Biological properties of Moringa oleifera: A systematic review of the last decade [version 2; peer review: 2 approved, 1 approved with reservations] by Andrea Catalina Gómez, Javier Andrés Soto, C. A. Zuniga-Gonzalez, Karen Shirley Molina, Andrea Natalia Barreto, Maryeli Vásquez

“…Therefore, it is critical to search for new therapeutic alternatives. Moringa oleifera is a plant well known for the properties of its phytocomponents and its role has been analyzed in a variety of fields, from medicine to biotechnology. …”
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Early characterization and prediction of glioblastoma and brain metastasis treatment efficacy using medical imaging-based radiomics and artificial intelligence algorithms by Noémie N. Moreau, Noémie N. Moreau, Samuel Valable, Cyril Jaudet, Loïse Dessoude, Leleu Thomas, Romain Hérault, Romain Modzelewski, Romain Modzelewski, Dinu Stefan, Juliette Thariat, Juliette Thariat, Alexis Lechervy, Aurélien Corroyer-Dulmont, Aurélien Corroyer-Dulmont

“…Differentiating non-responders from responders as early as possible in order to tailor treatment in a personalized medicine fashion to optimize tumor control and preserve healthy brain tissue is the most pressing unmet therapeutic challenge. Innovative computer solutions recently emerged and could provide help to this challenge. …”
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Substituted piperazine conjugated to quinoline-thiosemicarbazide as potent α-glucosidase inhibitors to target hyperglycemia by Mehran Ghasemi, Mohammad Mahdavi, Maryam Dehghan, Mohammadreza Eftekharian, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Aida Iraji, Ahmed Al-Harrasi

“…Abstract Diabetes mellitus, particularly type 2 diabetes, is a growing global health challenge characterized by chronic hyperglycemia due to insulin resistance. One therapeutic approach to managing this condition is the inhibition of α-glucosidase, an enzyme involved in carbohydrate digestion, to reduce postprandial blood glucose levels. …”
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Oral Squamous Cell Carcinoma: Features and Medico-Legal Implications of Diagnostic Omission by Davide Albano, Antonina Argo, Giuseppa Bilello, Enzo Cumbo, Melania Lupatelli, Pietro Messina, Fabio Massimo Sciarra, Mario Sessa, Stefania Zerbo, Giuseppe Alessandro Scardina

“…Early diagnosis of oncologic pathologies has a crucial role to determine patient’s prognosis and therapeutic path. Nonetheless, clinical errors and omissions that can occur during diagnostic, as well as detection of preneoplastic or neoplastic condition, may result in devasting consequences both for patients in terms of health and for professionals in terms of medico-legal responsibility. …”
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Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments by Jia-Haur Chen, John Vincent Lim, Yih-Chih Hsu

“…Collectively, the combined PDT with LPC nanoparticles showed significant therapeutic outcomes with promising potential for clinical applications.…”
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SP-1-activated LINC01016 overexpression promotes gastric cancer invasion and metastasis through inhibiting EIF4A3-mediated MMP9 mRNA decay by Ying Sun, Hui Zhang, Duan-bo Shi, Peng Gao

“…LINC01016 or LINC01016-mediated EIF4A3/MMP9 may be potential therapeutic targets for patients with GC.…”
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Arginine methyltransferase PRMT1 promotes ferroptosis through EGR1/GLS2 axis in sepsis-related acute lung injury by Min Li, Longhui Hu, Qiao Ke, Zhao Li, Chujun Ruan, Hanjing Lu, Xiaoran Liu

“…Our findings suggest that PRMT1-mediated stabilization of EGR1 promoted sepsis induced ALI via GLS2, highlighting the therapeutic potential of targeting PRMT1 or EGR1 in the treatment of sepsis-induced ALI.…”
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Mesenchymal Stem/Stromal Cells Reverse Adipose Tissue Inflammation in Pigs with Metabolic Syndrome and Renovascular Hypertension by Alexander B. C. Krueger, Xiangyang Zhu, Sarosh Siddiqi, Emma C. Whitehead, Hui Tang, Kyra L. Jordan, Amir Lerman, Lilach O. Lerman

“…The MSC therapy attenuated fat inflammation and improved metabolic outcomes in pigs with MetS + RAS, suggesting that adipose-derived MSCs may offer a promising therapeutic approach for metabolic disorders.…”
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Efficient Predictor for Immunotherapy Efficacy: Detecting Pan‐Clones Effector Tumor Antigen‐Specific T Cells in Blood by Nanoparticles Loading Whole Tumor Antigens by Weibiao Zeng, Jin Wang, Zhike Chen, Jian Yang, Ao Zhu, Yan Zheng, Xianlan Chen, Yuhan Liu, Leilei Wu, Yufeng Xie, Sheng Ju, Jun Chen, Cheng Ding, Chang Li, Xin Tong, Mi Liu, Jun Zhao

“…ETASTs in patients with lung cancer are higher than those in healthy individuals and those with benign pulmonary nodules. Therapeutic efficacy positively correlated with the number of ETASTs in the blood. …”
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Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles by Marta Machado-Pereira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Raquel Ferreira

“…Altogether, our data indicate that RA-NP may be envisioned as a promising therapeutic agent for brain inflammatory diseases.…”
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Comorbidities related to the COVID-19 severity in adults. Hospital San Vicente de Paul. 2021 by Mónica Echeverría Martínez, Jorge Luis Anaya González, Secundino González Pardo, Juan Francisco Vaca Oña

“…<br /><strong>Conclusions:</strong> the study favors monitoring the association between comorbidities as the pandemic progressed and using the information as a prognostic factor to guide early intervention and an appropriate therapeutic approach.</p>…”
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Towards Improved Prognostic Scores Predicting Survival in Patients with Brain Metastases: A Pilot Study of Serum Lactate Dehydrogenase Levels by Carsten Nieder, Kirsten Marienhagen, Astrid Dalhaug, Jan Norum

“…Accurate prognostic information is desirable when counselling patients with brain metastases regarding their therapeutic options and life expectancy. Based on previous studies, we selected serum lactate dehydrogenase (LDH) as a promising factor on which we perform a pilot study investigating methodological aspects of biomarker studies in patients with brain metastases, before embarking on large-scale studies that will look at a larger number of candidate markers in an expanded patient cohort. …”
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ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner by Ziqi Zheng, Feizhi Lin, Baiwei Zhao, Guoming Chen, Chengzhi Wei, Xiaojiang Chen, Runcong Nie, Ruopeng Zhang, Zhoukai Zhao, Zhiwei Zhou, Yuanfang Li, Weigang Dai, Yijia Lin, Yongming Chen

“…These findings highlight the pivotal role of ALKBH5-mediated m6A demethylation in inhibiting GC progression and the potential role of ALKBH5 as a promising biomarker and therapeutic target for GC intervention.…”
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Mesenchymal Stem Cells Ameliorate Hepatic Ischemia/Reperfusion Injury via Inhibition of Neutrophil Recruitment by Shihui Li, Xu Zheng, Hui Li, Jun Zheng, Xiaolong Chen, Wei Liu, Yan Tai, Yingcai Zhang, Genshu Wang, Yang Yang

“…Mesenchymal stem cells (MSCs) have been shown to be immunomodulatory cells and have the therapeutic action on IRI in several organs. However, the mechanism of regulatory effect of MSCs on IRI remains unclear. …”
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IL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4+ T cell proliferation by Seema Bachoo, Nancy Gudgeon, Rebecca Mann, Victoria Stavrou, Emma L. Bishop, Audrey Kelly, Alejandro Huerta Uribe, Jordan Loeliger, Corina Frick, Oliver D.K. Maddocks, Paul Lavender, Christoph Hess, Sarah Dimeloe

“…Clinically, CD4+ T cells from stem cell transplant recipients demonstrate coordinated upregulation of glycolytic and TCA cycle enzymes, amino acid-sensing machinery, and mTOR targets, highlighting the potential to therapeutically target this pathway to fine-tune lymphopenia-induced T cell proliferation.…”
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Whole Exome Sequencing Uncovers Germline Variants of Cancer-Related Genes in Sporadic Pheochromocytoma by Milena Urbini, Margherita Nannini, Annalisa Astolfi, Valentina Indio, Valentina Vicennati, Matilde De Luca, Giuseppe Tarantino, Federica Corso, Maristella Saponara, Lidia Gatto, Donatella Santini, Guido Di Dalmazi, Uberto Pagotto, Renato Pasquali, Andrea Pession, Guido Biasco, Maria A. Pantaleo

“…Therefore, many efforts should be aimed to better define the pathogenetic role of all these germline variants for discovering novel potential therapeutic targets for this disease still orphan of effective treatments.…”
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Stem Cells: A Historical Review about Biological, Religious, and Ethical Issues by Ioannis Alexandros Charitos, Andrea Ballini, Stefania Cantore, Mariarosaria Boccellino, Marina Di Domenico, Elisa Borsani, Riccardo Nocini, Michele Di Cosola, Luigi Santacroce, Lucrezia Bottalico

“…Hence, their biological hypostasis regarding the concepts of “conception” and “fertilization” and their development and therapeutic use compared to those of the main theological doctrines.…”
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The Role of PPARs in Placental Immunology: A Systematic Review of the Literature by Stefan Hutter, Julia Knabl, Ulrich Andergassen, Udo Jeschke

“…Within this paper we would like to give an update on today’s knowledge about PPARs and immune cells in reproduction and highlight interesting interferences in regard of future therapeutic targets.…”
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Autoantibody Response to Murine Double Minute 2 Protein in Immunodiagnosis of Hepatocellular Carcinoma by Mei Liu, Su-jun Zheng, Yu Chen, Ning Li, Peng-fei Ren, Li-ping Dai, Zhong-ping Duan, Jian-Ying Zhang

“…Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. Although new therapeutic strategies have been continuously developed and applied to clinical treatment for HCC, the prognosis is still very poor. …”
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Antioxidant Properties of Albumin and Diseases Related to Obstetrics and Gynecology by Kazushi Watanabe, Hiroyuki Kinoshita, Tomohito Okamoto, Kazumasa Sugiura, Shingo Kawashima, Tetsuro Kimura

“…Understanding the antioxidant properties of albumin opens new avenues for therapeutic intervention and sheds light on novel strategies for combating preeclampsia associated with oxidative damage. …”
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