Fecal microbiota transplantation attenuates Alzheimer’s disease symptoms in APP/PS1 transgenic mice via inhibition of the TLR4-MyD88-NF-κB signaling pathway-mediated inflammation... by Xiang Li, Qingyong Ding, Xinxin Wan, Qilong Wu, Shiqing Ye, Yongliang Lou

“…Additionally, disruption of the gut microbiota has been found to be associated with AD, and fecal microbiota transplantation (FMT) has emerged as a potential therapeutic approach. However, the precise mechanism of FMT in the treatment of AD remains elusive. …”
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Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway by Wang Fengling, Ye Xi, Zhai Dandan, Dai Wenting, Wu Yifan, Chen Jin, Chen Weidong

“…Therefore, Cur-NLC induced activation of the extrinsic apoptosis pathway via modulating the DR5/caspase-8/-3 mediated apoptosis pathway in HepG2 cells, suggesting that Cur-NLC is a promising therapeutic agent or supplement for the treatment of hepatocellular carcinoma.…”
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Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy by Xingren Liu, Xin Wang, Xue Wu, Shuhua Zhan, Yan Yang, Caiyu Jiang

“…Recently, airway basal stem cells (BSCs) have emerged as a novel therapeutic strategy in pulmonary regenerative medicine because of their substantial potential in repairing lung structure and function. …”
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HIV RNA Suppression and Immune Restoration: Can We Do Better? by Marilia Rita Pinzone, Michelino Di Rosa, Bruno Cacopardo, Giuseppe Nunnari

“…Considering that poor immunologic responders are exposed to a higher risk of both AIDS-related and non-AIDS-related diseases, there is a need of new therapeutic strategies, including immunomodulators and drugs targeting the latent viral reservoirs, in order to face residual viremia but also to “drive” the host immunologic responses.…”
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Single-port non-lipolytic endoscopic surgery via the axillary approach for the treatment of benign breast tumors has better clinical outcomes: a case control study by Tianyi Ma, Jian Cui, Qian Wang, Changgen Liu, Bin Wang, Haibo Wang

“…Abstract Background Endoscopic surgery provides good cosmetic results while ensuring therapeutic outcomes. This study aimed to evaluate the efficacy, safety, and cosmetic outcome of endoscopic surgery for benign breast tumors. …”
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Basic Statistics for Radiologists: Part 1—Basic Data Interpretation and Inferential Statistics by Adarsh Anil Kumar, Jineesh Valakkada, Anoop Ayyappan, Santhosh Kannath

“…As radiology continues to push the boundaries of technology and therapeutic interventions, mastering these statistical principles will empower radiologists to critically assess literature, conduct rigorous research, and contribute to evidence-based practices. …”
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Adapting Lymphedema Treatment in Patients with a Mental Disability by Maria de Fátima Guerreiro Godoy, Lívia Maria Pereira de Godoy, Rodrigo Ocampos Troitino, José Maria Pereira de Godoy

“…The objective of this study is to report the treatment of lymphedema using only one therapeutic technique, a low-stretch grosgrain stocking. …”
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Targeting KRAS‐mutant pancreatic cancer through simultaneous inhibition of KRAS, MEK, and JAK2 by Satoru Miyazaki, Masato Kitazawa, Satoshi Nakamura, Makoto Koyama, Yuta Yamamoto, Nao Hondo, Masahiro Kataoka, Hirokazu Tanaka, Michiko Takeoka, Daisuke Komatsu, Yuji Soejima

“…Accordingly, simultaneous inhibition of KRAS, MEK, and JAK2 could be an innovative therapeutic strategy against KRAS‐mutant pancreatic cancer.…”
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Phytochemical Analysis and Anti-Inflammatory Activity of the Extracts of the African Medicinal Plant Ximenia caffra by Jing Zhen, Yue Guo, Tom Villani, Steve Carr, Thomas Brendler, Davis R. Mumbengegwi, Ah-Ng Tony Kong, James E. Simon, Qingli Wu

“…It was further demonstrated that the underlying therapeutic mechanism involves the suppression of NF-κB, a shared pathway between cell death and inflammation.…”
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Effects of Carbon Dioxide Therapy on Skin Wound Healing by José Prazeres, Ana Lima, Gesiane Ribeiro

“…This scoping review aimed to explore the literature and synthesize existing knowledge on the therapeutic use of CO₂ in treating cutaneous wounds. …”
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Comparative proteomic analysis of astrocytoma tissues from patients with and without seizures by Thanakorn Khaosuwan, Kittinun Leetanaporn, Pongsakorn Choochuen, Raphatphorn Navakanitworakul, Anukoon Kaewborisutsakul, Thara Tunthanatip, Surasak Sangkhathat, Wararat Chiangjong, Kanitpong Phabphal

“…Further studies of the proteins identified here are required to determine their potential as biomarkers and therapeutic targets.…”
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Lithium Improves Survival of PC12 Pheochromocytoma Cells in High-Density Cultures and after Exposure to Toxic Compounds by Cinzia Fabrizi, Stefania De Vito, Francesca Somma, Elena Pompili, Angela Catizone, Stefano Leone, Paola Lenzi, Francesco Fornai, Lorenzo Fumagalli

“…Our data show that lithium (used within its therapeutic window) stimulates the overgrowth of the rat Pheochromocytoma cell line PC12. …”
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WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis by Weiliang Jiang, Bingjie Guan, Hongcheng Sun, Yushuai Mi, Sanjun Cai, Rong Wan, Xinxiang Li, Peng Lian, Dawei Li, Senlin Zhao

“…Abstract Liver metastasis (LM) poses a significant challenge in cancer treatment, with limited available therapeutic options and poor prognosis. Understanding the dynamics of tumor microenvironment (TME) and immune interactions is crucial for developing effective treatments. …”
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Is oxidative stress - antioxidants imbalance the physiopathogenic core in pediatric obesity? by Ancuta Lupu, Silvia Fotea, Elena Jechel, Iuliana Magdalena Starcea, Ileana Ioniuc, Anton Knieling, Delia Lidia Salaru, Maria Oana Sasaran, Olga Cirstea, Ninel Revenco, Cristina Maria Mihai, Vasile Valeriu Lupu, Alin Horatiu Nedelcu

“…Despite the early recognition of obesity as an epidemic with global implications, research on its pathogenesis and therapeutic approach is still on the rise. The literature of the 21st century records an excess weight found in up to 1/3 of children. …”
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Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow by Tongling Huang, Zhaocheng Lu, Zihui Wang, Lixin Cheng, Lu Gao, Jun Gao, Ning Zhang, Chang-An Geng, Xiaoli Zhao, Huaiyu Wang, Chi-Wai Wong, Kelvin W. K. Yeung, Haobo Pan, William Weijia Lu, Min Guan

“…Thus, our findings highlight a therapeutic approach via targeting adipocyte ESRRA to preserve bone formation especially in detrimental adipocyte-rich bone milieu.…”
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Hair Loss Associated with Sertraline: A Case Report by Seyed Hamzeh Hosseini, Hamed Ghazvini, Seyedeh Masoumeh Seyedhosseini Tamijani, Raheleh Rafaiee

“…Although rare, this side effect can considerably affect a patient’s overall quality of life and compliance with therapeutic regimens. …”
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Modulation of miRNAs in Pulmonary Hypertension by Sudhiranjan Gupta, Li Li

“…This review provides an overview of recent discoveries on the role of miRNAs in the pathogenesis of PH and discusses the potential for miRNAs as therapeutic targets and biomarkers of PH at clinical setting.…”
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Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats by Maria Vittoria Micioni Di Bonaventura, Giovanni Vitale, Maurizio Massi, Carlo Cifani

“…The present results indicate for the first time that Hypericum perforatum extracts may have therapeutic properties in bingeing-related eating disorders.…”
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Curcumin: Synthesis optimization and in silico interaction with cyclin dependent kinase by Ahmed Mahmood, Abdul Qadir Muhammad, Imtiaz Shafiq Muhammad, Muddassar Muhammad, Hameed Abdul, Nadeem Arshad Muhammad, Asiri Abdullah M.

“…To computationally assess its therapeutic potential against cyclin dependent kinases (CDKs), curcumin was docked in different isoforms of CDKs. …”
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Donor-Derived Urothelial Carcinoma in Renal Transplant Recipients by Zhiyu Qian, Emily Chou, Jing Yang, Hanwei Zhang, HuiHui Ye, Sandy T. Liu, Arnold I. Chin

“…Both patient tumors expressed PD-L1 suggesting an additional therapeutic avenue for these rare tumors.…”
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