Tiny but mighty, an exploration of microbes and plants as sources of small novel bioactive compounds against invasive mycoses. by Hannah Mai Peacock, James Anthony O'Connor

“…Osmanthus delavayi warrants further study, with an aim to separate out each component, test it for bioactivity and/or asses for the presence of synergism between two or more components, determine their interactions with the blood brain barrier and any potential toxicities and therefore assess the therapeutic potential.…”
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Possibilities for the Application of Low-Temperature Argon Plasma in the Treatment of Postoperative and Long-Term Non-Healing Wounds by S. A. Frolov, A. M. Kuzminov, D. V. Vyshegorodtsev, V. Yu. Korolik, N. V. Tuktagulov, M. A. Sukhina, I. A. Mukhin

“…Low-temperature argon plasma is an ionised gas, one of the four classical aggregate states of matter. Its therapeutic effect is achieved by means of the gas-dynamic effect, i.e. an argon flow with a high heat content and wide-spectrum recombination radiation — from the vacuum ultraviolet region to the near infrared range, as well as by means of the pronounced catalytic properties of gaseous argon, which is important for a number of biochemical reactions. …”
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Recent Nanotechnological Trends in the Management of Microbial Keratitis by Shraddha Jaiswal, Prabhavati Shinde, Vidya Tale

“…The failure and ineffectiveness of current therapies have necessitated the development of novel therapeutic strategies to manage MK. With advances in nanotechnology in the biomedical field, various nanomaterials can be employed to control MK. …”
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Modeling critical dosing strategies for stromal-induced resistance to cancer therapy by Anna K. Kraut, Colleen M. Garvey, Carly Strelez, Shannon M. Mumenthaler, Jasmine Foo

“…We demonstrate that the presence of this interaction modulates the therapeutic dose window of efficacy and can lead to nonmonotonic treatment response. …”
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Funicular Myelosis in a Butcher: It Was the Cream Cans by Fabian Wolpert, Krisztina Baráth, Janis Brakowski, Roland Renzel, Michael Linnebank, Andreas R. Gantenbein

“…Since there are emerging reports of increasing misuse, this should be considered in the diagnostic and therapeutic care of patients with nitrous oxide abuse. …”
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A pair of promising immune checkpoints PSGL-1 and VISTA from immunotolerance to immunotherapy by Manqing Peng, Xiaofang Lu, Junshuang Guo, Xiangli Yin, Jing Zhang, Xin Li, Yizhou Zou

“…Our review provides a comprehensive analysis of the structure, expression, and biological functions of PSGL-1 and VISTA and emphasizes their therapeutic potential in cancer treatment, autoimmune diseases, and transplantation. …”
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A Brief Review on Medicinal Plants-At-Arms against COVID-19 by Shivani Srivastava, Fangzhou He, Yuanding Huang, Meng Niu, Alok Adholeya, Weng Kung Peng

“…Accordingly, this review highlights the unprecedented opportunities offered by medicinal plants and their compounds, candidates as the therapeutic agent, against COVID-19 by acting as viral protein inhibitors and immunomodulator in (32 clinical trials and hundreds of in silico experiments) conjecture with modern science. …”
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Alternative treatment for schizophrenia with a local wisdom approach in the Tidung tribe community of Tarakan City: a descriptive qualitative study by Darni Darni, Sulidah Sulidah, Ramdya Akbar Tukan, Rts Netisa Martawinarti, Siti Khadijah, Putri Irwanti Sari

“…Four major themes emerged from the study: i) the conventional methods used to treat schizophrenia; ii) the reasons for the shortcomings of these methods; iii) the role of supernatural elements in the therapeutic process; and iv) the expectations of traditional healers regarding patient recovery. …”
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Folic Acid and Birth Defects: A Case Study (Iran) by Mohammad Bager Hosseini, Zhila Khamnian, Saeed Dastgiri, Bahram Samadi Raad, Yalda Ravanshad

“…The prevalence of NTDs among pregnant women who were referred for therapeutic termination of pregnancy was 24.7 percent. …”
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What are biopharmaceuticals? by Abhay H. Pande, Yenisetti Rajendra Prasad, J. Anakha

“…We assert that biopharmaceuticals not only offer superior therapeutic benefits for human health but also contribute to environmental sustainability, promoting a healthier planet. …”
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Two Patients with Therapy-Resistant Pemphigus Vulgaris and Severe Underlying Disease Showing Good Response to a New IVIg Preparation by Katharina Hogrefe, Julia K. Winkler, Alexander H. Enk

“…Standard therapy with steroids often administered together with another immunosuppressant does not respond in all patients or may not be a good therapeutic option in patients with severe underlying diseases. …”
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Ultrasonic/compound enzyme extraction, comparative characterisation and biological activity of Lonicera macranthoides polysaccharides by Mengdie Ren, Yiru Hou, Danli Peng, Hui Li, Xuxiang Zhang, Lei Qiao, XiaoShuang Wang, Yongmei Jiang, FaMing Wu, Gang Wang

“…This study investigates two extraction methods—ultrasound-assisted extraction (UAE) and compound enzyme extraction (CE)—for the isolation of Lonicera macranthoides polysaccharides (LMP) and evaluates their physicochemical properties, bioactivity, and therapeutic potential. The optimization of extraction conditions was performed using single-factor experiments and response surface methodology. …”
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A one-two punch of inflammation and oxidative stress promotes revascularization for diabetic foot ulcers by Li Chen, Yunrong Li, Xuanxuan Zhang, Lixin Ma, Cheng Zhang, Huanhuan Chen

“…We believe that our engineered probiotic represents a promising therapeutic avenue for managing ischemic injuries associated with DFU.…”
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A multiplex method for rapidly identifying viral protease inhibitors by Seo Jung Hong, Samuel J Resnick, Sho Iketani, Ji Won Cha, Benjamin Alexander Albert, Christopher T Fazekas, Ching-Wen Chang, Hengrui Liu, Shlomi Dagan, Michael R Abagyan, Pavla Fajtová, Bruce Culbertson, Brooklyn Brace, Eswar R Reddem, Farhad Forouhar, J Fraser Glickman, James M Balkovec, Brent R Stockwell, Lawrence Shapiro, Anthony J O’Donoghue, Yosef Sabo, Joel S Freundlich, David D Ho, Alejandro Chavez

“…Abstract With current treatments addressing only a fraction of pathogens and new viral threats constantly evolving, there is a critical need to expand our existing therapeutic arsenal. To speed the rate of discovery and better prepare against future threats, we establish a high-throughput platform capable of screening compounds against 40 diverse viral proteases simultaneously. …”
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Successful Intravascular Correction of Intratumoral Pseudoaneurysm by Erosion of the Aorta in a Patient with Thoracic Giant Cell Tumor of Bone Responding to Denosumab by Natalia M. P. Fraile, Diego Toloi, Ceci O. Kurimori, Adriana R. B. Matutino, Alberto Codima, Veridiana P. Camargo, Olavo Feher, Rodrigo R. Munhoz

“…In cases amenable to surgical resection, very few therapeutic options were available until the recent demonstration of significant activity of the anti-RANK-ligand monoclonal antibody denosumab. …”
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Advancements in the Treatment of Mucopolysaccharidoses: From Established Therapies to Gene Therapy by Joanna Wanat, Wojciech Homa, Aleksandra Warunek, Gabriela Gronowicz, Izabela Dzikowska, Agata Siejka, Daria Stefaniak, Weronika Zielińska, Michał Chról

“…Early diagnosis is essential for optimizing therapeutic outcomes. In recent years, significant progress has been made not only in the diagnostic process but also in the development of therapies. …”
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Exploring similarities and differences in anti-atherosclerotic potential bioactives among Dendrobium species by UPLC-Q-Exactive Orbitrap MS by Yu Zhang, Xi Chen, Oushan Tang, Keyun Cheng, Lijun Ge, Weibo Lu, Jing Zheng, Yeshun Wu, Si-wei Wang, Xi-xi Zeng, Jing Xue, Yiwei Cui, Liting Ji, Qing Shen

“…A total of 12 different and 65 common components were identified. Key therapeutic targets included SRC, STAT3, and PIK3CA, along with relevant signaling pathways linked to AS prevention. …”
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Mining the Virgin Land of Neurotoxicology: A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels by Zhirui Liu, Jie Tao, Pin Ye, Yonghua Ji

“…This paper will cover the state-of-the-art advances of researches on glycosylation-mediated VGSCs function and the possible underlying mechanisms of interactions between toxin and glycosylated VGSCs, which may therefore, fulfill the knowledge in identifying the pharmacological targets and therapeutic values of VGSCs.…”
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Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma by Nassir Mokarram, Ayden Case, Nadia N. Hossainy, Johnathan G. Lyon, Tobey J. MacDonald, Ravi Bellamkonda

“…Thus, delivering drugs across the blood-brain barrier is an active research area in immunology, oncology, and neurology; moreover, novel methods are urgently needed to expand therapeutic options for central nervous system pathologies. …”
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ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis by Marina B.R. de Santana, Giulia O. Miranda, Lucas P. Carvalho

“…One way to potentially overcome SbV resistance may be a combined therapeutic strategy involving anti-Leishmania drugs administered together with ABC transporter inhibitors; however, toxicity poses a major challenge to the adoption of this approach.…”
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