Glutamate Receptors in Neuroinflammatory Demyelinating Disease

“…The use of receptor antagonists to control EAE is also discussed together with the possibility of therapeutic application in demyelinating disease.</p>…”
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Dual-Modality Probes for in Vivo Molecular Imaging by Seulki Lee, Xiaoyuan Chen

“…The combination of two popular imaging modalities that investigates the strengths of different methods might offer the prospect of improved diagnostic and therapeutic monitoring abilities. To date, only a few hybrid systems have become clinically adopted, but there are encouraging signs that the new generation of multimodality systems will be undergoing evaluation in the near future. …”
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Biofilm-associated proteins: from the gut biofilms to neurodegeneration by Jaione Valle

“…This review contributes to the understanding of complex interactions among the microbiota, transmissible elements, and host, which is crucial for developing novel therapeutic approaches to combat microbiota-related diseases and improve overall health outcomes.…”
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Genetically Encoded Libraries of Nonstandard Peptides by Takashi Kawakami, Hiroshi Murakami

“…Non-standard peptide libraries are therefore used to obtain valuable molecules for biological, therapeutic, and diagnostic applications. Highly diverse non-standard peptide libraries can be generated by chemically or enzymatically modifying standard peptide libraries synthesized by the ribosomal machinery, using posttranslational modifications. …”
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Visual Outcome after Vitrectomy with Subretinal tPA Injection to Treat Submacular Hemorrhage Secondary to Age-Related Macular Degeneration or Macroaneurysm by Yasmin Ali Said, Evelien Dewilde, Peter Stalmans

“…Larger multicenter randomized controlled studies are warranted to determine the therapeutic effect of this surgical approach.…”
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Potential Adverse Consequences of Combination Therapy with Gabapentin and Pregabalin by Muhammad Nabeel Ghayur

“…Once the patient medication profile was revisited, the pharmacy staff was able to identify the therapeutic duplications (gabapentin and pregabalin). …”
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A 2-decade survival from a double hemolytic disease: A case of paroxysmal nocturnal hemoglobinuria with hemoglobinopathy by Aria Namiq Chaqmachi, Brwa Ali Hussein

“…This case emphasizes how crucial it is to perform a thorough hematologic examination on patients who have hemolytic anemia to customize treatment plans and enhance patient outcomes. We will discuss therapeutic hurdles, possible treatment choices, and the clinical journey of the patient with a classical type of PNH with access only to steroids, blood transfusions, and supplements.…”
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Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells by Seulah Choi, Tae Sung Kim, Hui Xuan Lim

“…These results demonstrated that lutein may exhibit immunosuppressive activity by inhibiting the phenotypic and functional maturation of DCs, and provide new evidence for the value of lutein in the search for novel therapeutic agents in the treatment of inflammatory diseases. …”
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Outcome of Coronary Edge In-stent Restenosis Management by Restenting Versus Drug-Eluting Balloon by Yasser Gaber Metwally, Khaled Yehia Elnady, Tarek Abd El-Ghaffar, Eman Hesham Seddik, Ahmed Shaker, Fathy Mohamed Swailem

“…Background: The optimal therapeutic strategy for coronary intervention in edge in-stent restenosis (edge ISR) remains less well-defined. …”
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miR-559 Inhibits Proliferation, Autophagy, and Angiogenesis of Hepatocellular Carcinoma Cells by Targeting PARD3 by Chunjing Wang, Chengcheng Li, Rui Hao

“…These results reveal the interaction between miR-559 and PARD3 in HCC cells and provide new insights into their potential targets as therapeutic treatment against HCC.…”
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Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration by Nan Jiang, Cheng Wu, Xunrong Zhou, Guanghua Zhai, Jian Wu

“…In the context of today’s modern medicine, these new therapeutic techniques are expected to be new tools in the treatment of cavernous nerve injury erectile dysfunction. …”
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Acute Lymphocytic Leukemia with Skin Infiltration. Case Report and Literature Review by Adrian Isacc Nieto Jiménez

“…The interest of this presentation lies in the fact that the appearance of skin lesions, even if they are non-specific, in a patient with leukemia, should alert the treating medical team for their rapid study and thus guide therapeutic behavior and due to their low incidence of presentation.…”
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Application of biomaterials in mesenchymal stem cell based endometrial reconstruction: current status and challenges by Ling He, Qianrong Li

“…Researchers have explored various approaches to enhance the therapeutic efficiency of MSCs. Among these, biomaterials have been frequently employed due to their biocompatibility, degradability, and ability to provide a conducive environment for cell growth. …”
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Influencing immunity: role of extracellular vesicles in tumor immune checkpoint dynamics by Ziyang Ye, Genpeng Li, Jianyong Lei

“…In this review, we summarize the interactions between EVs and several widely studied ICPs as well as their potential clinical implications, providing a theoretical basis for further investigation of EV-related ICB therapeutic approaches.…”
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Advances in intrahepatic and extrahepatic vascular dysregulations in cirrhotic portal hypertension by Yanqiu Li, Bingbing Zhu, Ke Shi, Yu Lu, Xuanwei Zeng, Yongqi Li, Qun Zhang, Ying Feng, Xianbo Wang

“…Hemodynamic changes in the extrahepatic circulation, including splanchnic vasodilation and hyperdynamic circulation, play a significant role in the development of portal hypertension. Additionally, therapeutic strategies targeting these vascular mechanisms are diverse, including improvement of sinusoidal microcirculation, therapies targeting hepatic stellate cells activation, and pharmacological modulation of systemic vascular tone. …”
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Suppression of epileptic seizures by transcranial activation of K+-selective channelrhodopsin by Xiaodong Duan, Chong Zhang, Yujie Wu, Jun Ju, Zhe Xu, Xuanyi Li, Yao Liu, Schugofa Ohdah, Oana M. Constantin, Yifan Pan, Zhonghua Lu, Cheng Wang, Xiaojing Chen, Christine E. Gee, Georg Nagel, Sheng-Tao Hou, Shiqiang Gao, Kun Song

“…Abstract Optogenetics is a valuable tool for studying the mechanisms of neurological diseases and is now being developed for therapeutic applications. In rodents and macaques, improved channelrhodopsins have been applied to achieve transcranial optogenetic stimulation. …”
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An idiopathic left internal iliac artery aneurysm in an 11-year-old boy: a case report by Meghdad Ghasemi Gorji, Amirhossein Baratinezhad, Rojan Abdollahzadeh Mirali

“…Abstract Background Idiopathic isolated aneurysms in pediatric patients are rare and present significant diagnostic and therapeutic challenges owing to their low incidence, small anatomical size, and the associated risks of injury to surrounding structures. …”
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De novo design of protein minibinder agonists of TLR3 by Chloe S. Adams, Hyojin Kim, Abigail E. Burtner, Dong Sun Lee, Craig Dobbins, Cameron Criswell, Brian Coventry, Adri Tran-Pearson, Ho Min Kim, Neil P. King

“…Multivalent forms of both minibinders induce NF-κB signaling in TLR3-expressing cell lines, demonstrating that they may have therapeutically relevant biological activity. Our work provides a foundation for the development of specific, stable, and easy-to-formulate protein-based agonists of TLRs and other pattern recognition receptors.…”
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iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways by Xiao Wu, Ming Yan, Jiamin Lu, Xingyun Ge, Yuzhi Li, Minxia Bian, Lin Fu, Jinhua Yu

“…Taken together, these findings demonstrate that iRoot SP promotes osteo/odontogenic differentiation of BMSCs via the NF-κB and MAPK signaling pathways, which could provide a new theoretical basis for clinical applications of iRoot SP and a new therapeutic target for the regeneration of bone and tooth tissue in the future.…”
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Massive endobronchial hemorrhage leading to Cardiac arrest during EBUS-TBNA: a case of successful resuscitation by Ping-Yang Hong, Mao-Hong Huang, Ling Cai, Yi-Yuan Chen, Yu-Xin Guo, Xiao-Bin Zhang

“…During the procedure, vascular invasion led to significant bleeding, requiring immediate interventions including suctioning and therapeutic bronchoscopy. Results The patient experienced massive hemorrhage, resulting in airway obstruction, oxygen desaturation, and cardiac arrest. …”
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