PSTK exerts protective role in cisplatin‐tubular cell injury via BAX/BCL2/Caspase3 pathway by Yifan Wu, Yuanyuan Xv, Limei Zhao, Ziqi Zhou, Miaomiao Wang, Jima Xi, Ying Liming, Jianling Gao, Bingqing Deng, Dong Zheng

“…The study is significant for developing therapeutic strategies that could manipulate PSTK to delay AKI progression.…”
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Strategies to Overcome Intrinsic and Acquired Resistance to Chemoradiotherapy in Head and Neck Cancer by Tycho de Bakker, Anouk Maes, Tatiana Dragan, Philippe Martinive, Sébastien Penninckx, Dirk Van Gestel

“…These mechanisms have been investigated for years and been exploited for therapeutic gain in resistant patients, paving the way to the development of new promising drugs. …”
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Natural products in the treatment of diabetic foot infection by Mohsen Nazari, Leili Shokoohizadeh, Mohammad Taheri

“…The growing prevalence of antibiotic-resistant pathogens has reduced the efficacy of conventional treatments, highlighting the need for alternative therapeutic strategies. Natural products, known for their antimicrobial, anti-inflammatory, and wound-healing properties, have garnered attention as potential treatments for DFIs. …”
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Unlocking nature’s pharmacy: an in-depth exploration of phytochemicals as potential sources of anti-cancer and anti-inflammatory molecules by Shifana C. Sadiq, Maria Pellissery Joy, Sreekumar U. Aiswarya, Abhishek Ajmani, Chenicheri K. Keerthana, Tennyson P. Rayginia, Noah Isakov, Ruby John Anto

“…Phytochemicals, the bioactive compounds derived from plants, play a significant role in modulating pathways leading to cancer and inflammation, rendering themselves promising candidates for therapeutic interventions. This review explores the multifaceted potential of various phytochemicals in modulating key mechanisms involved in the development and progression of cancer and inflammation. …”
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Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells by Junhao Deng, Yiling Zhang, Yong Xie, Licheng Zhang, Peifu Tang

“…Neural stem/progenitor cell (NS/PC) transplantation derived from fetal tissues or embryonic stem cells (ESCs) has demonstrated therapeutic effects via replacement of lost neurons and severed axons and creation of permissive microenvironment to promote repair of spinal cord and axon regeneration but causes ethnical concerns and immunological rejections as well. …”
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A Review of the Mechanism of Bailing for Diabetic Nephropathy Based on ChatGPT and Network Pharmacology by Weiwei Xi, Xuming Zhao, Boya Wang, Yichen Zhu, Hua Li

“…Key active ingredients in Bailing that contribute to its therapeutic effects include arachidonic acid, linalyl acetate, β-sitosterol, and CLR. …”
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Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation by Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony

“…The poor prognosis can be attributed to the complex tumor microenvironment (TME) in OSCC, which is crucial for tumor progression, angiogenesis, invasion, metastasis, and therapeutic resistance. In recent years, three-dimensional (3D) in vitro models have emerged as powerful tools to study OSCC biology and evaluate targeted therapies in a more physiologically relevant context. …”
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Increasing Possibilities of Nanosuspension by Kumar Bishwajit Sutradhar, Sabera Khatun, Irin Parven Luna

“…., molecular) scales with a high degree of specificity and can be potentially translated into targeted cellular and tissue-specific clinical applications designed to achieve maximal therapeutic efficacy with minimal side effects. Production of drugs as nanosuspensions can be developed for drug delivery systems as an oral formulation and nonoral administration. …”
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MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI by Jun Hong, Bang-Chuan Hu, Liang Xu, Yang Zheng, Zi-Qiang Shao, Run Zhang, Xiang-Hong Yang, Ren-Hua Sun, Shi-Jing Mo

“…Our findings implicate that miR-19a may serve as a promising therapeutic candidate in the prevention of septic AKI.…”
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Knockdown of Annexin A1 induces apoptosis, causing G2/M arrest and facilitating phagocytosis activity in human leukemia cell lines by Hasan Masyitah, Kumolosasi Endang, Jantan Ibrahim, Jasamai Malina, Nazarudin Norlaili

“…This suggests that ANXA1 knockdown might be a potential approach in the therapeutic strategy for leukemia.…”
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Comparative hemodynamic responses to upright and recumbent cycling in patients with exercise intolerance by Arif Albulushi, Arif Albulushi, Faisal Al Harthi, Gamal Aly, Yahya Al-Wahshi, Mohammed H. El-Deeb

“…IntroductionUnderstanding the influence of body position on cardiovascular responses during exercise is crucial for precise diagnostic and therapeutic strategies, particularly in patients with exercise intolerance.AimThis study aims to compare the hemodynamic responses to exercise in upright and recumbent cycling positions in patients with exercise intolerance.MethodsA cross-over study design was employed, enrolling 21 patients for right heart catheterization during exercise in both upright and recumbent positions. …”
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γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell Differentiation by Weixi Zhang, Xueya Zhang, Anqun Sheng, Cuiye Weng, Tingting Zhu, Wei Zhao, Changchong Li

“…These findings suggest that GSI directly regulates Th17 responses through a Notch signaling-dependent pathway in mouse model of allergic asthma, supporting the notion that GSI is a potential therapeutic agent for the treatment of allergic asthma.…”
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Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung Inflammation by Nikolaos S. Lotsios, Chrysi Keskinidou, Sotirios P. Karagiannis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou, Anastasia Kotanidou, Ioanna Dimopoulou, Stylianos E. Orfanos, Alice G. Vassiliou

“…Finally, we explore recent pharmacological advancements targeting HIF signalling, which have emerged as promising alternatives to existing therapeutic approaches, potentially enabling more effective management strategies.…”
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Steroid Pulse Therapy for Severe Central Nervous System Involvement in Shiga Toxin-Producing Escherichia coli-Related Hemolytic Uremic Syndrome by Chiara Rosazza, Alberto M Cappellari, Cristiano Gandini, Elisa Scola, Gianluigi Ardissino

“…Therefore, neurologic manifestations were thought to be related to reperfusion damage to the CNS and high-dose IV steroid pulse therapy was empirically administered. Following this therapeutic scheme, neurologic involvement resolved with no sequelae. …”
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Self-control and Problematic Social Media Use: A Meta-Analysis by Zeynep Simsir-Gokalp, Muhammet Ibrahim Akyurek

“…The study’s findings are expected to inspire future investigations and therapeutic approaches. …”
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The Efficacy of Parent-Child Interaction Therapy (PCIT) in Children with Attention Problems, Hyperactivity, and Impulsivity in Dubai by Saad A. Al Sehli, Maya Helou, Meshal A. Sultan

“…PCIT may serve as an effective therapeutic option for young children with externalizing symptoms in Dubai.…”
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MAP: Mutation Arranger for Defining Phenotype-Related Single-Nucleotide Variant by In-Pyo Baek, Yong-Bok Jeong, Seung-Hyun Jung, Yeun-Jun Chung

“…Next-generation sequencing (NGS) is widely used to identify the causative mutations underlying diverse human diseases, including cancers, which can be useful for discovering the diagnostic and therapeutic targets. Currently, a number of single-nucleotide variant (SNV)-calling algorithms are available; however, there is no tool for visualizing the recurrent and phenotype-specific mutations for general researchers. …”
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Konjac-mulberry leaf compound powder alleviates OVA-induced allergic rhinitis in BALB/c mice by Yiyun Zhang, Jinxing Wang, Qi Zhang, Liling Deng, Siyao Miao, Geng Zhong

“…Overall findings suggest that KMCP could suppress the inflammatory response in AR mice, and serve as a novel curative therapeutic for AR without side effects.…”
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Supramolecular Biopolymers for Tissue Engineering by Rosario Pérez-Pedroza, Alan Ávila-Ramírez, Zainab Khan, Manola Moretti, Charlotte A. E. Hauser

“…Then, we will discuss the role that SBPs will be playing in TE as dynamic scaffolds, therapeutic scaffolds, and bioinks. Finally, we will describe possible outlooks of SBPs for TE.…”
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Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery by Go-Woon Kim, Goran Gocevski, Chao-Jung Wu, Xiang-Jiao Yang

“…These enzymes have been pursued by vigorous efforts for therapeutic development in the past 15 years or so. …”
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