Swift Onset, Swift Recovery: Unusual Nonrheumatic Myocarditis in a Young Adult Post Group A Streptococcal Pharyngitis by Andres Rios, Colby Wood, Ricardo Isaiah Garcia, Emily C. Mitchell, Jacob Nichols

“…The insights from this report contribute to the broader understanding of nonrheumatic myocarditis, emphasizing the significance of tailored diagnostic and therapeutic strategies to ensure optimal patient outcomes.…”
Get full text

Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms by Rahul Singh, Ryan C. Turner, Linda Nguyen, Kartik Motwani, Michelle Swatek, Brandon P. Lucke-Wold

“…We discuss potential therapeutic and pharmacologic options as well as potential novel drug targets. …”
Get full text

The Role of Macrophages in the Pathogenesis of ALI/ARDS by Xiaofang Huang, Huiqing Xiu, Shufang Zhang, Gensheng Zhang

“…According to the current literature, regulating the function of macrophages and monocytes might be a promising therapeutic strategy against ALI/ARDS.…”
Get full text

Subcapsular Renal Hematoma in Simultaneous Pancreas Kidney Transplantation by Daniele Cappellani, Chiara Terrenzio, Elena Gianetti, Walter Baronti, Valerio Borrelli, Lorella Marselli, Fabio Vistoli, Alessandro Campatelli, Ugo Boggi, Piero Marchetti

“…Herein, we report the case of a 51-year-old simultaneous pancreas-kidney transplantation recipient who presented a SRH following a mild trauma. The therapeutic choices were carefully balanced on the specific case, and the conservative management proved successful.…”
Get full text

The Interplay between the Bone and the Immune System by Giorgio Mori, Patrizia D'Amelio, Roberta Faccio, Giacomina Brunetti

“…Research in this field has great potential to provide a better understanding of the pathogenesis of several diseases affecting both the bone and immune systems, thus providing the molecular basis for novel therapeutic strategies. In these review, we reported the latest findings about the reciprocal regulation of bone and immune cells.…”
Get full text

Late diagnosed factor VII deficiency – a rare but significant haemorrhagic diathesis by Karolina Małgorzata Różycka, Beata Kuczyńska, Kinga Podsiadło, Małgorzata Mitura-Lesiuk, Irena Woźnica- Karczmarz

“…Factor VII deficiency is a rare coagulation disorder, so each described case is important to better understand the clinical spectrum and therapeutic options.…”
Get full text

Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury by Kim Joo-Il, Park Sang-Wook, Lim Jhong-Jae, Sohn Se-Il, Shin Ji-Su, Park Sang Cheol, Jang Young Pyo, Chung Eun Kyoung, Lee Hong-Woo, Lee Kyung-Tae

“…Based on these data, our data suggest that IPAP-FR has an improved therapeutic potential for the treatment of gastric ulcer.…”
Get full text

Ameliorative Potential of Tamarindus indica on High Fat Diet Induced Nonalcoholic Fatty Liver Disease in Rats by Suja Rani Sasidharan, Joshua Allan Joseph, Senthilkumar Anandakumar, Vijayabalaji Venkatesan, Chandrasekharan Nair Ariyattu Madhavan, Amit Agarwal

“…The study findings, therefore suggested the therapeutic potential of ETS against NAFLD, acting in part through antiobesity, insulin sensitizing, and antioxidant mechanisms.…”
Get full text

Earlier Intervention with Deep Brain Stimulation for Parkinson’s Disease by Gerson Suarez-Cedeno, Jessika Suescun, Mya C. Schiess

“…The implantation of tens of thousands of patients in North America and Europe ignited research into its potential role in early disease stages and the therapeutic benefit of DBS compared to best medical therapy. …”
Get full text

Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i> by Hovakim Grabski, Siranuysh Grabska, Ruben Abagyan

“…The development of new therapeutic strategies based on inhibiting essential viral enzymes or viral–host protein interactions is problematic due to the fast mutation rate and rapid emergence of drug resistance. …”
Get full text

Apoptosis, Inflammatory Bowel Disease and Carcinogenesis: Overview of International and Greek Experience by Jannis Kountouras, Georgios Kouklakis, Christos Zavos, Dimitrios Chatzopoulos, John Moschos, Epaminodas Molyvas, Nikolaos Zavos

“…The use of antitumour necrosis factor-alpha, anti-interleukin-6R and anti-interleukin-12 antibodies suppresses colitis activity by induction of T-cell apoptosis, thereby having important implications for the design of effective therapeutic strategies in inflammatory bowel diseases. …”
Get full text

Ocular manifestations of COVID-19 by Sandra Saray Quignón Santana, Osbel Alfonso Sánchez, Sandra Alfonso Quignón, Talía Alfonso Quignón

“…Due to the global repercussion that the pandemic has had, the multisystemic damage it causes and the presence of ocular manifestations, which could be the presentation of the disease, it is decided to carry out the present work to offer a theoretical reference about the ocular manifestations of Covid-19 and some therapeutic guidelines to consider. A bibliographic search was carried out in the Pubmed, Infomed, SciELO and academic Google databases, of articles in Spanish and English, which included new information related to the disease and its impact on eye health. …”
Get full text

Antibodies against the multifaceted cathepsin D protein open new avenues for TNBC immunotherapy by Valérie Laurent-Matha, Pascal Roger, Séverine Guiu, Thierry Chardès, Emmanuelle Liaudet-Coopman, Pénélope Desroys du Roure, Timothée David, Aude Mallavialle

“…Therefore, immunotherapy, which has demonstrated its efficacy in different cancer types, could be a promising strategy for TNBC, given the limited therapeutic options currently available besides conventional chemotherapy. …”
Get full text

Advance in identified targets of berberine by Penghai Sun, Ziyuan Wang, Yinchao Ma, Yuan Liu, Yintong Xue, Yan Li, Xiang Gao, Yuedan Wang, Ming Chu, Ming Chu, Ming Chu, Ming Chu

“…Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. …”
Get full text

Artificial intelligence in rheumatology research: what is it good for? by Diego Benavent, José Miguel Sequí-Sabater

“…Machine learning, a key element of discriminative AI, has demonstrated the ability of accurately classifying rheumatic diseases and predicting therapeutic outcomes by using diverse data types, including structured databases, imaging and text. …”
Get full text

Ellis-van Creveld Syndrome: Mutations Uncovered in Lebanese Families by Maria Valencia, Lara Tabet, Nadine Yazbeck, Alia Araj, Victor L. Ruiz-Perez, Khalil Charaffedine, Farah Fares, Rebecca Badra, Chantal Farra

“…While more research is required to explore other genes involved in EvC, early diagnosis and therapeutic care are important to achieve a better quality of life.…”
Get full text

Chemogenomics for steroid hormone receptors (NR3) by Espen Schallmayer, Laura Isigkeit, Lewis Elson, Susanne Müller, Stefan Knapp, Julian A. Marschner, Daniel Merk

“…Although several NR3 ligands such as glucocorticoids are invaluable drugs, this family is only partially explored, for example, in autoimmune diseases and neurodegeneration, but may hold therapeutic potential in new areas. Here we report a chemogenomics (CG) library to reveal elusive effects of NR3 receptor modulation in phenotypic settings. 34 highly annotated and chemically diverse ligands covering all NR3 receptors were selected considering complementary modes of action and activity, selectivity and lack of toxicity. …”
Get full text

GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration by Tomasz Jaworski, Ewa Banach-Kasper, Katarzyna Gralec

“…Thus, GSK-3β is a relevant therapeutic target for the treatment of many brain disorders. …”
Get full text

EPO-Mimetic Peptide Pegmolesatide Therapy for Pure Red Cell Aplasia in a Patient with Non-dialysis-dependent Type 1 Diabetic Nephropathy: A Case Report by Qiong Chen, Xuan Liu, Juan Wang, Man Yang, Qiu-ling Fan

“…Based on these findings, we speculate that pegmolesatide can provide a safe, effective, and convenient therapeutic strategy for PRCA in Chinese patients with chronic kidney disease.…”
Get full text

Histopathology and proteomics are synergistic for high-grade serous ovarian cancer platinum response prediction by Oz Kilim, Alex Olar, András Biricz, Lilla Madaras, Péter Pollner, Zoltán Szállási, Zsofia Sztupinszki, István Csabai

“…This integrative approach has the potential to improve personalized treatment and provide insights into the therapeutic vulnerabilities of HGSOC.…”
Get full text