Serotonin circuits act cooperatively with pathophysiology of opioid use disorder by Arakawa Hiroyuki, Ozawa Akihiko

“…We interrogate the potential neural roles of 5-HT in OUD-related symptoms including 5-HT toxicity and pathophysiology and discuss potential availability of 5-HT-related agents as a neuromodulatory therapeutic interacting with opioid mediated neural mechanisms and the OUD-related symptoms.…”
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Highly effective treatment of bacterial infection-accompanied wounds by fat extract-embedded phototherapeutic hydrogel by Haonan Wang, Yingnan Xiao, Deli Zhuge, Genghe Shi, Chengping Liu, Hui Liang, Jing Wu, Yunxuan Huang, Yilin Xie, Chunnan Hu, Jiafeng Xie, Xinyi Wang, Yao Yao, Fang Wang, Xufei Zhang, Chengke Huang, Yingzheng Zhao, Weiyang Meng, Yijie Chen, Mengchun Chen

“…Abstract Phototherapy presents an effective approach for treating localized methicillin-resistant Staphylococcus aureus (MRSA) infections; however, the tradeoff between therapeutic efficacy and negative off-target effect persists. …”
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Reform and Development of Rare Diseases Drug Evaluation and Approval in China by HUANG Guo, YANG Zhimin, TANG Ling, ZHANG Jie, AI Xing, SE RI Geleng, ZHAO Tian

“…Additionally, the long development cycles, high costs, and high risks have led to a number of potential therapeutic drug failures at the early stages of development. …”
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The Role of Lung Ultrasound Scan in Different Heart Failure Scenarios: Current Applications and Lacks of Evidences by Alessandro Campora, Matteo Beltrami, Anita Di Renzo, Alessia Petrini, Alberto Palazzuoli

“…Pulmonary congestion is a critical factor influencing the clinical presentation, therapeutic decisions, and outcomes of heart failure (HF) patients. …”
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Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model by Juan Sebastian Yakisich, Neelam Azad, Rajkumar Venkatadri, Yogesh Kulkarni, Clayton Wright, Vivek Kaushik, Anand Krishnan V. Iyer

“…In addition, we report that the FDA-approved drug Digitoxin, at concentration close to its therapeutic level, decreased the viability of LTSs and downregulated Sox2 independent of the PI3K/AKT pathway. …”
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Cholesterol Targeted Catalytic Hydrogel Fueled by Tumor Debris can Enhance Microwave Ablation Therapy and Anti‐Tumor Immune Response by Lin Shen, Zhijuan Yang, Yi Zhong, Yanran Bi, Junchao Yu, Qinwei Lu, Yanping Su, Xiaoxiao Chen, Zhongwei Zhao, Gaofeng Shu, Minjiang Chen, Liang Cheng, Liangzhu Feng, Chenying Lu, Zhuang Liu, Jiansong Ji

“…This work highlights that cholesterol‐targeting catalytic hydrogels fueled by tumor debris can significantly improve the efficacy of MWA and ICIs, offering a novel therapeutic approach for HCC.…”
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Chemical compositions and health promoting effects of edible mushrooms from genus Russula by Xinwen Hu, Baojun Xu

“…Extensive research in the past two decades has delved into the bioactive compounds of Russula mushrooms, exploring their therapeutic potential. Purpose: This comprehensive review aims to examine the chemical diversity within the genus Russula and elucidate the contribution of these compounds to various health benefits, including antioxidant, antimicrobial, anticancer, immunoenhancing properties, observed in different Russula species. …”
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Genetic and molecular insights in oral squamous cell carcinoma therapy - Advancing the horizon by Prathiksha Srikanthan, Suresh Malakondaiah, Iadalin Ryntathiang, Mukesh Kumar Dharmalingam Jothinathan

“…Immune cell dynamics and personalized immunotherapy are important to be understood to achieve better therapeutic results. Some of them are tumor relapse, and the requirement of accurate prognostic indicators and diagnostic tests. …”
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OCH Ameliorates Bone Marrow Failure in Mice via Downregulation of T-Bet Expression by Xiaohong Qiao, Xiaotian Xie, Wei Shi, Jinqing Tang, Yuexia Shao, Fuxing Li

“…In conclusion, treatment of OCH prior to the induction of BMF could prevent the incidence of BMF possibly through downregulating T-bet expression leading to the transition of immune response from Th1 to Th2, suggesting OCH might be a new therapeutic approach in the treatment of BMF or AA.…”
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Relief of Urinary Urgency, Hesitancy, and Male Pelvic Pain with Pulse Radiofrequency Ablation of the Pudendal Nerve: A Case Presentation by Christopher Bui, Sanjog Pangarkar, Scott I. Zeitlin

“…It may also hold some therapeutic value in the treatment of urinary urgency and hesitancy as our case demonstrated. …”
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Hypoxia-Induced Reactive Oxygen Species: Their Role in Cancer Resistance and Emerging Therapies to Overcome It by Eleicy Nathaly Mendoza, Maria Rosa Ciriolo, Fabio Ciccarone

“…Overcoming hypoxia-induced ROS cancer resistance requires a multifaceted approach that targets various aspects of tumor biology. Emerging therapeutic strategies target hypoxia-induced resistance, focusing on hypoxia-inducible factors, ROS levels, and tumor microenvironment subpopulations. …”
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KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer by Shanshan Cong, Yao Fu, Xibo Zhao, Qiuyan Guo, Tian Liang, Di Wu, Jing Wang, Guangmei Zhang

“…Researches on pathogenesis and therapeutic targets for OV need to be continued. This study mainly analyzed the immune-related pathogenesis and discovered the key immunotherapy targets for OV. …”
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Dual graph-embedded fusion network for predicting potential microbe-disease associations with sequence learning by Junlong Wu, Liqi Xiao, Liu Fan, Lei Wang, Xianyou Zhu, Xianyou Zhu

“…This comprehensive approach allows DuGEL to achieve a high level of accuracy in predicting potential microbe-disease associations, making it a valuable tool for biomedical research and the discovery of new therapeutic targets. By combining advanced graph-based and sequence-based learning techniques, DuGEL addresses the limitations of existing methods and provides a robust framework for the prediction of microbe-disease associations. …”
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Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics by Julia Velz, Lena K. Freudenmann, Gioele Medici, Marissa Dubbelaar, Malte Mohme, David R. Ghasemi, Jonas Scheid, Daniel J. Kowalewski, Angelica B. Patterson, Anna M. Zeitlberger, Katrin Lamszus, Manfred Westphal, Matthias Eyrich, Martina Messing-Jünger, Andreas Röhrig, Harald Reinhard, Kévin Beccaria, Rogeiro B. Craveiro, Beat M. Frey, Martin Sill, Sven Nahnsen, Marie Gauder, Konstantina Kapolou, Manuela Silginer, Tobias Weiss, Hans-Georg Wirsching, Patrick Roth, Michael Grotzer, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Hans-Georg Rammensee, Elisabeth J. Rushing, Felix Sahm, Juliane S. Walz, Michael Weller, Marian C. Neidert

“…Despite recent advances in integrated genomics, the prognosis in children with high-risk medulloblastoma remains devastating, and new tumor-specific therapeutic approaches are needed. Here, we present an atlas of naturally presented T cell antigens in medulloblastoma. …”
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The Molecular Imaging of Natural Killer Cells by Mariya Shapovalova, Sean R. Pyper MD, PhD, Branden S. Moriarity PhD, Aaron M. LeBeau PhD

“…The molecular imaging of NK cells in vivo will be crucial for the development of new therapies allowing for the immediate assessment of therapeutic response and off-target effects. A number of groups have investigated methods for detecting NK cells by optical, nuclear, and magnetic resonance imaging. …”
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Strongyloides Colitis as a Harmful Mimicker of Inflammatory Bowel Disease by Julio Poveda, Farah El-Sharkawy, Leopoldo R. Arosemena, Monica T. Garcia-Buitrago, Claudia P. Rojas

“…Definitive diagnosis is crucial as each disease carries distinct therapeutic implications and outcome.…”
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Bifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia by Zeng Zhang, Quan Guo, Zhihan Yang, Yukai Sun, Shuaiming Jiang, Yangli He, Jiahe Li, Jiachao Zhang

“…Our findings suggest that B. adolescentis-derived nicotinic acid could be a promising therapeutic strategy for individuals with sarcopenia.…”
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The Role of Myeloid Cells on the Development of Hepatic Metastases in Gastrointestinal Cancer by Austin R. Dosch, Mary P. Martos, Samara Singh, Karishma Kodia, Nipun B. Merchant, Nagaraj S. Nagathihalli

“…Lastly, we describe burgeoning therapeutic approaches aimed at targeting specific myeloid populations to reduce liver metastases and highlight the inherent challenges that exist in studying the efficacy of these treatments in preclinical models. …”
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Exploring effector protein dynamics and natural fungicidal potential in rice blast pathogen Magnaporthe oryzae. by Jannatul Ferdousy, Tanjin Barketullah Robin, Mst Sanjida Nasrin, Istiak Ahmed, Tawsif Hossain, Md Mehedi Hasan, Mehrab Hassan Soaeb, Md Ahsanul Tamim, Nusrat Jahan Yeasmin, Ummay Habiba, Nadim Ahmed, Nurul Amin Rani, Md Shishir Bhuyian, Suvarna N Vakare, Abu Tayab Moin, Rajesh B Patil, Mohammad Shahadat Hossain

“…Molecular dynamics simulations further confirmed that these compounds form stable, strong interactions with the target proteins, validating their potential as therapeutic agents. Additionally, the compounds were evaluated based on Lipinski's rule of five and toxicity predictions, indicating their suitability for agricultural use. …”
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Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment by Arghavan Fatahi, Neda Soleimani, Parviz Afrough

“…Numerous investigation have been accomplished in the field of the therapeutic property of probiotic products. In the present study, we assessed the cytotoxic effect of kefir on the rate of growth and increase of glioblastoma cancer cell as the most severe form of brain tumors. …”
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