Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

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Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer by Jiangang Zhao, Jiahui Li, Hans A. Schlößer, Felix Popp, Marie Christine Popp, Hakan Alakus, Karl-Walter Jauch, Christiane J. Bruns, Yue Zhao

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Potential therapeutic effects of apigenin for colorectal adenocarcinoma: A systematic review and meta‐analysis by Koohyar Ahmadzadeh, Shayan Roshdi Dizaji, Fatemeh Ramezani, Farnad Imani, Jebreil Shamseddin, Arash Sarveazad, Mahmoud Yousefifard

“…Abstract Purpose Therapeutic management of colorectal cancer (CRC) does not yet yield promising long‐term results. …”
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Therapeutic Applicability of Anti-Inflammatory and Proresolving Polyunsaturated Fatty Acid-Derived Lipid Mediators by Gerard L. Bannenberg

“…Different aspects of the therapeutic applicability of lipid mediators have been addressed here, and indicate that the development of innovative pharmacotherapy based on anti-inflammatory and proresolution lipid mediators presents novel prospects for the treatment of inflammatory disease.…”
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Predictive and Prognostic Molecular Markers of Oral Cancers and Potential Therapeutic Agents Targeting These Markers by Shilpa Jain, Anil Goel, Arpita H Patel, Sarvatnida Shaikh

“…With the unveiling of various signaling pathways and molecular markers involved in oncogenesis, efforts are being made to develop therapeutic agents targeted at these molecular levels. …”
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Therapeutic Anticoagulation with Argatroban and Heparins Reduces Granulocyte Migration: Possible Impact on ECLS-Therapy? by Andre Bredthauer, Manuel Kopfmueller, Michael Gruber, Sophie-Marie Pfaehler, Karla Lehle, Walter Petermichl, Timo Seyfried, Diane Bitzinger, Andreas Redel

“…Cardiovascular Therapeutics…”
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Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases by Jiao Lv, Honghai Yu, Sasa Du, Pengyu Xu, Yunyun Zhao, Wenxiu Qi, Xiuge Wang

“…This study examines recent advancements in understanding the effects of excessive ERS on podocytes across various kidney diseases, highlights the role of podocyte ERS in disease progression, and explores the potential therapeutic benefits of targeting the UPR to manage ERS in kidney diseases, thereby providing a scientific basis for clinical interventions. …”
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Feasibility of Early Definitive Internal Fixation of Pelvic Bone Fractures in Therapeutic Open Abdomen by Kyunghak Choi, Kwang-Hwan Jung, Min Ae Keum, Sungjeep Kim, Jihoon T Kim, Kyu-Hyouck Kyoung

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The microenvironment cell index is a novel indicator for the prognosis and therapeutic regimen selection of cancers by Xian-Yan Yang, Nian Chen, Qian Wen, Yu Zhou, Tao Zhang, Ji Zhou, Cheng-Hui Liang, Li-Ping Han, Xiao-Ya Wang, Qing-Mei Kang, Xiao-Xia Zheng, Xue-Jia Zhai, Hong-Ying Jiang, Tian-Hua Shen, Jin-Wei Xiao, Yu-Xin Zou, Yun Deng, Shuang Lin, Jiang-Jie Duan, Jun Wang, Shi-Cang Yu

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Meta Analysis of Therapeutic Effect of Jichuan Decoction Combined with Acupuncture and Moxibustion for Functional Constipation by Haibing QIN, Aiyuan ZOU, Lianhuan YANG, Zhaotian WU

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Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects by Yufei Wang, Guangliang Li, Hanying Wang, Quan Qi, Xian Wang, Haiqi Lu

“…Nectin-4 is a cell adhesion molecule which has gained more and more attention as a therapeutic target in cancer recently. Overexpression of Nectin-4 has been observed in various tumors, including breast cancer, and is associated with tumor progression. …”
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Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment by Fatih Ciftci, Ali Can Özarslan, İmran Cagri Kantarci, Aslihan Yelkenci, Ozlem Tavukcuoglu, Mansour Ghorbanpour

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Therapeutic reduction of neurocan in murine intracerebral hemorrhage lesions promotes oligodendrogenesis and functional recovery by Hongmin Li, Samira Ghorbani, Olayinka Oladosu, Ping Zhang, Frank Visser, Jeff Dunn, Yunyan Zhang, Chang-Chun Ling, V. Wee Yong, Mengzhou Xue

“…In tissue culture, neurocan impedes the properties of oligodendrocytes. Whether therapeutic reduction of neurocan promotes oligodendrogenesis and functional recovery in ICH is unknown. …”
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On the Reorganization of Incentive Structure to Promote Delay Tolerance: A Therapeutic Possibility for AD/HD? by Edmund J. S. Sonuga-Barke

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Circulating tumor DNA as a therapeutic approach for HPV (+) oropharyngeal squamous cell carcinoma by Raghul Murugan

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DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities by Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang

“…We discuss the underlying mechanisms that enable these therapeutic synergies, preclinical and clinical evidence supporting the approach, and the challenges posed by tumor heterogeneity, drug resistance, and toxicity. …”
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APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage by Xiaojing Wang, Keisuke Ishimatsu, Junjie Li, Xiaodong Wen, Weijun Ou, Arnida Anwar, Jaideep Chaudhary, Masaya Takahashi, A Dean Sherry, Ian R Corbin

“…Direct injections of LDL-DHA nanoparticles into HepG2 xenografts also showed similar therapeutic responses.Conclusion: We have demonstrated the utility of APTw imaging in the diagnostic/therapeutic management of HCC.…”
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Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies by Min-Hee Yi, Jinkyung Lee, Subin Moon, EunA So, Geonhyeok Bang, Kyung-Sub Moon, Kyung-Hwa Lee

“…<b>Background</b>: Brain cancers represent a formidable oncological challenge characterized by their aggressive nature and resistance to conventional therapeutic interventions. The tumor microenvironment has emerged as a critical determinant of tumor progression and treatment efficacy. …”
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Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches by David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R. Karow-Zwick, Giuseppe Licari

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Promising new drugs and therapeutic approaches for treatment of ovarian cancer—targeting the hallmarks of cancer by Julia Hillmann, Nicolai Maass, Dirk O. Bauerschlag, Inken Flörkemeier

“…Thus, there is an urgent need for new therapeutics. New advancements in therapeutic strategies target the pivotal hallmarks of cancer. …”
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