Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke by Ying-Sheng Lee, Chung-Ching Chio, Ching-Ping Chang, Liang-Chao Wang, Po-Min Chiang, Kuo-Chi Niu, Kuen-Jer Tsai

“…These effects may help in neuronal repair after ischemic stroke, and increasing the course of HBO therapy might enhance therapeutic effects on ischemic stroke.…”
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Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC by Yujie Hao, Mingchen Li, Wenxu Liu, Zhenyi Ma, Zhe Liu, Zhe Liu, Zhe Liu

“…In vitro, increasing autophagy induced NE features in non-NE cell lines, while autophagy inhibition in NE cell lines promoted non-NE characteristics.DiscussionThis study provides a novel model for investigating autophagy in vivo and underscores its critical role in driving SCLC heterogeneity and plasticity, offering potential therapeutic insights.…”
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Epigenetic Alterations in Bladder Cancer and Their Potential Clinical Implications by Han Han, Erika M. Wolff, Gangning Liang

“…Future research is needed to address efficacy and potential toxicity issues before it can be implemented as a therapeutic strategy for solid tumors.…”
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Novel anti-inflammatory properties of mannose oligosaccharides in the treatment of inflammatory bowel disease via LGALS3 modulation by Yaqi Du, Yan Fan, Xin Li, Fenqin Chen

“…These results underscore the potential of dietary polysaccharides like GA-MOS as therapeutic agents in managing dysbiosis and inflammatory conditions in the gut, offering a promising approach for enhancing microbial health and overall disease management in IBD. …”
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T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall by Jie Xu, Xiaojun Wu, Vishnu Reddy

“…Correct recognition of this entity is critical, because of the difference in therapeutic impact on these patients.…”
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MOF-derived intelligent arenobufagin nanocomposites with glucose metabolism inhibition for enhanced bioenergetic therapy and integrated photothermal-chemodynamic-chemotherapy by Lihua Chen, Jiaying Yang, Lingyu Jia, Xiaolu Wei, Huijun Wang, Zhuo Liu, Shan Jiang, Pengyue Li, Yanyan Zhou, Hongjie Wang, Nan Si, Baolin Bian, Qinghe Zhao, Haiyu Zhao

“…Abstract Bioenergetic therapy based on tumor glucose metabolism is emerging as a promising therapeutic modality. To overcome the poor bioavailability and toxicity of arenobufagin (ArBu), a MOF-derived intelligent nanosystem, ZIAMH, was designed to facilitate energy deprivation by simultaneous interventions of glycolysis, OXPHOS and TCA cycle. …”
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Reproducibility of the Time of Intraocular Pressure Peaks During Water-drinking Test in Patients Treated for Open-angle Glaucoma by Carolina TN Susanna, C. Gustavo De Moraes, Paula Alhadeff, Bianca TN Susanna, Fernanda TN Susanna, Renato Antunes Schiave Germano, Remo Susanna Jr

“…All patients underwent the WDT performed in two consecutive visits without any change in the therapeutic regimen. The interval between tests was 4 to 6 months. …”
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Paediatric Inflammatory Bowel Disease: A Mechanistic Approach to Investigate Exclusive Enteral Nutrition Treatment by Lily Nahidi, Andrew S. Day, Daniel A. Lemberg, Steven T. Leach

“…The introduction of EEN as a therapeutic option for IBD was through prudent observation; however, EEN has become an established and reliable option for the treatment of paediatric IBD. …”
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PPAR Agonists for the Prevention and Treatment of Lung Cancer by Sowmya P. Lakshmi, Aravind T. Reddy, Asoka Banno, Raju C. Reddy

“…This review of current literature emphasizes the multifaceted effects of PPAR agonists in lung cancer and discusses how they may be applied as novel therapeutic strategies for the disease.…”
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A case report of an early neonatal death accompanied by disseminated intravascular coagulation caused by severe acute respiratory syndrome Coronavirus-2 infection by Mitić Gorana P., Spasić Igor G., Panjković Milana D., Vučković Biljana A.

“…Conclusion: The presented clinical case indicates the importance of an early diagnosis of DIC in SARS-CoV-2-positive pregnant women, timely therapeutic decisions, psychological support, and long-term follow-up of physical and psychological conditions.…”
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Advancements in Nanorobots: Innovating Bladder Cancer Treatments, Diagnosis and Patient Outcomes by Zehra Hussain, Alyssa Di Fonzo, Hermela Merhawi, Mary Gallant, Robert Girlan, Muhammad Hasibul Hasan

“…This report emphasizes the potential of nanorobots to revolutionize the treatment of bladder cancer by improving both therapeutic precision and patient quality of life. …”
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Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals by Kathrin Badstuebner, Ulrike Gimsa, Immo Weber, Armin Tuchscherer, Jan Gimsa

“…The latter two parameters were found to be most appropriate for judging therapeutic DBS effects.…”
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Nanotherapeutics for Meningitis: Enhancing Drug Delivery Across the Blood-Brain Barrier by Hitaishi Sharma, Kannan Badri Narayanan, Shampa Ghosh, Krishna Kumar Singh, Prarthana Rehan, Aparajita Dasgupta Amist, Rakesh Bhaskar, Jitendra Kumar Sinha

“…Nanoparticle (NP)-based therapeutic approaches have the potential to address the limitations such as penetrating the BBB and achieving targeted drug release in specific cells and tissues. …”
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Exosomes in Human Immunodeficiency Virus Type I Pathogenesis: Threat or Opportunity? by Sin-Yeang Teow, Alif Che Nordin, Syed A. Ali, Alan Soo-Beng Khoo

“…Deeper understanding on how exosomes promote or abate HIV infection can significantly contribute to the development of new and potent antiviral therapeutic strategy and vaccine designs.…”
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Golgi protein 73: the driver of inflammation in the immune and tumor microenvironment by Pingping Feng, Pingping Feng, Xinyang Hu, Xinyang Hu, Sining Zhou, Xianyong Liu, Linghui Zeng, Yiming Liu, Yiming Liu, Yiming Liu, Yiming Liu

“…In this review, we aim to summarize the findings, providing insights for future investigations on GP73 and its potential as a therapeutic target in ameliorating chronic inflammation in the immune and tumor microenvironment.…”
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Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry by Ron M. Versteegen, Raffaella Rossin, Ivo A. W. Filot, Freek J. M. Hoeben, Arthur H. A. M. van Onzen, Henk M. Janssen, Marc S. Robillard

“…Applied to on-tumor activation of a click-cleavable ADC in mice, these tetrazines afforded near-quantitative ADC conversion at a ca. 10- to 20-fold lower dose than what was previously needed, resulting in a strong therapeutic response.…”
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Genetic and molecular mechanisms of hydrocephalus by Xuehai Deng, Xuehai Deng, Yiqian Chen, Yiqian Chen, Qiyue Duan, Qiyue Duan, Jianlin Ding, Jianlin Ding, Zhong Wang, Zhong Wang, Junchi Wang, Xinlong Chen, Liangxue Zhou, Long Zhao

“…Further research on the pathogenesis of hydrocephalus is essential for developing new diagnostic, preventive, and therapeutic strategies. Various genetic and molecular abnormalities contribute to the mechanisms of hydrocephalus, including gene deletions or mutations, the activation of cellular inflammatory signaling pathways, alterations in water channel proteins, and disruptions in iron metabolism. …”
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Control of Cryptococcus Gattii Biofilms by an Ethanolic Extract of Cochlospermum Regium (Schrank) Pilger Leaves by Adriana A. Almeida-Apolonio, Wellinton J. Cupozak-Pinheiro, Vagner M. Berres, Fabiana G. S. Dantas, Terezinha I. E. Svidzinski, Kelly M. P. Oliveira, Marilene R. Chang

“…Cryptococcus gattii is an etiologic agent of cryptococcosis and a serious disease that affects immunocompromised and immunocompetent patients worldwide. The therapeutic arsenal used to treat cryptococcosis is limited to a few antifungal agents, and the ability of C. gattii to form biofilms may hinder treatment and decrease its susceptibility to antifungal agents. …”
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Graves’ Ophthalmopathy: VISA versus EUGOGO Classification, Assessment, and Management by Jesús Barrio-Barrio, Alfonso L. Sabater, Elvira Bonet-Farriol, Álvaro Velázquez-Villoria, Juan C. Galofré

“…The VISA (vision, inflammation, strabismus, and appearance), and the European Group of Graves’ Orbitopathy (EUGOGO) classifications are the two widely used grading systems conceived to assess the activity and severity of GO and guide the therapeutic decision making. A critical analysis of classification, assessment, and management systems is reported. …”
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Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer by Agnieszka Chytła, Stephanie Rattay, Baki Akgül, Martin Sztacho

“…Understanding the PI(4,5)P2-related mechanisms underlying metastasis may provide insights into potential therapeutic targets, paving the way for more effective therapies and improved patient outcomes.…”
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