Fingolimod exerts in vitro anticancer activity against hepatocellular carcinoma cell lines via YAP/TAZ suppression by Du Jiamin, Qian Meijia, Yuan Tao, Zhang Bo, Chen Xueqin, An Ning, He Qiaojun, Yang Bo, Ye Song, Zhu Hong

“…Overall, our current study not only identifies fingolimod as a novel YAP-targeting in hibitor, but also indicates that this clinically-approved drug could be utilized as a potential and feasible therapeutic drug for HCC.…”
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Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility by Maurizio Vitti, Giovanna Di Emidio, Michela Di Carlo, Gaspare Carta, Andrea Antonosante, Paolo Giovanni Artini, Annamaria Cimini, Carla Tatone, Elisabetta Benedetti

“…In the present review, we discuss the recent evidence about PPARs expression in the hypothalamic-pituitary-gonadal axis and their involvement in female reproduction. Finally, the therapeutic potential of their manipulation through several drugs is also discussed.…”
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The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? by Sonja S. Mojsilovic, Slavko Mojsilovic, Victor H. Villar, Juan F. Santibanez

“…Also, new macrophage-based cell therapeutic technologies recently developed using chimeric antigen receptor bioengineering are exposed, which may overcome all solid tumor physical barriers impeding the current adoptive cell therapies and contribute to developing novel cancer immunotherapies.…”
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Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway by Xiaoqiong Duan, Yujuan Guan, Yujia Li, Shan Chen, Shilin Li, Limin Chen

“…All these findings may contribute to the development of novel anti-HCV therapeutic strategies although the antiviral mechanism needs to be further investigated.…”
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Pharmacological inhibition of carbonic anhydrases with a positively charged pyridinium sulfonamide phenocopies the neuroprotective effects of Car9 genetic ablation in a murine sett... by Sara Amiranda, Mariangela Succoio, Serenella Anzilotti, Ornella Cuomo, Tiziana Petrozziello, Valentina Tedeschi, Arianna Finizio, Giorgia Mele, Seppo Parkkila, Lucio Annunziato, Giuseppina De Simone, Giuseppe Pignataro, Agnese Secondo, Nicola Zambrano

“…These findings suggest carbonic anhydrases as potential therapeutic targets for treating pH-associated disorders, including cerebral ischemia, to mitigate hypoxia- and reoxygenation-induced neuronal damage. …”
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Human stem cell models for Marfan syndrome: a brief overview of the rising star in disease modelling by Jeffrey Aalders, Laura Muiño Mosquera, Laura Muiño Mosquera, Jolanda van Hengel

“…The use of pluripotent stem cells will help to uncover disease mechanisms and to identify new therapeutic strategies in Marfan syndrome.…”
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The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability by Tiewei Li, Xiaojuan Li, Yichuan Feng, Geng Dong, Yuewu Wang, Junmei Yang

“…All of these results suggest that MMP-9 may be a useful predictive biomarker for vulnerable atherosclerotic plaques, as well as a therapeutic target for preventing atherosclerotic plaque instability. …”
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Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems by Matteo Perra, Ines Castangia, Matteo Aroffu, Federica Fulgheri, Rita Abi-Rached, Maria Letizia Manca, Hernán Cortés, María Luisa Del Prado-Audelo, Carla Nomura-Contreras, Alejandra Romero-Montero, Dietrich Büsselberg, Gerardo Leyva-Gómez, Javad Sharifi-Rad, Daniela Calina

“…Ongoing research aims to enhance the safety and efficacy of AMCs, integrate nanotechnology for drug delivery, and identify novel therapeutic targets. These advancements hold potential to transform maytansinoid-based cancer treatments in the future.…”
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AI‐Powered Multimodal Modeling of Personalized Hemodynamics in Aortic Stenosis by Caglar Ozturk, Daniel H. Pak, Luca Rosalia, Debkalpa Goswami, Mary E. Robakowski, Raymond McKay, Christopher T. Nguyen, James S. Duncan, Ellen T. Roche

“…High‐fidelity preclinical models can improve AS management by enabling therapeutic innovation, early diagnosis, and tailored treatment planning. …”
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Myenteric Denervation of the Gut with Benzalkonium Chloride: A Review of Forty Years of an Experimental Model by Sérgio Britto Garcia, Stefânia Bovo Minto, Isabela de Souza Marques, Vinicius Kannen

“…Promising reports in the literature have shed light on the possibilities for the development of new uses of the BAC-denervation experimental model as a therapeutic tool in some pathological situations. This review aims to shed light on the main historical and recent findings provided by this experimental model.…”
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Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications by Hai Jiang, Ranil Vikraman Kumarasamy, JinJin Pei, Kamaraj Raju, Gopalakrishnan Velliyur Kanniappan, Chella Perumal Palanisamy, Ion Dan Mironescu

“…Extracellular vesicles (EVs), natural membrane-bound structures released by cells, offer a promising platform for precise and targeted delivery of therapeutic payloads, including drugs and nanoparticles. …”
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Elucidating the Role of the T Cell Receptor Repertoire in Myelodysplastic Neoplasms and Acute Myeloid Leukemia by Georgios Petros Barakos, Vasileios Georgoulis, Epameinondas Koumpis, Eleftheria Hatzimichael

“…These insights could guide patient stratification and treatment selection, ultimately improving therapeutic outcomes in MDS and AML.…”
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Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold by J. M. Keppel Hesselink, Tineke de Boer, Renger F. Witkamp

“…Research on PEA has been conducted for more than 50 years, and over 350 papers are referenced in PubMed describing the physiological properties of this endogenous modulator and its pharmacological and therapeutical profile. The major focus of PEA research, since the work of the Nobel laureate Levi-Montalcini in 1993, has been neuropathic pain states and mast cell related disorders. …”
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Role of MicroRNA in Governing Synaptic Plasticity by Yuqin Ye, Hongyu Xu, Xinhong Su, Xiaosheng He

“…Understanding of the way in which miRNAs contribute to synaptic plasticity provides rational clues in establishing the novel therapeutic strategy for plasticity-related diseases.…”
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The mitochondria as an emerging target of self-renewal in T-cell acute lymphoblastic leukemia by Majd A. Al-Hamaly, Evelyn Winter, Jessica S. Blackburn

“…Mitochondria have been recognized as a therapeutic vulnerability for cancer stem cells, including LSCs. …”
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Laser-Based Propagation of Human iPS and ES Cells Generates Reproducible Cultures with Enhanced Differentiation Potential by Kristi A. Hohenstein Elliott, Cory Peterson, Anuradha Soundararajan, Natalia Kan, Brandon Nelson, Sean Spiering, Mark Mercola, Gary R. Bright

“…Adoption of standardized protocols would allow researchers to understand the role of genetics, environment, and/or procedural effects on stem cells and would ensure reproducible production of stem cell cultures for use in clinical/therapeutic applications.…”
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Goji berry (Lycium barbarum) has positive effects on the mucosa and colonic myoenteric innervation of obese rats by Samara Cristina Dossena, Isabela Ramos Mariano Furlan, Maria Montserrat Diaz Pedrosa, Rosângela Fernandes Garcia, Fernando Carlos de Sousa, Maria Raquel Marçal Natali

“…The use of the Goji berry extract had therapeutic effect on the obese animals (group OGB), decreasing body mass and mesenteric fat and increasing HDL cholesterol. …”
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Inraoperative and Histological Visualization of Disrupted Vulnerable Plaques following Diagnostic Angiography of Moderate Carotid Stenosis by Tatsushi Mutoh, Tatsuya Ishikawa, Akifumi Suzuki, Nobuyuki Yasui

“…A 64-year-old man diagnosed to have a 60% right carotid stenosis received diagnostic DSA for therapeutic decision-making. He developed transient left hand numbness and weakness immediately after the procedure. …”
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Circulating LncRNA Is Potentially Up-regulated in Coronary Artery Disease by Niloofar Avazpour, Mohammadreza Hajjari, Saeed Yazdankhah, Azita Sahni, Ali Mohammad Foroughmand

“…Recent research on the role of the HOTAIR in cardiovascular disease lays the basis for the development of new studies considering this lncRNA as a potential biomarker and therapeutic target in CAD. In this study, we aimed to compare the expression of HOTAIR lncRNA in the blood samples of patients with CAD and control samples. …”
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Dopamine Agonists and Pathologic Behaviors by Brendan J. Kelley, Andrew P. Duker, Peter Chiu

“…These observations suggest the D3 receptor as a therapeutic target for obsessive-compulsive disorder and substance abuse, and improved understanding of D3 receptor function may aid drug design of future atypical antipsychotics.…”
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