FXYD3 Is Frequently Expressed in Pancreatic Ductal Adenocarcinoma but Does Not Predict Survival by Nathalie B. Rasko, Christopher B. Nahm, John Turchini, Rachel Teh, Helge Rasmussen, Sooin Byeon, Sumit Sahni, Jaswinder S. Samra, Anthony J. Gill, Anubhav Mittal

“…The high rate of FXYD3 overexpression warrants therapeutic evaluation.…”
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Value contribution of leniolisib in the Treatment of Activated PI3Kδ syndrome (APDS) in Spain using Multi-Criteria Decision Analysis (MCDA) by María Reyes Abad, Carmen Alerany, Luis Ignacio Gonzalez, Olaf Neth, Concepción Payares-Herrera, Carlos Rodríguez-Gallego, Jose Luis Trillo, Kirsten H. Herrmann, Raquel Figueiredo, Alicia Gil

“…It was deemed highly valuable as the first disease-modifying treatment, with a positive therapeutic impact and potential to improve patients’ quality of life. …”
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Patient and Physician Perspectives of Diabetic Retinopathy and Diabetic Macular Edema Diagnosis, Treatment and Progression: A Podcast Article by Daniel Newman, Bernadette Warren, Randall Barker, Charles C. Wykoff, Stela Vujosevic

“…However, the large burden of current treatments calls for new therapeutic approaches that meet patients’ needs better. …”
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Self‐Healing Hyaluronic Acid‐based Hydrogel with miRNA140‐5p Loaded MON‐PEI Nanoparticles for Chondrocyte Regeneration: Schiff Base Self‐Assembly Approach by Wei Zhu, Han Wang, Bin Feng, Guangli Liu, Yixin Bian, Tianhao Zhao, Qi Wang, Xisheng Weng

“…Abstract Articular cartilage defects present a significant therapeutic challenge due to the inherent avascular and aneural characteristics of cartilage tissue. …”
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Adipokines regulate the development and progression of MASLD through organellar oxidative stress by Ke Zhao, Heng Zhang, Wenyu Ding, Xiaoshuai Yu, Yanli Hou, Xihong Liu, Xinhua Li, Xiaolei Wang

“…Due to the emerging correlation between adipokines and the development of MASLD positions, these adipokines are potential targets for the development of innovative therapeutic interventions for MASLD management. A comprehensive understanding of the pathogenesis of MASLD/MASH is instrumental for identifying therapies for MASH.…”
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Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications by Hao Peng, Zheng Chao, Zefeng Wang, Xiaodong Hao, Zirui Xi, Sheng Ma, Xiangdong Guo, Junbiao Zhang, Qiang Zhou, Guanyu Qu, Yuan Gao, Jing Luo, Zhihua Wang, Jing Wang, Le Li

“…This comprehensive review of biomechanics will enhance the understanding of the functional role of biomechanical forces and provide basic knowledge for the discovery of novel therapeutic targets.…”
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The role of the extracellular matrix in cardiac regeneration by Xiying Wang, Shuo Yu, Lan Xie, Meixiang Xiang, Hong Ma

“…Understanding the ECM and its involvement in mechanotransduction holds significant potential for advancing therapeutic approaches in heart repair and regeneration.…”
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Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence by Mariacristina Amato, Alessandro Polizzi, Gaia Viglianisi, Francesco Leonforte, Marco Mascitti, Gaetano Isola

“…This review will analyze the current literature about the intricate interplay between periodontitis, oral dysbiosis, and the processes of senescence, shedding light on their collective impact on the modulation and accelerated ageing and age-related diseases. Lastly, therapeutic strategies targeting periodontitis and oral dysbiosis to mitigate senescence and its associated morbidities will be discussed.…”
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Gut Microbiota and its Metabolites in Pathogenesis of NAFLD by M. S. Reshetova, O. Yu. Zolnikova, V. T. Ivashkin, K. V. Ivashkin, S. A. Appolonova, T. L. Lapina

“…A more detailed understanding of the role of individual metabolites or their combinations in the NAFLD pathogenesis will allow us to determine the vector of further diagnostic and therapeutic approaches for this nosology. The research results of the probiotics effect on the levels of certain metabolites are currently being discussed.Conclusion. …”
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Reactivation of mTOR signaling slows neurodegeneration in a lysosomal sphingolipid storage disease by Hongling Zhu, Y. Terry Lee, Colleen Byrnes, Jabili Angina, Danielle A. Springer, Galina Tuymetova, Mari Kono, Cynthia J. Tifft, Richard L. Proia

“…These findings imply that enhancing mTOR signaling could be a potential therapeutic strategy for lysosomal-based neurodegenerative diseases.…”
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Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseas... by Lindner Ewald, Langner-Wegscheider Beate, Sarny Stephanie, Renner Wilfried, El-Shabrawi Yosuf

“…Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.…”
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Treatment of Nonvariceal Gastrointestinal Hemorrhage by Transcatheter Embolization by Muhammad Ali, Tanveer Ul Haq, Basit Salam, Madiha Beg, Raza Sayani, Muhammad Azeemuddin

“…Conclusion. The use of therapeutic transcatheter embolization for treatment of acute gastrointestinal hemorrhage is highly successful and relatively safe with 98% technical success and 2.4% postembolization ischemia in our series. …”
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Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation by Shi-Qing Mu, Jia-Jie Lin, Yu Wang, Li-Yun Yang, Sen Wang, Zhao-Yi Wang, An-Qi Zhao, Wen-Jun Luo, Zi-Qi Dong, Yu-Guang Cao, Ze-An Jiang, Si-Fan Wang, Shan-Hu Cao, Li Meng, Yang Li, Shu-Yan Yang, Shao-Guang Sun

“…Therefore, circ-1304 may serve as a potential therapeutic target for vascular remodeling diseases.…”
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Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer by Yanbo Pan, Olena Berkovska, Soumitra Marathe, Georgios Mermelekas, Greta Gudoityte, Amare D. Wolide, Taner Arslan, Brinton Seashore-Ludlow, Janne Lehtiö, Lukas M. Orre

“…Key findings include the potential therapeutic value of FTIs for NRAS-mutated melanoma and GNAQ/GNA11-mutated uveal melanoma by inhibiting INPP5A farnesylation. …”
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Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models by Rubén Fernández-Santiago, Mario Ezquerra

“…Moreover, elucidating epigenetic regulation using patient-specific iPSC-derived neural models is expected to have a great impact to unravel the pathophysiology of neurodegenerative diseases and to hopefully expand future therapeutic possibilities. Here we will critically review current knowledge of epigenetic involvement in neurodegenerative disorders focusing on the potential of iPSCs as a promising tool for epigenetic research of these diseases.…”
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Loss of Sirtuin 7 impairs cell motility and proliferation and enhances S-phase cell arrest after 5-fluorouracil treatment in head and neck cancer by Marta Halasa, Syeda Afshan, Anna Wawruszak, Agata Borkowska, Klaudia Brodaczewska, Alicja Przybyszewska-Podstawka, Joanna Kalafut, Marzena Baran, Adolfo Rivero-Müller, Andrzej Stepulak, Matthias Nees

“…Altogether, our study highlights SIRT7 as a promising therapeutic target in HNSCC, enhancing the effectiveness of treatment modalities such as combinational treatment.…”
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Emergence of Digital Workflow in Minimally Invasive Implant Surgery: A Case Report by Ranjith Mari, Mohan Valiathan, Sajid, K Rudhra, Angelin Fiona

“…In contemporary dentistry, computer-assisted implant planning has become a significant diagnostic and therapeutic tool. The present case study highlights the potential of modern implantology by integrating virtual implant planning, guided surgery with tooth-supported templates, implant placement with immediate loading and in-office milling. …”
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Privacy preservation in data intensive environment by Jyotir Moy Chatterjee, Raghvendra Kumar, Prasant Kumar Pattnaik, Vijender Kumar Solanki, Noor Zaman

“…For medicinal services, maybe related exploration thinks about the therapeutic records of patients ought to be recovered from various destinations with various regulations on the divulgence of healthcare data. …”
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Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses by Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk

“…This pipeline is tailored to monitor ecDNA dynamics during drug treatment.ResultsOur approach effectively quantified ecDNA changes, providing a robust framework for analyzing the adaptive responses of cancer cells under therapeutic pressure.DiscussionThe pipeline not only serves as a valuable resource for automating ecDNA detection in metaphase FISH images but also highlights the role of ecDNA in facilitating swift and reversible adaptation to epigenetic remodeling agents such as JQ1.…”
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Ofatumumab successfully treats myelin oligodendrocyte glycoprotein antibody-associated disease accompanied by Epstein-Barr viral infection: a case series by Chen Min, Bi Zhuajin, Liu Peidong, Li Ruoyu, Liu Ju, Liu Hongbo

“…This is the first report on subcutaneous ofatumumab treatment for MOGAD triggered by EBV, suggesting that this is a potentially valuable therapeutic option.…”
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