Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regul... by Weisheng Hu, Yinlan Wang, Yingjie Zhou, Junbao Shi, Zengyan Li, Xiaoling Jiang, Qinyuan Wu, Changming Zhong, Huilan Weng, Sijie Ouyang, Yuan Jing, Xianxiang Cai, Mingda Ye, Ning Huang

“…An AD mouse model induced by DNCB was established to evaluate Lithospermum erythrorhizon oil's therapeutic efficacy, its influence on inflammatory markers, and the PI3K-Akt pathway. …”
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The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib by Jing Zhang, Zequn Wang, Xihua Wei, Mengyuan Han, Ribai Yan, Lijie Ma, Yan Pan

“…Despite significant advancements in therapeutic strategies and a deeper understanding of targeted therapies in recent years, tumor resistance remains an inevitable challenge, leading to poor prognostic outcomes. …”
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Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness by Nan Wang, Nan Wang, Nan Wang, Yifang He, Sipeng Zhu, Dongsheng Liu, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Jianghong He, Jingqi Li, Juanning Si, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

“…By providing real-time feedback on cortical activation, fNIRS facilitates optimizing therapeutic strategies and supports individualized treatment planning. …”
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uN2CpolyG-mediated p65 nuclear sequestration suppresses the NF-κB-NLRP3 pathway in neuronal intranuclear inclusion disease by Yu Shen, Kaiyan Jiang, Dandan Tan, Min Zhu, Yusen Qiu, Pencheng Huang, Wenquan Zou, Jianwen Deng, Zhaoxia Wang, Ying Xiong, Daojun Hong

“…This mechanism highlights a novel therapeutic target for NIID and provides potentially broader insights into similar mechanisms in other neurodegenerative diseases characterized by misfolded protein aggregates.…”
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Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects by Ada Alice Dona, Theophilus Tandoh, Lokesh Nigam, Mahmoud Singer, Enrico Caserta, Mariam Murtadha, Yinghui Zhu, Milad Moloudizargari, Preeti Sharma, Ottavio Napolitano, Janet Winchester, Arnab Chowdhury, Alex Pozhitkov, James F. Sanchez, Hawa Vahed, Guido Marcucci, Matt Coffey, Gerard Nuovo, Douglas W. Sborov, Flavia Pichiorri, Craig C Hofmeister

“…The combination with proteasome inhibitors (PIs) has shown to enhance RV therapeutic activity, but the mechanisms of action have not been fully elucidated. …”
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Effects of plant active substances in rheumatoid arthritis—a systematic review and network meta-analysis by Qiuwei Peng, Jian Wang, Kesong Li, Congming Xia, Chuanhui Yao, Qiuyan Guo, Xun Gong, Xiaopo Tang, Quan Jiang

“…We performed data analysis using StataMP 15.1 software and ranked the therapeutic effects based on the Surface Under the Cumulative Ranking Curve (SUCRA) probability values.ResultsBased on screening procedures, 18 eligible studies were incorporated into the analysis. …”
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Shi-Zhen-An-Shen Decoction, a Herbal Medicine That Reverses Cuprizone-Induced Demyelination and Behavioral Deficits in Mice Independent of the Neuregulin-1 Pathway by Chao Ma, Yan Wu, Xinyao Liu, Yi He, Yuan Jia, Pei Chen, Dongqing Yin, Yanzhe Ning, Guoqiang Xing, Zuoli Sun, Hongxiao Jia

“…The QTP and medium-dose SZASD resulted in better therapeutic effects compared to the low and high SZASD doses. …”
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Tenofovir and Doravirine Are Potential Reverse-Transcriptase Analogs in Combination with the New Reverse-Transcriptase Translocation Inhibitor (Islatravir) Among Treatment-Experien... by Alex Durand Nka, Yagai Bouba, Wilfried Rooker Tsapi Lontsi, Davy-Hyacinte Gouissi Anguechia, Georges Teto, Aude christelle Ka’e, Ezechiel Ngoufack Jagni Semengue, Collins Ambe Chenwi, Désiré Takou, Lum Forgwei, Tatiana Anim-Keng Tekoh, Aurelie Minelle Kengni Ngueko, Bernadette Bomgning Fokou, Jeremiah Efakika Gabisa, Michel Carlos Tommo Tchouaket, Willy Leroi TognaPabo, Derrick Tambe Ayuk Ngwese, Jacky Njiki Bikoi, Daniele Armenia, Vittorio Colizzi, Marcel Yotebieng, Nicaise Ndembi, Maria-Mercedes Santoro, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Alexis Ndjolo, Joseph Fokam

“…Although ISL is a long-acting antiretroviral, it will provide other therapeutic options in combination with other reverse transcriptase inhibitors that remain effective. …”
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A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer by Shuailei Dong, Chen Wei, Xueting Wang, Xinyi Yang, Wei Shen, Shuyi Li, Jiye Xu, Yijie Ma, Liangyu Bie, Wenyue Yu, Ning Li

“…Abstract Novel therapeutic agents including disitamab vedotin (RC48, an antibody-drug conjugate) and immune-checkpoint inhibitors (e.g., PD-1 inhibitors) have provided new hope as an advanced gastric-cancer (GC) treatment. …”
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Autophagy in Inflammatory Diseases by Alexander J. S. Choi, Stefan W. Ryter

“…Strategies aimed at modulating autophagy may lead to therapeutic interventions for diseases associated with inflammation.…”
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Unveiling the complex double-edged sword role of exosomes in nasopharyngeal carcinoma by Xueyan Huang, Yuedi Tang

“…Exosomes could serve as biomarkers and therapeutic agents, as well as the molecular mechanisms by which they promote cell growth, angiogenesis, metastasis, immunosuppression, radiation resistance, and chemotherapy resistance in NPC. …”
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Research Progress on Mesenchymal Stem Cells for the Treatment of Diabetes and Its Complications by Jiarui Zhang, Yongqin Zheng, Lichenlu Huang, Jundong He

“…In conclusion, MSCs have shown superior potential for use in the treatment of DM and its complications and will hopefully become a novel therapeutic approach in the future.…”
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Benefits from Long-Term Treatment in Irritable Bowel Syndrome by Stefano Evangelista

“…IBS patients should receive, as initial therapeutic approach a short course of treatment which, if effective, has the additional value of confirming the diagnosis. …”
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The Auto/biographical Nature of Ukrainian Women’s Literature on the War in Donbas by Anna Gaidash

“…In the close reading of Natal’ya Vorozhbit’s drama Bad Roads (2017), Yevgeniya Podobna’s book of stories and memoirs titled Girls Cutting Their Locks (2018), and Tamara Duda’s novel Daughter (2019), the author of the article examines the relations between subject and object of the Donbas war texts in the framework of their creation, auto/biographic nature, gender optics, and therapeutic effect. The goal of the study is to analyze how auto/biographical narratives employ actualization of life, leading to the fictionalization of drama and prose texts, which results in heterobiography or synthesis of auto/biographical narratives with heterobiographies. …”
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Gold Nanorods Targeted to Delta Opioid Receptor: Plasmon-Resonant Contrast and Photothermal Agents by Kvar C. Black, Nathaniel D. Kirkpatrick, Timothy S. Troutman, Liping Xu, Josef Vagner, Robert J. Gillies, Jennifer K. Barton, Urs Utzinger, Marek Romanowski

“…The molecularly targeted nanorods can be used as an in vitro ligand-binding and cytotoxic treatment assay platform and could potentially be applied in vivo for diagnostic and therapeutic purposes with endoscopic technology.…”
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Classifying Lupus Nephritis: An Ongoing Story by Saba Kiremitci, Arzu Ensari

“…The role of the renal biopsy in lupus nephritis is to provide the diagnosis and to define the parameters of prognostic and therapeutic significance for an effective clinicopathological correlation. …”
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Understanding the Pathogenesis of Angelman Syndrome through Animal Models by Nihar Ranjan Jana

“…This paper mainly discusses various animal models of AS and how these models provide fundamental insight into understanding the disease biology for potential therapeutic intervention.…”
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Blood glucose response to kratom tea (Mitragyna speciosa Korth.) by Fadly Dzul

“…Studying its effects on blood glucose is crucial for validating its therapeutic potential. Objective: This study evaluated the blood glucose response to kratom tea from West Kalimantan, Indonesia. …”
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Focal Bronchiectasis Causing Abnormal Pulmonary Radioiodine Uptake in a Patient with Well-Differentiated Papillary Thyroid Carcinoma by Ash Gargya, Elizabeth Chua

“…Recognition of potential false-positive chest radioactive iodine uptake, simulating pulmonary metastases, is needed to avoid unnecessary exposure to further radiation from repeated therapeutic doses of radioactive iodine.…”
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A Case of New-Onset Obsessive-Compulsive Disorder and Schizophrenia in a 14-Year-Old Male following the COVID-19 Pandemic by Daniel Bibawy, Jennyferd Barco, Yeghia Sounboolian, Priya Atodaria

“…The novelty of this case lies in the onset of the patient’s symptoms in the context of the COVID-19 pandemic, without prior predisposing risks in the environmental, social, or biological aspects. We provided therapeutic treatment to the patient in an inpatient setting, while examining the patient to decipher the root cause of his symptoms. …”
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