Open Trial of Cyclosporine in Patients with Severe Active Crohn's Disease Refractory to Conventional Therapy by Kevork M. Peltekian, C. Noel Williams, Allan S. MacDonald, Peter D. Roy, Elizabeth Czolpinska

“…T he remaining 10 patients all improved within four weeks as measured by three different clinical indices: Crohn's Disease Activity Index, Simple Index of Crohn's Disease Activity and Mean Score of Therapeutic Goals (MSTG). Seven patients maintained this initial improvement and prednisone was either reduced or discontinued. …”
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AXL: shapers of tumor progression and immunosuppressive microenvironments by Yihui Liu, Lei Xu, Yuanyao Dou, Yong He

“…The TME evolves with the developmental stages of cancer and the implementation of therapeutic interventions, transitioning from an immune-promoting to an immunosuppressive microenvironment. …”
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Deciphering consciousness: The role of corticothalamocortical interactions in general anesthesia by Yuxi Zhou, Shiqian Huang, Tianhao Zhang, Daling Deng, Li Huang, Xiangdong Chen

“…These findings highlight the intricate interplay between the cortical and subcortical networks in maintaining and restoring consciousness under anesthesia, offering potential therapeutic targets for enhancing anesthesia management.…”
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Current Trends in Targeted Therapies for Glioblastoma Multiforme by Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

“…In this paper, we review up-to-date clinical trials of GBM treatments in order to overcome these 4 hurdles and to aim at more therapeutical effect than conventional therapies that are ongoing or are about to launch in clinical settings and discuss future perspectives.…”
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A Knotless Technique for Kidney Transplantation in the Mouse by Song Rong, Alfor G. Lewis, Uta Kunter, Hermann Haller, Faikah Gueler

“…Mouse models of kidney transplantation are important to study molecular mechanisms of organ transplant rejection as well as to develop new therapeutic strategies aimed at improving allograft survival. …”
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Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models by Alejandra de Moreno de LeBlanc, Silvina del Carmen, Jean-Marc Chatel, Anderson Miyoshi, Vasco Azevedo, Philippe Langella, Luis G. Bermúdez-Humarán, Jean Guy LeBlanc

“…These microorganisms could be used in the near future for the development of therapeutic products with anti-inflammatory properties that can improve the quality of life of IBD patients.…”
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An emotion regulation skills training for adolescents and parents: perceptions and acceptability of methodological aspects by Kristina Holmqvist Larsson, Kristina Holmqvist Larsson, Maria Zetterqvist, Maria Zetterqvist

“…Adolescents particularly requested variety in the pedagogy and found long sessions to be challenging.DiscussionRecommendations for therapeutic practices are discussed.…”
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Endoscopic Resection of Sinonasal Hemangiopericytoma following Preoperative Embolisation: A Case Report and Literature Review by Georg J. Ledderose, Donata Gellrich, Markus Holtmannspötter, Andreas Leunig

“…Further, to support the new treatment option, we review the literature concerning all features of sinonasal hemangiopericytomas and their therapeutical management. Results/Conclusion. Onyx, which has not been described in the context of hemangiopericytoma yet, is a very effective embolic agent for a preoperative embolisation of sinonasal hemangiopericytoma allowing a safe endoscopic surgery.…”
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Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis by Qiang Ma, Jin-Lan Tian, Yao Lou, Ran Guo, Xiao-Ru Ma, Jian-Bin Wu, Jing Yang, Bing-Jie Tang, Shun Li, Mengsheng Qiu, Shumin Duan, Jing-Wei Zhao, Jing Zhang, Zhen-Zhong Xu

“…Thus, our results reveal that dopaminergic neurons interact with oligodendrocytes via secreted PSAP, and our findings identify the PSAP-GPR37-IL-6 axis as a driver of PD pathogenesis and a potential therapeutic target that might alleviate PD progression in patients.…”
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Taichi on the brain: an activation likelihood estimated meta-analysis of functional neuroimaging data by Shengxin Wang, Tianyu Liu, Jingtao Du, Jun Chen, Xiufen Luo, Yujie Meng, Chun Zeng, Xupeng Zhang, Binghua Shao

“…The present research endeavor aims to elucidate the neurocognitive impacts of TCC compared to alternative exercise modalities or therapeutic interventions.MethodsA systematic meta-analysis was undertaken, encompassing a rigorous review of diverse datasets, wherein 422 scholarly articles were examined, with a subset of 18 articles meeting the stringent criteria for inclusion in the analytical framework.ResultsThe study cohort comprised 677 participants, characterized by a mean age of 56.52 ± 14.89 years and an average educational attainment of 11.06 ± 3.32 years. …”
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Preclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson’s disease by Luisa Di Menna, Marika Alborghetti, Maria Ilenia De Bartolo, Marina Borro, Giovanna Gentile, Manuela Zinni, Matteo Bologna, Carolina Cutrona, Giovanna D’Errico, Tiziana Imbriglio, Domenico Bucci, Sara Merlo, Roxana Paula Ginerete, Rosamaria Orlando, Federica Carrillo, Giorgio Fortunato, Milena Cannella, Maria Angela Sortino, Julien Pansiot, Olivier Baud, Ferdinando Nicoletti, Valeria Bruno, Maurizio Simmaco, Francesco Ernesto Pontieri, Edoardo Bianchini, Domiziana Rinaldi, Amalia de Curtis, Giovanni De Gaetano, Licia Iacoviello, Teresa Esposito, Alfredo Berardelli, Giuseppe Battaglia

“…Abstract Metabotropic glutamate (mGlu) receptors are candidate drug targets for therapeutic intervention in Parkinson’s disease (PD). …”
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Investigating the Structural Model of Predicting Sleep Disorders Through Symptoms of Rumination with the Mediating Role of Social Support in Dialysis Patients by Farhad Ghorbani, Amin Rafiepoor, Niloufar Tahmouresi, Reza, Hosseinpour

“…Therefore, it is essential to focus on identifying and addressing the effective and causal factors when developing therapeutic interventions for these sleep disorders.…”
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Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis by Peter Lialios, Peter Lialios, Stella Alimperti, Stella Alimperti

“…Finally, potential therapeutic interventions that may harness E-cadherin to mitigate barrier-associated tissue damage are explored. …”
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Occurring of In Vitro Functional Vasculogenic Pericytes from Human Circulating Early Endothelial Precursor Cell Culture by Silvia Cantoni, Francesca Bianchi, Margherita Galletti, Elena Olivi, Francesco Alviano, Nazzareno Galiè, Carlo Ventura

“…Our findings could be helpful to develop innovative cell-based therapies for future clinical applications with distinct therapeutic purposes.…”
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Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes by Jianqing Fang, Zhe Wang, Yu Shen, Xuenong Wu, Hao Fang, Xiaokui Sun, Ting Yu, Qingqing Zhang

“…We discuss experience with them and the shortcomings in their treatment by summarizing their medical history, disease evolution, tests, and diagnostic and therapeutic processes.ResultsIn both patients, the diagnosis of Legionnaires’ disease was confirmed through analysis of the bronchoalveolar lavage fluid (BALF). …”
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Comparing the Effectiveness of Acceptance and Commitment Therapy and Schema Therapy in Spirituality and Conflict Resolution Styles of Working Women by Mahboubeh Amouei, Mohammad Ghamari, Mehdi Zare Bahramabadi

“…Objective: The aim of this study is to examine the efficacy of two therapeutic approaches, acceptance and commitment therapy (ACT) and schema therapy in addressing promoting spiritualism and conflict resolution styles among employed women. …”
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Contribution of long-lived plasma cells to antibody-mediated allograft rejection by Eunkyeong Jang, Jeehee Youn

“…This review offers insights into the biology of LLPCs and discusses ongoing therapeutic trials that target LLPCs in the context of antibody-mediated allograft rejection.…”
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Diagnosing and Managing LADA: A Review of the Overlooked Diabetes Subtype by Maciej Wojszczyk, Julia Kulbacka, Karol Dziedzic, Filip Arczewski, Michalina Wójcikiewicz, Marta Chuncia-Ileczko, Julia Kacperczyk, Witold Czyż, Piotr Pasek, Julia Ryniecka

“…The review also discusses the significance of early insulin therapy aimed at beta-cell preservation and the role of alternative treatments, such as DPP-4 inhibitors, which may influence disease progression. Diagnostic and therapeutic challenges stemming from the phenotypic similarities between LADA and type 2 diabetes are highlighted, along with potential benefits of early detection. …”
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Emerging Norovirus GII.12 infection in 2010 in Northern Taiwan by Chi-Neu Tsai, Yu-Chung Chang, Hsun-Ching Chao, Yi-Hsiang Hsu, Yuan-Hung Wang, Shih-Yen Chen

“…Continued research is essential to unravel the intricate relationship between NoV genotypes and clinical outcomes, guiding public health interventions and therapeutic strategies.…”
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Case Report: Severe acute pancreatitis accompanied by gastric mucosal exfoliation hemorrhage: clinical alerts and novel insights by Yanquan Liu, Hehui Zhang, Minjuan Zeng, Jian Luo, Yun Lai, He Huang, Qinglin Xu, Yuan Liu

“…This study delves into a retrospective analysis of a singular, yet remarkable clinical case, where SAP's therapeutic odyssey unexpectedly led to gastric mucosa stripping and catastrophic gastrointestinal bleeding. …”
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