Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents by Inês Cruz, Ploenthip Puthongking, Sara Cravo, Andreia Palmeira, Honorina Cidade, Madalena Pinto, Emília Sousa

“…Due to their low efficacy there is a considerable need for other therapeutic strategies. Considering that the malfunctions of different, but interconnected, biochemical complex pathways play an important role in the pathogenesis of this disease, a promising therapy may consist in administration of drugs that act on more than a target on biochemical scenery of AD. …”
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Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration by Mishal Rao, Ziming Luo, Chia-Chun Liu, Chi-Yu Chen, Shining Wang, Michael Nahmou, Bogdan Tanasa, Aman Virmani, Leah Byrne, Jeffrey L. Goldberg, José-Alain Sahel, Kun-Che Chang

“…Our findings advance regenerative medicine by developing a new therapeutic strategy for RGC neuroprotection and axon regeneration.…”
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Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy by Qingchao Shang, Qingchao Shang, Pei Zhang, Xiao Lei, Lehui Du, Baolin Qu

“…Recently, the promising therapeutic potential of CSF-1/CSF-1R signaling pathway inhibition in cancer treatment is widely used. …”
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A Review of Human Studies Assessing the Efficacy of Cannabidiol for Anxiety Disorders by Kuba Borys Romańczuk, Katarzyna Kamińska-Omasta, Bartosz Omasta, Olga Krupa, Paulina Dorota Pietrukaniec, Zofia Martyna Wójcik, Kinga Furtak, Szymon Przemysław Stolarczyk, Magdalena Agata Czerska, Daria Rybak

“…Further research is needed to clarify CBD’s therapeutic potential in diverse clinical contexts. …”
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Nicotinamide mononucleotide restores impaired metabolism, endothelial cell proliferation and angiogenesis in old sedentary male mice by Kevin Kiesworo, Thomas Agius, Michael R. Macarthur, Martine Lambelet, Arnaud Lyon, Jing Zhang, Guillermo Turiel, Zheng Fan, Sènan d’Almeida, Korkut Uygun, Heidi Yeh, Sébastien Déglise, Katrien de Bock, Sarah J. Mitchell, Alejandro Ocampo, Florent Allagnat, Alban Longchamp

“…Taken together, our study illustrates the importance of NAD+-dependent metabolism in the maintenance of EC proliferation capacity with age, and the therapeutic potential of NAD precursors.…”
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GATD3A-deficiency-induced mitochondrial dysfunction facilitates senescence of fibroblast-like synoviocytes and osteoarthritis progression by Kai Shen, Hao Zhou, Qiang Zuo, Yue Gu, Jiangqi Cheng, Kai Yan, Huiwen Zhang, Huanghe Song, Wenwei Liang, Jinchun Zhou, Jiuxiang Liu, Feng Liu, Chenjun Zhai, Weimin Fan

“…In particular, we reveal a novel mechanism of fibroblast-like synoviocyte senescence, suggesting that targeting GATD3A is a potential therapeutic approach for osteoarthritis.…”
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Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE by Sifan Liu, Nan Zhang, Xu Ji, Shuyue Yang, Zheng Zhao, Peng Li

“…In summary, our findings highlight the crucial role of the CagA-SQLE-PD-L1 axis in gastric cancer progression, suggesting potential therapeutic strategies for targeting CagA-positive gastric cancer.…”
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Computational Modeling of the Interaction of Silver Nanoparticles with the Lipid Layer of the Skin by Andrea Fabara, Sebastián Cuesta, Fernanda Pilaquinga, Lorena Meneses

“…Their main uses in the medical field comprise diagnostic and therapeutic applications. In this project, the interaction between silver nanoparticles and the lipid layer of the skin was studied in order to know how nanoparticles behave when they are in contact with the skin. …”
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Functional and structural segregation of overlapping helices in HIV-1 by Maliheh Safari, Bhargavi Jayaraman, Henni Zommer, Shumin Yang, Cynthia Smith, Jason D Fernandes, Alan D Frankel

“…Additionally, our experiments reveal novel and critical functional residues in Env and have implications for the therapeutic targeting of HIV-1.…”
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Nanodrug‐Engineered Exosomes Achieve a Jointly Dual‐Pathway Inhibition on Cuproptosis by Hanxiao Sun, Yang Zou, Zhengtai Chen, Yan He, Kai Ye, Huan Liu, Lihong Qiu, Yufan Zhang, Yuexue Mai, Xinghong Chen, Zhengwei Mao, Wei Wang, Chenggang Yi

“…The local and controlled release of EXOsiFDX1‐PDA@CQ ensures the retention of the therapeutic agent at wound beds, effectively promoting wound healing. …”
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Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury by Yujing Huang, Yujing Zhang, Chen Yang, Mengze Xu, Zhen Yuan

“…Therefore, the potential of NIR-PBM as a therapeutic intervention in ABI was demonstrated and it is also expected that further work can facilitate its clinical applications.…”
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Cerebrovascular ageing: how zebrafish can contribute to solving the puzzle by Guy Malkinson, Guy Malkinson, Catarina M. Henriques, Catarina M. Henriques

“…Understanding the fundamental mechanisms responsible for the switch from health to morbidity with ageing are key to identifying potential therapeutic targets to decrease age-associated morbidity and increase years spent in good health. …”
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Nursing management for a patient with erysipelas infection leads to sepsis combined with multiple organ dysfunction syndromes (1例丹毒感染致脓毒症合并多功能脏器衰竭患者的护理体会)... by ZHOU Jie (周洁), REN Yaxing (任亚星), TANG Ling (唐玲), LI Ye (李野), ZHANG Jing (张敬), ZHANG Tingting (张婷婷), LIU Huan (刘欢), LI Shuo (李硕), GAO Chunli (高春利), DONG Ying (董樱)

“…Targeted nursing strategies including non-invasive ventilation nursing, medication care and fluid-management, fever nursing, catheter maintenance, skin care were carried out to ensure the therapeutic efficacy and symptom relieving. (本文总结1例丹毒感染致脓毒症合并多功能脏器衰竭患者的护理措施, 在给予抗感染、利尿、强心、维持循环功能治疗的同时还要加强护理, 从无创通气护理、用药监护及液体管理、发热护理、管路护理、皮肤护理等方面给予以针对性护理干预, 确保有效改善患者症状。)…”
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Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol by Huang Zhiwei, Wang Lianqiu, Chen Lifeng, Zhang Yifei, Shi Ping

“…This suggests that clioquinol may have a therapeutic potential as an anticancer drug for certain malignances.…”
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Abuse potential of fentanyl and fentanyl analogues by Anusha Thumma, Kwadwo Mfoafo, Niloofar Babanejad, Alborz Omidian, Yadollah Omidi, Hamid Omidian

“…Conclusions: By educating patients and physicians, making rescue kits easily accessible, developing vaccines to prevent opioid addiction, and perhaps even creating new tamper-resistant fentanyl formulations, it may be possible to prevent fentanyl misuse, therapeutic errors, and the repercussions that follow.…”
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The Role of Laparoscopy in the Management of a Diagnostic Dilemma: Jejunal Ectopic Pancreas Developing into Jejunojejunal Intussusception by Alessio Giordano, Giovanni Alemanno, Carlo Bergamini, Paolo Prosperi, Alessandro Bruscino, Andrea Valeri

“…The development of laparoscopic surgery has changed the way to manage such conditions, especially in the setting of emergency surgery, thanks to its diagnostic and therapeutic role with excellent results. We decided to perform an emergency diagnostic exploratory laparoscopy in a 29-year-old man with an acute abdomen and nonspecific radiological images for intestinal occlusion. …”
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Metabolic reprogramming of naïve regulatory T cells by IL-7 and IL-15 promotes their persistence and performance upon adoptive transfer by Jessica Filoni, Arianna Ferrari, Tatiana Jofra, Anna Rita Putignano, Lorenzo Da Dalt, Susanna Cesarano, Carla Di Dedda, Fabrizia Bonacina, Federica Marchesi, Danilo Norata, Chiara Bonini, Lorenzo Piemonti, Paolo Monti

“…However, the final Treg product has limited survival once infused in patients, potentially affecting therapeutic effectiveness. Here, we tested a novel expansion protocol in which highly purified naïve Tregs were expanded with a combination of IL-7 and IL-15, in the absence of IL-2. …”
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Biochemical Evaluation and Green Synthesis of Nano Silver Using Peroxidase from Euphorbia (Euphorbia amygdaloides) and Its Antibacterial Activity by Semra Cicek, Azize Alaylı Gungor, Ahmet Adiguzel, Hayrunnisa Nadaroglu

“…Synthesized silver nanoparticles have wide spectrum antibacterial activity in low concentration and may be a good alternative therapeutic approach in medicine and pharmaceutical fields in future.…”
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CCR9 Antagonists in the Treatment of Ulcerative Colitis by Pirow Bekker, Karen Ebsworth, Matthew J. Walters, Robert D. Berahovich, Linda S. Ertl, Trevor T. Charvat, Sreenivas Punna, Jay P. Powers, James J. Campbell, Timothy J. Sullivan, Juan C. Jaen, Thomas J. Schall

“…These findings indicate that the CCR9:CCL25 pair plays a causative role in ulcerative colitis and suggest that CCR9 antagonists will provide a therapeutic benefit in patients with colonic inflammation.…”
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Cardiomyocyte-specific Piezo1 deficiency mitigates ischemia-reperfusion injury by preserving mitochondrial homeostasis by Honglin Xu, Xin Chen, Shangfei Luo, Jintao Jiang, Xianmei Pan, Yu He, Bo Deng, Silin Liu, Rentao Wan, Liwen Lin, Qiaorui Tan, Xiaoting Chen, Youfen Yao, Bin He, Yajuan An, Jing Li

“…This study suggests an innovative therapeutic strategy to alleviate cardiac I/R injury.…”
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