Cytokines and HCV-Related Disorders by Poupak Fallahi, Clodoveo Ferri, Silvia Martina Ferrari, Alda Corrado, Domenico Sansonno, Alessandro Antonelli

“…The most important systemic HCV-related extrahepatic diseases—mixed cryoglobulinemia, lymphoproliferative disorders, thyroid autoimmune disorders, and type 2 diabetes—are associated with a complex dysregulation of the cytokine/chemokine network, involving proinflammatory and Th1 chemokines. The therapeutical administration of cytokines such as IFN-alpha may result in viral clearance during persistent infection and reverts this process.…”
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Comparative Evaluation of Efficacy of Self-Assembling Peptide (P11-4), Bioactive Glass, and Arginine Bicarbonate Remineralizing Agents on Simulated Carious Lesion by Rashmi P Yadahalli, Yazeed Abdullah Alotaibi, Ravinder Singh, Mohammed Najmuddin, Mohamed Tharwat Salama, Radha Prasanna Dalai, Noura Alessa, Vardarajula Venkat Ramaiah

“…Conclusion: Higher remineralizing capacity was found in bioactive glass and self-assembling peptide (P11-4), which can be employed therapeutically to treat early carious lesions.…”
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Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy by Qingrong Zhang, Raissa S. L. Rosa, Ankita Ray, Kimberley Durlet, Gol Mohammad Dorrazehi, Rafael C. Bernardi, David Alsteens

“…Together, these findings highlight the importance of membrane composition and peptide structure in SARS-CoV-2 infectivity and suggest that targeting the disulfide bridge could provide a therapeutic strategy against infection.…”
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In Vitro Systems for the Study of Hepatitis C Virus Infection by Garrick K. Wilson, Zania Stamataki

“…Furthermore, culture models provide a platform in which therapeutic interventions can be devised or monitored. …”
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Hybrid Carcinoma of the Larynx: A Case Report (Adenoid Cystic and Adenocarcinoma) and Review of the Literature by Ilias Karasmanis, John K. Goudakos, Iosif Vital, Thomas Zarampoukas, Victor Vital, Konstantinos Markou

“…The histopathologic examination revealed a hybrid carcinoma coexistence of two different carcinomas, an adenoid cystic carcinoma and an adenocarcinoma, not otherwise specified with poor differentiation. Regarding the therapeutic plan, the mass was considered inoperable due to its expansion to trachea and the patient received radiotherapy. …”
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Deciphering the anti-obesity mechanisms of pharmabiotic probiotics through advanced multiomics analysis by Ye-Rim Kim, Tae-Rim Choi, Sung-Hyun Jo, Won-Suk Song, TaeHyun Kim, Min-Gyu Kim, Ji-Hyun Baek, Seo-Young Kwon, Bo-Gyeong Choi, Sang Woo Seo, Chol-Soon Jang, Yung-Hun Yang, Yun-Gon Kim

“…This study not only demonstrates the effectiveness of our approach in revealing complex host-microbe interactions but also significantly advances probiotic therapeutic development, offering promising avenues for obesity management.…”
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Local and Systemic Antibody Responses in Humans with Helicobacter pylori Infection by Thomas G Blanchard, John G Nedrud, Steven J Czinn

“…Whereas a broad range of H pylori antigens was recognized in chronically infected patients (including the patient who ultimately cleared the infection spontaneously), resolution of infection in the absence of therapeutic agents resulted in the recognition of only several immunodominant antigens. …”
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Aggressive Central Nervous System Relapse after Autologous Stem Cell Transplant in Multiple Myeloma: Case Reports and Literature Review by Rui Bergantim, Juliana Bastos, Maria José Soares, Bruno Carvalho, Pedro Soares, Cristina Marques, Jennifer Costa, José Eduardo Guimarães, Fernanda Trigo

“…We present two patients with CNS-MM at relapse after autologous stem cell transplant highlighting the importance of clinical suspicion and interdisciplinarity at diagnostic workup as well as the need for intensive therapeutic options on such rare and aggressive cases. …”
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Analytical Methods Used for the Detection and Quantification of Benzodiazepines by Zidane Qriouet, Zineb Qmichou, Nadia Bouchoutrouch, Hassan Mahi, Yahia Cherrah, Hassan Sefrioui

“…Indeed, the BZDs have been used in different therapeutic areas including insomnia, anxiety, seizure disorders, or general anesthesia. …”
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Medicarpin induces G1 arrest and mitochondria-mediated intrinsic apoptotic pathway in bladder cancer cells by Chen Yuan, Yin Liqi, Hao Mingxuan, Xu Wenkai, Gao Jixian, Sun Yuxin, Wang Qiao, Chen Shi, Liang Youfeng, Guo Rui, Zhang Jinku, Li Jinmei, Zhai Qiongli, Cheng Runfen, Wang Jiansong, Wang Haifeng, Yang Zhao

“…High recurrence, chemoresistance, and low response rate hinder the effective treatment of BC. Hence, a novel therapeutic strategy in the clinical management of BC is urgently needed. …”
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What’s in a name? Memory NK cells for cancer immunotherapy by William J Murphy, Robert J Canter, Sean J Judge, Megan C Purl

“…This ability to “remember” prior stimulation to bring about enhanced protection of the host sparked significant excitement regarding potential therapeutic applications. Yet, how closely the features of naïve and memory NK cells recapitulate those of T cells remains unclear. …”
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Risk Factors Causing Preterm Labor by Evren Kurtul Çam, Nejat Demircan, Ülkü Özmen Bayar, Füruzan Köktürk, İlker İnan Arıkan

“…CONCLUSIONS: Conditions related to low socio-cultural level, high blood pressure, stress, multiple pregnancies, therapeutic pregnancies, vaginal infections, presence of a chronic disease, or severe anemia led us to suspect about preterm labor; risk factors should be eliminated by intensive monitoring of these pregnant women. …”
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A Chromosome level assembly of pomegranate (Punica granatum L.) variety grown in arid environment by Himanshu V. Patankar, Luis F. Rivera, Fatima Omari Alzahrani, Rod A. Wing, Ikram Blilou

“…The new reference genome will contribute to identifying stress resistance traits in pomegranates thriving in arid environments as well as new dietary antioxidants and antimicrobial peptides with pharmaceutical and therapeutic applications.…”
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Novel research model for in vitro immunotherapy: co-culturing tumor organoids with peripheral blood mononuclear cells by Peng Li, Minli Huang, Yifan Ma, Yongbin Zhang, Changhong Shi

“…This model stands as a robust instrument for dissecting the TME, elucidating the molecular interactions, and exploring the therapeutic applications of chimeric antigen receptor (CAR)-engineered lymphocytes, as well as other cancer treatment modalities. …”
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Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation by Meng Sun, Meng Sun, Yiru Yu, Yiru Yu, Weixing Zhang, Yi Ding, Yi Ding, Ang Li, Ang Li, Ye Li

“…In summary, this study suggests the critical role of the dental follicle in tooth eruption through EVs, which may provide therapeutic targets for abnormal tooth eruption and effective approaches for the eruption of regenerated teeth.…”
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Down-Regulation of Tristetraprolin Expression Results in Enhanced IL-12 and MIP-2 Production and Reduced MIP-3α Synthesis in Activated Macrophages by Ulla Jalonen, Riina Nieminen, Katriina Vuolteenaho, Hannu Kankaanranta, Eeva Moilanen

“…In inflammation, the post-transcriptional regulation of transiently expressed genes provides a potential therapeutic target. Tristetraprolin (TTP) is of the factors regulating decay of cytokine mRNAs. …”
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An Overview of the Current Scientific Evidence on the Biological Properties of <i>Abelmoschus esculentus</i> (L.) Moench (Okra) by Carsten Tsun-Ka Kwok, Yam-Fung Ng, Hei-Tung Lydia Chan, Shun-Wan Chan

“…Despite its promising therapeutic potential, research on the active compounds in okra and evaluating efficacy in clinical settings remains limited. …”
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Bakuchiol ameliorates glycolipid homeostasis by reducing inflammation by Zhenhua Liu, Xiaoqing Xu, Zhenhua Liang, Yixiao Chen, Qiuyi Wang, Wenyi Kang, Yan Zhang, Bin Cong

“…Therefore, it is crucial to identify therapeutic agents that can alleviate insulin resistance by targeting inflammation. …”
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Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects by Kiran Shah, Tara Drury, Ivelise Roic, Peter Hansen, Mark Malin, Richard Boyd, Huseyin Sumer, Ray Ferguson

“…This report provides the support for the safety and efficacies of allogeneic adipose-derived mesenchymal stem cells in a regenerative therapeutic veterinary model.…”
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Lymphatic vessel network injury reduces local tumor control despite preservation of the tumor-draining lymph node by Lauren N. Liebman, Yang Shen, Zachary S. Buchwald, Zhanna Nepiyushchikh, Zhiming Qi, Andrés J. García, J. Brandon Dixon

“…Advancing our understanding of lymphatic vessel involvement in regulating tumor growth and immune response may provide new therapeutic targets or treatment plans to enhance the efficacy of existing therapies. …”
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