Recent advances in the anti-tumor activities of saponins through cholesterol regulation by Min Jiang, Chao Hong, Chao Hong, Wenkui Zou, Zheng Ye, Lu Lu, Lu Lu, Yun Liu, Yun Liu, Tong Zhang, Tong Zhang, Yue Ding, Yue Ding, Yue Ding

“…Abnormal cholesterol metabolism has become a popular therapeutic target in cancer therapy. In recent years there has been a surge in interest in the anti-tumor activities of saponins, particularly their ability to disrupt cholesterol homeostasis in tumor cells. …”
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Molecular characterization of the TUBG1 meshwork's influence on Cytoskeletal organization by Darina Malycheva, Maria Alvarado-Kristensson

“…This study highlights the critical hubbing properties of TUBG in coordinating cytoskeletal integrity and its potential as a therapeutic target in cytoskeleton-related disorders.…”
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Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases by Pei Wen, Zhixin Sun, Dongming Yang, Jie Li, Zhiping Li, Mengyang Zhao, DongDong Wang, Fengting Gou, Jingjing Wang, Yuexin Dai, Deming Zhao, Lifeng Yang

“…These results suggest that irisin represents a novel and promising therapeutic approach for treating prion diseases.…”
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Clostridium difficile-derived membrane vesicles promote fetal growth restriction via inhibiting trophoblast motility through PPARγ/RXRα/ANGPTL4 axis by Zhiqiang Zha, Chunhong Jia, Ruisi Zhou, Qinlan Yin, Yu Hu, Zhipeng Huang, Linyu Peng, Yichi Zhang, Xiaowei Qiu, Ying Chen, Yawen Zhong, Yu Wang, Menglan Pang, Shijing Lu, Chao Sheng, Liping Huang

“…Abstract Fetal growth restriction (FGR) is a common complication of pregnancy, which seriously endangers fetal health and still lacks effective therapeutic targets. Clostridium difficile (C. difficile) is associated with fetal birth weight, and its membrane vesicles (MVs) are pathogenic vectors. …”
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The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate by Dimitrios Velissaris, Vasilios Karamouzos, Nikolaos Ktenopoulos, Charalampos Pierrakos, Menelaos Karanikolas

“…Although correction of metabolic acidosis with sodium bicarbonate seems a reasonable approach, there is ongoing debate regarding the role of bicarbonates as a therapeutic option. Methods. We conducted a PubMed literature search in order to identify published literature related to the effects of sodium bicarbonate treatment on metabolic acidosis due to sepsis. …”
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Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics by Cara R. Ravasio, Krishnakanth Kondabolu, Samuel Zhou, Eric Lowet, Erynne San Antonio, Rebecca A. Mount, Sukhneet K. Bhogal, Xue Han

“…Abstract Intracranial electrical kilohertz stimulation has recently been shown to achieve similar therapeutic benefit as conventional frequencies around 140 Hz. …”
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Investigating DNA Methylation of Solute Carrier Genes in Colorectal Cancer: A Comprehensive Analysis Using Microarray and Bioinformatics Tools by Nur Alia Natasya Zabidi, Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Nur Alyaa Afifah Md Shahri, Francis Tieng Yew Fu, Imilia Ismail, Muhammad Redha Abdullah Zawawi, Jodi Woan-Fei Law, Learn-Han Lee, Nurul-Syakima Ab Mutalib

“…Results: This study decoded the epigenetic landscape of SLC genes in CRC, promising innovative therapeutic strategies and improved patient outcomes to combat this prevalent malignancy. …”
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Research Advances in Antitumor Mechanism of Evodiamine by Luning Li, Cunxin Zhang, Chen Huang, Xinchen Tian, Wenxue Sun, Shulong Jiang

“…In this article, the antitumor mechanism of evodiamine was reviewed to provide the basis for its clinical application and therapeutic development in the future.…”
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Multimodal Surgical and Medical Treatment for Extensive Rhinocerebral Mucormycosis in an Elderly Diabetic Patient: A Case Report and Literature Review by Paola Di Carlo, Roberto Pirrello, Giuliana Guadagnino, Pierina Richiusa, Antonio Lo Casto, Caterina Sarno, Francesco Moschella, Daniela Cabibi

“…Any diabetic patient with sinonasal disease, regardless of their degree of metabolic control, is a candidate for prompt evaluation to rule out mucormycosis. Therapeutic and surgical strategies and adjunctive treatments are essential for successful disease management. …”
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Biometallic ions and derivatives: a new direction for cancer immunotherapy by Lin Zhao, Yajun Gui, Jing Cai, Xiangying Deng

“…This review explores the role and potential application prospects of biometallic ions in cancer immunotherapy, providing new ideas for future clinical application of metal ions as part of cancer immunotherapy and helping to guide the development of more effective and safe therapeutic regimens.…”
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Spatially controlled multicellular differentiation of stem cells using triple factor-releasing metal–organic framework-coated nanoline arrays by Yeon-Woo Cho, Min-Ji Kang, Joon-Ha Park, Yun-Sik Eom, Tae-Hyung Kim

“…The sustained release patterned array holds potential for constructing advanced therapeutic and disease state in vitro cellular models.…”
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Improving systemic delivery of oncolytic virus by cellular carriers by Ziyi Peng, Muhammad Kalim, Yong Lu

“…Despite promising potential, OVT faces critical challenges, including insufficient tumor-specific targeting, which results in limited tumor penetration and variability in therapeutic efficacy. These challenges are particularly pronounced in solid tumors with complex microenvironments and heterogeneous vascularization. …”
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Beneficial effects of baicalein on a model of allergic rhinitis by Liu Tao, Xu Jing, Wu Yungang, Li Xiaoxia, Ding Detao, Ma Dengdian, Yao Mengwei, Wei Wenzhong, Zhang Wei, Wang Shaohua, Yao Jing, Li Xiaoyu

“…In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.…”
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A qualitative analysis of the psychedelic mushroom come-up and come-down by Ari Brouwer, Joshua K. Brown, Earth Erowid, Fire Erowid, Sylvia Thyssen, Charles L. Raison, Robin L. Carhart-Harris

“…Focusing on psilocybin or psilocybin-containing mushroom experience reports submitted to Erowid.org, we use phenomenological, thematic content and word frequency analysis to show that the come-up is more often characterized by negatively valenced feeling states that resemble an acute stress reaction, while the come-down phase is more often characterized by positively valenced feeling states of the sort often observed following recovery from illness or resolution of stress. The therapeutic and theoretical relevance of these findings are discussed.…”
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The Role of Noncoding RNA in Airway Allergic Diseases through Regulation of T Cell Subsets by Shenghao Cheng, Qingping Tang, Shaobing Xie, Sihui Wen, Hua Zhang, Zhihai Xie, Weihong Jiang

“…This article reviews the current state of understanding of the role of noncoding RNAs in airway allergic diseases, highlights the limitations of recent studies, and outlines the prospects for further research to facilitate the clinical translation of noncoding RNAs as therapeutic targets and biomarkers.…”
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Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports by Jeffrey Thomas, Leonard J. Soloniuk, Chris Mehdizadeh, Peter Cheng, Ashish Sinha

“…These cases underscore the need for exploring novel therapeutic options, especially in obstetric patients where safe and prompt relief is essential for maternal and newborn well-being. …”
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Catecholaminergic dysfunction drives postural and locomotor deficits in a mouse model of spinal muscular atrophy by John G. Pagiazitis, Nicolas Delestrée, Leonie Sowoidnich, Nandhini Sivakumar, Christian M. Simon, Athanasios Chatzisotiriou, Maria Albani, George Z. Mentis

“…These findings uncover the synaptic and cellular mechanisms responsible for the postural and motor symptoms in SMA and identify catecholaminergic neuromodulation as a potential therapeutic target.…”
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Treatment of Thoracolumbar Spinal Infections through Anterolateral Approaches Using Expandable Titanium Mesh Cage for Spine Reconstruction by Tarantino Roberto, Marruzzo Daniele, Cappelletti Martina, De Giacomo Tiziano, Delfini Roberto

“…This study was undertaken in order to identify the correct diagnostic and therapeutic treatment needed in such cases. From the cases studied here, it is evident that spinal infections can be extremely insidious and that diagnosis tends to be reached late. …”
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Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation by Takao Yogo, Hans Jiro Becker, Takaharu Kimura, Satoshi Iwano, Takahiro Kuchimaru, Atsushi Miyawaki, Tomomasa Yokomizo, Toshio Suda, Atsushi Iwama, Satoshi Yamazaki

“…Human universal exCMPs have the potential to be a viable therapeutic enhancement for all HSC transplant patients.…”
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A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease by Qin Shen, Yongjie Jiang, Jing Chen, Xueling Wang, Jiao Zheng

“…The dry powder inhaler is a new form of drug delivery that is widely used as an alternative to traditional drug delivery methods, addressing the shortcomings of traditional drug delivery methods and obtaining better therapeutic results. This mode of delivery is also one of the most rational ways to treat pulmonary diseases such as chronic obstructive pulmonary disease (COPD). …”
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