Myelodysplasia and Mast Cell Leukemia with t(9;22) by Kathryn J. Lago, Matthew P. Shupe, William N. Hannah, Gopalrao V. N. Velagaleti, Christina Mendiola, Veronica Ortega, Brian R. Haney

“…Further research on the relationship between t(9;22) and MCL could lead to development of improved therapeutic options.…”
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Discovering the interactome, functions, and clinical relevance of enhancer RNAs in kidney renal clear cell carcinoma by Zhaohui Sun, Haojie Du, Xudong Zheng, Hepeng Zhang, Huajie Hu

“…In summary, Our study highlights the clinical significance of eRNAs in KIRC and underscores their potential as therapeutic targets.…”
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The Transcultural Diabetes Nutrition Algorithm: A Canadian Perspective by Réjeanne Gougeon, John L. Sievenpiper, David Jenkins, Jean-François Yale, Rhonda Bell, Jean-Pierre Després, Thomas P. P. Ransom, Kathryn Camelon, John Dupre, Cyril Kendall, Refaat A. Hegazi, Albert Marchetti, Osama Hamdy, Jeffrey I. Mechanick

“…The Transcultural Diabetes Nutrition Algorithm (tDNA) is a clinical tool designed to facilitate implementation of therapeutic lifestyle recommendations for people with or at risk for type 2 diabetes. …”
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Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair by Jean-Baptiste Huré, Louis Foucault, Litsa Maria Ghayad, Corentine Marie, Nicolas Vachoud, Lucas Baudouin, Rihab Azmani, Natalija Ivljanin, Alvaro Arevalo-Nuevo, Morgane Pigache, Lamia Bouslama-Oueghlani, Julie-Anne Chemelle, Marie-Aimée Dronne, Raphaël Terreux, Bassem Hassan, François Gueyffier, Olivier Raineteau, Carlos Parras

“…These findings support the repurposing of leucovorin and dyclonine for clinical trials targeting myelin disorders, offering potential therapeutic avenues for PBI and MS.…”
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Histone lactylation promotes multidrug resistance in hepatocellular carcinoma by forming a positive feedback loop with PTEN by Yuan Zeng, Haoran Jiang, Zhoufeng Chen, Jun Xu, Xiangting Zhang, Weimin Cai, Xianjie Zeng, Peipei Ma, Rong lin, Huilin Yu, Yuanhang He, Huiya Ying, Ruoru Zhou, Xiao Wu, Fujun Yu

“…This study elucidates a shared mechanism underlying OXA and 5-Fu resistance in hepatocellular carcinoma and highlights a promising therapeutic target for overcoming clinical chemotherapy resistance.…”
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Anticancer effects of PEP06 (TB01) in combination with Trifluridine/Tipiracil (TAS-102) in a xenograft model of human colorectal cancer by Ruohong Lin, Jiaxing Cheng, Jinlong Zhao, Liang Zhou, Jian Li, Xinchun Yang

“…Objective To evaluate the therapeutic efficacy of the combination of the anti-angiogenic drug PEP06 (TB01) and the cytotoxic drug Trifluridine/Tipiracil (TAS-102) in human CRC HCT-116 xenograft mouse model. …”
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Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies by Apolline Lefèvre, Apolline Lefèvre, Zinnia P. Parra-Guillen, Zinnia P. Parra-Guillen, Iñaki F. Trocóniz, Iñaki F. Trocóniz, Iñaki F. Trocóniz, Christophe Boetsch, Nicolas Frances

“…IntroductionT-cell engagers (TCE), a therapeutic class of cancer immunotherapy (CIT), offer a novel approach to cancer treatment by harnessing and reactivating the patient’s immune system to eradicate tumor cells. …”
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Hypoglycemic polysaccharides from Auricularia auricula and Auricularia polytricha inhibit oxidative stress, NF-κB signaling and proinflammatory cytokine production in streptozotoci... by Huan Xiang, Dongxiao Sun-Waterhouse, Chun Cui

“…APP and AAP with different molecular weights and monosaccharide molar ratios could be therapeutic options for diabetes with a low dose (100 mg/kg/day) likely working better. …”
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A review of bismuth‐based nanoparticles and their applications in radiosensitising and dose enhancement for cancer radiation therapy by Daryoush Shahbazi‐Gahrouei, Yazdan Choghazardi, Arezoo Kazemzadeh, Paria Naseri, Saghar Shahbazi‐Gahrouei

“…Abstract About 50% of cancer patients receive radiation therapy. Despite the therapeutic benefits of this method, the toxicity of radiation in the normal tissues is unavoidable To improve the quality of radiation therapy, in addition to other methods such as IMRT, IGRT, and high radiation dose, nanoparticles have shown excellent potential when ionising radiation is applied to the target volume. …”
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Life stage impact on the human skin ecosystem: lipids and the microbial community by Martin P. Pagac, Bala Davient, Luca Antonio Plado, Hilbert Yuen In Lam, Shi Mun Lee, Aarthi Ravikrishnan, Wee Ling Esther Chua, Sneha Muralidharan, Aishwarya Sridharan, Antony S. Irudayaswamy, Ramasamy Srinivas, Stephen Wearne, Ahmad Nazri Mohamed Naim, Eliza Xin Pei Ho, H. Q. Amanda Ng, Junmei Samantha Kwah, Eileen Png, Anne K. Bendt, Markus R. Wenk, Federico Torta, Niranjan Nagarajan, John Common, Yap Seng Chong, Elizabeth Huiwen Tham, Lynette Pei-Chi Shek, Evelyn Xiu Ling Loo, John Chambers, Yik Weng Yew, Marie Loh, Thomas L. Dawson

“…Our findings imply a complex host-microbe communication system mediated by lipid metabolism occurring on human skin, warranting further research into its role in skin health and disease and paving the way towards novel therapeutic targets and treatments.…”
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Investigating Past, Present, and Future Trends on Interface Between Marine and Medical Research and Development: A Bibliometric Review by Mehdi Zamani, Tetyana Melnychuk, Anton Eisenhauer, Ralph Gäbler, Carsten Schultz

“…The paper identifies two main areas of active research, “natural product biochemistry” and “trace substance and genetics”, both with great therapeutic potential. We used social network analysis to map the collaborative networks and identify the prominent scholars and institutions driving this research and development progress. …”
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Identification of a novel immunogenic cell death-related classifier to predict prognosis and optimize precision treatment in hepatocellular carcinoma by Dongjing Zhang, Bingyun Lu, Qianqian Ma, Wen Xu, Qi Zhang, Zhiqi Xiao, Yuanheng Li, Ren Chen, An-jiang Wang

“…A reliable risk model named ICD score was constructed via machine learning algorithms to assess the immunological status, therapeutic responses, and clinical outcomes of individual HCC patients. …”
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Basic self-disorders may play a role in the development of depression in schizophrenia: a seven-year follow-up study by Elisabeth Haug, Merete Glenne Øie, Merete Glenne Øie, Ingrid Hartveit Svendsen, Ingrid Hartveit Svendsen, Paul Møller, Barnaby Nelson, Barnaby Nelson, Ingrid Melle, Ingrid Melle

“…This may have implications for therapeutic approaches targeting a condition that is characterized by considerable suffering and an elevated risk of suicide.…”
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Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy by Hadil M. Alahdal, Sumya Ayad Abdullrezzaq, Hawraz Ibrahim M. Amin, Sitah F. Alanazi, Abduladheem Turki Jalil, Mehrdad Khatami, Marwan Mahmood Saleh

“…These magnetic nanoparticles with targeted control and transfer to the tumour tissue led to uniform heating of malignant tumours as the most efficient therapeutic agent.…”
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Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential by I. J. Asiedu-Gyekye, T. G. Borovskaya, M. E. Poluektova, А. V. Vychuzhanina, Y. А. Shchemerovа, S. I. Kamalova, V. A. Grgoreva, P. Amoateng, K. E. Kukuia, A. A. Kwapong, L. Allotey Babington, S. K. Amponsah, B. B. N’guessan

“…A preliminary genotoxic potential was evaluated by the DNA comet assay test using C57Bl/6 mice. Both therapeutic dose (TD; 900 mg/kg) and high dose (HD; 9000 mg/kg) of UNCP were used. …”
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Microfluidic Nanoparticle Separation for Precision Medicine by Zhenwei Lan, Rui Chen, Da Zou, Chun‐Xia Zhao

“…As nanoparticles, both of biological origin and for therapeutic purposes, become increasingly important in precision medicine, microfluidic nanoparticle separation proves particularly advantageous for handling valuable samples in personalized medicine. …”
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Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical Trials by Deana S. Shenaq, Farbod Rastegar, Djuro Petkovic, Bing-Qiang Zhang, Bai-Cheng He, Liang Chen, Guo-Wei Zuo, Qing Luo, Qiong Shi, Eric R. Wagner, Enyi Huang, Yanhong Gao, Jian-Li Gao, Stephanie H. Kim, Ke Yang, Yang Bi, Yuxi Su, Gaohui Zhu, Jinyong Luo, Xiaoji Luo, Jiaqiang Qin, Russell R. Reid, Hue H. Luu, Rex C. Haydon, Tong-Chuan He

“…Thus, engineering such cells to maximize therapeutic potential has been the focus of cell/gene therapy to date. …”
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Verbascoside exerts an anti-atherosclerotic effect by regulating liver glycerophospholipid metabolism by Peng Lei, Jialin Lü, Tie Yao, Peng Zhang, Xin Chai, Yuefei Wang, Miaomiao Jiang

“…In addition, based on untargeted lipidomic analysis, verbascoside stabilized glycerophospholipid metabolism, modulated lipid metabolism disorders and reduced lipid deposition in the liver to achieve the therapeutic efficacy against atherosclerosis by regulating cardiolipin (CL), ether-linked phosphatidylcholine (ether-PC), lysophophatidylcholine (LPC), phosphatidylcholine (PC), oxidized phosphatidylcholine (OxPC), oxidized phosphatidylethanolamine (OxPE), triacylglycerol (TG), sphingomyelin (SM) back to normal levels.…”
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The zinc receptor, ZnR/GPR39, modulates taste sensitivity by regulating ion secretion in mouse salivary gland by Moran Melamed, Hila Asraf, Noa Livne, Milos Bogdanovic, Anil Shendge, Gilad Shamir, Maayan Mero, Omer Adir, Avi Schroeder, Israel Sekler, Michal Hershfinkel

“…Altogether, we demonstrate that salivary ZnR/GPR39 activity controls saliva ion composition and secretion, and provides a target for therapeutic approaches for dry mouth and taste disorders.…”
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Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection by Gabriela Gonzalez Aleman, George D. Vavougios, George D. Vavougios, Carmela Tartaglia, Carmela Tartaglia, Nalakath A. Uvais, Alla Guekht, Alla Guekht, Akram A. Hosseini, Akram A. Hosseini, Vincenzina Lo Re, Vincenzina Lo Re, Catterina Ferreccio, Catterina Ferreccio, Giovanni D'Avossa, Hernan P. Zamponi, Mariana Figueredo Aguiar, Agustin Yecora, Agustin Yecora, Mohammad Zia Ul Haq Katshu, Vasileios T. Stavrou, Vasileios T. Stavrou, Stylianos Boutlas, Konstantinos I. Gourgoulianis, Camila Botero, Francisco González Insúa, Santiago Perez-Lloret, Mikhail Zinchuk, Anna Gersamija, Sofya Popova, Yulia Bryzgalova, Ekaterina Sviatskaya, Giovanna Russelli, Giovanna Russelli, Federica Avorio, Federica Avorio, Sophia Wang, Sophia Wang, Paul Edison, Paul Edison, Yoshiki Niimi, Hamid R. Sohrabi, Elizabeta B. Mukaetova Ladinska, Elizabeta B. Mukaetova Ladinska, Daria Neidre, Gabriel A. de Erausquin, Gabriel A. de Erausquin, Gabriel A. de Erausquin

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