Mesenchymal stem cells transplantation in the treatment of tendon disorders by Adrian Różycki, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej, Alicja Kot, Marta Wojtczak, Natalia Myśliwiec

“… Introduction and purpose: Tendon disorders are conditions that lead to pain, reduced mobility, and are often associated with recurrences and complications. A novel therapeutic approach for these conditions is the transplantation of mesenchymal stem cells (MSCs) into the affected area. …”
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Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy by I Nyoman Bayu Mahendra, I Gde Sastra Winata, William Alexander Setiawan, Ida Bagus Agung Widnyana Putra, Putu Bagus Darmayasa

“…Clinical evidence highlights substantial variability in the sensitivity of chemotherapy regimens among cervical cancer patients, often resulting in suboptimal therapeutic outcomes and increased risk of complications. …”
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The Effects of Forodesine in Murine and Human Multiple Myeloma Cells by Liesbeth Bieghs, Jo Caers, Elke De Bruyne, Els Van Valckenborgh, Fiona Higginbotham, Karin Vanderkerken, Eline Menu

“…Despite recent advances in treatment strategies, MM remains incurable and new therapeutical targets are needed. Recently forodesine, a purine nucleoside phosphorylase inhibitor, was found to induce apoptosis in leukemic cells of chronic lymphocytic leukemia patients by increasing the dGTP levels. …”
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Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications by Md. Mahamudul Hasan Rumon, Md. Sohanur Rahman, Anwarul Azim Akib, Md. Shafiuzzaman Sohag, Md. Rakibul Alam Rakib, Md. Abu Rayhan Khan, Farzana Yesmin, Md Salman Shakil, Mohammad Mizanur Rahman Khan

“…Recent research has been focused on developing biocompatible hydrogel materials for therapeutic applications. Recent advancements have spurred researchers to develop biocompatible hydrogels having acceptable mechanical toughness. …”
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Hemoadsorption in Multiorgan Failure Due to Viscerocutaneous Loxoscelism by Raúl Valenzuela Córdova, David Rivera Estrella, José F. Bernardo, Darío Jiménez, Celia Rodríguez Tudero, Raúl Elías, José C. De La Flor

“…<i>Conclusions</i>: This case presents hemoadsorption as a therapeutic option, based on its capacity to reduce the intensity of hyperinflammation and to regulate the immunological response.…”
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DLK-dependent axonal mitochondrial fission drives degeneration after axotomy by Jorge Gómez-Deza, Matthew Nebiyou, Mor R. Alkaslasi, Francisco M. Nadal-Nicolás, Preethi Somasundaram, Anastasia L. Slavutsky, Wei Li, Michael E. Ward, Trent A. Watkins, Claire E. Le Pichon

“…Our results provide a platform for studying degeneration of human neurons, pinpoint key early events in damage related neural death and provide potential focus for therapeutic intervention.…”
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Flow rate modulates focused ultrasound-mediated vascular delivery of microRNA by Stephanie He, Davindra Singh, Brandon Helfield

“…Gene therapy targeting ischemic heart disease is a promising therapeutic avenue, but it is mostly restricted to viral-based delivery approaches which are limited due to off-target immunological responses. …”
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Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo by Jiwoong Kim, Joo Young Kweon, Seongwook Choi, Hyunseo Jeon, Minsik Sung, Rongkang Gao, Chengbo Liu, Chulhong Kim, Yong Joo Ahn

“…They highlight the usefulness of whole‐brain PACT as a potentially powerful tool for early diagnosis and therapeutic decision‐making in treating ischemic stroke.…”
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Thermosensitive Porcine Myocardial Extracellular Matrix Hydrogel Coupled with Proanthocyanidins for Cardiac Tissue Engineering by José Luis Hidalgo-Vicelis, Angélica Raquel Rivera-Contreras, Beatriz Hernández-Téllez, Gabriela Piñón-Zárate, Katia Jarquín-Yáñez, Tatiana Fiordelisio-Coll, José Manuel Saniger-Blesa, Gertrudis Hortensia González-Gómez, María Alicia Falcón-Neri, María Margarita Canales-Martínez, Andrés Eliú Castell-Rodríguez

“…Reactive oxygen species generated by ischemia-reperfusion damage can limit the therapeutic efficacy of injectable hydrogels. In order to overcome this limitation, grape seed proanthocyanidins were incorporated as antioxidant compounds into a thermosensitive myocardial extracellular matrix hydrogel in this study. …”
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Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes by Zongheng Wang, Zhipeng Hou, Shuguang Zhang, Shuangyi Ren, Liqun Yang, Qianshi Zhang

“…To address these limitations, the development of novel drug delivery systems for sustained drug release is essential to improve therapeutic outcomes.MethodsThis study aimed to develop a poly(trimethylene carbonate) (PTMC) membrane capable of sustained drug release of 5-FU to enhance its antitumor activity. …”
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Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies by Lorenzo Drago, Lorenzo Drago, Luigi Regenburgh De La Motte, Loredana Deflorio, Delia Francesca Sansico, Michela Salvatici, Emanuele Micaglio, Manuele Biazzo, Fabiana Giarritiello, Fabiana Giarritiello

“…This systematic review provides an overview of miRNAs, their regulatory effects on bacterial strains, and their associations with specific diseases. It also explores therapeutic advances and the potential of miRNA-based therapies to restore microbial balance and reduce inflammation.…”
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A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser by Shengsheng Cui, Xinni Pan, Shanshan Fan, Cheng Cao, Yingao Jiao, Yanfei Fu, Jiaqi Niu, Shujin Lin, Jingmao Lao, Yanlei Liu

“…This work comprehensively investigates the photothermal properties of PPAPA and evaluates its efficacy in tumor PTT, demonstrating its potential as a novel and effective therapeutic strategy for cancer treatment, offering new hope for patients.…”
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An in-depth study of indolone derivatives as potential lung cancer treatment by Mohammed Er-rajy, Mohamed El fadili, Radwan Alnajjar, Sara Zarougui, Somdutt Mujwar, Khalil Azzaoui, Hatem A. Abuelizz, Belkheir Hammouti, Menana Elhallaoui

“…The ADMET analysis revealed that these compounds exhibited favourable drug-like properties, meeting nearly all the key pharmacological criteria required for potential therapeutic agents. Molecular docking studies of the most active compounds revealed strong interactions with critical amino acid residues in the PDK1 receptor’s binding site, underscoring their potential as effective PDK1 inhibitors. …”
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Triple Viral Infections in Advanced Breast Cancer: Insights from a Three-Case Report and Literature Review by Ashraf I. Khasawneh, Nisreen Himsawi, Mohammed Alorjani, Hadeel Al-Momani, Uruk Shahin, Ashraf Sammour, Tareq Saleh, Hafez Al-Momani, Rame Khasawneh, Sofian Al Shboul

“…<b>Conclusions:</b> The findings contribute to growing evidence that viral infections may influence the progression and therapeutic response of breast cancer, warranting further investigation into targeted preventive measures including vaccinations.…”
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Platelet Rich Plasma in the Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw: Personal Experience and Review of the Literature by F. Longo, A. Guida, C. Aversa, E. Pavone, G. Di Costanzo, L. Ramaglia, F. Ionna

“…In our study, we considered 72 patients with BRONJ with nonsurgical therapy, surgical therapy, and surgical therapy with platelet rich plasma (PRP) gel to evaluate its therapeutic effect in promoting ONJ wounds healing. …”
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AI-Based Advanced Approaches and Dry Eye Disease Detection Based on Multi-Source Evidence: Cases, Applications, Issues, and Future Directions by Mini Han Wang, Lumin Xing, Yi Pan, Feng Gu, Junbin Fang, Xiangrong Yu, Chi Pui Pang, Kelvin Kam-Lung Chong, Carol Yim-Lui Cheung, Xulin Liao, Xiaoxiao Fang, Jie Yang, Ruoyu Zhou, Xiaoshu Zhou, Fengling Wang, Wenjian Liu

“…This study explores the potential of Artificial Intelligence (AI) in early screening and prognosis of Dry Eye Disease (DED), aiming to enhance the accuracy of therapeutic approaches for eye-care practitioners. Despite the promising opportunities, challenges such as diverse diagnostic evidence, complex etiology, and interdisciplinary knowledge integration impede the interpretability, reliability, and applicability of AI-based DED detection methods. …”
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Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods by Jakub Dziewic, Maria Przygoda, Joanna Śnieżna, Gabriela Trestka, Kamila Stępień, Sabina Adamczyk, Urszula Zelik, Wojciech Florczak, Wiktoria Domino, Jagienka Włodyka, Karol Dzwonnik

“…Another discussion concerns macrophages, modulators of the inflammatory environment of the joint, and whether they could serve as potential therapeutic targets. The need for further investigation, in order to modify the existing methods and create other effective regenerative approaches in patients suffering from OA, is presented. …”
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Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma by Sonja Kabatnik, Xiang Zheng, Georgios Pappas, Sophia Steigerwald, Matthew P. Padula, Matthias Mann

“…Our results provide novel insights into the proteomic landscape of SRCC, identify potential targets, and open up for personalized therapeutic strategies in managing SRCC.…”
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Effectiveness of Schema Therapy on the Interpersonal Relationships Dimensions in Clients with Substance Dependence by Atefeh Mehdifar, Fataneh Amirmahmoudi, Hamid Sabaghian Baghdadabad, Esmaeil Zaighaminejad, Marzieh Shahabizadeh

“…Conclusion: According to our research outcomes, the implementation of schema therapy holds significant importance in the enhancement of interpersonal relationships dimensions throughout the duration of the therapeutic process for individuals receiving treatment for substance abuse.…”
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MicroRNA in Cervical Cancer: OncomiRs and Tumor Suppressor miRs in Diagnosis and Treatment by Kouji Banno, Miho Iida, Megumi Yanokura, Iori Kisu, Takashi Iwata, Eiichiro Tominaga, Kyoko Tanaka, Daisuke Aoki

“…Supplementation of miR-143 or inhibition of miR-21 activity in vivo may be therapeutic strategy for cervical cancer. Previous approaches to development of siRNA as a drug have provided information for establishment of therapy based on these approaches, and an anti-miR-21 inhibitor has been developed. miRNAs also have effects on drug resistance and may be useful in combination therapy with other drugs.…”
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