
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The forgotten link: how the oral microbiome shapes childhood growth and development by Raymond Rubianto Tjandrawinata, Nurlinah Amalia, Nurlinah Amalia, Nurlinah Amalia, Yosi Yohanes Putra Tandi, Ariq Fadhil Athallah, Caesaroy Afif Wibowo, Muhammad Reva Aditya, Muhammad Reva Aditya, Athaya Rahmanardi Muhammad, Athaya Rahmanardi Muhammad, Maghfira Rahma Azizah, Maghfira Rahma Azizah, Farizky Martriano Humardani, Ammar Nojaid, Jeremy Alvaro Christabel, Alfi Agnuristyaningrum, Fahrul Nurkolis, Fahrul Nurkolis

“…A deeper understanding of these interactions may inform innovative diagnostic tools and therapeutic interventions aimed at mitigating stunting through oral microbiome modulation. …”
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Extracellular HMGB1 Induced Glomerular Endothelial Cell Injury via TLR4/MyD88 Signaling Pathway in Lupus Nephritis by Tian Yu, Feng Xiaojuan, Liu Jinxi, Miao Xinyan, Xu Jie, Tian Yuexin, Liu Qingjuan, Zhang Wei, Gu Cunyang, Huang Jie, Wu Lunbi, Zhao Hang, Liu Shuxia, Guo Huifang

“…These results suggested that extracellular HMGB1 might involve in GEC injury by activating the TLR4/MyD88 signaling pathway in LN, which provided novel insights and potential therapeutic target for the treatment of lupus nephritis.…”
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Characterizing the patient experience of physical restraint in psychiatric settings via a linguistic, sentiment, and metaphor analysis by Cristiano Nichini, Chiara Barattieri di San Pietro, Biagio Scalingi, Eleonora Alecci, Luca Toschi, Simone Cavallotti, Anna Chiara Cigognini, Federico Durbano, Silvia Ferraris, Patrizia Santinon, Chiara Pompei, Federico Frau, Veronica Mangiaterra, Luca Bischetti, Marta Bosia, Gianluca Peschi, Pierluigi Politi, Valentina Bambini

“…Overall, the study highlights the importance of Natural Language Processing as an unobtrusive window into subjective experience, offering insights for therapeutic choices.…”
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Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients by Cristina Deflorio, Emanuela Onesti, Clotilde Lauro, Giorgio Tartaglia, Aldo Giovannelli, Cristina Limatola, Maurizio Inghilleri, Francesca Grassi

“…In myotubes, riluzole (1 μM, a therapeutic concentration) reduced Na+ current by 20%. …”
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Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression by Georgia Tsaouli, Elisabetta Ferretti, Diana Bellavia, Alessandra Vacca, Maria Pia Felli

“…Further studies are required to identify new challenges and opportunities to develop more selective and safer therapeutic strategies in ALL progression, possibly contributing to improve conventional hematological cancer therapy.…”
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Selective Gene Transfer to the Retina Using Intravitreal Ultrasound Irradiation by Shozo Sonoda, Katsuro Tachibana, Toshifumi Yamashita, Makoto Shirasawa, Hiroto Terasaki, Eisuke Uchino, Ryo Suzuki, Kazuo Maruyama, Taiji Sakamoto

“…This procedure could be used to transfer genes and drugs directly to the retina and therefore has potential therapeutic value.…”
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Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides by Akiyuki Nishimura, Tomohiro Tanaka, Kakeru Shimoda, Tomoaki Ida, Shota Sasaki, Keitaro Umezawa, Hiromi Imamura, Yasuteru Urano, Fumito Ichinose, Toshiro Kaneko, Takaaki Akaike, Motohiro Nishida

“…Abnormal sulfide catabolism, especially hydrogen sulfide accumulation, impedes mitochondrial respiration and worsens the prognosis after ischemic insults, but the substantial therapeutic strategy has not been established. Non-thermal atmospheric pressure plasma irradiation therapy is attracted attention as it exerts beneficial effects by producing various reactive molecular species. …”
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Factors affecting fatigue progression in multiple sclerosis patients by Dima Machtoub, Callie Fares, Hassan Sinan, Moustafa Al Hariri, Rim Nehme, Joelle Chami, Ronny Joukhdar, Raya Tcheroyan, Salim Adib, Samia J. Khoury

“…This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens that are correlated with worsening fatigue over time in patients diagnosed with MS. …”
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CircXYLT1 suppresses oxidative stress and promotes vascular remodeling in aging mice carotid artery injury model of atherosclerosis via PTBP1 by Gang Li, Donghui Li, Yajing Li, Bingqi Liu

“…These findings suggest that CircXYLT1 plays a critical role in vascular remodeling and oxidative stress regulation, offering potential as a therapeutic target for managing cardiovascular diseases in aging populations.…”
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Building a Genomics-Informed Nursing Workforce: Recommendations for Oncology Nursing Practice and Beyond by Jacqueline Limoges, Rebecca Puddester, Andrea Gretchev, Patrick Chiu, Kathy Calzone, Kathleen Leslie, April Pike, Nicole Letourneau

“…Background: Genomics is a foundational element of precision health and can be used to identify inherited cancers, cancer related risks, therapeutic decisions, and to address health disparities. …”
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Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections by Rukavina Zora, Jøraholmen May Wenche, Božić Dunja, Frankol Ivana, Gašparović Petra Golja, Škalko-Basnet Nataša, Klarić Maja Šegvić, Vanić Željka

“…Incorporation of AZT-liposomes into CHG (liposomal CHGs) was intended to ensure proper viscosity and texture properties of the formulation, modification of antibiotic release, and enhanced antibacterial activity, aiming to upgrade the therapeutical potential of AZT-liposomes in localized treatment of MRSA-related skin infections. …”
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Melanoma genomics – will we go beyond BRAF in clinics? by Justyna Mirek, Wiesław Bal, Magdalena Olbryt

“…This question is rather urgent because new therapeutic targets and biomarkers are needed to implement more personalized, patient-tailored therapy in clinics. …”
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