CpG Oligodeoxynucleotides Enhance the Efficacy of Adoptive Cell Transfer Using Tumor Infiltrating Lymphocytes by Modifying the Th1 Polarization and Local Infiltration of Th17 Cells by Lin Xu, Chunhong Wang, Zhenke Wen, Ya Zhou, Zhongmin Liu, Yongjie Liang, Zengguang Xu, Tao Ren

“…Adoptive cell transfer immunotherapy using tumor infiltrating lymphocytes (TILs) was an important therapeutic strategy against tumors. But the efficacy remains limited and development of new strategies is urgent. …”
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A Historical Approach to the Mirror Neuron System by Palacios-Sánchez, Leonardo, Botía, Inés, Palacios-Espinosa, Ximena

“…The initial enthusiasm manifested with the discovery of MN has been progressively nuanced, giving rise to a functional, neuroscientific perspective that requires more evidence on its therapeutic utility and applicability in areas of knowledge beyond health sciences.…”
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Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma by Yamhilette Licón-Muñoz, Vanessa Avalos, Suganya Subramanian, Bryan Granger, Frank Martinez, Leopoldo A. García-Montaño, Samantha Varela, Drew Moore, Eddie Perkins, Michael Kogan, Stefano Berto, Muhammad O. Chohan, Christian A. Bowers, Sara G.M. Piccirillo

“…Last, differential gene expression analyses, predictions of ligand-receptor and incoming/outgoing interactions, and functional assays reveal that the interleukin (IL)-1β/IL-1RAcP and Wnt-5a/Frizzled-3 pathways represent potential therapeutic targets in the SVZ. Our data provide insights into the biology of the SVZ in patients with GBM and identify potential targets of this microenvironment.…”
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Cholesterol metabolism regulator SREBP2 inhibits HBV replication via suppression of HBx nuclear translocation by Fan Yang, Fan Yang, Feng Hu, Hongxiao Song, Tie Li, Fengchao Xu, Jing Xu, Le Wang, Fei Wang, Yujia Zhu, Mian Huang, Yanli Gao, Min Rao, Haichun Ma, Guangyun Tan

“…This insight provides a potential basis for new therapeutic strategies against HBV infection, addressing an important global health issue.…”
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PPARγ in Bacterial Infections: A Friend or Foe? by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…In this review we discuss the role of PPARγ and its activation during bacterial infections, with focus on the potential of PPARγ agonists and perhaps antagonists as novel therapeutic modalities. We conclude that adjustment in the dosage and timing of PPARγ agonist administration, based on the competence of host antimicrobial defenses and the extent of inflammatory response and tissue injury, is critical for achieving the essential balance between pro- and anti-inflammatory effects on the immune system.…”
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T follicular helper and memory B cells in IgE recall responses by Joshua F.E. Koenig

“…This review investigates the mechanisms governing IgE production and Tfh activation in the primary and recall responses, towards the objective of identifying molecular targets for therapeutic intervention that durably inactivate the IgE recall response.…”
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Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians by Pearse A. Keane, Srinivas R. Sadda

“…Around this time, it also became clear that increased intraocular VEGF production was not limited to ischemic retinal diseases but was also a feature of choroidal vascular diseases such as neovascular age-related macular degeneration (AMD). Thus, a new therapeutic era emerged, utilizing VEGF blockade for the management of chorioretinal diseases characterized by vascular hyperpermeability and/or neovascularization. …”
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Enuresis, a problem to be faced in Primary Health Care due to its educational component by Mislandy Caridad González Guevara, Helena Fernández Esperanza, Marta Amelia Hernández Martínez, Owen Daniel González Cruz

“…Conclusions: enuresis is a disease that affects children and the family with a high biopsychosocial significance, which is why an integrative approach is necessary in its clinical-therapeutic approach.…”
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Playing stereoscopic video games enhances the precision but not the accuracy of depth perception by Roger W. Li, Betty Z. Li, Sandy W. Chat, Dennis M. Levi

“…These types of video games have potential therapeutic applications for improving stereo vision in patients with binocular vision anomalies.…”
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Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow by Paolo Severino, Andrea D’Amato, Lucrezia Netti, Mariateresa Pucci, Fabio Infusino, Viviana Maestrini, Massimo Mancone, Francesco Fedele

“…For this reason, considering the role of oxidative and ion channels in the pathophysiology of myocardial ischemia, it is allowed to consider new therapeutic perspectives in the treatment of IHD.…”
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Alpha-1 Antitrypsin as a Regulatory Protease Inhibitor Modulating Inflammation and Shaping the Tumor Microenvironment in Cancer by Siyu Xiang, Liu Yang, Yun He, Feng Ding, Shuangying Qiao, Zonghua Su, Zheng Chen, Aiping Lu, Fangfei Li

“…Therefore, in this review, we have elucidated the pivotal roles of AAT in inflammation and the tumor microenvironment, including the structure and molecular properties of AAT, its molecular functions in the regulation of the inflammatory response and tumor microenvironment, and its clinical implications in cancer including its diagnosis, prognosis, and therapeutic intervention. This review seeks to bridge the gap in the understanding of AAT between inflammatory diseases and cancer, and to foster deeper investigations into its translational potential in cancer immunotherapy in the future.…”
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Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML by Zhanglin Zhang, Xiang Lin, Yaling Yang, Xuemei Wang, Yi Wang, Xianbao Huang, Miao Hong, Wei Gao, Hua He, M. James You, Yi Yang, Guangyao Kong

“…Altogether, these results suggest that targeting USP48 may represent a novel therapeutic strategy in AML.…”
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Analysis of the Effects of Infusion Drips on Flow Rate and Volume Determination in IV Systems by Halid Ceylan, Ogan Karabaş, Kadri Süleyman Yiğit

“… In this study, drop form flow examinations, which form the basis of IV applications used for therapeutic purposes, were performed. Fluid Intravenous (IV) is the practice of administering fluids into a vein. …”
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A cell-penetrating bispecific antibody suppresses hepatitis B virus replication and secretion by Chongwei Xie, Bing Zhou, Da Yao, Xin Wang, Lihong Zhong, Chuanghua Qiu, Junfang Zhang

“…This cell-penetrating bispecific antibody is a novel approach to suppressing HBV replication and secretion and is a promising anti-HBV therapeutic antibody candidate.…”
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Implication of protein post translational modifications in gastric cancer by Houji Song, Mingze Zhang, Chengwang Guo, Xi Guo, Yuqi Ma, Yuntao Ma, Yuntao Ma

“…Therefore, in-depth investigation into the mechanisms of PTM and the development of targeted therapeutic strategies hold promise for advancing early diagnosis, treatment, and prognostic evaluation of GC, offering novel insights and future research directions.…”
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Protective effect of rhizome extracts of the herb, vacha (Acorus calamus) against oxidative damage: An in vivo and in vitro study by M. Devaki, R. Nirupama, M. Nirupama, H.N. Yajurvedi

“…The study for the first time, clearly demonstrates a potent anti-oxidant activity of A. calamus combining in vitro and in vivo results. Hence, the therapeutic value of this herb maybe due to its anti-oxidant property.…”
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Self-Management for People with Inflammatory Bowel Disease by Fred Saibil, Emily Lai, Andrew Hayward, Jeanne Yip, Cameron Gilbert

“…Many patients with chronic diseases are ready to participate in the therapeutic decision-making process, and join their physicians in a co-management model. …”
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Determinants of functional diagnosis and strategies of work in school relations with students with diverse educational needs by Marta Ewa Niemiec

“…This study also contains conclusions from the research, observations and implications for pedagogical practice regarding factors that may foster better effectiveness of the diagnostic process and the strategies applied in educational and therapeutic work with students with diverse needs in institutions available to general public. …”
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A multiple time-scale computational model of a tumor and its micro environment by Christopher DuBois, Jesse Farnham, Eric Aaron, Ami Radunskaya

“…Experimental evidence suggests that a tumor's environment may be criticalto designing successful therapeutic protocols: Modeling interactionsbetween a tumor and its environment could improve our understanding oftumor growth and inform approaches to treatment. …”
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Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applications by Yu Yin, Wu Wei, Kai Zhang

“…Key applications of CMSNs, especially in drug delivery systems, are explored in detail, highlighting their potential to enhance bioavailability and therapeutic efficacy. Looking ahead, CMSN research presents exciting opportunities, including precise control over chiral structures, the development of novel templating strategies, and the exploration of broader applications. …”
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