LC-MS/MS assisted pharmacokinetic and tissue distribution study of ropivacaine and 3-OH-ropivacaine on rats after plane block anesthesia by Mihaela Butiulca, Mihaela Butiulca, Lenard Farczadi, Silvia Imre, Silvia Imre, Camil Eugen Vari, Laurian Vlase, Bogdan Cordos, Leonard Azamfirei, Leonard Azamfirei, Alexandra Elena Lazar, Alexandra Elena Lazar

“…The varied use of local anesthetics, as well as the fact that anesthetics can sometimes have low therapeutic indices and numerous adverse drug reactions, makes any novel pharmacokinetics information valuable. …”
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The Impact of Polyphenol on General Nutrient Metabolism in the Monogastric Gastrointestinal Tract by Mohammed Sharif Swallah, Hongling Fu, He Sun, Raïfatou Affoh, Hansong Yu

“…Therefore, improved understanding of the biological properties and stages of dietary phenols is essential for the effective utilization of their therapeutic potentials. This review will explore, summarise, and collate current information on how polyphenols influence nutrient metabolism, bioavailability, and the biotransformation stages.…”
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Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy by Cong Xu, Shaodi Wen, Xiaoyue Du, Xinhua Zou, Elaine Lai-Han Leung, Guoren Zhou, Qibiao Wu, Bo Shen

“…Mutations in cancer cells may prevent the RCD pathway; therefore, targeting RCD in tumors has become a promising therapeutic approach. Sesquiterpene lactones represent a diverse and extensive class of plant-derived phytochemicals that serve as potential sources for developing various drugs. …”
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A Perspective Review on Numerical Simulations of Hemodynamics in Aortic Dissection by Wan Naimah Wan Ab Naim, Poo Balan Ganesan, Zhonghua Sun, Kok Han Chee, Shahrul Amry Hashim, Einly Lim

“…Due to the limitations of cardiac imaging modalities, numerical simulations have been widely used for the prediction of disease progression and therapeutic outcomes, by providing detailed insights into the hemodynamics. …”
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Environmental factors inducing gastric cancer: insights into risk and prevention strategies by Puyi He, Xiaomei Li, Dan Zou, Futian Tang, Hao chen, Yumin Li

“…Additionally, the article discusses current research directions and aims to provide a reference for researchers, paving the way for future preventive and therapeutic strategies.…”
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Penfluridol targets septin7 to suppress endometrial cancer by septin7-Orai/IP3R-Ca2+-PIK3CA pathway by Lingyi Song, Huiwen Wu, Xiao Sun, Xiaohu Liu, Xianwu Ling, Wei Ni, Lijuan Li, Beibei Liu, Jinlian Wei, Xiaokang Li, Jian Li, Yudong Wang, Fei Mao

“…In summary, this study revealed a target and mechanistic insights into EC therapeutic strategies and identified a potential candidate agent for the treatment of EC.…”
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The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer by Runzhi Huang, Jiaqi Zhang, Mingxiao Li, Penghui Yan, Huabin Yin, Suna Zhai, Xiaolong Zhu, Peng Hu, Jiaxin Zhang, Ling Huang, Man Li, Zehui Sun, Tong Meng, Daoke Yang, Zongqiang Huang

“…This analysis reveals various expression patterns of the PPAR family at a level of pan-cancer and provides new clues for the therapeutic strategies of cancer.…”
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Tissue engineering and biosensing applications of carbon-based nanomaterials by Seydanur Yücer, Begüm Sarac, Fatih Ciftci

“…The findings underline the transformative potential of CNMs in revolutionizing therapeutic and diagnostic approaches, paving the way for innovative solutions in healthcare.…”
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Repeated Long-Term DT Application in the DEREG Mouse Induces a Neutralizing Anti-DT Antibody Response by Junhua Wang, Myriam Siffert, Markus Spiliotis, Bruno Gottstein

“…Genetic tools exploiting the foxp3 locus including bacterial artificial chromosome- (BAC-) transgenic DEpletion of REGulatory T cells (DEREG) mice have provided essential information on Treg biology and the potential therapeutic modulation of tolerance. In DEREG mice, Foxp3+ Tregs selectively express enhanced green fluorescent protein (eGFP) and diphtheria toxin (DT) receptor, allowing for the specific depletion of Tregs through DT administration. …”
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Life-Threatening Adenovirus Infections in the Setting of the Immunocompromised Allogeneic Stem Cell Transplant Patients by Cedar J. Fowler, Jennifer Dunlap, Darcy Troyer, Peter Stenzel, Elliot Epner, Richard T. Maziarz

“…Recent developments has yielded an assay that can be used in the early detection and for serial determinations of adenovirus in patients with advanced GVHD, as well as a new therapeutic agent currently undergoing clinical trials.…”
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Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy by Xi Li, Hanzhe Liu, Peiyu Xing, Tian Li, Yi Fang, Shuang Chen, Siyuan Dong

“…This review underscores the critical role of exosomal circRNAs in cancer biology and drug resistance, highlighting their potential as non-invasive biomarkers and therapeutic targets that could transform the clinical management of cancer.…”
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Immunogenetic Factors Associated with Severe Respiratory Illness Caused by Zoonotic H1N1 and H5N1 Influenza Viruses by Jennifer Juno, Keith R. Fowke, Yoav Keynan

“…By better defining the role of genetic variability in influenza infection and identifying key polymorphisms that impair the host immune response or correlate with protection, we will be able to better identify at-risk populations and new targets for therapeutic interventions and vaccines. This paper will summarize known immunogenetic factors associated with susceptibility or severity of both pH1N1 and H5N1 infections and will also identify genetic pathways and polymorphisms of high relevance for future study.…”
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Promising Neuroprotective Effects of Dracocephalum Species: Mechanistic Perspectives by Marjan Talebi, Alireza Ghassempour, Afsoon Feizi, Seyed Abdulmajid Ayatollahi, Mehrdad Faizi

“…Natural products offer various health benefits, and Dracocephalum species, belonging to the Lamiaceae family, have been traditionally used for several therapeutic values. The genus Dracocephalum and its metabolites have demonstrated numerous pharmacological activities such as antioxidative, anti-inflammatory, antiviral, antiparasitic, antibacterial, antifungal, nephroprotective, hepatoprotective, neuroprotective, gastroprotective, cardioprotective, antiapoptotic, and anticancer effects. …”
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The Role of the Microbiota in the Diabetic Peripheral Artery Disease by Federico Biscetti, Elisabetta Nardella, Andrea Leonardo Cecchini, Raffaele Landolfi, Andrea Flex

“…The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the microbiota in this field, from biomarker to possible therapeutic target.…”
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Hemobilia: Perspective and Role of the Advanced Endoscopist by Rani Berry, James Han, Mohit Girotra, James H. Tabibian

“…., computed tomography) and therapeutic endoscopy, owing to advances in and the less invasive nature of both, while saving interventional radiological and/or surgical intervention for refractory or imminently life-threatening cases.…”
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Using artificial intelligence to optimize anti-seizure treatment and EEG-guided decisions in severe brain injury by Zade Akras, Jin Jing, M. Brandon Westover, Sahar F. Zafar

“…Manual annotation by expert neurophysiologists is a major resource limitation in investigating the prognostic and therapeutic implications of these EEG patterns and in expanding EEG use to a broader set of patients who are likely to benefit. …”
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Nursing of a patient with early-stage acute mastitis of Qi-stagnation and heat-obstruction type treated by Bian-stone therapy (砭石技术治疗1例乳痈初起气滞热壅型患者的护理体会)... by LIU Shanshan (刘姗姗), CHEN Hong (陈宏), ZHEN Ruiwen (郑睿文), XU Jingjin (徐京巾), ZHANG Jing (张敬), TANG Ling (唐玲)

“…This paper reported the therapeutic effect of Bian-stone therapy for a patient with with early-stage acute mastitis of Qi-stagnation and heat-obstruction type, and summarized the technical principle and operation process of Bian-stone therapy. …”
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Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration by Yang Liu, Chenguang Wang, Guanfang Su

“…Understanding the specific characteristic of Müller glia to generate lost neurons will inspire an attractive and alternative therapeutic strategy for treating visual impairment with regenerative research. …”
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Cerebral Venous Sinus Thrombosis and Hydrocephalus in a Vegan Secondary to Acquired Hyperhomocystinaemia by W. D. D. Priyankara, A.V. I. Chandimal, F. G. Sivagnanam, E. M. Manoj

“…He was found to have widespread cerebral venous sinus thrombosis, hyperintensities in basal ganglia, and acute hydrocephalus in magnetic resonance imaging, necessitating cerebrospinal fluid diversion, by way of an external ventricular drain and therapeutic anticoagulation. He had otherwise normal routine biochemistry, except for macrocytosis, which prompted us to suspect acquired hyperhomocysteinemia secondary to cobalamin and folate deficiency, in the background of him being a vegan. …”
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Comparative Glycopeptide Analysis for Protein Glycosylation by Liquid Chromatography and Tandem Mass Spectrometry: Variation in Glycosylation Patterns of Site-Directed Mutagenized... by Young Hye Hahm, Sung Ho Hahm, Hyoun Young Jo, Yeong Hee Ahn

“…Glycosylation is one of the most important posttranslational modifications for proteins, including therapeutic antibodies, and greatly influences protein physiochemical properties. …”
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