Self-assembled nanoparticles in ocular delivery: a comprehensive review by Shanmugam Saraswathi Tenpattinam, Sarad Pawar Naik Bukke, Praveen Kumar Kusuma, Hope Onohuean, Mohan Mothilal, Umasankar Krishnamaraju, Narayana Goruntla, Tadele Mekuriya Yadesa

“…The encapsulated medicine is released under regulated conditions, allowing therapeutic doses to be maintained for an extended time period. …”
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Multifunctional health-promoting effects of oolong tea and its products by Shuzhen Wang, Ting Zeng, Shuang Zhao, Yu Zhu, Changchun Feng, Jianfeng Zhan, Shiming Li, Chi-Tang Ho, Alexander Gosslau

“…However, potential health beneficial effects of oolong tea in humans should be further complemented by large-sized, randomized double-blind and placebo-controlled trials to consolidate potential therapeutic applications.…”
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Chlorotoxin-functionalized mesoporous silica nanoparticles for pH-responsive paclitaxel delivery to Glioblastoma multiforme by Mirjana Mundžić, Amelia Ultimo, Minja Mladenović, Aleksandra Pavlović, Oliviero L. Gobbo, Eduardo Ruiz-Hernandez, Maria Jose Santos-Martinez, Nikola Ž. Knežević

“…We developed novel mesoporous silica nanoparticles (MSNs)-based nanocarriers for pH-responsive delivery of a therapeutic drug Paclitaxel (PTX) to GBM tumor cells. …”
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TOTAL FLAVONOID CONTENT OF KAPUL FRUIT PEEL EXTRACT (Baccaurea macrocarpa) BASED ON SOLVENT TYPE VARIATION USING UV-VIS SPECTROPHOTOMETRY by Rahmadani Rahmadani, Risa Supriningrum, Hayatus Sa'adah

“…These results highlight the importance of solvent selection in maximizing the extraction efficiency of flavonoids from kapul fruit peel, which may have implications for its potential therapeutic applications.…”
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Advances and Challenges in Antiviral Development for Respiratory Viruses by Luis Adrián De Jesús-González, Moisés León-Juárez, Flor Itzel Lira-Hernández, Bruno Rivas-Santiago, Manuel Adrián Velázquez-Cervantes, Iridiana Monserrat Méndez-Delgado, Daniela Itzel Macías-Guerrero, Jonathan Hernández-Castillo, Ximena Hernández-Rodríguez, Daniela Nahomi Calderón-Sandate, Willy Salvador Mata-Martínez, José Manuel Reyes-Ruíz, Juan Fidel Osuna-Ramos, Ana Cristina García-Herrera

“…This article reviews the advances and challenges in this field, highlighting therapeutic strategies that target critical stages of the viral replication cycle, including inhibitors of viral entry, replication, and assembly. …”
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A Novel Cause of Biliary Peritonitis after Endoscopic Retrograde Cholangiopancreatography: Case Report and Literature Review by Andrija Karačić, Paula Batur, Domagoj Štritof, Taro Fukui, Branko Bakula, Inka Kekez

“…The incidence of pneumoperitoneum post-ERCP is rarely seen (<1%) and is associated with perforations of the duodenum or common bile duct in therapeutic ERCP after sphincterotomy. In this case, we disclose a novel cause of biliary peritonitis after ERCP. …”
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A Multicentre Randomized Controlled Trial of Recombinant Interferon-Alpha-2a in the Treatment of Patients with Chronic Hepatitis C by Masafumi Komatsu, Tsuyoshi Ono, Ko Nakajima, Itaru Toyoshima, Mitsuro Chiba, Osamu Masamune, Shunji Ohkubo, Tsukasa Yoshida, Hitoshi Yagisawa, Kanji Komatsu, Hideki Wakamatsu, Nobuo Yamada, Hiroyuki Watanabe, Tsuyoshi Mukojima, Mitsuo Goto

“…Thus, this study provides no evidence of therapeutic benefit from increasing the initial dose of IFNα-2a. …”
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Tumor cells escape immunosurveillance by hampering LFA-1 by Shishir Upadhyay, Lewis Murugu, Lena Svensson, Lena Svensson

“…Moreover, we discuss therapeutic strategies targeting LFA-1, including inhibitors tested in laboratory studies and animal models, highlighting their potential as anticancer interventions and the need for further research to evaluate their clinical utility.…”
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Psychiatric poetics: mental healthcare and Giovanni Stanghellini's ‘Logics of Discovery’ by George Ikkos, Alastair Morgan

“…The importance of art and humanities in mental health is widely recognised, and consumption and creation of poetry, prose, drama and the plastic arts are now considered to be relevant knowledge-generating and therapeutic activities. However, literary and art criticism remain at the margins. …”
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Brown rice: a missing nutrient-rich health food by Xiuxiu Wu, Tianyi Guo, Feijun Luo, Qinlu Lin

“…Brown rice (BR) is a traditional health food being rich in various active substances, which have effective preventive and therapeutic effects on many diseases. In this review, we systemically summarized the efficacy of BR on cardiovascular diseases (CVDs), hyperlipidemia, hypertension, diabetes, obesity, osteoporosis, neurodegenerative diseases, cancer, immune disorders, inflammation, anxiety, liver and stomach damage, etc. …”
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Abdominoplasty: An Easy Approach to Giant Abdominal Lipomas by Bayan Alsharif, Hatan Mortada, Aeshah Mandili, Fahad Aljindan

“…The objective of this case report is to highlight an easy approach to treat giant abdominal lipoma through therapeutic abdominoplasty. Case History. In this case, a 29-year-old man with a known case of hypothyroidism and HCV was in remission but had a huge abdominal mass on his lower left side; it progressed for 7 years and increased in size and caused discomfort. …”
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Novel 2-Thiazolylhydrazone with Druggable Properties for Antifungal Application by Wallace Cordeiro de Morais, Gustavo Henrique Oliveira Costa, Vinícius Leal Pitcella, João Victor Vanolli Protti, Carolina Paula de Souza Moreira, José Eduardo Gonçalves, Susana Johann, Renata Barbosa de Oliveira

“…The results suggest RW3 as a promising lead for further development as a therapeutic agent for systemic fungal infections. These findings underscore the importance of optimizing drug properties to enhance efficacy and safety profiles, opening the path for the development of innovative antifungal treatments.…”
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CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells by Kiel T. Tietz, Braedan M. McCluskey, Conor R. Miller, Yingming Li, Sarah A. Munro, Scott M. Dehm

“…These findings uncover a role for CPSF1 in the suppression of intergenic poly(A) sites in prostate cancer and nominate CPSF1 as a therapeutic target in advanced prostate cancer.…”
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Regenerative Therapy of Type 1 Diabetes Mellitus: From Pancreatic Islet Transplantation to Mesenchymal Stem Cells by Nadine E. Rekittke, Meidjie Ang, Divya Rawat, Rahul Khatri, Thomas Linn

“…Clinical trials demonstrated that even partial islet graft function reduces severe hypoglycemic events in patients. However, therapeutic impact is restrained due to shortage of pancreas organ donors and instant inflammation occurring in the hepatic environment of the graft. …”
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Discovery of a heparan sulfate binding domain in monkeypox virus H3 as an anti-poxviral drug target combining AI and MD simulations by Bin Zheng, Meimei Duan, Yifen Huang, Shangchen Wang, Jun Qiu, Zhuojian Lu, Lichao Liu, Guojin Tang, Lin Cheng, Peng Zheng

“…Our findings reveal a novel therapeutic target of MPXV, demonstrating the potential of combination of AI-driven methods and MD simulations to accelerate antiviral drug discovery.…”
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Efferent compared to afferent neural substrates of the vergence eye movement system evoked via fMRI by Ayushi Sangoi, Farzin Hajebrahimi, Suril Gohel, Mitchell Scheiman, Tara L. Alvarez

“…Implications with clinical populations and future therapeutic intervention studies are discussed.…”
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Mechanism of action of 5-arninosalicylic acid by N. A. Punchard, S. M. Greenfield, R. P. H. Thompson

“…However whether the therapeutic properties of SASP are due to the intact molecule, the 5-ASA or sulphapyridine components is unknown. …”
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CAR-T CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA by Ugo Testa, Elvira Pelosi, Germana Castelli, Alberto Fresa, Luca Laurenti

“…However, despite these consistent improvements, patients who become resistant to these agents have poor outcomes and need new and more productive therapeutic strategies. Among these new treatments, a potentially curative approach consists of the use of chimeric antigen receptor T (CAR-T) cell therapy, which achieved remarkable success in various B-cell malignancies, including B-cell Non-Hodgkin Lymphomas (NHLs) and B-acute lymphoblastic Leukemia (ALL). …”
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Post-angiography spontaneous closure of cavernous sinus dural arteriovenous fistula: case report in Indonesia by Affan Permana, Stevanus Samudra, Fabianto Santoso, Adiguno Wicaksono

“…The contrast could not fill the superior ophthalmic vein at the second DSA. At the therapeutic DSA a month later, the fistula between left and right meningohypophyseal trunk toward the cavernous sinus was no longer identified. …”
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Efficacy of Lurasidone in First-Episode Psychosis: Patient Phenotypes, Dosage, and Recommendations from an Expert Panel by Miquel Bernardo, Marina Díaz Marsá, Ana González-Pinto, Manuel Martín Carrasco, Víctor Pérez Sola, Pilar Alejandra Sáiz, Eduard Vieta, Marta Torrens, Celso Arango, Benedicto Crespo-Facorro

“…Abstract Introduction For patients with psychosis, early, intensive therapeutic intervention is thought to improve long-term outcomes. …”
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