MicroRNAs in the DNA Damage/Repair Network and Cancer by Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Davide Vecchiotti, Daria Capece, Francesca Zazzeroni, Edoardo Alesse

“…Chemotherapy and/or radiation therapy are the most commonly used therapeutic approaches to manage cancer and act mainly through the induction of DNA damage. …”
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Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway by Ryosuke Isotani, Masaki Igarashi, Masaomi Miura, Kyoko Naruse, Satoshi Kuranami, Manami Katoh, Seitaro Nomura, Toshimasa Yamauchi

“…Hence, this study identifies a NIC-triggered pathway regulating the stemness and tumorigenicity of ISCs and suggests the use of DBZ as a potential therapeutic strategy for treating intestinal tumors.…”
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Role of mitochondrial and lysosomal dysfunction in acute pancreatitis pathogenesis by Yuliya V Yevsyutina, V. T. Ivashkin, E. Z. Abgadzhava

“…Therefore new studies aimed for therapeutic impact on mitochondrions and lysosomes are required. …”
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Retroperitoneal Teratoma in an Adult: A Potential Pitfall in the Differential Diagnosis of Adrenal Myelolipoma by Madoka Kataoka, Hiroshi Fukushima, Yasukazu Nakanishi, Minato Yokoyama, Nobuaki Funata, Toru Motoi, Ken-ichi Tobisu, Fumitaka Koga

“…In a case of an adrenal mass difficult to clinically distinguish retroperitoneal teratoma from adrenal myelolipoma, surgical resection via a minimally invasive approach would be the best therapeutic option.…”
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Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone by Azhar Rasul, Muhammad Khan, Muhammad Ali, Jiang Li, Xiaomeng Li

“…This review suggests that alantolactone and isoalantolactone are potential promising anticancer candidates, but additional studies and clinical trials are required to determine their specific intracellular sites of actions and derivative targets in order to fully understand the mechanisms of therapeutic effects to further validate in cancer chemotherapy.…”
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Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives by Pablo Olivero, Carlo Lozano, Ramón Sotomayor-Zárate, Nicolás Meza-Concha, Marcelo Arancibia, Claudio Córdova, Wilfredo González-Arriagada, Ricardo Ramírez-Barrantes, Ivanny Marchant

“…It is expected that with the increasing evidence about proteostasis in neuropsychiatric disorders, new therapeutic alternatives will emerge.…”
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Vitamin A and its influence on tumour extracellular matrix by Guoqing Xie, Shun Cao, Guangchun Wang, Xianzhong Zhang, Yu Zhang, Haofan Wu, Shuxian Shen, Jiandong Le, Keqiang Li, Zhenlin Huang

“…Despite promising laboratory findings, their clinical application remains limited due to challenges in translating these effects into therapeutic outcomes. Future research should focus on the modulation of retinol metabolism within tumours and the development of targeted therapies to enhance treatment efficacy and improve patient prognosis.…”
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In situ-formed cryomicroneedles for intradermal cell delivery by Mengjia Zheng, Tianli Hu, Yating Yang, Xuan Qie, Huaxin Yang, Yuyue Zhang, Qizheng Zhang, Ken-Tye Yong, Wei Liu, Chenjie Xu

“…Abstract Cryomicroneedles (cryoMNs) offer a convenient and minimally invasive way to precisely deliver therapeutic cells intradermally for treating local and systemic diseases. cryoMNs are manufactured by shaping and freezing the cell-containing cryogenic media in a microneedle template, which allows cells to be packaged in advance for direct usage in the clinic. …”
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High-fat diet triggers transcriptomic changes in the olfactory bulb by Young-Kook Kim, Danbi Jo, Seoyoon Choi, Juhyun Song

“…Thus, our findings suggest potential therapeutic targets for treating olfactory dysfunction and related neural disorders in individuals with metabolic syndrome.…”
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Analytical Methods to Characterize and Purify Polymeric Nanoparticles by Cristina Fornaguera, Conxita Solans

“…Advances in polymeric nanoparticles as novel nanomedicines have opened a new class of diagnostic and therapeutic tools for many diseases. However, although the benchtop research studies in the nanoworld are numerous, their translation to currently marketed products is still limited. …”
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Progress in Regenerative Dentistry Approaches: An Update by Maham shah, Reshma khatoon, Rashid Iqbal, Zaheer Ahmed Soomro, Mohsin Ali Dehraj, Muhammad Amin sahito

“…This paper provides an overview of the most current therapeutic approaches that have been used in clinical settings and highlights the importance of dental tissue-derived stem cells for regenerative dentistry. …”
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Drug delivery strategies to improve the treatment of corneal disorders by Mahsa Fallah Tafti, Zeinab Fayyaz, Hossein Aghamollaei, Khosrow Jadidi, Shahab Faghihi

“…Developing alternative therapeutic methods is required to overcome drug bioavailability from ocular barriers. …”
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Canadian Helicobacter Study Group Consensus Conference on the Approach to Helicobacter Pylori Infection in Children and Adolescents by P Sherman, E Hassall, RH Hunt, CA Fallone, S Veldhuyzen van Zanten, ABR Thomson, Canadian Helicobacter Study Group

“…As a result, the risk to benefit ratio of diagnostic studies and therapeutic regimens for H pylori in adults are likely different from those in paediatric populations. …”
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Ephedra extract-mediated gold nanoparticles on Kaolin: A natural approach for reduction and stabilization, with evaluation of antioxidant and anti-ovarian cancer activities by Hui Yang, Cui Wang, Qingjiang Wang, Feng Han

“…Based on the results, the bio-composite material is found promising as a therapeutic agent for treating human ovarian cancer.…”
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CYP1A1 Relieves Lipopolysaccharide-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells by Wen-Yao Zhang, Hao Wang, Shaopei Qi, Xixi Wang, Xueru Li, Kun Zhou, Yong Zhang, Ming-Qing Gao

“…These findings suggest that CYP1A1 has immense potential in the regulation of inflammatory responses in bovine mammary epithelial cells during mastitis and may serve as a useful therapeutic target in mitigating injuries caused by inflammatory overreaction.…”
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Short- and long-term complications of bariatric surgery by Miguel Licea Videaux, Roberto Santana Caballero, Jesús Javier Sánchez Mata, Isabel García Morales, Dania Piñeiro Pérez, Daryl Rodríguez Denis

“…Pharmacological treatments have proven to be ineffective, leaving surgery as the only therapeutic option. Bariatric procedures, despite being performed by minimally invasive surgery, are not free from presenting postoperative complications. …”
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The Podocyte in Diabetic Kidney Disease by Erin Stitt-Cavanagh, Laura MacLoed, Chris R.J. Kennedy

“…These factors include members of the renin-angiotensin system (RAS), including angiotensin-converting enzyme (ACE) types 1 and 2, prorenin and its receptor, reactive oxygen species (ROS), prostanoids, peroxisome proliferator-activated receptors (PPAR), advanced glycation end-products (AGEs) and their receptors (RAGE), adiponectin, and microRNAs. As the number of therapeutic options that slow, but do not halt, the progression of DKD to ESRD remains limited, a more comprehensive understanding of the signaling events that contribute to this increasingly prevalent disease may identify novel avenues for treatment and prevention.…”
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Antioxidants from microalgae and their potential impact on human well-being by Leonel Pereira, João Cotas, Ana Valado

“…As microalgae continue to revolutionize antioxidant research, they hold immense promise in developing novel preventive and therapeutic strategies to promote human health and wellbeing.…”
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Ground-state flavin-dependent enzymes catalyzed enantioselective radical trifluoromethylation by Xinyu Duan, Dong Cui, Mengdi Wang, Chenlu Jin, Xiaochen Cai, Zhiguo Wang, Jian Xu

“…Abstract The introduction of fluoroalkyl groups into pharmaceutical compounds has the potential to enhance their therapeutic properties. Nevertheless, the synthesis of enantiomerically pure C(sp³)–CF₃ compounds poses a significant challenge. …”
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Alkaloid-rich fraction from Luffa cylindrica Linn fruit enhances memory and mitigates oxidative stress in hippocampus of ozone-exposed sprague Dawley rat via LCMS and network pharm... by Ankul Singh S, Chitra Vellapandian

“…It provides a holistic understanding of the medicinal properties of ARF, encouraging further exploration for potential therapeutic interventions in neurological diseases.…”
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