Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases by Leilei Chen, Qingqing Shen, Yingjuan Liu, Yunqi Zhang, Liping Sun, Xizhen Ma, Ning Song, Junxia Xie

“…Then, the upstream regulators, downstream effector, and crosstalk of mental ions under both physiologic and pathologic conditions will be summarized. Finally, the therapeutic effects of metal ion chelators, such as clioquinol, quercetin, curcumin, coumarin, and their derivatives for the treatment of neurodegenerative diseases will be discussed. …”
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Protocol for engineering bone organoids from mesenchymal stem cells by Jian Wang, Dongyang Zhou, Ruiyang Li, Shihao Sheng, Guangfeng Li, Yue Sun, Peng Wang, Yulin Mo, Han Liu, Xiao Chen, Zhen Geng, Qin Zhang, Yingying Jing, Long Bai, Ke Xu, Jiacan Su

“…This in vivo bone organoid model offers a novel platform for studying bone development, exploring congenital diseases, testing drugs, and developing therapeutic applications.…”
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Extraction of American ginseng polysaccharide by ultrasound-assisted deep eutectic solvents-based three-phase partitioning: Process optimization, structural characterization, and a... by Zhongnan Wu, Chong Li, Junhao Li, Tanggan Wang, Meifeng Li, Leyi Zhao, Huimei Ye, Jiaheng Chen, Jiajia Zan, Lijun Song, Qian Zhang, Shaojie Zhang

“…Our results highlight the effectiveness of the AGP-DES-4 extraction method and its potential therapeutic value for treating UC.…”
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PPAR-γ Agonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer by A. Belfiore, M. Genua, R. Malaguarnera

“…These therapies are limited by the development of insulin resistance and compensatory hyperinsulinemia, which in turn, may stimulate cancer growth. Novel therapeutic approaches are, therefore, required. Synthetic PPAR-γ agonists, such as thiazolidinediones (TZDs), are drugs universally used as antidiabetic agents in patients with type 2 diabetes. …”
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Biological evaluation and interaction mechanism of beta-site APP cleaving enzyme 1 inhibitory pentapeptide from egg albumin by Zhipeng Yu, Sijia Wu, Wenzhu Zhao, Long Ding, David Shiuan, Fuping Zheng, Jianrong Li, Jingbo Liu

“…Inhibition of beta-site APP cleaving enzyme1 (BACE1) is one of the most promising therapeutic approaches for Alzheimer’s disease. To find natural products for the treatment of Alzheimer's disease, absorption, distribution, metabolism, excretion and toxicity (ADMET) properties and in vitro BACE1 inhibitory activity of the peptides isolated from egg albumin were evaluated. …”
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Time-series single-cell transcriptomic profiling of luteal-phase endometrium uncovers dynamic characteristics and its dysregulation in recurrent implantation failures by Dandan Cao, Yijun Liu, Yanfei Cheng, Jue Wang, Bolun Zhang, Yanhui Zhai, Kongfu Zhu, Ye Liu, Ye Shang, Xiao Xiao, Yi Chang, Yin Lau Lee, William Shu Biu Yeung, Yuanhua Huang, Yuanqing Yao

“…The holistic characterization of the physiological and pathophysiological window of implantation and a computational tool trained on this temporal atlas provide a platform for future therapeutic developments.…”
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A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions by Xi Xi, Jiaqi Li, Jinmeng Jia, Qiuchen Meng, Chen Li, Xiaowo Wang, Lei Wei, Xuegong Zhang

“…Some regulators reveal potential new therapeutic targets, drug repurposing possibilities, and putative causal single nucleotide polymorphisms. …”
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Amino Acid-Mediated Metabolism: A New Power to Influence Properties of Stem Cells by Jilan Liu, Xianyun Qin, Dongfeng Pan, Bin Zhang, Feng Jin

“…In addition, we briefly survey new therapeutic modalities that may help eradicate cancer stem cells by exploiting nutrient deprivation. …”
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RevCAR-mediated T-cell response against PD-L1-expressing cells turns suppression into activation by Eugenia Crespo, Liliana R. Loureiro, Antonia Stammberger, Lydia Hoffmann, Nicole Berndt, Anja Hoffmann, Claudia Dagostino, Karla E. G. Soto, Luise Rupp, Claudia Arndt, Martin Schneider, Claudia R. Ball, Michael Bachmann, Marc Schmitz, Anja Feldmann

“…Our findings suggest that RevCAR-mediated targeting of PD-L1 could be a promising therapeutic approach for modulating the TME and improving solid tumor treatment.…”
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Immunosenescence and its related comorbidities in older people living with HIV by Xiao-Yan He, Xiu-Wen Wang, Shuang Li, Na Li, Wei Li, Yan Hu, Na Guo, Yong-Tang Zheng, Hong-Yi Zheng, Bin Su, Haijuan Wang

“…A comprehensive understanding of the relationship between immunosenescence and HIV infection is crucial for developing targeted therapeutic strategies for this vulnerable population.…”
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Practical solutions for overcoming artificial disulfide scrambling in the non-reduced peptide mapping characterization of monoclonal antibodies by Andrew Kleinberg, Yuan Mao, Ning Li

“…Non-reduced peptide mapping provides essential data for characterizing therapeutic monoclonal antibodies by isolating disulfide connections between specific cysteines. …”
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Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations by Huilai Tian, Eliot Davidowitz, Patricia Lopez, Sharareh Emadi, James Moe, Michael Sierks

“…Further characterization of tau oligomer species with disease-specific modifications and morphologies is necessary to identify the best targets for the development of biomarker and therapeutic development for AD and related tauopathies.…”
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Endothelial calcium firing mediates the extravasation of metastatic tumor cells by Marina Peralta, Amandine Dupas, Annabel Larnicol, Olivier Lefebvre, Ruchi Goswami, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Salvatore Girardo, Naël Osmani, Jacky G. Goetz

“…These results further highlight the central role of endothelial remodeling during the extravasation of TCs and open avenues for successful therapeutic targeting.…”
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The role of the early-life gut microbiome in childhood asthma by Ulrika Boulund, Jonathan Thorsen, Urvish Trivedi, Kaare Tranæs, Jie Jiang, Shiraz A. Shah, Jakob Stokholm

“…In this review, we examine the current literature on the role of the gut microbiome in childhood asthma and identify research gaps to allow for future microbial-focused therapeutic applications in asthma.…”
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Lutein, Zeaxanthin, and meso-Zeaxanthin in the Clinical Management of Eye Disease by Nicole K. Scripsema, Dan-Ning Hu, Richard B. Rosen

“…Current publications on the preventive and therapeutic effects of lutein and zeaxanthin on cataracts, diabetic retinopathy, and retinopathy of prematurity have reported encouraging results.…”
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Single-Incision Laparoscopic Surgery for Undiagnosed Small Bowel Obstruction in a Patient without a History of Abdominal Surgery by Noriaki Koizumi, Hiroki Kobayashi, Tsuyoshi Takagi, Kanehisa Fukumoto

“…As a much less invasive therapeutic strategy, we have performed single-incision laparoscopic surgery for the treatment of an undiagnosed small bowel obstruction. …”
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A Rare Case of Duodenal Adenocarcinoma Presenting as a Subepithelial Lesion in a Patient Undergoing Investigation for Iron Deficiency Anaemia by Xinxin Hu, Karina Aivazian, Catriona McKenzie, May Wong, Arthur Kaffes, Payal Saxena

“…Advances in endoscopic diagnostic modalities could facilitate early diagnosis and improve therapeutic outcomes.…”
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Biomaterials in Guided Bone and Tissue Regenerations: An Update by Reza Abdollahi Namanloo, Maedeh Ommani, Kamyar Abbasi, Mostafa Alam, Ashkan Badkoobeh, Mahdi Rahbar, Hadi Kokabi Arasteh, Emran Hajmohammadi, Reza Sayyad Soufdoost, Seyed Ali Mosaddad

“…Secondly, biomaterials are examined for their therapeutic uses such as growth factors, stem cells, and gene delivery vehicles. …”
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A Safe Framework for Quantitative In Vivo Human Evaluation of Image Guidance by Piper C. Cannon, James M. Ferguson, E. Bryn Pitt, Jason A. Shrand, Shaan A. Setia, Naren Nimmagadda, Eric J. Barth, Nicholas L. Kavoussi, Robert L. Galloway, S. Duke Herrell, Robert J. Webster

“…<italic>Methods:</italic> This framework (called the &#x201C;bystander protocol&#x201D;) involves two surgeons, one who solely performs the therapeutic process without image guidance, and another who solely periodically collects data to evaluate image guidance. …”
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Recent Advances in Our Understanding of Human Inflammatory Dendritic Cells in Human Immunodeficiency Virus Infection by Freja A. Warner van Dijk, Kirstie M. Bertram, Thomas R. O’Neil, Yuchen Li, Daniel J. Buffa, Andrew N. Harman, Anthony L. Cunningham, Najla Nasr

“…Gaining insight into how HIV interacts with specific inflammatory DC subsets could inform the development of new therapeutic strategies to block HIV transmission. However, little is known about the early stages of HIV capture and transmission in inflammatory environments. …”
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