Evaluation of Stature Development During Childhood and Adolescence in Individuals with Familial Hypophosphatemic Rickets by Mauro M.S. Borghi, Veronica Coates, Hatim A. Omar

“…Article selection was done by comparing the evaluation of the growth in patients with familial hypophosphatemic rickets, including the variables that might affect them, for possible future therapeutic proposals. It is concluded that the most significant fact in the treatment of familial hypophosphatemic rickets in infancy was the magnitude of the final stature. …”
Get full text

Perceptions and attitudes concerning individuals with disabilities in ancient Greece: physical exercise as a means of prevention and treatment of health-related problems by Iordanis Stavrianos, Vasilios Kaimakamis, Vasilios Tsimaras, Athanasios Anastasiou

“…In the ancient times Greeks made use of physical exercise as a mean for therapeutic as well as prevention purposes against various diseases. …”
Get full text

High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana by Naomi Hauser, Tanmay Sahai, Rocco Richards, Todd Roberts

“…Tacrolimus has a narrow therapeutic index with variable oral bioavailability and metabolism via cytochrome P-450 3A enzyme. …”
Get full text

Recent advances in research on common targets of neurological and sex hormonal influences on asthma by Wenting Zhou, Huan Chen, Xinyu Chen, Jing Gao, Wenting Ji

“…Conclusion We summarize several common important targets in the pathways of action of sex hormones and the nervous system in asthma, provide new directions and ideas for asthma treatment, and discuss current therapeutic limitations and future possibilities. Finally, the article predicts future applications of several important targets in asthma therapy.…”
Get full text

Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage by Diego Alem, César X. García-Laviña, Francisco Garagorry, Dardo Centurión, Joaquina Farias, Hany Pazos-Espinosa, María Noel Cuitiño-Mendiberry, Carolina Villadóniga, Susana Castro-Sowinski, Martín Fló, Federico Carrión, Brenda Iglesias, Kevin Madauss, Lucía Canclini

“…Abstract Despite the current diagnostic and therapeutic approaches to bladder cancer being widely accepted, there have been few significant advancements in this field over the past decades. …”
Get full text

Use of Hyaluronic Acid as Adjuvant in Periodontal Therapy and Healing: a Bibliographic Review by Marcelo Fernando Armijos Briones, Cinthya Lisbeth Sinchiguano Moreano, Coralia de los Ángeles Ortega Medina

“…Perform a synthesis of information on the properties of hyaluronic acid and its use as an adjuvant in the therapy of gingivitis, chronic periodontitis and periodontal healing to verify its therapeutic effect and benefits in the field of dentistry. …”
Get full text

Single-Agent Thalidomide for Treatment of Malignant Paraganglioma of the Organ of Zuckerkandl by Mackenzie L. Shindorf, Prabir K. Chaudhuri

“…The standard of care for benign pheochromocytomas and paragangliomas is surgical resection; however, there is no definitive curative or standard therapy for the treatment of malignant pheochromocytomas or paragangliomas. Current therapeutic options include surgical resection, chemotherapy (CVD therapy), MIBG-radiotherapy, somatostatin analogues, and combination targeted therapies such as temozolomide and thalidomide. …”
Get full text

Novel design of drug delivery in stented arteries:A numerical comparative study by Mario Grassi, Giuseppe Pontrelli, Luciano Teresi, Gabriele Grassi, Lorenzo Comel, Alessio Ferluga, Luigi Galasso

“…Implantation of drug eluting stents following percutaneoustransluminal angioplasty has revealed a well establishedtechnique for treating occlusions caused bythe atherosclerotic plaque.However, due to the risk of vascular re-occlusion,other alternative therapeutic strategiesof drug delivery are currently being investigated.Polymeric endoluminal pave stenting is an emerging technologyfor preventing blood erosion and for optimizing drug release.The classical and novel methodologies are compared througha mathematical model able to predict the evolution ofthe drug concentration in a cross-section of the wall.Though limited to an idealized configuration, the presentmodel is shown to catch most of the relevant aspects ofthe drug dynamics in a delivery system.Results of numerical simulations shows that a bi-layer gel paved stenting guarantees a uniform drug elution anda prolonged perfusionof the tissues, and remains a promising and effective techniquein drug delivery.…”
Get full text

Evaluation of Prognostic Factors Following Flow-Cytometric DNA Analysis after Cytokeratin Labelling: I. Breast Cancer by Pauline Wimberger, Peter Hillemanns, Thomas Kapsner, Hermann Hepp, Rainer Kimmig

“…In gynecologic oncology valid prognostic factors are necessary to estimate the course of disease and to define biologically similar subgroups for analysis of therapeutic efficacy. The presented study is a prospective study concerning prognostic significance of DNA ploidy and S‐phase fraction in breast cancer following enrichment of tumor cells by cytokeratin labelling. …”
Get full text

TILs and Anti-PD1 Therapy: An Alternative Combination Therapy for PDL1 Negative Metastatic Cervical Cancer by Huanhuan Yin, Wei Guo, Xiangling Sun, Ruili Li, Cuihua Feng, Yujie Tan

“…The objective response rate was 25%, whereas the mPFS and mOS were 6.1 and 11.3 months, respectively. The therapeutic efficacy was influenced by the characteristics of TILs, infection with HPV, and development of fever just after the therapy. …”
Get full text

The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus by Ju-El Kim, Jong-Won Lee, Gi Doo Cha, Jeong-Kee Yoon

“…In this review, we will introduce the potential of MSC-derived exosomes for the treatment of DM by discussing the studies that have used MSC-derived exosomes to treat DM, which have shown therapeutic effects in both type 1 and type 2 DM.…”
Get full text

When molecular biology transforms clinical oncology: the EGFR journey in colorectal cancer by Pietro Paolo Vitiello, Nadia Saoudi González, Alberto Bardelli

“…The preclinical and clinical development of agents targeting epidermal growth factor receptor (EGFR) in colorectal cancer (CRC) were accompanied by big hype and hopes, though the clinical testing of such agents clashed with intrinsic and acquired resistance, greatly limiting their therapeutic value. However, a better understanding of the biology of the EGFR signaling pathway in CRC, coupled with the development of liquid biopsy methodologies to study cancer evolution in real time, fostered the clinical refinement of anti‐EGFR treatment in CRC. …”
Get full text

Transdiaphragmatic surgical access by thoracoscopy for epicardial pacemaker implantation in horses by A.R.C. Gomes, A.D. Lorga, L. Strugava, V.L. Bosak, J.C.D. Moreno, P.T. Dornbusch

“…Pacemaker implantation via thoracoscopy and intercostal access is innovative and represents a potential therapeutic novelty in the treatment of horses with severe cardiac arrhythmias.…”
Get full text

Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis by Jong-Chan Jang, Kang Min Lee, Seong-Gyu Ko

“…Collectively, these findings indicate the therapeutic potentials of AAK as an effective complementary or alternative modality for the treatment of ulcerative colitis.…”
Get full text

INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses by Jason Ho, Chelsie Macedo, Garrett Cyprus, Rajay Pandit, Anya Polovina, Nadja Kern, Abrahim Hussain, Sae Jeong Ahn, William Crago, Emily Rowell, Florian J Sulzmaier, John C Timmer, Brendan P Eckelman

“…Despite promising activity in a subset of patients, wider therapeutic utility of IL-2 (aldesleukin) has been hampered by severe dose-limiting toxicities, the expansion of immunosuppressive regulatory T cells and a poor pharmacokinetic (PK) profile. …”
Get full text

A multicenter, cross‐sectional analysis to assess the safety and usage pattern of brivaracetam in the management of partial‐onset seizure with BAEs—BREEZE study: A post‐hoc analysi... by Arvind Sharma, Krishnaprasad Korukonda, Amit Haldar, Usha Kant Misra, R. V. Anand, Yakshdeep Dave, Girish Kulkarni

“…Significance BRV remains a pertinent therapeutic choice for FoS for the treatment naïve and/or BAE cases. …”
Get full text

Exploring lipidome mediated inflammatory pathways in acute pancreatitis using mendelian randomization by Wenbin Liu, Song Yang, Yuhan Li, Dava Tenzing, Ruizi Shi, Yang Jiang, Hao Deng, Enqiang Mao, Ying Chen, Yihui Wang

“…Further studies are warranted to confirm our observations in laboratory models and assess their translational value in developing AP preventive and therapeutic strategies.…”
Get full text

Harnessing the Power of Machine Learning Guided Discovery of NLRP3 Inhibitors Towards the Effective Treatment of Rheumatoid Arthritis by Sidra Ilyas, Abdul Manan, Chanyoon Park, Hee-Geun Jo, Donghun Lee

“…The outcomes obtained can be used to design more potent and selective NLRP3 inhibitors as therapeutic agents for the treatment of inflammatory diseases such as RA. …”
Get full text

Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury by Shijie Yang, Beibei Yu, Qing Zhang, Yongfeng Zhang, Longhui Fu, Bisheng Zhou, Haining Wu, Jianzhong Li, Shouping Gong

“…The modulation of macrophage phenotypes is thus considered a promising therapeutic strategy to mitigate inflammation and promote regeneration. …”
Get full text

Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study by Li X, Liu S, Yu M, Xi W, Wu X, Liu D, Liu A, Wang H

“…It has been successfully applied to the pharmacokinetic studies of PPIs and P-CABs, offering a valuable tool for clinical research and therapeutic drug monitoring.Keywords: acid-suppressing drugs, PPIs, P-CAB, UPLC-MS/MS…”
Get full text