Case report: Transarterial chemoembolization for nasal hemangiosarcoma in a dog by Keunho Kim, Changgyu Lim, Songyi Kim, Hearang Lim, Sang-Hwan Hyun, Byeong-Teck Kang, Dongwoo Chang, Namsoon Lee

“…Interestingly, there was no reperfusion of the embolized vessels, indicating a prolonged therapeutic effect. No significant complications were observed during follow-up. …”
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Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case report by Xuejun Jiang, Zujin Ji, Peng Li, Fangjun Yuan, Xinyi Lei, Yong Yang

“…The results indicated that we successfully achieved the goal of sphincter preservation and therapeutic efficacy. The patient derived significant benefits from the cryoablation treatment.ConclusionsUltrasound-guided trans-anal cryoablation, when combined with adjuvant PD-1 therapy, offers a novel treatment approach for patients with anorectal malignant melanoma. …”
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Orthokeratinized Odontogenic Cyst: A Report of Three Clinical Cases by María del Carmen González Galván, Abel García-García, Eduardo Anitua-Aldecoa, Rafael Martinez-Conde Llamosas, José Manuel Aguirre-Urizar

“…In this report, we presented three cases of this pathology, and we review the principal clinical, histological, radiological, and therapeutic aspects. Case 1. A 73-year-old female presents with a slight swelling on the right mandible, associated with an unilocular well-defined radiolucent lesion. …”
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RUNX2 enhances bladder cancer progression by promoting glutamine metabolism by Zhigang Huang, Bin Liu, Xiaoju Li, Chenghua Jin, Quansen Hu, Zhiwei Zhao, Yimin Sun, Qian Wang

“…Targeting RUNX2 could represent a promising therapeutic approach for addressing aberrant glutamine metabolism in bladder cancer.…”
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New insights into anti-depression effects of bioactive phytochemicals by Ruohan Zhao, Jingwen Wang, Sookja Kim Chung, Baojun Xu

“…Phytochemicals exert therapeutic effects through multiple pathways and targets, making traditional Chinese medicine (TCM) a promising adjunctive antidepressant for the prevention, alleviation, and treatment of depression. …”
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Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice by Haoyu Wang, Shengnan Yu, Kunyi Zhao, Tongyuan Hu, Zhinan Wu, Hewei Liang, Xiaoqian Lin, Luwen Cui, Jingtong Yao, Xiaomin Liu, Xin Tong, Ningning He, Liang Xiao, Karsten Kristiansen, Shangyong Li, Yuanqiang Zou

“…In conclusion, our results point to a potential therapeutic potential of F. longum CM04–06.…”
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<i>Akkermansia muciniphila</i>: A Potential Target for the Prevention of Diabetes by Kairu He, Feiyu An, Henan Zhang, Danli Yan, Tong Li, Junrui Wu, Rina Wu

“…The potential and challenges of using <i>A. muciniphila</i> are also highlighted, and it is anticipated that this work will serve as a reference for more in-depth studies on <i>A. muciniphila</i> and diabetes development, as well as the creation of new therapeutic targets by colleagues domestically and internationally.…”
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Case report: a rare case of diffusely metastatic BRAF V600E-mutated colorectal cancer with concomitant infiltration of the skin and parotid gland by Aristeidis E. Boukouris, Ioannis Kokkinakis, Elias Drakos, Maria Sfakianaki, Maria Tzardi, Dimitrios Mavroudis, Dimitrios Mavroudis, John Souglakos, John Souglakos

“…The patient’s rapid disease progression did not allow for any therapeutic interventions. This is only the second report of concomitant metastatic infiltration of the skin and parotid gland by CRC, and the first with a documented molecular background of BRAF V600E mutation. …”
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Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies by Zinovia Kefalopoulou, Iciar Aviles-Olmos, Thomas Foltynie

“…Neural cell transplantation and gene therapy have attracted considerable interest as promising therapeutic alternatives for patients with Parkinson's disease (PD). …”
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TRAIL-Dependent Resolution of Pulmonary Fibrosis by David M. Habiel, Ana Paula Moreira, Ugur B. Ismailoglu, Michael P. Dunleavy, Karen A. Cavassani, Nico van Rooijen, Ana Lucia Coelho, Cory M. Hogaboam

“…Together, these results identified TRAIL+ myeloid cells as a critical mechanism in the resolution of pulmonary fibrosis, and strategies directed at promoting its function might have therapeutic potential in IPF.…”
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Self-Expandable Metallic Stents in Nonmalignant Large Airway Disease by Marc Fortin, Paul MacEachern, Christopher A Hergott, Alex Chee, Elaine Dumoulin, Alain Tremblay

“…Reported complications include infection, granulation tissue formation, stent migration, stent fracture, airway perforation and fistula formation, as well as extension of the initial injury, potentially eliminating other therapeutic options such as surgical resection. Therefore, SEMS should only be used in nonmalignant large airway disease as a last resort for patients in whom other endoscopic methods, including silicone stents and dilations, as well as surgical options have failed or are technically not feasible.…”
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Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C by Manuela G. Neuman, Hemda Schmilovitz-Weiss, Nir Hilzenrat, Marc Bourliere, Patrick Marcellin, Cristhian Trepo, Tony Mazulli, George Moussa, Ankit Patel, Asad A. Baig, Lawrence Cohen

“…A combination of these markers was useful in predicting and diagnosing the stages of inflammation and fibrosis in HCV and ALD. Conclusion. Therapeutic monitoring of TGF-β and metalloproteases provides important insights into fibrosis.…”
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IS IT POSSIBLE TO PREDICT TUMOR PROGRESSION THROUGH GENOMIC CHARACTERIZATION OF MONOCLONAL GAMMOPATHY AND SMOLDERING MULTIPLE MYELOMA? by Ugo Testa, Giuseppe Leone, Elvira Pelosi, Germana Castelli, Valerio De Stefano

“…The identification of MGUS and SMM patients with a molecularly defined high risk of progression to MM offers the unique opportunity of early intervention with a therapeutic approach on a low tumor burden.   …”
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Adding checkpoint inhibitors to first-line chemotherapy for NUT carcinoma patients by Sarah Haebe, Gesa Schuebbe, Philipp Jurmeister, Michael von Bergwelt-Baildon, C. Benedikt Westphalen, Ulrich M. Lauer, Wolfgang G. Kunz, Marion Subklewe, Oliver Weigert

“…Our findings indicate that checkpoint inhibitors could play a critical role in treating NUT carcinoma, offering new therapeutic avenues and hope for patients with this challenging diagnosis. …”
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Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies by Piotr Robert Bakuła, Kamila Jałocha, Joanna Zygadło

“…Recent advancements in understanding OA pathophysiology have spurred the development of innovative therapeutic strategies targeting disease progression. …”
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Role of the Forkhead box family protein FOXF2 in the progression of solid tumor: systematic review by Yuzhen Zheng, Liusheng Wu, Zhenyu Hu, Hongying Liao, Xiaoqiang Li

“…Purpose Understanding how FOXF2 influences the growth and development of cancer could provide valuable insights for researchers to develop novel therapeutic strategies. Results In this review, we investigate the underlying impact of FOXF2 on tumor cells, including the transformation of cellular phenotype, capacity for migration, invasion, and proliferation, colonization of circulating cells, and formation of metastatic nodules. …”
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Inventory of a Neurological Intensive Care Unit: Who Is Treated and How Long? by Roland Backhaus, Franz Aigner, Felix Schlachetzki, Dagmar Steffling, Wolfgang Jakob, Andreas Steinbrecher, Bernhard Kaiser, Peter Hau, Sandra Boy, Kornelius Fuchs, Ulrich Bogdahn, Markus Ritzka

“…Data reflects close relationship and overlap of treatment on nICU with a standardized stroke unit treatment and suggests, regarding increasing therapeutic options, the high impact of acute high-level treatment to reduce consequential complications.…”
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Axillary Metastasis from an Occult Tubal Serous Carcinoma in a Patient with Ipsilateral Breast Carcinoma: A Potential Diagnostic Pitfall by Chantal Atallah, Gulbeyaz Altinel, Lili Fu, Jocelyne Arseneau, Atilla Omeroglu

“…In this context, the poorly differentiated appearance of the metastatic tumor and positive staining for estrogen receptor, might lead to a misdiagnosis of metastatic breast carcinoma. As the therapeutic implications differ, it is important for the pathologist to critically assess axillary lymph node metastases, even in patients with a past history of ipsilateral breast carcinoma and no other known primary tumors.…”
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Chinese and western medicine treatment of myocardial fibrosis drugs by Yuxi Zhu, Yuxi Zhu, Fangmei Zhang, Zhongcheng Li, Yu Zhou, Yi Shu, Jian Ruan, Guo Chen

“…Currently, modern drugs such as angiotensin-converting enzyme inhibitors, diuretics, and β-blockers can improve myocardial fibrosis in clinical treatment, but their therapeutic effect on this disease is limited, with obvious side effects and high cost. …”
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Gene Expression Profile Analysis in Epilepsy by Using the Partial Least Squares Method by Dong Wang, Xixiao Song, Yan Wang, Xia Li, Shanshan Jia, Zhijing Wang

“…Network analysis revealed two hub genes, CUL3 and EP300, which may serve as potential targets in further therapeutic studies. Conclusion. Our results here may provide new understanding for the underlying mechanisms of epilepsy pathogenesis and will offer potential targets for producing new treatments.…”
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