Protozoocidal activity of Stemona collinsiae against Giardia duodenalis by Khuanchai Koompapong, Supaluk Popruk, Onrapak Reamtong, Tipparat Thiangtrongjit, Sumate Ampawong, Aurapa Sakulpanich, Ruenruetai Udonsom, Kanthinich Thima, Preeyaporn M. Sreepian, Kittiyod Poovorawan, Hirotake Mori, Christen Rune Stensvold, Aongart Mahittikorn

“…The ongoing issues with drug resistance and the side effects of current anti-Giardia treatments highlight the urgent need for new therapeutic options. This study focused on investigating the in vitro efficacy of crude extracts of Stemona collinsiae from Thailand against G. duodenalis. …”
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Medicarpin suppresses lung cancer cell growth in vitro and in vivo by inducing cell apoptosis by Shen Zongyi, Yin Liqi, Chang Manxia, Wang Haifeng, Hao Mingxuan, Liang Youfeng, Guo Rui, Bi Ying, Wang Jiansong, Yu Changyuan, Li Jinmei, Zhai Qiongli, Cheng Runfen, Zhang Jinku, Sun Jirui, Yang Zhao

“…Overall, MED inhibited LC cell growth in vitro and in vivo via suppressing cell proliferation and inducing cell apoptosis, suggesting the therapeutic potential of MED in treating LC.…”
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Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis by Yao Wang, Lin Sun, Zhenglin Dong, Tianyu Zhang, Leining Wang, Yihui Cao, Hui Xu, Chenglei Liu, Bo Chen

“…In summary, this study highlights the combination of genetic engineering and hydrophobic diacylglycerol insertion as a novel targeted therapeutic approach for SROP.…”
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Cycloastragenol promotes dorsal column axon regeneration in mice by Tao Zihan, Tao Zihan, Teng Wenwen, Teng Wenwen, Ma Yanxia, Saijilafu

“…Our results further indicate that CAG administration can promote the recovery of sensory and urinary function in SCI mice.ConclusionTogether, our findings highlight the therapeutic potential of CAG in spinal cord injury repair.…”
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Targeting ferroptosis: a promising approach for treating lung carcinoma by Ziyang Wu, Yan Zhang, Wendi Zhong, Kunjian Wu, Tian Zhong, Tao Jiang

“…The efficacy of targeted therapies and immunotherapies is commonly compromised by the emergence of drug resistance and other factors, resulting in a lack of durable therapeutic benefits. Ferroptosis, a distinct pattern of cell death marked by the buildup of iron-dependent lipid peroxides, has been shown to be a novel and potentially more effective treatment for lung carcinoma. …”
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Isolation and characterization of novel peptides from fermented products of Lactobacillus for ulcerative colitis prevention and treatment by Dong He, Wen Zeng, Yi Wang, Yifan Xing, Kang Xiong, Nan Su, Chong Zhang, Yuan Lu, Xinhui Xing

“…Compared to the current therapeutic drugs, bioactive peptides are more promising and safe substances as functional foods or drugs for the prevention and treatment of UC. …”
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Inhibition of lanosterol synthase linking with MAPK/JNK signaling pathway suppresses endometrial cancer by Liangjian Ma, Wunan Huang, Xiaolei Liang, Hongli Li, Wei Yu, Lexin Liu, Yuelin Guan, Chang Liu, Xiangjun Chen, Lidan Hu

“…These findings establish LSS as a novel oncogene in EC, promoting tumor progression through MAPK/JNK signaling activation and cholesterol ester accumulation, and highlight the therapeutic potential of targeting LSS in EC treatment.…”
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Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage by Weibin Du, Wenxiang Zeng, Zhenwei Wang, Huahui Hu, Hongfeng Ruan, Gang Qu

“…These insights are expected to advance the development of preventive and therapeutic strategies aimed at mitigating the adverse effects of CPF exposure on the skin.…”
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Outcomes of dietary interventions in the prevention and progression of Parkinson's disease: A literature review by Ubaid Ansari, Alexi Omid, Dawnica Nadora, Jimmy Wen, Arman Omid, Forshing Lui

“…Given the increasing prevalence of PD, particularly in aging populations, effective preventive and therapeutic strategies are urgently needed. Emerging research suggests that dietary interventions might offer promising approaches to managing PD progression. …”
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Protein Disulfide Isomerase and Host-Pathogen Interaction by Beatriz S. Stolf, Ioannis Smyrnias, Lucia R. Lopes, Alcione Vendramin, Hiro Goto, Francisco R. M. Laurindo, Ajay M. Shah, Celio X. C. Santos

“…A better understanding of these complex regulatory steps will provide insightful information on the redox role and coevolutional biological process, and assist the development of more specific therapeutic strategies in pathogen-mediated infections.…”
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COph100: A comprehensive fundus image registration dataset from infants constituting the “RIDIRP” database by Yan Hu, Mingdao Gong, Zhongxi Qiu, Jiabao Liu, Hongli Shen, Mingzhen Yuan, Xiaoqing Zhang, Heng Li, Hai Lu, Jiang Liu

“…Abstract Retinal image registration is vital for diagnostic therapeutic applications within the field of ophthalmology. …”
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Comparison of Psychotherapeutic Supervision Paradigms: A Literature Review by Greta Kaluževičiūtė-Moreton, Paulius Skruibis, Marija Vaštakė, Neringa Grigutytė

“…Considering the theoretical underpinnings of each tradition, the paper discusses epistemological assumptions that could determine the effectiveness of supervision in the context of each therapeutic paradigm. …”
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Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function by Atenea A. Perez-Serna, Daniel Guzman-Llorens, Reinaldo S. Dos Santos, Laura Marroqui

“…Thus, understanding the biological processes in which these proteins are involved may be crucial to designing new therapeutic targets. This review summarizes the roles of Bcl-2 and Bcl-xL in apoptosis and metabolic homeostasis. …”
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Potentiometric Multisensory Systems with Novel Ion-Exchange Polymer-Based Sensors for Analysis of Drugs by Olga V. Bobreshova, Anna V. Parshina, Ksenia A. Polumestnaya

“…The developed multisensory systems were used to determine the composition of a therapeutic “Mineral salt with low content of sodium chloride” and to determine concentrations of novocaine in sewage samples from a dental clinic.…”
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Effect of Geometry on the Dissolution Behaviour of Complex Additively Manufactured Tablets by Seyedebrahim Afkhami, Meisam Abdi, Reza Baserinia

“…By leveraging the geometric design freedom provided by AM technologies, this research underscores the potential for optimising drug delivery systems to improve therapeutic outcomes and patient compliance.…”
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Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons by Eun-Hae Jang, Aeri Sim, Sun-Kyoung Im, Eun-Mi Hur

“…Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. …”
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Context-Aware Dual-Task Deep Network for Concurrent Bone Segmentation and Clinical Assessment to Enhance Shoulder Arthroplasty Preoperative planning by Luca Marsilio, Andrea Moglia, Alfonso Manzotti, Pietro Cerveri

“…<italic>Conclusions:</italic> this framework delivers accurate 3D bone surface reconstructions and dependable clinical assessments of the GH joint, offering robust support for therapeutic decision-making in shoulder arthroplasty.…”
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Metabolic reprogramming of glucose: the metabolic basis for the occurrence and development of hepatocellular carcinoma by Kai Wang, Xiaodan Li, Shuwei Guo, Junsheng Chen, Yandong Lv, Zhiqiang Guo, Hongzhou Liu

“…It is characterized by high malignancy, insidious onset, and a lack of specific early diagnostic and therapeutic markers, posing a serious threat to human health. …”
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GPX modulation promotes regenerative axonal fusion and functional recovery after injury through PSR-1 condensation by Su-Hyuk Ko, Kyung-Ah Cho, Xin Li, Qitao Ran, Zhijie Liu, Lizhen Chen

“…Our study reveals an evolutionarily conserved function of lipid peroxidation in promoting axonal fusion, providing insights for developing therapeutic strategies for nerve injury.…”
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CLINICAL AND RADIOLOGICAL PARAMETERS IN MALIGNANT SPINAL TUMORS: A DESCRIPTIVE ANALYSIS by Marcelo Diniz de Menezes, Mariana Demétrio de Sousa Pontes, Carlos Fernando Pereira da Silva Herrero

“…Methods: This is a therapeutic study of the descriptive retrospective type. …”
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