Exosome-Derived microRNA: Potential Target for Diagnosis and Treatment of Sepsis by Yujie Xiao, Yixuan Yuan, Dahai Hu, Hongtao Wang

“…Furthermore, this review evaluates exosome-based therapeutic miRNA delivery systems in sepsis, which may pave the way for targeted modulation of the septic response and personalized treatment options.…”
Get full text

Clinical Experience with 5-Aminosalicylate Preparations in Inflammatory Bowel Disease - A Review by C.N. Williams

“…There are no controlled dose-response studies of 5-ASA in patients with Crohn's disease. Thus, the most "therapeutic" dose is not known. The author's anecdotal evidence reports char patients with Crohn's disease affecting the rectum or left colon respond poorly to 5-ASA enemas. …”
Get full text

The Protective Potential Role of ACE2 against COVID-19 by Fereshteh Golab, Gelareh Vahabzadeh, Leila SadeghRoudbari, Arefeh Shirazi, Robabeh Shabani, Sara Tanbakooei, Lida Kooshesh

“…Due to the coronavirus disease 2019 (COVID-19), researchers all over the world have tried to find an appropriate therapeutic approach for the disease. The angiotensin-converting enzyme 2 (ACE2) has been shown as a necessary receptor to cell fusion, which is involved in infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …”
Get full text

Torsion-Induced Traumatic Optic Neuropathy (TITON): A physiologically relevant animal model of traumatic optic neuropathy. by Annie K Ryan, Brooke I Asemota, Tyler Heisler-Taylor, Claire Mello, Luis Rodriguez, William E Sponsel, Julie Racine, Tonia S Rex, Randolph D Glickman, Matthew A Reilly

“…TON is characterized by axon damage in the optic nerve followed by retinal ganglion cell death in the days and weeks following injury. At present, no therapeutic or surgical approach has been found to offer any benefit beyond observation alone. …”
Get full text

FBXW7 metabolic reprogramming inhibits the development of colon cancer by down-regulating the activity of arginine/mToR pathways. by Qing Li, Yan Li, Tong Zhou, Yong Zhang, Huiyu Li, Fajia Yuan, Yanghui Bi

“…The research findings provide a theoretical foundation for the prognostic prediction and therapeutic planning of CRC based on metabolic reprogramming.…”
Get full text

Mistakes in the diagnosis and treatment of atopic dermatitis by Monika Marko, Rafał Pawliczak

“…We emphasized that current diagnostic and therapeutic guidelines are recommended. Therefore, based on European Guideline EuroGuiDerm, we indicate what is inappropriate in treating AD and highlight the most important aspects of this disease management that practitioners should remember. …”
Get full text

Integrating psychological and mental health perspectives in disease management: improving patient well-being by Francesca Grosso

“…Communication gaps between health professionals and patients, influenced by beliefs and expectations, risk giving rise to two errors that can compromise the therapeutic alliance: the concept of self-fulfilling prophecy and the nocebo effect. …”
Get full text

Monte Carlo Simulations in Nanomedicine: Advancing Cancer Imaging and Therapy by James C. L. Chow

“…This review explores the critical role of MC simulations in modeling complex biological interactions, optimizing NP designs, and enhancing the precision of therapeutic and diagnostic strategies. Key findings highlight the ability of MC simulations to predict NP bio-distribution, radiation dosimetry, and treatment efficacy, providing a robust framework for addressing the stochastic nature of biological systems. …”
Get full text

Radical-Scavenging Effect, Ferric Reducing Ability and Phytochemical Analysis of Urtica urens (L.) and Mercurialis annua (L.) by Doukkali Zouhra, Meryem El Jemli, Abdelhakim Bouyahya, Khang Wen Goh, Ganesh Sritheran Paneerselvam, Belatar Bahia, Yahia Cherrah, Katim Alaoui

“…In addition, all active extracts were subjected to phytochemical screening to determine the key groups of chemicals implicated in their therapeutic activity. Total phenolic and flavonoid concentrations were also measured to see how they affected the antioxidant properties of the plant extracts. …”
Get full text

Role of Macrophages in the Pathogenesis of Atopic Dermatitis by Sadaf Kasraie, Thomas Werfel

“…Further studies should be performed to clarify the dysregulated mechanism of macrophages activation in AD, and this would allow us to target these cells with versatile functions for therapeutic purpose and improve and control the disease. …”
Get full text

Calcium Mass Balances in Bicarbonate Hemodialysis by Carlo Basile

“…Dialysate calcium (Ca) concentration should be viewed as part of the integrated therapeutic regimen to control renal osteodystrophy and maintain normal mineral metabolism. …”
Get full text

Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature within the Process of Vascular Remodeling: Cellular Basis, Clinical Relevance, and Implications for Stem Cell Th... by Diana Klein

“…Further, a particular advantage for the therapeutic application of VW-MPSCs for improving vascular function or preventing vascular damage will be discussed.…”
Get full text

Uncommon BRAF Mutations Associated with Durable Response to Immunotherapy in Patients with Metastatic Melanoma by Brenen P. Swofford, Jade Homsi

“…Further research and clinical trials are needed to study patients with uncommon BRAF mutations and the potential therapeutic benefit of immunotherapy.…”
Get full text

The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics by Preethi Krishnan, Sambasivarao Damaraju

“…They have also demonstrated clinical significance as potential biomarkers and therapeutic targets for several diseases, including cancer. …”
Get full text

deutetrabenazine for the treatment of chorea associated with Huntington’s disease by Harshit Gupta, Wil Perkins, Cain Stark, Sathya Kikkeri, Juyeon Kakazu, Adam D. Kaye, Alan D. Kaye

“…Deutetrabenazine is thought to function as an inhibitor of the VMAT2 vesicular monoamine transporter resulting in decreased monoamine release, including dopamine, in the synaptic cleft which has a therapeutic effect in management of chorea. This drug was approved by the FDA in 2017 with a specific indication for tardive dyskinesia and choreiform movement in Huntington’s disease. …”
Get full text

State-of-the-Art Techniques to Causally Link Neural Plasticity to Functional Recovery in Experimental Stroke Research by Anna-Sophia Wahl

“…The tools discussed are useful to close the loop from our understanding of stroke pathology to the behavioral outcome and may allow discovering new targets for therapeutic approaches. The here presented methods open up new possibilities to assess the efficiency of rehabilitative strategies by understanding their external influence for intrinsic repair mechanisms on a neurobiological basis.…”
Get full text

CAR-T CELL THERAPY FOR T-CELL MALIGNANCIES by Ugo Testa, Patrizia Chiusolo, Elvira Pelosi, Germana Castelli, Giuseppe Leone

“…Thus, six FDA-approved commercial CAR-T cell products that target antigens preferentially expressed on malignant B-cells or plasma cells have been introduced in the therapy of B-cell lymphomas, B-ALLs and multiple myeloma. These therapeutic successes have triggered the application of CAR-T cell therapy to other hematologic tumors, including T-cell malignancies. …”
Get full text

Video assisted thoracic surgery. Experiences in Dr. Gustavo Aldereguia Lima hospital. by Arístides Sánchez Sánchez, Lidia Torres Aja, Rubén Mena Guerra, Francisco Cabarroca Castillo

“…There was a prevalence of therapeutic surgeries (55 %), over diagnostic surgeries. …”
Get full text

Structural insights into antibody-based immunotherapy for hepatocellular carcinoma by Masaud Shah, Muhammad Hussain, Hyun Goo Woo

“…While traditional approaches like surgical resection and tyrosine kinase inhibitors struggle against the tumor’s immune evasion, monoclonal antibody (mAb)-based immunotherapies have emerged as promising alternatives. Several therapeutic antibodies that counter the immunosuppressive tumor microenvironment have demonstrated efficacy in clinical trials, leading to FDA approvals for advanced HCC treatment. …”
Get full text

Advances in retina genetics: Progress, potential, and challenges by Mayank Bansal

“…We highlight key advancements such as the advent of next-generation sequencing, which has exponentially enhanced the discovery of genetic mutations, thus also enabling personalized medicine/therapeutic approaches. Stem cells, gene augmentation, and gene-editing techniques such as CRISPR/Cas9 are discussed, in which we highlight ongoing research as well as their potential in the targeted treatment of retinal diseases. …”
Get full text