Vaccine adjuvants for immunotherapy: type, mechanisms and clinical applications by Nimeet Desai, Sherrin Gotru, Sagar Salave, Lalitkumar K. Vora

“…Immunotherapy has emerged as a powerful approach in treating various diseases, yet its success often hinges on the efficacy of adjuvants, agents that boost immune responses to therapeutic targets. Traditional adjuvants have offered foundational support but may fall short in achieving the specificity and potency required for advanced therapies. …”
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Generalized Anxiety Disorder and Hypoglycemia Symptoms Improved with Diet Modification by Monique Aucoin, Sukriti Bhardwaj

“…This case strengthens the hypothesis that dietary glycemic index may play a role in the pathogenesis or progression of mental illnesses such as generalized anxiety disorder and subsequently that dietary modification as a therapeutic intervention in the treatment of mental illness warrants further study.…”
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Optimising artificial intelligence ultrasound tools in anaesthesiology and perioperative medicine: The next frontier for advanced technology application by Anastasia Jones, Ryan Tang, Anahita Dabo-Trubelja, Cindy B. Yeoh, Leshawn Richards, Vijaya Gottumukkala

“…While AI-driven diagnostic and therapeutic applications already exist in medicine, a chasm remains between the potential of AI and its clinical applications. …”
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Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia by Guillermo Santos-Sánchez, Ana Isabel Álvarez-López, Eduardo Ponce-España, Patricia Judith Lardone, Antonio Carrillo-Vico, Ivan Cruz-Chamorro

“…However, clinical approaches are mandatory to confirm their therapeutic hypercholesterolemic effect.…”
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Xeroderma Pigmentosum: Man Deprived of His Right to Light by Subhash Mareddy, Jithendra Reddy, Subhas Babu, Preethi Balan

“…Oral isotretinoin and topical application of 5-fluorouracil to treat actinic keratoses are other therapeutic options. T4N5 and photolyase liposomal lotions are innovations in the therapy of XP. …”
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PPAR𝜸 and Oxidative Stress: Con(𝜷) Catenating NRF2 and FOXO by Simone Polvani, Mirko Tarocchi, Andrea Galli

“…Here we reviewed the role of PPARγ in response to oxidative stress and its interaction with other signaling pathways implicated in this process, an interaction that emerged as a potential new therapeutic target for several oxidative-related diseases.…”
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Role of Vitamin D in the Prevention of Pancreatic Cancer by Pubudu Bulathsinghala, Kostas N. Syrigos, Muhammad W. Saif

“…Current treatment modalities are very limited creating great interest for novel preventive and therapeutic options. Vitamin D seems to have a protective effect against pancreatic cancer by participating in numerous proapoptotic, antiangiogenic, anti-inflammatory, prodifferentiating, and immunomodulating mechanisms. 25-hydroxyvitamin D [25(OH)D] serum concentrations are currently the best indicator of vitamin D status. …”
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Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications by Muhammad Sufyan bin Masroni, Evelyn Siew-Chuan Koay, Victor Kwan Min Lee, Siok Bian Ng, Soo Yong Tan, Karen Meiling Tan, Marco Archetti, Sai Mun Leong

“…Finally, we discuss how molecular insights gleaned from these mechanistic dissections may fuel advancements in our comprehension of altruism among cancer cells, with implications across multiple disciplines, offering innovative prospects for therapeutic strategies, molecular discoveries, and evolutionary investigations.…”
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Metformin and Fibrosis: A Review of Existing Evidence and Mechanisms by Maoyan Wu, Huiwen Xu, Jingyu Liu, Xiaozhen Tan, Shengrong Wan, Man Guo, Yang Long, Yong Xu

“…To date, there are no effective therapeutic strategies for controlling fibrosis. A class of metabolically targeted chemicals, such as adenosine monophosphate-activated protein kinase (AMPK) activators and peroxisome proliferator-activated receptor (PPAR) agonists, shows strong potential in fighting fibrosis. …”
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Cell-Based Therapy for Cerebral Palsy: A Puzzle in Progress by Masoumeh Nouri, Morteza Zarrabi, Safdar Masoumi, Elaheh Khodadoust, Anahita Majmae, Man Amanat, Mahmoud Reza Ashrafi, Massoud Vosough

“…However, there is noconsensus on a standard therapeutic protocol regarding the source of cells, optimal cell dose, timing and frequencyof cell injections, route of administration, or the use of combination therapy. …”
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A Case of Vaginal Stillbirth in the Presence of Placenta Previa at 33 Weeks of Gestation by Yukiko Chinen, Tadatsugu Kinjo, Hayase Nitta, Yui Kinjo, Hitoshi Masamoto, Yoichi Aoki

“…It was demonstrated that second- and third-trimester therapeutic termination of pregnancy (TOP) is feasible in cases with placenta previa. …”
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Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases by Lixin Liu, Siwen Chen, Yantao Song, Longwei Cui, Yiman Chen, Jiangli Xia, Yibo Fan, Liqun Yang, Lina Yang

“…Hydrogels, acting as an ideal carrier, can enhance the therapeutic effects and application range of MSCs and Exos derived from MSCs (MSC-Exos). …”
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Percutaneous large-bore mechanical thrombectomy for macroscopic fat pulmonary embolism: a case report by James M. Chan, Zeyad Aljeboori, Angajendra Ghosh, Benjamin Peake, Moira N. Rush, Alexandra Du Guesclin, Hui Yin Lim, Miranda Siemienowicz, Hong Kuan Kok, Goran Mitreski

“…Mechanical thrombectomy is an emerging technique in interventional radiology, primarily investigated as a therapeutic approach for thrombotic pulmonary embolism. …”
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HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells by Feixin Liang, Shinichiro Kina, Hiroyuki Takemoto, Akira Matayoshi, Thongsavanh Phonaphonh, Nao Sunagawa, Keiichi Arakaki, Akira Arasaki, Hai Kuang, Hajime Sunakawa

“…Thus, our results provide the first evidence that HPV16E6 contributes to AP-1 complex formation after both ligand-dependent and independent EGFR activation, suggesting a new therapeutic approach to the treatment of HPV-associated tumors.…”
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Follistatin like-1 aggravates silica-induced mouse lung injury by Yinshan Fang, Si Zhang, Xiaohe Li, Fangxin Jiang, Qiao Ye, Wen Ning

“…Our data suggest that Fstl1 plays an important role in lung fibrosis, and may serve as a novel therapeutic target for treatment of silicosis.…”
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Toll-Like Receptors and Diabetic Nephropathy: A Review of Recent Advances by Mohammad Sadra Gholami Chahkand, Yasaman Tavakoli, Ava Aghakhani, Monireh Askarzadeh, Hosein Azimi, Nogol Ghalamkarpour, Alaleh Alizadeh, Iman Archin, Sajad Kermani, Akram Ansari, Mohadeseh Poudineh, Zahra Mali, Elaheh Foroughi, Gisou Erabi, Seyed Amirhossein Mazhari, Mohammad Sadegh Fallahi, Niloofar Deravi, Parisa Alsadat Dadkhah

“…TLR2 and TLR4 may be helpful therapeutic targets to prevent or delay DN in patients with type 2 diabetes mellitus. …”
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The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis by Nazar Trotsko, Agnieszka Głogowska, Barbara Kaproń, Katarzyna Kozieł, Ewa Augustynowicz-Kopeć, Agata Paneth

“…The ever-increasing drug-resistant tuberculosis (TB) has invigorated the focus on the discovery and development of novel therapeutic agents and treatment options. Thiazolidinone-based compounds have shown good antitubercular properties in vitro. …”
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Unmasking cerebral infarction: hemianopia and heavy menstrual bleeding in a patient with adenomyosis and vascular abnormalities by Qing Wan, Chao Wang, Weiyue Zhang, Weijia Zhong, Haoran Wang, Hee King SU, Mei Hwa Joanne HNG, Fan Yang, Xiaoguang Li

“…The findings underscore the importance of considering gynecological, vascular, and coagulation abnormalities in the evaluation of cerebrovascular events, offering new insights into diagnostic and therapeutic strategies.…”
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Ecological System Influences in the Treatment of Pediatric Chronic Pain by Deirdre E Logan, Lisa Engle, Amanda B Feinstein, Christine B Sieberg, Penny Sparling, Lindsey L Cohen, Caitlin Conroy, Dana Driesman, Akihiko Masuda

“…Finally, an acceptance and commitment therapy-focused group intervention for children with sickle cell disease and their parents demonstrates the benefits of peer contact as an element of the therapeutic intervention.…”
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The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study by Min Ouyang, Hanquan Sun, Xiaoyu Liu, Haijun Wu, Feilong Deng, Erdong Shen, Guozheng Peng, Hanbing Wu, Yinshan Zhao, Hui Xiong, Bin Liu, Shasha He, Ying Hu, Ping Liu

“…Abstract Objective This study aims to elucidate the therapeutic efficacy and safety of a taxane-based chemotherapy in combination with immune checkpoint inhibitors regimen in patients diagnosed with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). …”
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