Molecular and Phylogenetic Analysis of Bovine Papillomavirus Type 1: First Report in Iraqi Cattle by Mohammed A. Hamad, Ahmed M. Al-Shammari, Shoni M. Odisho, Nahi Y. Yaseen

“…The results of this study will aid in the development of appropriate control measures and therapeutic strategies.…”
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Broadening horizons: molecular mechanisms and disease implications of endothelial-to-mesenchymal transition by Cheng Qian, Guanglu Dong, Chunmei Yang, Weiwei Zheng, Chongjin Zhong, Qiuhong Shen, Yin Lu, Yang Zhao

“…Furthermore, we discuss the significant impact of EndMT on worsening vasculature-related diseases, including cancer, cardiovascular diseases, atherosclerosis, pulmonary vascular diseases, diabetes-associated fibrotic conditions, and cerebral cavernous malformation, providing the implications that targeting EndMT holds promise as a therapeutic strategy to mitigate disease progression.…”
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Parvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats by Muhammad Jahangir, S. Mudasser Shah, Jian-Song Zhou, Bing Lang, Xiao-Ping Wang

“…Completely elucidating the underlying mechanism and circuitry will open up therapeutic choices for associated disorders.…”
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Immunotherapy in colorectal cancer: Statuses and strategies by Yuan Li, Zewei Cheng, Shengli Li, Jiwei Zhang

“…Immunotherapy, an emerging frontier in oncology, represents a novel therapeutic approach that leverages the body's immune system to target cancer cells. …”
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Amygdalin isolated from Amygdalus mongolica protects against hepatic fibrosis in rats by Wang Jia, Zhou Hongbing, Wu Tong, Wu Peisai, Liu Quanli, Shi Songli

“…Amygdalin from A. mongolica represents a therapeutic candidate for hepatic fibrosis prevention and treatment.…”
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Twist-Induced Epithelial-to-Mesenchymal Transition Confers Specific Metabolic and Mitochondrial Alterations by Haleigh N. Parker, Kayla L. Haberman, Tolulope Ojo, Juli Watkins, Adhwaitha Nambiar, Kayla Morales, Bernd Zechmann, Joseph H. Taube

“…In disease, these adaptations could be leveraged as therapeutic targets. Here, we analyze Twist-induced EMT in non-transformed HMLE cells as well as a breast cancer cell line with (MDA-MB-231) and without (MCF7) EMT features to compare differences in metabolic pathways and mitochondrial morphology. …”
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Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation by Jinjing Wu, Yulu Qian, Kuang Yang, Shuhua Zhang, Erming Zeng, Daya Luo

“…In recent years, monotherapy with antiangiogenic drugs has encountered therapeutic bottlenecks because of the short-term effect of ‘vascular normalization’. …”
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A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke by Cesar Reis, Michael Wilkinson, Haley Reis, Onat Akyol, Vadim Gospodarev, Camila Araujo, Sheng Chen, John H. Zhang

“…Neural stem cells (NSCs) offer a potential therapeutic benefit in the recovery from ischemic stroke. …”
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Esophageal Foreign Bodies in Pediatric Patients: A Thirteen-Year Retrospective Study by Beata Rybojad, Grazyna Niedzielska, Artur Niedzielski, Ewa Rudnicka-Drozak, Pawel Rybojad

“…We discuss clinical symptoms and radiological findings of variable esophageal foreign bodies as well as therapeutic procedures in Caucasian pediatric patients. …”
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MOX Nanosensors to Detect Colorectal Cancer Relapses from Patient’s Blood at Three Years Follow-Up, and Gender Correlation by Michele Astolfi, Giulia Zonta, Cesare Malagù, Gabriele Anania, Giorgio Rispoli

“…To this aim, a device equipped with nanostructured gas sensors has been employed to detect the airborne molecules of blood samples collected from healthy subjects, and from colorectal cancer affected patients at different stages of their pre- and post-surgery therapeutic path. Data was scrutinized by using statistical standard techniques to highlight their statistical differences, and through principal component analysis and support vector machine to classify them. …”
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Serpina3k lactylation protects from cardiac ischemia reperfusion injury by Le Wang, Dandan Li, Fang Yao, Shanshan Feng, Chao Tong, Rongjia Rao, Meiyan Zhong, Xianqiang Wang, Wei Feng, Zhan Hu, Bo Jin, Li Wang, Shengshou Hu, Bingying Zhou

“…Our results demonstrate the pivotal role of protein lactylation in cardiac ischemia-reperfusion injury, which may hold therapeutic value.…”
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MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer by Zhiguang Liu, Xinlian Wang, Liqiang Cao, Xiaowei Yin, Qian Zhang, Lan Wang

“…This research aimed to explore the biological role and mechanisms of miR-877-5p, which may help patients with non-small-cell lung cancer (NSCLC) find effective therapeutic targets. Methods. The downstream targets of miR-877-5p were predicted by Bioinformatics software. …”
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Identification of Two Novel HLA-A∗0201-Restricted CTL Epitopes Derived from MAGE-A4 by Zheng-Cai Jia, Bing Ni, Ze-Min Huang, Yi Tian, Jun Tang, Jing-Xue Wang, Xiao-Lan Fu, Yu-Zhang Wu

“…And the induced CTLs could lyse target cells in an HLA-A∗0201-restricted fashion, demonstrating that the two peptides are HLA-A∗0201-restricted CTL epitopes and could serve as targets for therapeutic antitumoral vaccination.…”
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Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated properties by Armenuhi Moghrovyan, Naira Sahakyan

“…Additionally, oregano EO holds promise as a natural therapeutic agent. Continued study of its complex chemical interactions will further elucidate its full potential in antimicrobial therapy. …”
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Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells by Luciana Melo Garcia, Achintyan Gangadharan, Pinaki Banerjee, Ye Li, Andy G.X. Zeng, Hind Rafei, Paul Lin, Bijender Kumar, Sunil Acharya, May Daher, Luis Muniz-Feliciano, Gary M. Deyter, Gabriel Dominguez, Jeong Min Park, Francia Reyes Silva, Ana Karen Nunez Cortes, Rafet Basar, Nadima Uprety, Mayra Shanley, Mecit Kaplan, Enli Liu, Elizabeth J. Shpall, Katayoun Rezvani

“…Our findings suggest that CAR38 NK cells could be an effective therapeutic strategy to overcome CD226-mediated immune evasion in AML.…”
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The Role of NK Cells in Pig-to-Human Xenotransplantation by Gisella Puga Yung, Mårten K. J. Schneider, Jörg D. Seebach

“…Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human NK cell-porcine endothelial cell (pEC) interactions have been elucidated in vitro to identify targets for therapeutic interventions. Specific molecular strategies to overcome human anti-pig NK cell responses include (1) blocking of the molecular events leading to recruitment (chemotaxis, adhesion, and transmigration), (2) expression of human MHC class I molecules on pECs that inhibit NK cells, and (3) elimination or blocking of pig ligands for activating human NK receptors. …”
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Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative Colitis by Kaoru Yokoyama, Kiyonori Kobayashi, Miyuki Mukae, Miwa Sada, Wasaburo Koizumi

“…Mucosal healing (MH) is considered an important therapeutic goal in ulcerative colitis (UC). We evaluate the severity of intestinal inflammation and clarify the relation between MH and long-term outcomes. …”
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Single-cell transcriptomics unveils multifaceted immune heterogeneity in early-onset versus late-onset cervical cancer by Qian Chen, Dongfeng Deng, Hong Zhu, Shan Li

“…Abstract Early-onset (EOCC) and late-onset cervical cancers (LOCC) represent two clinically distinct subtypes, each defined by unique clinical manifestations and therapeutic responses. However, their immunological profiles remain poorly explored. …”
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A Case of Non-Small Cell Lung Cancer with Mutually Exclusive <i>EGFR</i> and <i>KRAS</i> Mutations by Abhimanyu Tushir, Israh Akhtar, Anjali Seth

“…In this case, the detection of both <i>EGFR</i> and <i>KRAS</i> mutations guided the selection of an appropriate targeted therapeutic strategy, including the use of Amivantamab.…”
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Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation by Lingyu Song, Yali Huang, Lu Liu, Xuebing Chang, Laying Hu, Guifang Wang, Lifen Xu, Tian Zhang, Yuanyuan Wang, Ying Xiao, Hong Yang, Suye Ran, Qing Shi, Tuanlao Wang, Mingjun Shi, Yuxia Zhou, Bing Guo

“…Collectively, these findings reveal unexpected roles of Metrnl as a factor in PC biosynthesis, TG secretion, and FAO, suggesting potential therapeutic application for NAFLD.…”
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