How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis? by Muhammad Babar Khawar, Fareeha Azam, Nadeem Sheikh, Khawaja Abdul Mujeeb

“…So, the present review is an effort to reveal the exact mechanism lying in the hepatoprotective activity of IL-22 and some of its future therapeutic implications.…”
Get full text

Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review by Mhd Bashir Almonajjed, Mahdi Wardeh, Abdallah Atlagh, Abdulrahman Ismaiel, Stefan-Lucian Popa, Flaviu Rusu, Dan L. Dumitrascu

“…This review examines the interactions between the gut microbiota, immune system, and brain, emphasizing the need for personalized therapeutic strategies. Future research should aim to identify reliable microbiota-based biomarkers for IBS and refine microbiome-targeted therapies to enhance patient outcomes.…”
Get full text

Antibody-mediated degradation of 4R-tau restores mitochondrial membrane polarization in human induced pluripotent stem cell-derived neurons with the MAPT 10+16 mutation by Dale O. Starkie, Charles Arber, Terry Baker, Daniel J. Lightwood, Selina Wray

“…For the first time, we demonstrate a causative link between excess 4 R-tau and mitochondrial membrane hyperpolarization with wide-ranging potential for elucidating novel therapeutic approaches to treat neurodegenerative disease.…”
Get full text

BIOMARKERS, NEOANGIOGENESIS AND GROWTH FACTORS IN PANCREATIC CANCER by E. M. Frantsiyants, O. I. Kit, V. I. Aleynov, I. A. Goroshinskaya

“…In this review, we also highlight the dual role of growth factor-β (TGF-β) and touch upon the prospects for therapeutic effects on targets associated with TGF-β signaling in pancreatic cancer. …”
Get full text

The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms by Wenli Jiao, Jiayi Lin, Yanfang Deng, Yelin Ji, Chuoyi Liang, Sijia Wei, Xi Jing, Fengxia Yan

“…Modulating both peripheral and central immune responses represent a promising multidimensional therapeutic strategy.…”
Get full text

Targeting multiple cancers: exploring the potential role of stem cells in treating 10 distinct types by Munawar Ali, Syeda Areej Imran, Hafiza Malaika Choudhary, Laiba Batool, Amna Amin, Muhammad Umair Aslam, Hafiz Muhammad Sultan

“…Stem cell research has gained significant prominence due to its therapeutic potential in addressing diseases that are difficult to treat with conventional therapies, particularly cancer. …”
Get full text

Nonfamilial, MPL S505N-Mutated Essential Thrombocythaemia by Ruth Morrell, Stephen E. Langabeer, Liam Smyth, Meegahage Perera, Gerard Crotty

“…Further MPN cases possessing this genotype require reporting in order to ascertain whether any particular morphological or clinical features, if present, determine clinical course and aid the refinement of therapeutic options.…”
Get full text

Psoriasis and Cardiovascular Risk: Assessment by CUORE Project Risk Score in Italian Patients by Spyridoula Doukaki, Valentina Caputo, Maria Rita Bongiorno

“…Increased focus on identifying cardiovascular risk factors and initiation of preventive lifestyle changes or therapeutic interventions in patients with psoriasis is warranted.…”
Get full text

Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering by Stefano Focaroli, Gabriella Teti, Viviana Salvatore, Isabella Orienti, Mirella Falconi

“…The field of tissue engineering currently offers some of the most promising strategies for cartilage restoration, in which assorted biomaterials and cell-based therapies are combined to develop new therapeutic regimens for tissue replacement. The current study describes the in vitro behavior of human adipose-derived mesenchymal stem cells (hADSCs) encapsulated within calcium/cobalt (Ca/Co) alginate beads. …”
Get full text

Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health by Jiaobo Cheng, Jielun Hu, Fang Geng, Shaoping Nie

“…In addition, the future perspectives in investigating new degradation pathways for polysaccharide, and using polysaccharides or their metabolites as therapeutic approaches for diseases mediated by the gut dysbiosis were also provided.…”
Get full text

Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase by Lorena Segale, Lorella Giovannelli, Paolo Mannina, Franco Pattarino

“…The rationale of this work was linked to the desire to improve celecoxib therapeutic effectiveness reducing its gastric adverse effects and to favor its use in the prophylaxis of colon cancer and as adjuvant in the therapy of familial polyposis. …”
Get full text

The Significance of Natural Environment in Reducing Long-Term Consequences of COVID-19. Tasks and Threats of Forest Pedagogy as Environmental Education by Marlena Baranowska, Anna Koprowicz, Martyna Korzeniewicz, Robert Korzeniewicz

“…The aim of the study was to summarize the long-term consequences of the COVID-19 pandemic, while indicating the therapeutic properties of the forest that can prevent or mitigate the effects of the disease caused by the SARS-CoV-2 virus. …”
Get full text

The role of cisplatin in modulating the tumor immune microenvironment and its combination therapy strategies: a new approach to enhance anti-tumor efficacy by Guandu Li, Xiangyu Che, Shijin Wang, Dequan Liu, Deqian Xie, Bowen Jiang, Zunwen Zheng, Xu Zheng, Guangzhen Wu

“…Exploring the interaction between cisplatin and the TIME will help identify potential therapeutic targets for improving the treatment outcomes in cancer patients.…”
Get full text

Investigation of photophysical properties and potential biological applications of substituted tris(polypyridyl)ruthenium(II) complexes by T. Sumitha Celin, G. Allen Gnana Raj, T. S. Prathima, M. M. Balamurali

“…Herein, the potential applications of [Ru(bpy)3]2+ in clinical diagnostics as antioxidants and therapeutic agents were evaluated.…”
Get full text

Enitociclib, a selective CDK9 inhibitor: in vitro and in vivo preclinical studies in multiple myeloma by Son Tran, Patrick Sipila, Melanie M. Frigault, Beatrix Stelte-Ludwig, Amy J. Johnson, Joseph Birkett, Raquel Izumi, Ahmed Hamdy, Ranjan Maity, Nizar J. Bahlis, Paola Neri, Aru Narendran

“…These results suggest that enitociclib may represent a promising therapeutic option for the treatment of MM, either as a single agent or in combination with other anti-MM agents.…”
Get full text

In Vivo Tracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging by Juan Cao, Shike Hou, Hui Ding, Ziquan Liu, Meijuan Song, Xiaojing Qin, Xue Wang, Mengyang Yu, Zhiguang Sun, Jinyang Liu, Shuli Sun, Peixin Xiao, Qi Lv, Haojun Fan

“…Dozens of clinical trials published demonstrated strikingly positive therapeutic effects of MSCs. However, as a specific agent, little research has focused on the dynamic distribution of MSCs after in vivo administration. …”
Get full text

Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy by Qing Nian, Yan Lin, Jinhao Zeng, Yanna Zhang, Rongxing Liu

“…We provide a comprehensive review of the mechanisms by which WT1 influences malignancies and summarize the resulting therapeutic approaches thoroughly. This article provides information on the roles of WT1 in the pathogenesis of different cancers and provides insights into drugs and immunotherapies targeting WT1. …”
Get full text

Cell-Oriented Modeling of Angiogenesis by Diego Guidolin, Piera Rebuffat, Giovanna Albertin

“…On the other side, models were also developed supporting “applied biomedical research” for the purpose of identifying new therapeutic targets and clinically relevant approaches for either inhibiting or stimulating angiogenesis.…”
Get full text

Emerging nanomedicine strategies for hepatocellular carcinoma therapy by Chen Guo, Jiayu Zhang, Xiaomeng Cai, Rui Dou, Jiaruo Tang, Zhengyuan Huang, Xueting Wang, Yan Guo, Hanqing Chen, Jun Chen

“…These systems demonstrate potential in HCC treatment by facilitating the transportation of diverse therapeutic drugs. This comprehensive review aims to delve into the application of nanoparticle drug delivery systems in the management of liver tumors, with particular emphasis on formulation, targeted strategies specific to liver tumors, and various methods of drug release. …”
Get full text

Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood by Maria Fernanda de Almeida Cavalcante Aranha, Maria Amélia Lopes dos Santos, Carla Andréa Avelar Pires, Leônidas Braga Dias Júnior, Rafaela Garcia Pereira, Marina Lopes de Freitas Freire, Tamara Tavares da Cruz, Luiza Rennó Rocha de Oliveira

“…ABSTRACT Objective: To highlight the importance of early recognition of hypopigmented mycosis fungoides (HMF) in cases of cutaneous hypochromia in children, with a view to an effective diagnostic and therapeutic approach. Case description: Two cases of HMF in children are reported. …”
Get full text