HIV, smoking, and the brain: a convergence of neurotoxicities by Benjamin L. Orlinick, Shelli F. Farhadian

“…Abstract Purpose of review The purpose of this review is to characterize the combined effects of tobacco smoking and human immunodeficiency virus (HIV) infection in people with HIV (PWH) and identify possible therapeutic targets through shared mechanisms for neurotoxicity. …”
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Cardiac Transthyretin Amyloidosis: Hidden in Plain Sight by Constantine N. Logothetis, Joel Fernandez, Damian A. Laber

“…The review of the literature focuses on the epidemiology, and clinical symptoms that should prompt an evaluation for cardiac amyloidosis as well as the diagnostic and therapeutic options are available. Transthyretin cardiac amyloidosis is a rare and underdiagnosed disease, while heart failure is a highly prevalent condition. …”
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Psychological Determinants and Consequences of COVID-19 Anxiety: A Web-Based Study in Iran by Reza Shabahang, Mara S. Aruguete, Sajjad Rezaei, Lynn E. McCutcheon

“…Understanding these risk factors can inform individualized therapeutic approaches to address the maladaptive outcomes of depression and false safety behaviors, such as panic buying.…”
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HCNetlas: A reference database of human cell type-specific gene networks to aid disease genetic analyses. by Jiwon Yu, Junha Cha, Geon Koh, Insuk Lee

“…These findings suggest that HCNetlas has the potential to link disease-associated genes to cell types of action, facilitating development of cell type-resolved diagnostics and therapeutic strategies for complex human diseases.…”
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Probiotics in the Prevention and Treatment of Periodontal Diseases: A Systematic Review by Nishath Sayed Abdul, Lara Ghassan Odeh, Asma Awadh Alenazi, Jumana Abdullah Alzahrani, Aldanah Tawfiq Almutib, Cristalle Soman

“…Introduction: Periodontal diseases (PDs) pose a significant challenge to dental health, leading to a growing interest in probiotics as potential therapeutic and prophylactic agents. Literature evidence has shown conflicting results on the use of probiotics in the management of PDs. …”
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Comparison of cellular-based therapies following a long-segmental peripheral nerve defect in a rat model. by Emily L Errante, Joseph Yunga Tigre, Ericka A Schaeffer, Meredith C Costello, Andrew J Kloehn, Aiko Puerto, Aisha Khan, Yelena Pressman, Risset Silvera, Francisco J Sanchez, Brian R Noga, W Dalton Dietrich, Allan D Levi, S Shelby Burks

“…Based on the results of the current study, more research is needed to understand the therapeutic role of exosomes in PNI.…”
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Combination PPARγ and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2 by Joshua P. Klopper, Vibha Sharma, Reid Bissonnette, Bryan R. Haugen

“…Nuclear hormone receptors, including RXR and PPARγ, represent novel therapeutic targets in melanoma. We have previously shown that the DRO subline of the amelanotic melanoma A375 responds to rexinoid and thiazolidinedione (TZD) treatment in vitro and in vivo. …”
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Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer by Xumin Zhou, Shilong Cheng, Zhongjie Chen, Jinming Zhang, Jiaqi Wang, Qiang Li, Xumin Zhou

“…In vivo, inhibition of EIF4G1 by the inhibitor, SBI-0640756, attenuated HnRNP l-induced tumor progression and immunosuppressive activity. And most of all, therapeutic synergy between HnRNP L knockdown and Anti-PD-1 could significantly suppress xenograft prostate cancer growth. …”
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Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis. by Javier Lozano-Gerona, Aida Oliván-Viguera, Pablo Delgado-Wicke, Vikrant Singh, Brandon M Brown, Elena Tapia-Casellas, Esther Pueyo, Marta Sofía Valero, Ángel-Luis Garcia-Otín, Pilar Giraldo, Edgar Abarca-Lachen, Joaquín C Surra, Jesús Osada, Kirk L Hamilton, Siba P Raychaudhuri, Miguel Marigil, Ángeles Juarranz, Heike Wulff, Hiroto Miura, Yolanda Gilaberte, Ralf Köhler

“…This skin condition resembles pathological features of eczematous dermatitis and identifies KCa3.1 as a regulator of epidermal homeostasis and spongiosis, and as a potential therapeutic target.…”
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Ultrasound-Targeted Microbubble Destruction Improves the Migration and Homing of Mesenchymal Stem Cells after Myocardial Infarction by Upregulating SDF-1/CXCR4: A Pilot Study by Lu Li, Shengzheng Wu, Zheng Liu, Zhongxiong Zhuo, Kaibin Tan, Hongmei Xia, Lisha Zhuo, Xiaojun Deng, Yunhua Gao, Yali Xu

“…However, the inefficient migration and homing of MSCs after systemic infusion have limited their therapeutic applications. Ultrasound-targeted microbubble destruction (UTMD) has proven to be promising to improve the homing of MSCs to the ischemic myocardium, but the concrete mechanism remains unclear. …”
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Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn’s Disease and Ulcerative Colitis by Maria Dobre, Elena Milanesi, Teodora Ecaterina Mănuc, Dorel Eugen Arsene, Cristian George Ţieranu, Carlo Maj, Gabriel Becheanu, Mircea Mănuc

“…Our results suggest that the transcript levels of CCL11, MMP10, C4BPB, and IL1RN are candidate biomarkers that could help in clinical practice for the differential diagnosis between UC and CD and could guide new research on future therapeutic targets.…”
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Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway by Taiqiu Chen, Pengfei Li, Jincheng Qiu, Wenjun Hu, Shaoguang Li, Huihong Shi, Xianjian Qiu, Dongsheng Huang, Wenjie Gao, Anjing Liang

“…This study supports that aloin can be a promising therapeutic agent for IDD.…”
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Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis by Li Chen, Yong Tao, Jing Feng, Yan Rong Jiang

“…These results suggest that apelin suppressed hypoxia-induced pericytes injury, which indicated that apelin could be a potential therapeutic target for retinal angiogenic diseases.…”
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Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function by Carola Stockburger, Davide Miano, Thea Pallas, Kristina Friedland, Walter E. Müller

“…We here report that piracetam at therapeutically relevant concentrations improves neuritogenesis in the human cell line SH-SY5Y over conditions mirroring the whole spectrum of age-associated cognitive decline. …”
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Ovariohysterectomy in Cat as An Alternative Handling of Fetus Mummification Cases by Cindy Ercha Aulia Putri, Erma Safitri, Winda Syafitri

“…Diagnostic confirmation was achieved through blood haematology tests and ultrasound examinations. The therapeutic approach consisted of administering a combination of normal saline fluid therapy, glycerin, ondansetron, ceftriaxone, intramox, doxycycline, acetylcysteine, sakatonic liver, vitamins, ventolin, Tripura, meloxicam, impacting, and furosemide. …”
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The Use of Thrombopoietin Receptor Agonists for Correction of Thrombocytopenia prior to Elective Procedures in Chronic Liver Diseases: Review of Current Evidence by Kamran Qureshi, Shyam Patel, Andrew Meillier

“…In recent years, compounds with thrombopoietin receptor agonist activity have been studied as therapeutic options to raise platelet counts in CLD. …”
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Successful Treatment of Pulmonary Arterial Hypertension in Systemic Sclerosis with Anticentriole Antibody by Yusho Ishii, Hiroshi Fujii, Koichiro Sugimura, Tsuyoshi Shirai, Yosuke Hoshi, Yoko Fujita, Yuko Shirota, Tomonori Ishii, Hiroaki Shimokawa, Hideo Harigae

“…In general, several vasodilators are used as therapeutic drugs for SSc-PAH, whereas immunosuppressive therapies are not. …”
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Evaluation of Histopathological Changes in Control Biopsies Which Taken 48 Sessions after NBUVB Phototherapy for Early-Stage Mycosis Fungoides by Ebru Zemheri, Seyma Ozkanli, Ilkin Zindanci, Serkan Senol, Ozge Akbulak, Elvan Turfanda, Mehtap Toprak, Duygu Kosemetin, Abdullah Aydin

“…We detected a significant decrease in linearly arranged cells after phototherapy, indicating that it is an “important diagnostic parameter" in evaluation of therapeutic response.…”
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Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder by Jie Wang, Qing Xue, Wenfeng Zhao, Huang Wang, Haixia Leng, Mao Peng, Xiukun Jin, Liucen Tan, Keming Gao, Hongxing Wang, Baoquan Min

“…Background Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.Aims To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain.Methods Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software.Results The electric field distributions of the sagittal, coronal and axial planes showed that the bilateral frontal lobes, bilateral temporal lobes, hippocampus, cingulate, hypothalamus, thalamus, amygdala, cerebellum and brainstem were visibly stimulated by the 15 mA tACS procedure.Conclusions Brain-wide activation, including the cortex, subcortical structures, cerebellum and brainstem, is involved in the 15 mA tACS intervention for first-episode major depressive disorder. …”
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Selected Aspects in the Pathogenesis of Autoimmune Diseases by György Nagy, Peter C. Huszthy, Even Fossum, Yrjö Konttinen, Britt Nakken, Peter Szodoray

“…Targeting these key players of disease progression in patients with autoimmune diseases by immunomodulating therapy may be beneficial in future therapeutic strategies.…”
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