Use of complementary and alternative medicine in head and neck cancer: Salutary or noxious by Nikunj Maniyar, Sachin C. Sarode, Shruti Thakkar, Gargi S. Sarode

“…CAM usage may lead to substantial treatment delays and adverse effects with persistent concerns regarding its efficacy, safety, and potential interactions with conventional treatments, ultimately compromising therapeutic outcomes. Addressing concerns to conventional cancer care and encouraging informed decision-making are critical in ensuring comprehensive and timely interferences for HNC patients. …”
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Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury (TBI) in rats by Cheng Guang, Yue Zhiwei, Wang Liwen, Miyauchi Yutaka, Suzawa Michiko, Li Shiming, Ho Chi‐Tang, Zhao Hui, Chen Naiyao

“…In this study, we explored whether the formatted citrus peel extract gold lotion (GL) could have a therapeutic effect on rats suffered TBI. TBI rat model was prepared by the electric Cortical Contusion Impactor (eCCI) device. …”
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ATF4-mediated expression of NOXA is critical for necroptosis driven by glucose deprivation by Sasiprapa Sonkaew, Sasiprapa Sonkaew, Ruwaida Rajna, Yeon-Ji Park, Jiong Yan, Zhaoshan Liu, Siriporn Jitkaew, Zheng-Gang Liu, Swati Choksi

“…These results provide insights into the regulatory mechanisms underlying Noxa dynamics during GD treatment and highlights its potential as a therapeutic target in cancer therapy and necroptosis-related diseases.…”
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Limb Regeneration in Axolotl: Is It Superhealing? by Stéphane Roy, Mathieu Lévesque

“…A better understanding of these animals' regenerative capacity could lead to major benefits by providing regenerative medicine with directions on how to develop therapeutic approaches leading to regeneration in humans.…”
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Acute Ascending Thrombosis of Abdominal and Suprarenal Aorta by Alessandro Robaldo, Stefano Pagliari, Patrizio Colotto

“…We report the diagnostic and successful therapeutic images of an acute occlusion of the abdominal and suprarenal aorta. …”
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Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery by Fanda Meng, Xinyu Qiao, Chenglong Xin, Xiaoli Ju, Meilin He

“…Long-acting polymeric MNs can reduce administration frequency to improve patient compliance and therapeutic outcomes, especially in the management of chronic diseases. …”
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The Application of Mechanical Stimulations in Tendon Tissue Engineering by Renwang Sheng, Yujie Jiang, Ludvig J. Backman, Wei Zhang, Jialin Chen

“…The current treatment methods have many limitations, such as poor therapeutic effects, functional loss of donor site, and immune rejection. …”
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Neuropathic Pain in Animal Models of Nervous System Autoimmune Diseases by David H. Tian, Chamini J. Perera, Gila Moalem-Taylor

“…This review examines the symptoms, mechanisms, and clinical therapeutic options in these conditions and highlights the value of EAE and EAN animal models for the study of neuropathic pain in MS and GBS.…”
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Advances in the application of multi-omics and machine learning technologies in sepsis research by Chen Pengpeng, Yang Jie, Jin Xinhao, Zhang Bo, Yang Suibi, Hong Yucai, Ni Hongying, Zhang Zhongheng

“…The personalized adjustments of traditional treatments, such as corticosteroids, fluid management, and antibiotics, along with the application of traditional Chinese medicine and ulinastatin in multi-omics studies, have expanded the therapeutic options for sepsis. Chinese Multi-omics Advances in Sepsis (CMAISE) integrates multi-omics data, including genomics, proteomics, and metabolomics, to explore the molecular mechanisms and biomarkers of sepsis. …”
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Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome by Saba Nayar, Jason D. Turner, Saba Asam, Eanna Fennell, Matthew Pugh, Serena Colafrancesco, Onorina Berardicurti, Charlotte G. Smith, Joe Flint, Ana Teodosio, Valentina Iannizzotto, David H. Gardner, Joel van Roon, Ilya Korsunsky, Dawn Howdle, Roche Fibroblast Network Consortium, Andreas P. Frei, Kara G. Lassen, Simon J. Bowman, Wan-Fai Ng, Adam P. Croft, Andrew Filer, Benjamin A. Fisher, Christopher D. Buckley, Francesca Barone

“…The identification of cellular properties associated with these structures and the molecular and functional interactions identified by this analysis may provide key therapeutic cues for tertiary lymphoid structures associated conditions in autoimmunity and cancer.…”
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Metabolic stability and its role in the discovery of new chemical entities by Słoczyńska Karolina, Gunia-Krzyżak Agnieszka, Koczurkiewicz Paulina, Wójcik-Pszczoła Katarzyna, Żelaszczyk Dorota, Popiół Justyna, Pękala Elżbieta

“…Determination of metabolic profiles of new chemical entities is a key step in the process of drug discovery, since it influences pharmacokinetic characteristics of therapeutic compounds. One of the main challenges of medicinal chemistry is not only to design compounds demonstrating beneficial activity, but also molecules exhibiting favourable pharmacokinetic parameters. …”
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Surgical Management of Calciphylaxis Associated with Primary Hyperparathyroidism: A Case Report and Review of the Literature by Jennifer Bishop, Eric Brown, Augusto Podesta, Cathrine Troy, Xiang (Eric) Dong

“…Currently, there have been sixteen cases described in the English literature, with only nine being offered a potentially therapeutic parathyroidectomy. It is contingent upon the vigilant physician to diagnose and properly manage this difficult yet treatable condition.…”
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Radiomics in rectal cancer: current status of use and advances in research by Wei-Qin Huang, Ruo-Xuan Lin, Xiao-Hui Ke, Xiao-Hong Deng, Shi-Xiong Ni, Lina Tang

“…In light of the advances made in therapeutic approaches such as neoadjuvant therapy and total mesorectal excision, precise preoperative assessment has become crucial for developing a personalized treatment plan. …”
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Targeting RNA splicing modulation: new perspectives for anticancer strategy? by Xuemei Lv, Xiaoyu Sun, Yang Gao, Xinyue Song, Xiaoyun Hu, Lang Gong, Li Han, Miao He, Minjie Wei

“…Therefore, identifying cancer-specific subtypes from aberrant processing offers new opportunities for therapeutic development. Numerous splicing modulators, each utilizing different mechanisms, have been developed as promising anticancer therapies, some of which are in clinical trials. …”
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Mirtazapine Treatment of a Severe Depressive Episode and Resolution of Elevated Inflammatory Markers by Shahzad M. Alikhan, Jessica A. Lee, Luiz Dratcu

“…Effects on immune system activity have also recently been observed in correlation with therapeutic response to mirtazapine in cardiac patients with depression, but no study has yet examined these effects in otherwise physically healthy depressed patients treated with mirtazapine. …”
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Challenges and Controversies in Human Mesenchymal Stem Cell Therapy by Barbara Lukomska, Luiza Stanaszek, Ewa Zuba-Surma, Pawel Legosz, Sylwia Sarzynska, Katarzyna Drela

“…On the other hand, most results of MSC administration in vivo have confirmed their safety and showed promising beneficial outcomes. However, the therapeutic effects of MSC-based treatment are still not spectacular and there is a potential risk related to MSC applications into specific cell niche that should be considered in long-term observations and follow-up outcomes. …”
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An Overview of the Impact of Statin Therapy on Cardiac Incident Risk by Urszula Świrk, Aleksandra Paprocka, Karolina Kalinowska, Paulina Fijałek, Jan Karczmarz, Marika Gutowska, Agnieszka Kosińska, Wiktoria Belcarz, Joanna Orzechowska, Michał Orzechowski

“…Patient adherence remains a critical factor in maximizing the therapeutic benefits of statin therapy.   …”
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Confirmatory identification and antibiotics resistance profiling of Pseudomonas aeruginosa: a laboratory-based study by Hafsa Abdulhamid Abdulsalam

“…The observed resistance to Imipenem underscores ongoing challenges in treating Pseudomonas aeruginosa infections, emphasizing the need for alternative therapeutic options such as phage therapy.  …”
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Curcumin as a Supportive Therapy in Type 2 Diabetic Patients by Anand Seth, Sravya Iyyuni, Saurabh Sharma, Ritu Sethi, Suresh Nath, Michael Imeokparia

“…However, the low bioavailability poses limitations to its therapeutic potential. In this paper, we discuss the benefits of curcumin in a healthy diet, its potential and limitations as a supportive therapy. …”
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Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney Disease by M. O. Pyatchenkov, A. A. Vlasov, E. V. Sherbakov, S. P. Salikova

“…MDUT are one of the key modulators of the pathogenetic relationship between the gut and kidneys. Therapeutic manipulations with intestinal microbiota can be considered a promising strategy for preventing complications associated with uremia.…”
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