Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury by Austen T. Lefebvre, Nicole E. Steiner, Carissa L. Rodriguez, Joseph P. Angelo, Eyal Bar-Kochba, Rohan Mathur, Marek Mirski, David W. Blodgett

“…In the metabolically active brain, early recognition of physiologic derangements is critical in enabling clinicians with the insight to adjust therapeutic interventions and reduce risk of ischemia and permanent injury. …”
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Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections by Xiaoyi Liu, Wenxiu Xu, Junkun Feng, Ying Wang, Kai Li, Yi Chen, Wenjun Wang, Weiwei Zhao, Shaohua Ge, Jianhua Li

“…Catalytic antibacterial nanoparticles that generate reactive oxygen species (ROS) are emerging, as a promising therapeutic approach in treating bacterial infection by boosting the innate immune defenses. …”
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Recent advances in pancreatic α-cell transdifferentiation for diabetes therapy by Yanjiao Li, Yanjiao Li, Jinyu Zhu, Congyang Yue, Siyuan Song, Limin Tian, Yi Wang, Yi Wang, Yi Wang

“…Recent research has focused on replenishing pancreatic β-cells through the transdifferentiation of α-cells, offering a promising therapeutic avenue. This review explores the molecular mechanisms underlying α-cell to β-cell transdifferentiation, emphasizing key transcription factors such as Dnmt1, Arx, Pdx1, MafA, and Nkx6.1. …”
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Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases? by Stefania Gonfloni, Emiliano Maiani, Claudia Di Bartolomeo, Marc Diederich, Gianni Cesareni

“…Finally, we propose that this may have an impact in the development of new therapeutic strategies.…”
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Seeking Out High Risk Population: The Prevalence Characteristics and Outcome of Diabetic Patients of Arab Ethnicity Hospitalized in Internal Medical and Acute Coronary Units in Isr... by William Nseir, Shehadeh Haj, Basma Beshara, Julnar Mograbi, Ohad Cohen

“…The average glycemia during hospitalization exceeded the recommended threshold of 180 mg% without major changes in the therapeutic regimens in comparison to preadmission regimens. …”
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Connection between oral health and chronic diseases by Di Fu, Xingyue Shu, Ge Zhou, Mengzhen Ji, Ga Liao, Ling Zou

“…Nevertheless, limited resources and lack of awareness often impede timely dental intervention, delaying optimal therapeutic measures. This review provides a comprehensive analysis of the impact of prevalent chronic diseases—such as diabetes mellitus, rheumatoid arthritis, cardiovascular disorders, and chronic respiratory diseases—on oral health, along with an exploration of how changes in oral health affect these chronic conditions through both deterioration and intervention mechanisms. …”
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The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis by Ruyi Zhang, Ruyi Zhang, Ning Ding, Xicui Feng, Wenli Liao

“…This article aims to clarify the complex interactions among gut microbiota, immune regulation, and cognitive disorders, evaluating their potential as therapeutic targets. The goal is to promote microbiome-based treatments and lay the groundwork for future research in this field.…”
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PLIN1 suppresses glioma progression through regulating lipid metabolism by Kui Luo, Kai Zhuang, Hao Wu, Yuanbing Chen, Yi Liu, Fan Yang, Zhifei Wang

“…Developing diagnostic and prognostic markers to identify and treat glioma early would significantly improve the therapeutic outcomes. Here, we conducted RNA next-generation sequencing with 33 glioma samples and 15 normal brain samples. …”
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α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation by Haowei Wang, Huijie Zhang, Lin Miao, Chan Wang, Hanxin Teng, Xiaodong Li, Xiaoxing Zhang, Genmeng Yang, Shangwen Wang, Xiaofeng Zeng

“…The study highlights the interplay between α-amanitin, NLRP3, and PPAR-γ in hepatotoxicity, proposing potential therapeutic targets for mushroom poisoning-induced liver diseases.…”
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β-Glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects by Wen Guo, Xinyue Zhang, Long Wan, Zhiqi Wang, Meiqi Han, Ziwei Yan, Jia Li, Ruizhu Deng, Shenglong Li, Yuling Mao, Siling Wang

“…The results also indicate that β-glucan-modified MSN, with a particle size of ∼100 nm, has a great potential as a vaccine delivery vehicle and immune adjuvant and offers a novel approach for the delivery of multiple therapeutic agents that target other lymph-mediated diseases.…”
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Click reaction-induced in situ nanoparticle aggregation for cancer imaging and treatment by Yun Yin, Xiaoyang Liu, Xuemei Li, Gaolin Liang

“…Herein, we introduce and classify in situ nanoparticle aggregation for biomedical imaging and therapeutic applications induced by four types of common click reactions: copper-catalyzed azide–alkyne cycloaddition (CuAAC), strain-promoted azide–alkyne cycloaddition (SPAAC), click condensation between 2-cyanobenzothiazole (CBT) and cysteine (Cys), and inverse electron-demand Diels–Alder (iEDDA). …”
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Polysaccharide-rich extract of Potentilla anserina ameliorates nonalcoholic fatty liver disease in free fatty acid-induced HepG2 cells and high-fat/sugar diet-fed mice by Xiujun Lin, Yimei Zheng, Yingying Yan, Hongting Deng, Shunxin Wang, Yuanju He, Yuting Tian, Wenhui Zhang, Hui Teng

“…The present results indicated the PAP could alleviate the damage of liver associated with obesity and PAP treatment might provide a dietary therapeutic option for the treatment of hyperlipidemia.…”
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Differences between SSRI and SNRI in depression treatment by Mateusz Grego, Katarzyna Grego, Łukasz Stojak, Dariusz Popiela, Karina Urbańska, Filip Kwiatkowski, Mateusz Baczewski, Witold Czyż

“…With the development of pharmacotherapy, selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have become preferred therapeutic options. SSRIs are the most commonly used first-line medications, but there are controversies regarding their efficacy compared to SNRIs.   …”
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A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease by Patricia Gómez-Suaga, Elena Fdez, Marian Blanca Ramírez, Sabine Hilfiker

“…Here, we will discuss current knowledge about mechanism(s) by which mutant LRRK2 may regulate autophagy, which highlights additional putative therapeutic targets.…”
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Influence of physicochemical factors on the interaction of metallic nanoparticles with immune system cells by Sinai G. Gutiérrez-Cruz, Alejandro Muñoz-Diosdado, Ramón A. Gutiérrez-Calleja, Octavio Rodríguez-Cortés, Ana E. Ortiz-Reyez, Raúl Flores-Mejía

“…Understanding and controlling physicochemical factors is essential for developing therapeutic applications based on MNPs and minimizing potential adverse effects on the immune system. …”
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Plant Resin Delivery by Nanovectors as an Emerging Approach to Boost Solubility, Permeability and Bioavailability by Eleonora Truzzi, Giulia Vanti, Lucia Grifoni, Eleonora Maretti, Eliana Leo, Anna Rita Bilia

“…Current research has evidenced their therapeutic value with a plethora of activities. The main limits of resins and their constituents for their clinical use are low water solubility, poor stability and bioavailability. …”
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Combination of High-Dose Intravenous Immunoglobulins and Itraconozole in Treating Chronic Mycotic Demyelinating Optic Neuritis by Andrew W. Campbell, Ebere C. Anyanwu, Aristo Vojdani

“…In spite of all the therapeutic services given to her for over 8 years, her illness persisted and was difficult to treat. …”
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Limosilactobacillus reuteri fermented brown rice alleviates anxiety improves cognition and modulates gut microbiota in stressed mice by Akanksha Tyagi, Yu-Yeong Choi, Lingyue Shan, Annadurai Vinothkanna, Eun-Seok Lee, Ramachandran Chelliah, Kaliyan Barathikannan, Sivakumar Thasma Raman, Se Jin Park, Ai-Qun Jia, Geun Pyo Choi, Deog Hwan Oh

“…These findings highlight FBR’s potential as a gut-brain axis-targeted therapeutic for anxiety and stress-related disorders.…”
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The Rise of Pluripotent Stem Cell-Derived Glia Models of Neuroinflammation by Srishti Kala, Andrew G. Strutz, Moriah E. Katt

“…Understanding and modeling neuroinflammation is critical for the identification of novel therapeutic targets in the treatment of CNS diseases. …”
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Mismatch prime editing gRNA increased efficiency and reduced indels by Jidong Fei, Dongdong Zhao, Caiyi Pang, Ju Li, Siwei Li, Wentao Qiao, Juan Tan, Changhao Bi, Xueli Zhang

“…The continuous presence of the prime editing system also leads to unintended indel formation, raising safety concerns for therapeutic applications. To address these challenges, we develop a mismatched pegRNA (mpegRNA) strategy that introduces mismatched bases into the pegRNA protospacer, reducing complementarity and secondary structure formation, and preventing sustained activity. …”
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