Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry by Charlotte Förster, André Eichert, Dominik Oberthür, Christian Betzel, Reinhard Geßner, Andreas Nitsche, Jens P. Fürste

“…This renders LNAs powerful tools for diagnostic and therapeutic applications. RNA molecules maintain the overall canonical A-type conformation upon substitution of single or multiple residues/nucleotides by LNA monomers. …”
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Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 by Huanyu Z. Li, Ashley C. W. Pike, Yung-Ning Chang, Dheeraj Prakaash, Zuzana Gelova, Josefina Stanka, Christophe Moreau, Hannah C. Scott, Frank Wunder, Gernot Wolf, Andreea Scacioc, Gavin McKinley, Helena Batoulis, Shubhashish Mukhopadhyay, Andrea Garofoli, Adán Pinto-Fernández, Benedikt M. Kessler, Nicola A. Burgess-Brown, Saša Štefanić, Tabea Wiedmer, Katharina L. Dürr, Vera Puetter, Alexander Ehrmann, Syma Khalid, Alvaro Ingles-Prieto, Giulio Superti-Furga, David B. Sauer

“…These results reveal the transporter’s binding mode to its native substrate S1P, the therapeutic FTY720-P, and the reported SPNS2-targeting inhibitor 33p. …”
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Therapy of Osteoporosis in Men with Teriparatide by Natalie E. Cusano, Aline G. Costa, Barbara C. Silva, John P. Bilezikian

“…Osteoanabolic therapy is an attractive therapeutic option for men with osteoporosis because it directly stimulates bone formation, an action not shared by any antiresorptive drug. …”
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Mayer-Rokitansky-Kuster-Hauser Syndrome Associated with Severe Inferior Vena Cava Stenosis by Laura Londra, Kyle Tobler, John Wu, Lisa Kolp

“…Despite DVT prophylaxis, extensive pelvic DVT of the femoral vein was diagnosed on postoperative day 7. Therapeutic anticoagulation was initiated, and pharmacological and mechanical thrombolysis were performed. …”
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Impact of the Implementation of a Postgraduate Mastology Course in the Province of Cienfuegos by Lidia Torres Ajá, Miriam Iglesias León, Carlos Zerquera Álvarez

“…<br /><strong>Results:</strong> A qualitative leap in the health status of breast cancer in the province of Cienfuegos and in the professional performance of specialists in general medicine as to the diagnosis and therapeutic management of breast diseases was evident. …”
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C-Reactive Protein and Breast Cancer: New Insights from Old Molecule by Shilpa Balaji Asegaonkar, Balaji Narayanrao Asegaonkar, Unmesh Vidyadhar Takalkar, Suresh Advani, Anand Pandurang Thorat

“…It also focuses on conflicting views on the role of CRP in breast cancer and its impact on therapeutic interventions.…”
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Internal Tremor in Long COVID May Be a Symptom of Dysautonomia and Small Fiber Neuropathy by Svetlana Blitshteyn, Ilene S. Ruhoy, Lauren R. Natbony, David S. Saperstein

“…Subjective description, objective findings, and diagnostic and therapeutic considerations in patients with IT and Long COVID are discussed.…”
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Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial Ischemia/Reperfusion Injury by Christine Herzog, Martina Schmitz, Bodo Levkau, Ilka Herrgott, Jan Mersmann, Jan Larmann, Kai Johanning, Michael Winterhalter, Jerold Chun, Frank Ulrich Müller, Frank Echtermeyer, Reinhard Hildebrand, Gregor Theilmeier

“…Infarct size was also reduced by postischemic, therapeutical administration of SPC. Immunohistochemistry revealed reduced polymorphonuclear neutrophil recruitment to the infarcted area after SPC treatment, and apoptosis was attenuated as measured by TUNEL. …”
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Human microbiomes in cancer development and therapy by Chenglai Xia, Jiyan Su, Can Liu, Zhikai Mai, Shuanghong Yin, Chuansheng Yang, Liwu Fu

“…We expect this review may open new perspectives on possible therapeutic approaches of patients with cancer.…”
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The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment by Ze-Tao Zhan, Lu Liu, Ming-Zhen Cheng, Yi Gao, Wei-Jie Zhou

“…In particular, acarbose significantly inhibited tumor growth and further enhanced the therapeutic effect of anti-PD1, which can be widely used in tumor therapy. …”
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Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review by Cintia Cristina Santi Martignago, Camila de Souza Barbosa, Homero Garcia Motta, Beatriz Soares-Silva, Erica Paloma Maso Lopes Peres, Lais Caroline Souza e Silva, Mirian Bonifácio, Karolyne dos Santos Jorge Sousa, Amanda Sardeli Alqualo, Júlia Parisi, Olivier Jordan, Ana Claudia Muniz Renno, Anna Caroline Campos Aguiar, Viorica Patrulea

“…These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. …”
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The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies by Dongqi Li, Xiangyu Chu, Weikang Liu, Yongsu Ma, Xiaodong Tian, Yinmo Yang

“…Further, while targeting RBPs offers a promising strategy for improving immunotherapy in GI cancers, the mechanisms by which RBPs regulate the TIME in these tumours remain poorly understood, and the therapeutic application is still in its early stages. …”
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The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis by Cheng Gong, Xian Qin, Jian Yang, Tao Guo

“…Consistency and inconsistency models were developed to identify differences among the therapeutic strategies. Cumulative probability was utilized to rank the strategies under examination. …”
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Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways by Yu Li, Li Jianying

“…Conclusively, the study’s observations suggest the potential therapeutic efficiency of punicalagin in allergic asthma.…”
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Single cell suppression profiling of human regulatory T cells by Jonas Nørskov Søndergaard, Janyerkye Tulyeu, David Priest, Shimon Sakaguchi, James B. Wing

“…Additionally, scSPOT identifies a Treg phenotypic split previously observed in viral infection and propose modes of action by the FDA-approved drugs Ipilimumab and Tazemetostat. scSPOT is thus scalable, robust, widely applicable, and may be used to better understand Treg immunobiology and screen for therapeutic compounds.…”
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A journey from darkness to dawn: Metaphoric variation in depression recovery stories posted on Chinese Wechat subscription accounts by Lin Lin, Rui Zhou, Jia-jia Wang

“…Despite volumes of research on depression-related conceptual metaphors and the therapeutic function of client-generated metaphors, seldom efforts have been made to unveil clients’ positive changes signified by metaphoric variation in the context of recovery. …”
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Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions by Pengjie Huang, Weichang Li, Jiezhong Guan, Yibing Jia, Dan Wang, Yurun Chen, Niu Xiao, Songyue Ou, Yan Wang, Bo Yang

“…As a result, there is a growing need for novel drug delivery systems that can enhance therapeutic efficacy, reduce side effects, and improve treatment outcomes. …”
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Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century by J.-F. Stoltz, N. de Isla, Y. P. Li, D. Bensoussan, L. Zhang, C. Huselstein, Y. Chen, V. Decot, J. Magdalou, N. Li, L. Reppel, Y. He

“…Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin, there has been an increasing interest in the study of undifferentiated progenitors that have the ability to proliferate and differentiate into various tissues. …”
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Positive feedback loop involving AMPK and CLYBL acetylation links metabolic rewiring and inflammatory responses by Wenke Wang, Boquan Wu, Mingjun Hao, Sichong Chen, Ruiting Cong, Wenjie Wu, Pengbo Wang, Qiaoyi Zhang, Pengyu Jia, Yuequn Song, Bo Liu, Siyao Qu, Jian-Fei Pei, Da Li, Naijin Zhang

“…These findings suggest that the AMPK-CLYBL acetylation positive feedback loop serves as a metabolic switch driving inflammatory response and inhibiting CLYBL-K154 acetylation may offer a promising therapeutic strategy for inflammatory response-related disorders.…”
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(+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats by William J. Banz, April D. Strader, Kolapo M. Ajuwon, Yuqing Hou, Cal Y. Meyers, Jeremy E. Davis

“…Further investigation is required to fully elucidate the mechanisms involved as well as to determine the potential therapeutic implications for (+)-Z-BDDA on obesity and its related pathologies.…”
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