Advances in Murine Models of Diabetic Nephropathy by Li-li Kong, Hao Wu, Wen-peng Cui, Wen-hua Zhou, Ping Luo, Jing Sun, Hang Yuan, Li-ning Miao

“…Thus, it is of great use to establish appropriate animal models of DN for doing research on pathogenesis and developing novel therapeutic strategies. Although a large number of murine models of DN including artificially induced, spontaneous, and genetically engineered (knockout and transgenic) animal models have been developed, none of them develops renal changes sufficiently reflecting those seen in humans. …”
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Progress on long non-coding RNAs in calcific aortic valve disease by Yan Shen, Jiahui Li, Zehao Zhao, Xiaomin Chen

“…In brief, this review discusses the mechanisms and potential therapeutic targets of lncRNAs in CAVD.…”
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An integrated protocol based on workflows of imaged capillary isoelectric focusing (icIEF) for in-depth protein heterogenous characterization: High-efficient fractionation and onli... by Teresa Kwok, She Lin Chan, Mike Zhou, Tong Chen, Niusheng Xu, Victor Li, Tiemin Huang, Tao Bo

“…We present an integrated protocol for studying the charge heterogeneity of therapeutic proteins combining two workflows: imaged capillary isoelectric focusing (icIEF) with fractionation and online mass spectrometry (MS) detection on a single platform. …”
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Treatment of neuropathic pain with repeated low-dose MDMA: a case report by Peter Gasser, Matthias E. Liechti, Friederike Holze

“…After increasing the LSD dose to 400 µg, he experienced subjective acute effects, and the first lasting therapeutic effects were observed. After changing from LSD to MDMA at both high doses (150-175 mg) and repeated low doses (12.5-25 mg), the patient exhibited marked improvements in neuropathic pain that were sustained even after stopping repeated MDMA treatment. …”
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Interaction of GPER-1 with the endocrine signaling axis in breast cancer by Luis Molina Calistro, Yennyfer Arancibia, Marcela Alejandra Olivera, Sigrid Domke, Rodrigo Flavio Torres

“…These findings open new perspectives in the understanding of breast tumor development and raise the possibility of future applications in the design of more personalized and effective therapeutic approaches.…”
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Myasthenia gravis and Lambert-Eaton myasthenic syndrome: treatment options and guidance for management during COVID-19 pandemic by A. Klimašauskienė, R. Bunevičiūtė

“…Thymectomy also has a therapeutic role for selected non-thymomatous MG patients. …”
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UFMylation maintains YAP stability to promote vascular endothelial cell senescence by Yanan Liu, Min Zuo, Aiwei Wu, Zhaoxiang Wang, Siting Wang, Yongping Bai, Junzhi Zhou, Hu Wang

“…Together, our finding provides molecular mechanism by which UFMylation maintains YAP stability and exerts an important role in promoting cell senescence, and identified that a previously unrecognized UFMylation is a potential therapeutic target for anti-aging.…”
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ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

“…These findings underscore the pivotal role of ACSL4 in HB progression and highlight its potential as a therapeutic target for aggressive HB subtypes.…”
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Multidisciplinary Vulvar Cancer Management: The Dermatologist’s Perspective by Marta Cebolla-Verdugo, Victor Alfredo Cassini-Gómez de Cádiz, Juan Pablo Velasco-Amador, María Zulaika-Lloret, Francisco Manuel Almazán-Fernández, Ricardo Ruiz-Villaverde

“…Vulvar cancer, particularly squamous cell carcinoma (SCC) and melanoma, poses significant diagnostic and therapeutic challenges due to its complex presentation and high rates of postoperative complications. …”
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Airway Remodelling in Asthma: From Benchside to Clinical Practice by Céline Bergeron, Meri K Tulic, Qutayba Hamid

“…The present review briefly describes the characteristic features of airway remodelling observed in asthma, its clinical consequences and relevance for physicians, and its modulation by therapeutic approaches used in the treatment of asthmatic patients.…”
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Critical Appraisal of Pharmaceutical Therapy in Diabetic Cardiomyopathy—Challenges and Prospectives by Elina Khattab, Michaelia Kyriakou, Elena Leonidou, Stefanos Sokratous, Angeliki Mouzarou, Michael M. Myrianthefs, Nikolaos P. E. Kadoglou

“…., which should guide the development of new therapeutic strategies. Up to now, HF treatment has not differed between patients with and without diabetes, which limits the expected benefits despite the high cardiovascular risk in the former group. …”
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Cellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma by Girolamo Pelaia, Alessandro Vatrella, Maria Teresa Busceti, Luca Gallelli, Cecilia Calabrese, Rosa Terracciano, Rosario Maselli

“…The recent advances in the knowledge of the cellular and molecular mechanisms underlying asthmatic inflammation are contributing to the identification of novel therapeutic targets, potentially suitable for the implementation of future improvements in antiasthma pharmacologic treatments.…”
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The Effects of Musical Sensorimotor Integrative Therapy on a Child with Speech Delay: Case Report by J. Laubová, J. Li, M. Kučera, J. Kantor

“… <p>Sensorimotor integrative therapy (SMITh) is a Czech therapeutic approach used for the rehabilitation of children with developmental and communication problems. …”
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Human Metabolic Enzymes Deficiency: A Genetic Mutation Based Approach by Swati Chaturvedi, Ashok K. Singh, Amit K. Keshari, Siddhartha Maity, Srimanta Sarkar, Sudipta Saha

“…In addition, the review also outlines the clinical presentations as well as diagnostic and therapeutic approaches.…”
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Recent advances of anti-tumor nano-strategies via overturning pH gradient: alkalization and acidification by Qiufang Gong, Xuejiao Song, Yao Tong, Lixuan Huo, Xuefen Zhao, Yingying Han, Wei Shen, Jiaxi Ru, Xian Shen, Chao Liang

“…This review aims to foster research on therapeutic approaches targeting the pH regulation of solid tumors and holds an optimistic outlook for the future development of this field.…”
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Use of ECT in Major Vascular Neurocognitive Disorder with Treatment-Resistant Behavioral Disturbance following an Acute Stroke in a Young Patient by Kyle E. Rodenbach, Daniel Varon, Timothey Denko, Ryan Peterson, Carmen Andreescu

“…Behavioral disturbance is common and may pose diagnostic and therapeutic difficulty in the poststroke patient. In most cases, first-line treatment includes pharmacologic intervention tailored to the most likely underlying syndrome. …”
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PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation... by Xiang You, Dan Dan Xu, Di Zhang, Jie Chen, Feng Guang Gao

“…PYR-41 and thalidomide have therapeutic effects on inflammation-associated diseases with side effects such as tumorigenesis. …”
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Immunomodulatory effect of efferocytosis at the maternal–fetal interface by Hui Tao, Ruilin Ma, Jianjian Cui, Zejun Yang, Wencong He, Yanan Li, Yin Zhao

“…These insights are expected to guide future basic research and clinical strategies for identifying efferocytosis-related molecules as potential predictors or therapeutic targets in obstetric diseases.…”
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Moringa oleifera is a Prominent Source of Nutrients with Potential Health Benefits by Zahidul Islam, S. M. Rashadul Islam, Faruk Hossen, Kazi Mahtab-ul-Islam, Md. Rakibul Hasan, Rezaul Karim

“…Leaves, flowers, seeds, and almost all parts of this tree are edible and have immense therapeutic properties including antidiabetic, anticancer, antiulcer, antimicrobial, and antioxidant. …”
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Reporting the Presence of an Incision Similar to a Cardiac Notch in the Right Lung: A Case Report by Mehran Kamani, Ali Razavinasab, Seyed Hassan Eftekhar Vaghefi, Abbas Mohammadi, Reza Sadeghi

“…The presence of a heart incision is important in terms of anatomical variation along the posterior border of the right lung in terms of lung pathologies and the therapeutic pattern of lung segmental resection.…”
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