Primary Bronchopulmonary Actinomycosis Masquerading as Lung Cancer: Apropos of Two Cases and Literature Review by Stamatis Katsenos, Iosif Galinos, Panagiota Styliara, Nikoletta Galanopoulou, Konstantinos Psathakis

“…Clinical, imaging, diagnostic, and therapeutical aspects of the disease are discussed, demonstrating the paramount importance of the histological examination of lung tissue specimens in the confirmation of the infection given either its low culture yield or the limited use of new molecular diagnostic tools in routine clinical practice.…”
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Positive and Negative Regulation of Cellular Immune Responses in Physiologic Conditions and Diseases by S. Viganò, M. Perreau, G. Pantaleo, A. Harari

“…The potential to revert exhausted or inactivated T-cell responses following selective blocking of their function made these markers interesting targets for therapeutic interventions in patients with persistent viral infections or cancer.…”
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Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma by JinSong Li, GuanBo Zhang, Gang Li, Jie Zhang, Zhi Yang, Lin Yang, ShiJie Jiang, JiaXing Wang

“…Recently, advancements in nanotechnology, coupled with a deeper understanding of cancer biology and nano-biological interactions, have led to the development of various nanoparticles aimed at enhancing therapeutic efficacy through specific targeting of tumor tissues. …”
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Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat by Jasińska-Stroschein Magdalena, Owczarek Jacek, Wesołowska Anna, Orszulak-Michalak Daria

“…The present study is aimed to assess whether therapeutic regimen provides any benefits. Seven days after pulmonary hypertension induction, hydrophilic rosuvastatin and sildenafil were given for 14 days to male Wistar outbred rats. …”
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PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs by Serena Vella, Pier Giulio Conaldi, Tullio Florio, Aldo Pagano

“…Thus, novel diagnostic, prognostic, and therapeutic approaches are required, mainly to improve treatment outcomes of high-risk NB patients. …”
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Management of Recurrent Lung Infections in a Case of Hyperimmunoglobulinemia E (or Job’s) Syndrome by M Arsenault, V Echave, C Fish, J-P Praud

“…A concerted medicosurgical therapeutic regimen can control severe pulmonary complications in patients with this rare syndrome.…”
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Effects of high-pressure homogenization on phenolics profile, antioxidant activity, α-glucosidase inhibitory activity, and insulin resistance of peach juice during simulated gastro... by Yijin Peng, Shenke Bie, Shengbao Cai, Linyan Zhou, Chaofan Guo

“…These findings highlighted HPH as an innovative strategy for developing functional fruit-based beverages with enhanced nutritional and therapeutic value.…”
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A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome by Clara Gallina, Valentina Turinetto, Claudia Giachino

“…In the cardiovascular disease (CVD) field, MSCs-based therapy is the subject of great expectations. Its therapeutic potential has been already shown in several preclinical models and both the safety and efficacy of MSCs-based therapy are being evaluated in humans. …”
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Transdermal delivery of PeptiCRAd cancer vaccine using microneedle patches by Carmine D'Amico, Manlio Fusciello, Firas Hamdan, Federica D'Alessio, Paolo Bottega, Milda Saklauskaite, Salvatore Russo, Justin Cerioni, Khalil Elbadri, Marianna Kemell, Jouni Hirvonen, Vincenzo Cerullo, Hélder A. Santos

“…Thus, the results of this study demonstrate that the combination of MN technology with PeptiCRAd may provide a safer, more tolerable, and efficient approach to cancer immunotherapy, potentially translatable to other therapeutic applications.…”
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PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury by Na Xu, Zihuan Sun, Weikang Guan, Yiming Liu, Yun Gao, Chaoxian Yang

“…Overall, the adhesion of MSCs to PLGA can enhance the therapeutic efficacy of PLGA in rats following TBI.…”
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Enhanced Interaction between Warfarin and High-Dose Ketoconazole: A Case Report by Cynthia A. Jackevicius, Mannhu N. Ton

“…After a total dose reduction of 43%, the INR returned to therapeutic range within two weeks. The Naranjo probability scale revealed a probable adverse reaction of increased anticoagulant effect associated with high dose ketoconazole. …”
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Efficacy of Rational Emotive Behaviour Therapy on Religious Intolerance Among Adolescents in Taraba State, Nigeria by Moses Godswill Alhassan, Muhammad Ahmad Baba

“…The study concludes that REBT is an effective therapeutic intervention for reducing religious intolerance and promoting interfaith tolerance among adolescents.…”
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Long term efficacy and safety of Lorlatinib in ALK-positive non-small cell lung cancer: A case report by Jialin Qian, Tianqing Chu

“…Exploring the optimal therapeutic regimens for ALK+ NSCLC patients is of crucial clinical significance. …”
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Immunopathogenesis of spondyloarthropathies – Concept of major histocompatibility locus-I-opathy by Amlan Kusum Datta, Uddalak Chakraborty, Swati Kumar, Atanu Chandra

“…Further studies are needed for understanding of its therapeutic implication in such diseases.…”
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Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes by Gina Manda, Alexandru-Ionel Checherita, Maria Victoria Comanescu, Mihail Eugen Hinescu

“…This will foster the discovery of reliable biomarkers for early diagnosis and prognosis, and will guide the discovery of new therapeutic approaches for personalized medicine in diabetic nephropathy.…”
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A Rare Case of Single-Rooted Mandibular Second Molar with Single Canal by Abdulmohsen Alfadley, Ahmad Alquraishi, Yaser Almazrou, Fahd Aljarbou

“…Furthermore, clinicians need to possess the proper knowledge and skills that allow them to utilize the diagnostic and therapeutic tools available at their disposal in order to optimize the quality of care provided to their patients.…”
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Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications by Min Li, Lu Ding, Lu Ding, Liyan Cao, Zepeng Zhang, Xueyan Li, Zirui Li, Qinjing Xia, Kai Yin, Siyu Song, Zihan Wang, Haijian Du, Daqing Zhao, Xiangyan Li, Zeyu Wang, Zeyu Wang

“…The adenylate-activated protein kinase (AMPK) signaling pathway is crucial in regulating cellular energy metabolism, marking it as a significant therapeutic target for diabetes and related complications. …”
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A Meta-Analysis of Adalimumab for Fistula in Crohn’s Disease by Yin-mei Fu, Ming Chen, Ai-jun Liao

“…This study aimed to evaluate the therapeutic value of adalimumab (ADA) for fistula in Crohn’s disease (CD). …”
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KL-6 Mucin as Serum Tumor Marker of Metastatic Renal Cancer: A Case Report by Kyohei Ishida, Go Hasegawa, Toshinori Takada, Akira Ogose, Gen Kawaguchi, Yohei Ikeda, Hiroki Nishiyama, Noboru Hara, Tsutomu Nishiyama

“…We encountered a case of metastatic renal cell carcinoma in which the serum level of KL-6, a therapeutic marker, was exceptionally high and fluctuated with the progression of treatment. …”
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The Use of Imatinib Mesylate as a Lifesaving Treatment of Chronic Myeloid Leukemia Relapse after Bone Marrow Transplantation by Monika Conchon, Sabri S. Sanabani, Israel Bendit, Carla Luana Dinardo, Lucia Dias, Dalton de Alencar Fischer Chamone, Pedro Enrique Dorlhiac-Llacer, Frederico Luiz Dulley

“…All these patients could be evaluated for the therapeutic efficacy. At a mean of follow-up of 1.9 years of therapy, all evaluable patients achieved major molecular response without compromising safety. …”
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