Importins and Exportins Regulating Allergic Immune Responses by Ankita Aggarwal, Devendra K. Agrawal

“…We also critically review the role and regulation of specific importin and exportin involved in the transport of activated transcription factors in allergic diseases, the underlying molecular mechanisms, and the potential target sites for developing better therapeutic approaches.…”
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Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma by Siu Ying Angel Nip, Kam Lun Hon, Wing Kwan Alex Leung, Alexander K. C. Leung, Paul C. L. Choi

“…We report a rare case of a male infant with neonatal hemangiomatosis with diffuse peritoneal involvement, which mimicked a malignant-looking tumor on imaging, and discuss therapeutic options and efficacy. Propranolol is efficacious for IH but generally not useful for other forms of vascular hemangiomas, tumors, and malformations. …”
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From Trauma to Resilience: A Comprehensive Review of Counseling and Intervention Methods for PTSD by Ade Rahayu Suhartat, Deasy Amaliyah Putri, Muhammad Haikal Basyari, Naeila Rifatil Muna

“…Utilizing a Library Research methodology, the study examines existing literature to identify gaps in age-specific interventions, the application of therapeutic approaches in non-clinical settings, and the role of family involvement in recovery. …”
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Beyond the usual challenges, a case of LV summit PVCs ablation in child with ASO for D-TGA by Mahmoud Abdelfattah, Eslam Ahmed, Ahmed Nasr, Mostafa El Husseny, Omnia Kamel

“…While often asymptomatic, PVCs can sometimes lead to palpitations, dyspnea, and hemodynamic compromise, requiring therapeutic intervention. The arterial switch operation is the preferred treatment for D-TGA, but these patients have a 2% incidence of ventricular arrhythmias and 1% incidence of sudden cardiac death post-operatively. …”
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TNF Tolerance in Monocytes and Macrophages: Characteristics and Molecular Mechanisms by René Huber, Rolf Bikker, Bastian Welz, Martin Christmann, Korbinian Brand

“…An improved understanding of TNF tolerance will presumably facilitate the implementation of diagnostic or therapeutic approaches to more precisely assess and treat inflammation-related diseases.…”
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Cell Therapy for Retinal Dystrophies: From Cell Suspension Formulation to Complex Retinal Tissue Bioengineering by Karim Ben M’Barek, Christelle Monville

“…Depending on the nature of the primary defect and the stage of the disease, RPE cells, PRs, or both might be transplanted to achieve therapeutic effects. We describe in this review the current knowledge and recent progress to develop such approaches. …”
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The PPARδ Ligand GW501516 Reduces Growth but Not Apoptosis in Mouse Inner Medullary Collecting Duct Cells by Jordan Clark, Rania Nasrallah, Richard L. Hébert

“…These results show that a PPARδ ligand inhibits growth but does not affect anisomycin-apoptosis in a mouse IMCD cell line. This could have therapeutic implications for renal diseases associated with increased CD growth responses.…”
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The effect of the Wnt pathway on the osteogenic differentiation of periodontal ligament stem cells in different environments by Qi Su, Fengqiong Huang, XiuLei Fang, Qiang Lin

“…This knowledge aids in influencing the pathway through bioengineering or the development of novel materials, thereby enhancing the osteogenic potential of stem cells and providing new diagnostic and therapeutic strategies for clinical practice.…”
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Mechanistic insights into vascular biology via methyltransferase-like 3-driven N6-adenosine methylation of RNA by Deshuang Zhang, Deshuang Zhang, Zhixian Gou, Yi Qu, Xiaojuan Su

“…Conversely, aberrant METTL3 activity is implicated as a risk factor, diagnostic biomarker, and therapeutic target for vascular pathologies. This comprehensive review offers an exhaustive synthesis of METTL3’s role in vascular biology, addressing existing knowledge gaps and serving as an essential reference for future research and potential clinical applications.…”
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Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases by Muneo Yamaguchi, Shintaro Nakao, Mitsuru Arima, Iori Wada, Yoshihiro Kaizu, Feng Hao, Shigeo Yoshida, Koh-hei Sonoda

“…The importance of ROCK in pathological vitreoretinal conditions has also been elucidated and is attracting attention as a potential therapeutic target. ROCK is involved in angiogenesis and hyperpermeability and also in the pathogenesis of various pathologies such as inflammation and fibrosis. …”
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Importance of Modulating Kynurenic Acid Metabolism—Approaches for the Treatment of Dementia by Halina Baran, Marcelin Jan Pietryja, Berthold Kepplinger

“…The discovery of new compounds with the ability to block kynurenine aminotransferases opens new therapeutic avenues for the treatment of memory impairment and dementia. …”
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GutBugDB: a web resource to predict the human gut microbiome-mediated biotransformation of biotic and xenobiotic molecules by Usha Longwani, Ashok K. Sharma, Aditya S. Malwe, Shubham K. Jaiswal, Vineet K. Sharma

“…The determination of species-specific contributions to the metabolism of biotic and xenobiotic molecules has the potential to aid in the development of new therapeutic and nutraceutical molecules that can modulate human gut microbiota. …”
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Intractable Posterior Epistaxis due to a Spontaneous Low-Flow Carotid-Cavernous Sinus Fistula: A Case Report and a Review of the Literature by A. Giotakis, F. Kral, H. Riechelmann, M. Freund

“…We also emphasize the significance of the radiological diagnostic and therapeutic procedures in the management of posterior epistaxis due to pathology of the cavernous sinus. …”
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Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung by William J. Mach, Amanda R. Thimmesch, J. Thomas Pierce, Janet D. Pierce

“…Oxygen (O2) is life essential but as a drug has a maximum positive biological benefit and accompanying toxicity effects. Oxygen is therapeutic for treatment of hypoxemia and hypoxia associated with many pathological processes. …”
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Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects by Yelei Guo, Yao Wang, Weidong Han

“…Importantly, we will suggest improvements that could increase the therapeutic effectiveness of CART cells for solid tumors and their future clinical applications. …”
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Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments by Elizaveta Vinogradova, Zharkyn Jarmukhanov, Madiyar Nurgaziyev, Alibek Kossumov, Ayaulym Nurgozhina, Nurislam Mukhanbetzhanov, Shynggys Sergazy, Laura Chulenabyeva, Argul Issilbayeva, Sholpan Askarova, Aiym Kaiyrlykyzy, Saule Rakhimova, Ulan Kozhamkulov, Ulykbek Kairov, Zhanagul Khassenbekova, Dinar Tarzhanova, Ainur Akilzhanova, Joseph H. Lee, Joseph Terwilliger, Aliya Sailybayeva, Makhabbat Bekbossynova, Zhaxybay Zhumadilov, Samat Kozhakhmetov, Almagul Kushugulova

“…This finding confirms a complex interplay between the gut microbiome, host metabolism, and cognitive health, highlighting the potential significance of targeting Enterococcus dysbiosis in future preventive and therapeutic strategies to address VitD deficiency-related memory impairments. …”
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Central nervous system involvement in Whipple's disease: Report of a rare pathological entity and comparative review of treatment strategies and outcomes by Moustafa A. Mansour, MD, MSc, MPhil, Reem W. Malaeb, BS, Islam E. Elnemr, MD, Mohamed Abdel-Fattah El-Salamoni, MD, Hamdi Nabawi Mostafa, MD, Zarina Ahmadi, MD

“…Whipple's disease, caused by the gram-positive actinomycete Tropheryma whipplei, is a rare chronic systemic illness with significant diagnostic and therapeutic challenges, particularly when the CNS is involved. …”
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SOD1 Transcriptional and Posttranscriptional Regulation and Its Potential Implications in ALS by Pamela Milani, Stella Gagliardi, Emanuela Cova, Cristina Cereda

“…Considering that changes in SOD1 mRNA levels have been associated with sporadic ALS (SALS), a molecular understanding of the processes involved in the regulation of SOD1 gene expression could not only unravel novel regulatory pathways that may govern cellular phenotypes and changes in diseases but also might reveal therapeutic targets and treatments. This review seeks to provide an overview of SOD1 gene structure and of the processes through which SOD1 transcription is controlled. …”
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Lipid Rafts in Signalling, Diseases, and Infections: What Can Be Learned from Fluorescence Techniques? by Sara Anselmo, Elisa Bonaccorso, Chiara Gangemi, Giuseppe Sancataldo, Valeria Conti Nibali, Giovanna D’Angelo

“…The findings emphasize the pivotal role of lipid rafts in health and disease, providing a foundation for future research and potential therapeutic interventions.…”
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Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma by Tatsuya Morinishi, Yasunori Tokuhara, Hiroyuki Ohsaki, Emi Ibuki, Kyuichi Kadota, Eiichiro Hirakawa

“…These findings indicate that activation of PPAR-α may be involved in anticancer effects in colorectal carcinomas, and nuclear expression of PPAR-α may be a therapeutic target for colorectal adenocarcinoma treatment.…”
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