The N17 domain of huntingtin as a multifaceted player in Huntington’s disease by Hyunju Cho

“…This review summarizes the four main roles of the N17 domain in regulating HD pathology and discusses potential therapeutic approaches targeting this N17 domain to mitigate HD progression.…”
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Study of the Use of Antinematode Drugs, Mebendazole and Pyrantel, in Galicia (Spain) from 2016 to 2020 by S. Vázquez- Prieto, A. Vaamonde, E. Paniagua

“…The main consequence of the excessive use of this drug compared to pyrantel may be the increased risk of the development of resistance and of therapeutic failure, as well as the consequent limitation of pharmacological options in the future.…”
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Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment by Loh Teng-Hern Tan, Pendru Raghunath, Long Chiau Ming, Jodi Woan-Fei Law

“…This article aims to provide a general overview and comparisons between the pathogenesis, diagnosis, prevention and therapeutic strategies for M. ulcerans and M. marinum. …”
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Phage Therapy -- Everything Old Is New again by Andrew M Kropinski

“…Western science is now having to re-evaluate the application of phage therapy -- a therapeutic modality that never went out of vogue in Eastern Europe -- because of the emergence of an alarming number of antibiotic-resistant bacteria. …”
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Innovative IOP-Independent Neuroprotection and Neuroregeneration Strategies in the Pipeline for Glaucoma by James C. Tsai

“…While sustained reduction of intraocular pressure (IOP) has been shown to halt and/or delay the progressive death of retinal ganglion cells (RGCs) in glaucoma, there exists great interest in the development and validation of IOP-independent therapeutic strategies for neuroprotection and/or neuroregeneration. …”
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Evaluating the effectiveness of the rehabilitation program for treating the anterior cruciate ligament (ACL) in team sport athletes" (Football - Basketball - Handball) by Hassan Saad Shallak, Abbas Zaki Abdul Hussein, Ali Sabah Nouri, Lamyaa Hassan Mohammed Al-Diwan

“…The sample was divided into two groups: one group underwent surgical rehabilitation after ACL reconstruction surgery, and another group underwent non-surgical rehabilitation through specialized therapeutic exercises. The researchers concluded that the study showed that surgical rehabilitation for ACL injuries was more effective in improving range of motion, reducing pain, and increasing muscle strength compared to non-surgical treatment. …”
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Relationship between programmed cell death and targeted therapy for thyroid cancer in patients with a poor prognosis: an update by Yuejia Zhao, Simeng Zhao, Zhe Fan, Yongfu Zhao, Guangzhi Wang

“…We also provide an outlook on future treatments for drug-resistant thyroid cancer, poorly differentiated thyroid cancer, and iodine-refractory thyroid cancer, aiming to accurately identify targets and offer effective targeted therapeutic strategies.…”
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Repeated Intra-Arterial Thrombectomy within 72 Hours in a Patient with a Clear Contraindication for Intravenous Thrombolysis by Mona Laible, Markus Möhlenbruch, Werner Hacke, Martin Bendszus, Peter Arthur Ringleb, Timolaos Rizos

“…Treating patients with acute ischemic stroke, proximal arterial vessel occlusion, and absolute contraindication for administering intravenous recombinant tissue plasminogen activator (rtPA) poses a therapeutic challenge. Intra-arterial thrombectomy constitutes an alternative treatment option. …”
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Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions by Michael Mullin, James McClory, Winston Haynes, Justin Grace, Nathan Robertson, Gino van Heeke

“…The development of bispecific antibodies that bind at least two different targets relies on bringing together multiple binding domains with different binding properties and biophysical characteristics to produce a drug-like therapeutic. These building blocks play an important role in the overall quality of the molecule and can influence many important aspects from potency and specificity to stability and half-life. …”
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Current Concepts on Gastric Carcinoid Tumors by George C. Nikou, Theodoros P. Angelopoulos

“…Moreover, the introduction of somatostatin analogues could represent another therapeutic option.…”
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Neurological Crisis Following Intravenous Ozone Therapy; a Case Report by Chloe Y Y Wong, Komal Saxena, John Meneer, Koshy George, Gerben Keijzers

“… Ozone therapy, often marketed as an immune-boosting alternative treatment, lacks robust evidence of efficacy and poses significant safety risks. Despite claims of therapeutic benefits, Regulatory agencies, such as the U.S. …”
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Late Onset Combined Immunodeficiency Presenting with Recurrent Pneumocystis jiroveci Pneumonia by Ilias Papakonstantinou, Ioannis G. Baraboutis, Lazaros Karnesis

“…Phenomena of immune reconstitution are described in various settings, including primary immunodeficiency, manifesting as temporary clinical and radiologic deterioration and leading to misperceptions of therapeutic failure and/or presence of alternative/additional diagnoses.…”
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Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury by Mariusz Sieminski, Michalina Reimus, Maria Kałas, Ewelina Stępniewska

“…Due to these properties, it is very reasonable to consider melatonin as a potential therapeutic molecule for TBI treatment. This review summarizes data from in vitro studies, animal models, and clinical trials that focus on the usage of melatonin in TBI.…”
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The role of Nrf2 transcription factors in various physiological and pathological states by Deasyka Yastani, Sri Widia A Jusman

“…Understanding Nrf2's diverse functions offers valuable insights into disease pathogenesis and potential therapeutic approaches. This review explores the pleiotropic role of Nrf2 regulation. …”
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Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis by Rahul Kumar, Jane Z. Spadaro, Jane Z. Spadaro, Alon Kahana, Alon Kahana, Alon Kahana

“…Complete surgical excision is therapeutic and allows for diagnostic confirmation. …”
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Application of machine learning techniques for warfarin dosage prediction: a case study on the MIMIC-III dataset by Aasim Ayaz Wani, Fatima Abeer

“…Warfarin, a commonly prescribed anticoagulant, poses significant dosing challenges due to its narrow therapeutic range and high variability in patient responses. …”
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Xeno-Free Strategies for Safe Human Mesenchymal Stem/Stromal Cell Expansion: Supplements and Coatings by M. Cimino, R. M. Gonçalves, C. C. Barrias, M. C. L. Martins

“…However, regulatory guidelines encourage novel xeno-free alternatives to define safer and standardized protocols for hMSC expansion that preserve their intrinsic therapeutic potential. Since hMSCs are adherent cells, the attachment surface and cell-adhesive components also play a crucial role on their successful expansion. …”
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Effect of a Complex Korean Medicine Treatment in a Patient with Chronic Ischemic Stroke Who Developed Neurological Complications after Posterior Lumbar Interbody Fusion: A Case Rep... by Shin-Hyeok Park, Sohae Cho, HyunSeung Lee, Jieun Kim, Nam Geun Cho

“…The recovery rates dramatically decline in the chronic phase (6 months post-onset), making it difficult to achieve meaningful therapeutic effects. Posterior lumbar interbody fusion (PLIF) is used to correct deformities in spinal disorders, but it can induce chronic radiculopathy, necessitating prolonged treatment. …”

Research progress on clinical application of fire dragon moxibustion (火龙灸临床应用的研究进展) by WANG Pu (王璞), WU Qiaomei (吴巧媚), LIU Yu (刘宇), XU Jianying (徐健莹), CHEN Lijia (陈莉佳), GUAN Lijuan (关丽娟)

“…Fire dragon moxibustion, as one type of sandwiched moxibustion, has advantages of larger area of moxibustion, bigger moxa, stronger heating power and therapeutic effect compared with other types of moxibustion. …”
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A Rare Case of Elbow Synovial Cyst with Radial Nerve Compression by Ting-Hsuan Hsu, Yen-Nung Lin

“…This advanced imaging capability not only effectively facilitated an accurate diagnosis but also enabled a targeted therapeutic intervention, thereby avoiding extensive surgical procedures and reducing the risk of nerve injury.…”
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