Comprehensive Analysis of TSPAN32 Regulatory Networks and Their Role in Immune Cell Biology by Grazia Scuderi, Katia Mangano, Maria Cristina Petralia, Maria Sofia Basile, Francesco Di Raimondo, Paolo Fagone, Ferdinando Nicoletti

“…These findings not only shed light on the biology of TSPAN32 but also provide the basis for exploring its diagnostic, prognostic, and therapeutic potential in autoimmune and inflammatory disorders, as well as in hematopoietic cancers.…”
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Investigation of Interactions between Thrombin and Ten Phenolic Compounds by Affinity Capillary Electrophoresis and Molecular Docking by Qiao-Qiao Li, Yu-Xiu Yang, Jing-Wen Qv, Guang Hu, Yuan-Jia Hu, Zhi-Ning Xia, Feng-Qing Yang

“…In the receptor concept, drugs produce their therapeutic effects via interactions with the targets. …”
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MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2 by Fang-Yuan Liu, Young-Lai Cho, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Seon-Jin Lee, Guo Nan Yin, Nam-Kyung Lee, Ji-Kan Ryu

“…Our findings not only provide conclusive evidence that MT-100 is a promising therapeutic strategy for the treatment of diabetic ED but also suggest it has substantial clinical applications for other complications associated with diabetes.…”
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Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces by W. van der Wulp, W. Luu, M. E. Ressing, J. Schuurman, S. I. van Kasteren, L. Guelen, R. C. Hoeben, B. Bleijlevens, M. H. M. Heemskerk

“…Antibody-mediated delivery of immunogenic viral CD8+ T-cell epitopes to redirect virus-specific T cells toward cancer cells is a promising new therapeutic avenue to increase the immunogenicity of tumors. …”
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OSAS-Related Inflammatory Mechanisms of Liver Injury in Nonalcoholic Fatty Liver Disease by Elena Paschetta, Paola Belci, Anna Alisi, Daniela Liccardo, Renato Cutrera, Giovanni Musso, Valerio Nobili

“…In this review, we focus on molecular mechanisms linking OSAS to NAFLD, including hypoxia inducible factor (HIF), nuclear factor kappa B (NF-κB), YKL-40, unfolded protein response, and hypoxic adipose tissue inflammation, which all could provide novel potential therapeutic approaches for the management of NAFLD patients with OSAS.…”
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The Classical Pathways of Occipital Lobe Epileptic Propagation Revised in the Light of White Matter Dissection by Francesco Latini, Mats Hjortberg, Håkan Aldskogius, Mats Ryttlefors

“…Merging semiology, white matter anatomy, and electrophysiology may lead us to a better understanding of these complex syndromes and tailored therapeutic options based on individual white matter connectivity.…”
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CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 Cell/μL: The DART Trial STI Substudy by Jennifer Serwanga, Susan Mugaba, Auma Betty, Edward Pimego, Sarah Walker, Paula Munderi, Charles Gilks, Frances Gotch, Heiner Grosskurth, Pontiano Kaleebu

“…To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed. Methods. CD8+ T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI substudy of the DART trial. …”
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Manganese-pyrochloric acid photosensitizer nanocomplexes against osteosarcoma: achieving both high activatability and high effectiveness by Xuran Zhang, Xuran Zhang, Jian Wang, Qun Feng, Li Lei, Zhiyong Zhu

“…IntroductionThe application of photodynamic therapy (PDT) is limited by unsatisfactory therapeutic efficacy and dose-dependent phototoxicity in clinical settings. …”
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Differential Gene Expression Profile of Human Neutrophils Cultured with Plasmodium falciparum-Parasitized Erythrocytes by Mohamad Alaa Terkawi, Ryo Takano, Kentaro Kato

“…The current study provides fundamental knowledge on the molecular responses of neutrophils to malarial parasites, which may aid in the discovery of novel therapeutic interventions.…”
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Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases by Heng Luo, Yu-fen Xia, Bao-fei Sun, Li-rong Huang, Xing-hui Wang, Hua-yong Lou, Xu-hui Zhu, Wei-dong Pan, Xiao-dong Zhang

“…Overall, our novel N,N-disubstituted Schiff bases possess unique antibacterial or antitumor activities that exhibit the potent application prospect in prophylactic or therapeutic interventions, providing new insights for developing new antibacterial and anticancer chemical agents.…”
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A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study by Li-Yuan Hung, Chan-Shuo Wu, Chia-Jung Chang, Peng Li, Kimberly Hicks, Joshua J. Dibble, Braxton Morrison, Chimere L. Smith, Ronald W. Davis, Wenzhong Xiao

“…These findings provide insights into the pathogenesis of ME/CFS from a network medicine perspective and highlight potential therapeutic targets. Further research is needed to validate these findings and explore their implications for improving diagnosis and treatment.…”
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A Case of Lymphocytic Myocarditis with Eosinophilic Degranulation Successfully Treated with Steroid Therapy by Tomoko Inoue, Fusako Sera, Shunsuke Nishimura, Kei Nakamoto, Yasumasa Tsukamoto, Isamu Mizote, Tomohito Ohtani, Shungo Hikoso, Yoshihiko Ikeda, Yumiko Hori, Hatsue Ishibashi-Ueda, Eiichi Morii, Tetsuo Minamino, Yasushi Sakata

“…This case indicates that eosinophil degranulation in lymphocytic myocarditis may be an important finding associated with a high therapeutic response to steroid therapy.…”
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Selectively expressed RNA molecules as a versatile tool for functionalized cell targeting by Frederik Rastfeld, Marco Hoffmann, Sylvie Krüger, Patrick Bohn, Anne-Sophie Gribling-Burrer, Laura Wagner, Nils Hersch, Carina Stegmayr, Lukas Lövenich, Sven Gerlach, Daniel Köninger, Christina Hoffmann, Helene L. Walter, Dirk Wiedermann, Hajaani Manoharan, Gereon R. Fink, Rudolf Merkel, Heribert Bohlen, Redmond P. Smyth, Maria A. Rueger, Bernd Hoffmann

“…Our data open up potential avenues for various therapeutic applications.…”
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Osteopontin at the Crossroads of Inflammation and Tumor Progression by Luigi Mario Castello, Davide Raineri, Livia Salmi, Nausicaa Clemente, Rosanna Vaschetto, Marco Quaglia, Massimiliano Garzaro, Sergio Gentilli, Paolo Navalesi, Vincenzo Cantaluppi, Umberto Dianzani, Anna Aspesi, Annalisa Chiocchetti

“…Thus, targeting OPN for therapeutic purposes needs to take into account the heterogeneous functions of the multiple OPN forms with regard to cancer formation and progression. …”
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Olive leaf extract activity against Candida albicans and C. dubliniensis – the in vitro viability study by Zorić Nataša, Kopjar Nevenka, Kraljić Klara, Oršolić Nada, Tomić Siniša, Kosalec Ivan

“…Olive leaf extract is characterized by a high content of polyphenols (oleuropein, hydroxytyrosol and their derivatives), which is associated with its therapeutic properties. The objective of the present research was to evaluate the antifungal activity of olive leaf extract against Candida albicans ATCC 10231 and C. dubliniensis CBS 7987 strains. …”
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Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer by Ge Li, Zhenke Wen, Sidong Xiong

“…Together, our findings highlight a β-TrCP-dependent mechanism in steering intrinsic metabolic adaptation and CD8+ Tex, emphasizing microenvironmental β-TrCP as an immune checkpoint for therapeutic exploration against human NSCLC.…”
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The Role of the Immune System in Huntington’s Disease by Gisa Ellrichmann, Christiane Reick, Carsten Saft, Ralf A. Linker

“…Further understanding the influence of inflammation in HD using mouse models may open various avenues for promising therapeutic approaches aiming at slowing disease progression or forestalling onset of disease.…”
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Nosocomial Infections in Burned Patients in Motahari Hospital, Tehran, Iran by Leila Azimi, Abbas Motevallian, Amirmorteza Ebrahimzadeh Namvar, Babak Asghari, Abdolaziz Rastegar Lari

“…Burn patients are at high risk of developing nosocomial infection because of their destroyed skin barrier and suppressed immune system, compounded by prolonged hospitalization and invasive therapeutic and diagnostic procedures. Studies on nosocomial infection in burn patients are not well described. …”
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Characteristics of Hydrogels as a Coating for Microneedle Transdermal Delivery Systems with Agomelatine by Monika Wojtyłko, Ariadna B. Nowicka, Anna Froelich, Mirosław Szybowicz, Tobiasz Banaszek, Dorota Tomczak, Wiesław Kuczko, Radosław Wichniarek, Irena Budnik, Barbara Jadach, Oliwia Kordyl, Antoni Białek, Julia Krysztofiak, Tomasz Osmałek, Dimitrios A. Lamprou

“…Transdermal administration of agomelatine may increase its bioavailability and reduce the doses necessary for therapeutic effects. However, transdermal delivery requires crossing the <i>stratum corneum</i> barrier. …”
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The State of the Art of the DSM-5 “with Mixed Features” Specifier by Norma Verdolini, Mark Agius, Laura Ferranti, Patrizia Moretti, Massimiliano Piselli, Roberto Quartesan

“…As for the clinical presentation, the epidemiological data, and the therapeutic outcomes, the latest literature does not point out a univocal point of view and further research is needed to fully assess the implications of the new DSM-5 MFS. …”
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