Alternative splicing of modulatory immune receptors in T lymphocytes: a newly identified and targetable mechanism for anticancer immunotherapy by Shay Tzaban, Ori Stern, Elad Zisman, Galit Eisenberg, Galit Eisenberg, Shiri Klein, Shiri Klein, Shoshana Frankenburg, Michal Lotem, Michal Lotem, Michal Lotem

“…Two developments have accelerated the use of AS dynamics for therapeutic interventions: advancements in long-read RNA sequencing and progress in nucleic acid chemical modifications. …”
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Screen of propionate-producing probiotic strains in attenuating murine colitis by modulating immune response and restoring the intestinal barrier by Ting Shu, Xizi Song, Silu Zhang, Xiaoli Zhou, Zhizhu Zhang, Pengfei Wang, Hu Canying, Jie Pan, Xiaoshuang Dai, Yan Tan, Wu Xiyang, Huicui Meng, Guoxun Xiao, Huaijie Hao

“…Furthermore, their therapeutic effects were verified by reduced body weight loss, shortening of the colon length, Disease Activity Index score and improvement in histological analysis.…”
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Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration by Peisheng Liu, Hao Guo, Xiaoyao Huang, Anqi Liu, Ting Zhu, Chenxi Zheng, Fei Fu, Kaichao Zhang, Shijie Li, Xinyan Luo, Jiongyi Tian, Yan Jin, Kun Xuan, Bingdong Sui

“…Importantly, in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice, suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration. …”
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Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures by Huilin Wang, Yuting Zhan, Jiadi Luo, Weiyuan Wang, Songqing Fan

“…In this review, we explore the tumor microenvironment of NPC to better understand the mechanisms of resistance to immunotherapy, evaluate current therapeutic strategies, and pinpoint emerging targets, such as tertiary lymphoid structures (TLSs), that could enhance treatment outcomes and prognostic accuracy. …”
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Despicable role of epithelial–mesenchymal transition in breast cancer metastasis: Exhibiting de novo restorative regimens by Paras Famta, Saurabh Shah, Biswajit Dey, Kondasingh Charan Kumar, Deepkumar Bagasariya, Ganesh Vambhurkar, Giriraj Pandey, Anamika Sharma, Dadi A. Srinivasarao, Rahul Kumar, Santosh Kumar Guru, Rajeev Singh Raghuvanshi, Saurabh Srivastava

“…This review provides a holistic picture of BC biology, molecular pathways, and recent advances in therapeutic strategies.…”
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Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis by Xuan-Ying Xin, Jing Zhou, Gao-Ge Liu, Mei-Yu Zhang, Xiang-Zi Li, Yan Wang

“…Based on these findings, collagen peptides could serve as potential therapeutic agents for managing ulcerative colitis.…”
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Bajka terapeutyczna jako medium edukacyjne: wzorce społeczne, kulturowe i językowe by Paulina Forma, Dorota Bełtkiewicz

“…A novel tool of influencing a child of a pre- and early school age is a therapeutic story, often being presented in a multimedia form. …”
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Use of Percutaneous Ethanol Injection Therapy for Recurrent Secondary Hyperparathyroidism after Subtotal Parathyroidectomy by Walter G. Douthat, Gabriela Cardozo, Gabriela Garay, Santiago Orozco, Carlos Chiurchiu, Jorge de la Fuente, Javier de Arteaga, Pablo U. Massari

“…We evaluated the efficacy of percutaneous ethanol injection therapy (PEIT) as a therapeutic option for recurrence of secondary hyperparathyroidism after subtotal parathyroidectomy in ESRD patients. …”
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TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells by Yijia Zhou, Yuandong Liao, Chunyu Zhang, Junxiu Liu, Wei Wang, Jiaming Huang, Qiqiao Du, Tianyu Liu, Qiaojian Zou, Hua Huang, Pan Liu, Shiyin Ooi, Run Chen, Meng Xia, Hongye Jiang, Manman Xu, Yuwen Pan, Shuzhong Yao

“…The cell function experiments demonstrated that knockdown of TAB2 reduced the stemness of cervical cancer cells and, importantly, prevented cervical cancer progression. Collectively, the therapeutic scheme targeting TAB2 may provide an option for overcoming tumor relapse and chemoresistance of cervical cancer via obstructing stemness maintenance.…”
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Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models by Pallavi Sontakke, Jenny Jaques, Edo Vellenga, Jan Jacob Schuringa

“…Over the past years, a wide variety of in vivo mouse models have been generated in order to unravel the molecular pathology of Chronic Myeloid Leukemia (CML) and to develop and improve therapeutic approaches. These models range from (conditional) transgenic models, knock-in models, and murine bone marrow retroviral transduction models followed by transplantation. …”
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The temporal relationship between the neural and vascular actions of kallidin within the nose by K. Rajakulasingam, L. C. K. Lau, R. Polosa, M. K. Church, S. T. Holgate, P. H. Howarth

“…These findings have implications for the understanding and therapeutic manipulation of rhinitis.…”
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Stability and Bioaccessibility of β-Arbutin in Simulated Digestion Conditions by Łukasz Sęczyk, Danuta Sugier, Piotr Sugier

“…The assessment of phytochemicals in terms of their stability and interactions with the digestion environment can help in the future evaluation of their applicability for therapeutic purposes. The high bioaccessibility of β-arbutin within its multifunctional biological activity makes it a promising substance for phytomedicinal applications.…”
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Research progress on early intervention of postoperative scar by SHEN Si, LI Zhouna, JIN Zhehu

“…This paper aims to overview the methods and mechanisms for early intervention of postoperative scars, including intraoperative tension reduction suture, reduction in postoperative pressure and injection therapy, laser, and topical medication, in order to provide valuable insights for related therapeutic approaches.…”
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Follicular T cells and the control of IgE responses by Pablo F. Cañete, Di Yu

“…Additionally, we will assess the current state of major monoclonal antibodies and allergen immunotherapies designed to counteract Th2-driven inflammation, as well as reflect on the need to investigate how these biologics impact Tfh cell activity, differentiation, and function, as these insights could pave the way for much-needed therapeutic innovation in the treatment of allergic diseases.…”
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Zinner’s Syndrome: A Rare Diagnosis of Dysuria Based on Imaging by Ahmed Ibrahimi, Abdelmoughit Hosni, Idriss Ziani, Fatima Zahra Laamrani, Hachem El Sayegh, Laila Jroundi, Lounis Benslimane, Yassine Nouini

“…The diagnosis is made with imaging techniques, notably Magnetic Resonance Imaging (MRI) which remains the gold standard exam for diagnosis confirmation and therapeutic management. Treatment options depend on the severity of symptoms, the size of the cyst, and the complications. …”
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Successfully treated osteomyelitis with 20 years of evolution, covering the whole humerus (case report) by Yavor Grigorov, Viktor Vasilev

“…Infections affecting the humerus are a serious therapeutic challenge, especially when they are spread along the entire length of the humerus and have a long evolution. …”
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Research progress on moxibustion in the treatment of urinary incontinence in the elderly (艾灸治疗老年尿失禁研究进展) by JIN Wenli (靳文丽), ZHANG Yuanchun (张元春), HAN Jingjing (韩京晶), LIU Jining (刘继宁), FAN Hongxue (范红雪)

“…This paper reviewed the clinical studies on moxibustion treatment from the perspective of its concept in Traditional Chinese Medicine, mechanisms and therapeutic methods, highlighted the importance of moxibustion in the treatment of urinary incontinence in the elderly, and provide reference and inspiration for future research on the treatment of urinary incontinence. …”
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An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice by Xiaojuan Wang, Guohui Zhang, Zhiwei Bian, Vimanda Chow, Marina Grimaldi, Coralie Carivenc, Savannah Sirounian, Hao Li, Lucia Sladekova, Stefano Mott, Yulia Luperi, Yufeng Gong, Cait Costello, Linhao Li, Matthew Jachimowicz, Miao Guo, Shian Hu, Derek Wilson, Patrick Balaguer, William Bourguet, Sridhar Mani, Laura Bonati, Hui Peng, John March, Hongbing Wang, Shengpeng Wang, Henry M. Krause, Jiabao Liu

“…Collectively, these results support the translational potential of FDN as a therapeutic agent for the treatment and prevention of colonic diseases.…”
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The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis by Changhui Du, Zhenjie Li, Jing Zhang, Ni Yin, Lirong Tang, Jie Li, Jingyin Sun, Xiaoqing Yu, Wei Chen, Hang Xiao, Xian Wu, Xuexiang Chen

“…Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.…”
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Genetically engineered biomimetic ATP-responsive nanozyme for the treatment of cardiac fibrosis by Xueli Zhao, Yuze Qin, Bowen Li, Yue Wang, Jiao Liu, Bo Wang, Jia Zhao, Jiaqi Yin, Lanlan Zhang, Jing Li, Junzhe Huang, Kun Chen, Liwen Liu, Yuanming Wu

“…However, currently, there are no therapeutic strategies available to prevent the onset of cardiac fibrosis. …”
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