The PPAR Ω Pocket: Renewed Opportunities for Drug Development by Åsmund Kaupang, Trond Vidar Hansen

“…The discoveries that lie at the heart of these developments have enabled the design of a new class of PPARγ ligands, capable of isolating central therapeutic effects of PPARγ modulation, while displaying markedly lower toxicities than previous generations of PPARγ ligands. …”
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The Older Gamer in Games Studies: Marginalised or Idealised? by Wu Huan, Guo Chen

“…After reviewing the literature about older gamers, we have found most studies focus on the therapeutic function of videogames for solving problems related to age. …”
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Biophysical aspects of mechanotransduction in cells and their physiological/biological implications in vocal fold vibration: a narrative review by Junseo Cha, Susan L. Thibeault

“…However, establishing a direct causal link between specific mechanical stimuli and therapeutic benefits is challenging due to the variability in voice therapy techniques. …”
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Allergic Rhinoconjunctivitis: the Role of Histamine by M. Andersson, L. Greiff, C. Svensson

“…Analysis of the pathogenesis of this condition permits identification of optimal therapeutic targets. The increased knowledge of the underlying pathophysiology suggests that multiple inflammatory mediators are involved in the pathogenesis of the allergic reaction in the ocular and nasal mucosa. …”
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Single-cell transcriptomics in thyroid eye disease by Sofia Ahsanuddin, Albert Y. Wu

“…Such studies have provided unprecedented insight regarding novel biomarkers and therapeutic targets in TED. This timely review summarizes recent breakthroughs and emerging opportunities for using single-cell and single-nuclei transcriptomic data to characterize this highly complex disease state. …”
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Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases by Young-Su Yi

“…This review describes the characteristics of MFG-E8-mediated signaling pathways, summarizes recent findings supporting the roles of MFG-E8 in inflammatory responses and inflammatory/autoimmune diseases, and discusses MFG-E8 targeting as a potential therapeutic strategy for the development of anti-inflammatory/autoimmune disease drugs.…”
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The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice by Sandro C. Esteves, Peter Humaidan

“…In this review, we delve into the molecular properties and functions of LH activity in spermatogenesis regulation and explore available preparations for therapeutic use. We also examine the evidence regarding the effectiveness of LH-containing drugs in treating specific male infertility conditions and identify the main areas for future research. …”
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ACE Insertion/Deletion Polymorphism and Diabetic Nephropathy: Clinical Implications of Genetic Information by Sung-Kyu Ha

“…In this review, we discuss the relationship between ACE I/D polymorphism and diabetic nephropathy and therapeutic response of RAAS blockers.…”
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Transports of Translation: Creativity and Healing by Sara GREAVES

“…The polysemy of the term “transport” – both conveyance from one place to another and “an intense exaltation of mind and feelings” that “lifts one out of oneself” (Merriam-Webster Dictionary), will help us conceptualise the pedagogic and therapeutic value of practising translation. This short article will look at creative translation workshops as a means to vindicate all languages, to heal conflicted identities by facilitating and fluidifying movement between languages.…”
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Impact of Built Environment on the Process of Psychological Treatment of Children and Youth by Agata Gawlak, Ewa Banaś

“…At the same time, programmes are being introduced to secure infrastructure and adequate therapeutic space by expanding or creating new, architecturally friendly centres. …”
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Protein Phosphatase 2A: Role in T Cells and Diseases by Suyasha Roy, Lalit Batra

“…In this review, we will discuss the structure and functions of PP2A in T cell differentiation and diseases and therapeutic applications of PP2A-mediated immunotherapy.…”
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Advances in modeling cellular state dynamics: integrating omics data and predictive techniques by Sungwon Jung

“…By evaluating strengths, limitations, and recent advancements of these methodologies, we aim to guide future research in developing more robust and interpretable models for understanding and manipulating cellular state dynamics in various biological contexts, ultimately advancing therapeutic strategies and precision medicine.…”
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Brugada Syndrome Caused by Autonomic Dysfunction in Multiple Sclerosis by Michel Ibrahim, Garly Saint-Croix, Rosario Colombo

“…In light of these similarly presenting but unique clinical entities, MS patients who develop a syncopal event in the setting of a spontaneous type I Brugada pattern pose a diagnostic and therapeutic dilemma. This case illustrates an approach to the risks and benefits of an ICD placement in an MS patient with the type 1 Brugada pattern.…”
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Potential Synergies of β-Hydroxybutyrate and Butyrate on the Modulation of Metabolism, Inflammation, Cognition, and General Health by Franco Cavaleri, Emran Bashar

“…The low-carbohydrate high-fat diet (LCHFD), also known as the ketogenic diet, has cycled in and out of popularity for decades as a therapeutic program to treat metabolic syndrome, weight mismanagement, and drug-resistant disorders as complex as epilepsy, cancer, dementia, and depression. …”
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Importance and Relevance of Phytochemicals Present in Galenia africana by Dario Heredia, Ivan Green, Jeremy Klaasen, Farzana Rahiman

“…This report concludes that the quantities of the phytochemicals present in G. africana should not cause undue risk to human health, which provides comfort to pursue future work on using and developing G. africana as a therapeutic agent.…”
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Relationship between Fibroblast Growth Factor-23 and Mineral Metabolism in Chronic Kidney Disease by Kosaku Nitta

“…FGF-23 may therefore prove to be an important therapeutic target for the management of CKD.…”
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Acute Pancreatitis: An Unusual Side Effect of Adalimumab in Crohn’s Disease Patient by Walid El Ouardi, Mustapha Benazzouz

“…The occurrence of acute pancreatitis induced by TNFα inhibitors exposes to the risk of pancreatitis with other drugs in this class, hence the need to switch to another therapeutic class, which was Ustekinumab in our case. …”
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Role of Apolipoprotein E in Anxiety by Jacob Raber

“…Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses.…”
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Functional Exercise and Physical Fitness Post Stroke: The Importance of Exercise Maintenance for Motor Control and Physical Fitness after Stroke by Birgitta Langhammer, Birgitta Lindmark

“…During the acute rehabilitation, both groups received functional task-oriented training, followed by regular self- or therapeutic driven training the first year after stroke and varied exercise patterns the following 24 months. …”
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Role of gp91phox Homolog Nox1 in Induction of Premalignant Spindle Phenotypes of HPV 16 E6/E7—Immortalized Human Keratinocytes by Walee Chamulitrat

“…Understanding these mechanisms may provide insight into Nox1 and redox signaling components as potential therapeutic targets to inhibit tumor progression.…”
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